Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

Publication Date:
2018-01-05
Publisher:
American Association for the Advancement of Science (AAAS)
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
Chemistry and Pharmacology
Geosciences
Computer Science
Medicine
Natural Sciences in General
Physics
Keywords:
Genetics, Immunology
Published by:
http://www.aaas.org/
_version_ 1836398735172567040
autor Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
beschreibung The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A–derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease.
citation_standardnr 6130876
datenlieferant ipn_articles
feed_id 25
feed_publisher American Association for the Advancement of Science (AAAS)
feed_publisher_url http://www.aaas.org/
insertion_date 2018-01-05
journaleissn 1095-9203
journalissn 0036-8075
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Association for the Advancement of Science (AAAS)
quelle Science
relation http://science.sciencemag.org/cgi/content/short/359/6371/86?rss=1
schlagwort Genetics, Immunology
search_space articles
shingle_author_1 Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
shingle_author_2 Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
shingle_author_3 Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
shingle_author_4 Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
shingle_catch_all_1 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Genetics, Immunology
The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A–derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease.
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
American Association for the Advancement of Science (AAAS)
0036-8075
00368075
1095-9203
10959203
shingle_catch_all_2 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Genetics, Immunology
The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A–derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease.
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
American Association for the Advancement of Science (AAAS)
0036-8075
00368075
1095-9203
10959203
shingle_catch_all_3 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Genetics, Immunology
The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A–derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease.
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
American Association for the Advancement of Science (AAAS)
0036-8075
00368075
1095-9203
10959203
shingle_catch_all_4 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Genetics, Immunology
The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A–derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease.
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
American Association for the Advancement of Science (AAAS)
0036-8075
00368075
1095-9203
10959203
shingle_title_1 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
shingle_title_2 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
shingle_title_3 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
shingle_title_4 Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
timestamp 2025-06-30T23:31:48.376Z
titel Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
titel_suche Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
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uid ipn_articles_6130876