Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice
Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f.
American Society of Hematology (ASH)
Published 2018
American Society of Hematology (ASH)
Published 2018
| Publication Date: |
2018-02-03
|
|---|---|
| Publisher: |
American Society of Hematology (ASH)
|
| Print ISSN: |
0006-4971
|
| Electronic ISSN: |
1528-0020
|
| Topics: |
Biology
Medicine
|
| Keywords: |
Thrombosis and Hemostasis
|
| Published by: |
| _version_ | 1836398773038743553 |
|---|---|
| autor | Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. |
| beschreibung | Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival. It achieved these protective effects by enhancing the clearance of circulating microvesicles through phosphatidylserine-mediated phagocytosis. Together, these results identify the scavenging system for apoptotic cells as a potential therapeutic target to prevent TBI-induced coagulopathy and improve the outcome of TBI. |
| citation_standardnr | 6152984 |
| datenlieferant | ipn_articles |
| feed_id | 310 |
| feed_publisher | American Society of Hematology (ASH) |
| feed_publisher_url | http://www.hematology.org/ |
| insertion_date | 2018-02-03 |
| journaleissn | 1528-0020 |
| journalissn | 0006-4971 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | American Society of Hematology (ASH) |
| quelle | Blood |
| relation | http://www.bloodjournal.org/cgi/content/short/131/5/563?rss=1 |
| schlagwort | Thrombosis and Hemostasis |
| search_space | articles |
| shingle_author_1 | Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. |
| shingle_author_2 | Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. |
| shingle_author_3 | Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. |
| shingle_author_4 | Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. |
| shingle_catch_all_1 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice Thrombosis and Hemostasis Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival. It achieved these protective effects by enhancing the clearance of circulating microvesicles through phosphatidylserine-mediated phagocytosis. Together, these results identify the scavenging system for apoptotic cells as a potential therapeutic target to prevent TBI-induced coagulopathy and improve the outcome of TBI. Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_2 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice Thrombosis and Hemostasis Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival. It achieved these protective effects by enhancing the clearance of circulating microvesicles through phosphatidylserine-mediated phagocytosis. Together, these results identify the scavenging system for apoptotic cells as a potential therapeutic target to prevent TBI-induced coagulopathy and improve the outcome of TBI. Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_3 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice Thrombosis and Hemostasis Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival. It achieved these protective effects by enhancing the clearance of circulating microvesicles through phosphatidylserine-mediated phagocytosis. Together, these results identify the scavenging system for apoptotic cells as a potential therapeutic target to prevent TBI-induced coagulopathy and improve the outcome of TBI. Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_4 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice Thrombosis and Hemostasis Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival. It achieved these protective effects by enhancing the clearance of circulating microvesicles through phosphatidylserine-mediated phagocytosis. Together, these results identify the scavenging system for apoptotic cells as a potential therapeutic target to prevent TBI-induced coagulopathy and improve the outcome of TBI. Zhou, Y., Cai, W., Zhao, Z., Hilton, T., Wang, M., Yeon, J., Liu, W., Zhang, F., Shi, F.-D., Wu, X., Thiagarajan, P., Li, M., Zhang, J., Dong, J.-f. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_title_1 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| shingle_title_2 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| shingle_title_3 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| shingle_title_4 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| timestamp | 2025-06-30T23:32:24.352Z |
| titel | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| titel_suche | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice |
| topic | W WW-YZ |
| uid | ipn_articles_6152984 |