The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

Publication Date:
2018-01-10
Publisher:
Nature Publishing Group (NPG)
Electronic ISSN:
2041-1723
Topics:
Biology
Chemistry and Pharmacology
Natural Sciences in General
Physics
Published by:
http://www.nature.com/
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autor Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
beschreibung The evolution of substrate discrimination in macrolide antibiotic resistance enzymes The evolution of substrate discrimination in macrolide antibiotic resistance enzymes, Published online: 09 January 2018; doi:10.1038/s41467-017-02680-0 New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
citation_standardnr 6135384
datenlieferant ipn_articles
feed_id 134647
feed_publisher Nature Publishing Group (NPG)
feed_publisher_url http://www.nature.com/
insertion_date 2018-01-10
journaleissn 2041-1723
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Nature Publishing Group (NPG)
quelle Nature Communications
relation http://feeds.nature.com/~r/ncomms/rss/current/~3/AHzRPSddE-Q/s41467-017-02680-0
search_space articles
shingle_author_1 Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
shingle_author_2 Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
shingle_author_3 Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
shingle_author_4 Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
shingle_catch_all_1 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes The evolution of substrate discrimination in macrolide antibiotic resistance enzymes, Published online: 09 January 2018; doi:10.1038/s41467-017-02680-0 New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_2 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes The evolution of substrate discrimination in macrolide antibiotic resistance enzymes, Published online: 09 January 2018; doi:10.1038/s41467-017-02680-0 New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_3 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes The evolution of substrate discrimination in macrolide antibiotic resistance enzymes, Published online: 09 January 2018; doi:10.1038/s41467-017-02680-0 New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_4 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes The evolution of substrate discrimination in macrolide antibiotic resistance enzymes, Published online: 09 January 2018; doi:10.1038/s41467-017-02680-0 New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
Andrew C. Pawlowski; Peter J. Stogios; Kalinka Koteva; Tatiana Skarina; Elena Evdokimova; Alexei Savchenko; Gerard D. Wright
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_title_1 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
shingle_title_2 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
shingle_title_3 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
shingle_title_4 The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
timestamp 2025-06-30T23:31:56.498Z
titel The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
titel_suche The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
topic W
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TA-TD
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uid ipn_articles_6135384