Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]

Publication Date:
2018-01-17
Publisher:
The American Society for Microbiology (ASM)
Print ISSN:
0270-7306
Electronic ISSN:
1098-5549
Topics:
Biology
Medicine
Published by:
http://www.asm.org/
_version_ 1836398752168935426
autor Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
beschreibung Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a 〉2-fold elevation of pancreatic HuR expression. Histologically, HuR-overexpressing pancreas displays a fibroinflammatory response and other pathological features characteristic of chronic pancreatitis. This pathology is reflected in changes in the pancreatic gene expression profile due, in part, to genes whose expression changes as a consequence of direct binding of their respective mRNAs to HuR. Older mice develop pancreatic steatosis and severe glucose intolerance. Elevated HuR cooperated with mutant K-ras G12D to result in a 3.4-fold increase in pancreatic ductal adenocarcinoma (PDAC) incidence compared to PDAC presence in K-ras G12D alone. These findings implicate HuR as a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation, and a novel therapeutic target for pancreatitis treatment.
citation_standardnr 6140292
datenlieferant ipn_articles
feed_id 2374
feed_publisher The American Society for Microbiology (ASM)
feed_publisher_url http://www.asm.org/
insertion_date 2018-01-17
journaleissn 1098-5549
journalissn 0270-7306
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Society for Microbiology (ASM)
quelle Molecular and Cellular Biology
relation http://mcb.asm.org/cgi/content/short/38/3/e00427-17?rss=1
search_space articles
shingle_author_1 Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
shingle_author_2 Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
shingle_author_3 Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
shingle_author_4 Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
shingle_catch_all_1 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Histologically, HuR-overexpressing pancreas displays a fibroinflammatory response and other pathological features characteristic of chronic pancreatitis. This pathology is reflected in changes in the pancreatic gene expression profile due, in part, to genes whose expression changes as a consequence of direct binding of their respective mRNAs to HuR. Older mice develop pancreatic steatosis and severe glucose intolerance. Elevated HuR cooperated with mutant K-ras G12D to result in a 3.4-fold increase in pancreatic ductal adenocarcinoma (PDAC) incidence compared to PDAC presence in K-ras G12D alone. These findings implicate HuR as a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation, and a novel therapeutic target for pancreatitis treatment.
Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
The American Society for Microbiology (ASM)
0270-7306
02707306
1098-5549
10985549
shingle_catch_all_2 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Histologically, HuR-overexpressing pancreas displays a fibroinflammatory response and other pathological features characteristic of chronic pancreatitis. This pathology is reflected in changes in the pancreatic gene expression profile due, in part, to genes whose expression changes as a consequence of direct binding of their respective mRNAs to HuR. Older mice develop pancreatic steatosis and severe glucose intolerance. Elevated HuR cooperated with mutant K-ras G12D to result in a 3.4-fold increase in pancreatic ductal adenocarcinoma (PDAC) incidence compared to PDAC presence in K-ras G12D alone. These findings implicate HuR as a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation, and a novel therapeutic target for pancreatitis treatment.
Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
The American Society for Microbiology (ASM)
0270-7306
02707306
1098-5549
10985549
shingle_catch_all_3 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Histologically, HuR-overexpressing pancreas displays a fibroinflammatory response and other pathological features characteristic of chronic pancreatitis. This pathology is reflected in changes in the pancreatic gene expression profile due, in part, to genes whose expression changes as a consequence of direct binding of their respective mRNAs to HuR. Older mice develop pancreatic steatosis and severe glucose intolerance. Elevated HuR cooperated with mutant K-ras G12D to result in a 3.4-fold increase in pancreatic ductal adenocarcinoma (PDAC) incidence compared to PDAC presence in K-ras G12D alone. These findings implicate HuR as a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation, and a novel therapeutic target for pancreatitis treatment.
Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
The American Society for Microbiology (ASM)
0270-7306
02707306
1098-5549
10985549
shingle_catch_all_4 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
Human antigen R (ELAVL1; HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes posttranscriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Histologically, HuR-overexpressing pancreas displays a fibroinflammatory response and other pathological features characteristic of chronic pancreatitis. This pathology is reflected in changes in the pancreatic gene expression profile due, in part, to genes whose expression changes as a consequence of direct binding of their respective mRNAs to HuR. Older mice develop pancreatic steatosis and severe glucose intolerance. Elevated HuR cooperated with mutant K-ras G12D to result in a 3.4-fold increase in pancreatic ductal adenocarcinoma (PDAC) incidence compared to PDAC presence in K-ras G12D alone. These findings implicate HuR as a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation, and a novel therapeutic target for pancreatitis treatment.
Peng, W., Furuuchi, N., Aslanukova, L., Huang, Y.-H., Brown, S. Z., Jiang, W., Addya, S., Vishwakarma, V., Peters, E., Brody, J. R., Dixon, D. A., Sawicki, J. A.
The American Society for Microbiology (ASM)
0270-7306
02707306
1098-5549
10985549
shingle_title_1 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
shingle_title_2 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
shingle_title_3 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
shingle_title_4 Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
timestamp 2025-06-30T23:32:04.178Z
titel Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
titel_suche Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development [Research Article]
topic W
WW-YZ
uid ipn_articles_6140292