A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study

Publication Date:
2018-02-09
Publisher:
BMJ Publishing
Electronic ISSN:
2044-6055
Topics:
Medicine
Keywords:
Open access, Oncology
Published by:
http://group.bmj.com/
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autor Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
beschreibung Objectives The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass Setting DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites. Participants Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET/CT. PET/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria. Primary and secondary outcome measures Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass. Results The sensitivity and specificity of PET/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%). Conclusions The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.
citation_standardnr 6159510
datenlieferant ipn_articles
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feed_publisher_url http://group.bmj.com/
insertion_date 2018-02-09
journaleissn 2044-6055
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher BMJ Publishing
quelle BMJ Open
relation http://bmjopen.bmj.com/cgi/content/short/8/2/e019471?rss=1
schlagwort Open access, Oncology
search_space articles
shingle_author_1 Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
shingle_author_2 Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
shingle_author_3 Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
shingle_author_4 Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
shingle_catch_all_1 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
Open access, Oncology
Objectives The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass Setting DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites. Participants Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET/CT. PET/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria. Primary and secondary outcome measures Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass. Results The sensitivity and specificity of PET/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%). Conclusions The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.
Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
BMJ Publishing
2044-6055
20446055
shingle_catch_all_2 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
Open access, Oncology
Objectives The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass Setting DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites. Participants Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET/CT. PET/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria. Primary and secondary outcome measures Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass. Results The sensitivity and specificity of PET/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%). Conclusions The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.
Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
BMJ Publishing
2044-6055
20446055
shingle_catch_all_3 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
Open access, Oncology
Objectives The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass Setting DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites. Participants Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET/CT. PET/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria. Primary and secondary outcome measures Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass. Results The sensitivity and specificity of PET/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%). Conclusions The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.
Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
BMJ Publishing
2044-6055
20446055
shingle_catch_all_4 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
Open access, Oncology
Objectives The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass Setting DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites. Participants Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET/CT. PET/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria. Primary and secondary outcome measures Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass. Results The sensitivity and specificity of PET/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%). Conclusions The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.
Proli, C., De Sousa, P., Jordan, S., Anikin, V., Devaraj, A., Love, S. M., Shackcloth, M., Kostoulas, N., Papagiannopoulos, K., Haqzad, Y., Loubani, M., Sellitri, F., Granato, F., Bush, A., Marchbank, A., Iyer, S., Scarci, M., Lim, E., on behalf of the UK Thoracic Surgery Research Collaborative
BMJ Publishing
2044-6055
20446055
shingle_title_1 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
shingle_title_2 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
shingle_title_3 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
shingle_title_4 A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
timestamp 2025-06-30T23:32:35.934Z
titel A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
titel_suche A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (18FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study
topic WW-YZ
uid ipn_articles_6159510