STAT4 and T-bet control follicular helper T cell development in viral infections

Publication Date:
2018-01-03
Publisher:
Rockefeller University Press
Print ISSN:
0022-1007
Electronic ISSN:
1540-9538
Topics:
Medicine
Published by:
_version_ 1836398729020571648
autor Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
beschreibung Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge.
citation_standardnr 6127777
datenlieferant ipn_articles
feed_id 96
feed_publisher Rockefeller University Press
feed_publisher_url http://www.rupress.org/
insertion_date 2018-01-03
journaleissn 1540-9538
journalissn 0022-1007
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Rockefeller University Press
quelle Journal of Experimental Medicine
relation http://jem.rupress.org/cgi/content/short/215/1/337?rss=1
search_space articles
shingle_author_1 Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
shingle_author_2 Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
shingle_author_3 Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
shingle_author_4 Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
shingle_catch_all_1 STAT4 and T-bet control follicular helper T cell development in viral infections
Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge.
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_2 STAT4 and T-bet control follicular helper T cell development in viral infections
Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge.
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_3 STAT4 and T-bet control follicular helper T cell development in viral infections
Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge.
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_4 STAT4 and T-bet control follicular helper T cell development in viral infections
Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge.
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_title_1 STAT4 and T-bet control follicular helper T cell development in viral infections
shingle_title_2 STAT4 and T-bet control follicular helper T cell development in viral infections
shingle_title_3 STAT4 and T-bet control follicular helper T cell development in viral infections
shingle_title_4 STAT4 and T-bet control follicular helper T cell development in viral infections
timestamp 2025-06-30T23:31:42.268Z
titel STAT4 and T-bet control follicular helper T cell development in viral infections
titel_suche STAT4 and T-bet control follicular helper T cell development in viral infections
topic WW-YZ
uid ipn_articles_6127777