Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Publication Date:
2018-02-02
Publisher:
Nature Publishing Group (NPG)
Electronic ISSN:
2041-1723
Topics:
Biology
Chemistry and Pharmacology
Natural Sciences in General
Physics
Published by:
http://www.nature.com/
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autor Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
beschreibung Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Published online: 01 February 2018; doi:10.1038/s41467-018-02912-x Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
citation_standardnr 6152386
datenlieferant ipn_articles
feed_id 134647
feed_publisher Nature Publishing Group (NPG)
feed_publisher_url http://www.nature.com/
insertion_date 2018-02-02
journaleissn 2041-1723
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Nature Publishing Group (NPG)
quelle Nature Communications
relation http://feeds.nature.com/~r/ncomms/rss/current/~3/MJQq7SSK0cA/s41467-018-02912-x
search_space articles
shingle_author_1 Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
shingle_author_2 Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
shingle_author_3 Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
shingle_author_4 Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
shingle_catch_all_1 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Published online: 01 February 2018; doi:10.1038/s41467-018-02912-x Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_2 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Published online: 01 February 2018; doi:10.1038/s41467-018-02912-x Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_3 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Published online: 01 February 2018; doi:10.1038/s41467-018-02912-x Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_4 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Published online: 01 February 2018; doi:10.1038/s41467-018-02912-x Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
Chungyong Han; Su-Jung Sim; Seon-Hee Kim; Rohit Singh; Sunhee Hwang; Yu I. Kim; Sang H. Park; Kwang H. Kim; Don G. Lee; Ho S. Oh; Sangeun Lee; Young H. Kim; Beom K. Choi; Byoung S. Kwon
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_title_1 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
shingle_title_2 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
shingle_title_3 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
shingle_title_4 Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
timestamp 2025-06-30T23:32:23.828Z
titel Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
titel_suche Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
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