STAT4 and T-bet control follicular helper T cell development in viral infections
Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J.
Rockefeller University Press
Published 2018
Rockefeller University Press
Published 2018
| Publication Date: |
2018-01-03
|
|---|---|
| Publisher: |
Rockefeller University Press
|
| Print ISSN: |
0022-1007
|
| Electronic ISSN: |
1540-9538
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398729020571648 |
|---|---|
| autor | Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. |
| beschreibung | Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge. |
| citation_standardnr | 6127777 |
| datenlieferant | ipn_articles |
| feed_id | 96 |
| feed_publisher | Rockefeller University Press |
| feed_publisher_url | http://www.rupress.org/ |
| insertion_date | 2018-01-03 |
| journaleissn | 1540-9538 |
| journalissn | 0022-1007 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Rockefeller University Press |
| quelle | Journal of Experimental Medicine |
| relation | http://jem.rupress.org/cgi/content/short/215/1/337?rss=1 |
| search_space | articles |
| shingle_author_1 | Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. |
| shingle_author_2 | Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. |
| shingle_author_3 | Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. |
| shingle_author_4 | Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. |
| shingle_catch_all_1 | STAT4 and T-bet control follicular helper T cell development in viral infections Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge. Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_2 | STAT4 and T-bet control follicular helper T cell development in viral infections Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge. Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_3 | STAT4 and T-bet control follicular helper T cell development in viral infections Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge. Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_4 | STAT4 and T-bet control follicular helper T cell development in viral infections Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-. IL-21 and IFN- are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN- and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN- production and for promotion of the GC response after acute viral challenge. Weinstein, J. S., Laidlaw, B. J., Lu, Y., Wang, J. K., Schulz, V. P., Li, N., Herman, E. I., Kaech, S. M., Gallagher, P. G., Craft, J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_title_1 | STAT4 and T-bet control follicular helper T cell development in viral infections |
| shingle_title_2 | STAT4 and T-bet control follicular helper T cell development in viral infections |
| shingle_title_3 | STAT4 and T-bet control follicular helper T cell development in viral infections |
| shingle_title_4 | STAT4 and T-bet control follicular helper T cell development in viral infections |
| timestamp | 2025-06-30T23:31:42.268Z |
| titel | STAT4 and T-bet control follicular helper T cell development in viral infections |
| titel_suche | STAT4 and T-bet control follicular helper T cell development in viral infections |
| topic | WW-YZ |
| uid | ipn_articles_6127777 |