Search Results - (Author, Cooperation:Z. Storchova)
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1DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-linksM. Raschle ; G. Smeenk ; R. K. Hansen ; T. Temu ; Y. Oka ; M. Y. Hein ; N. Nagaraj ; D. T. Long ; J. C. Walter ; K. Hofmann ; Z. Storchova ; J. Cox ; S. Bekker-Jensen ; N. Mailand ; M. Mann
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-05-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chromatin/chemistry/metabolism ; *DNA Damage ; *DNA Repair ; DNA Repair Enzymes/*metabolism ; *DNA Replication ; DNA-Binding Proteins/metabolism ; Mass Spectrometry/methods ; Proteomics/methods ; RNA-Binding Proteins/metabolism ; XenopusPublished by: -
2Staff View
Publication Date: 2018-12-04Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyKeywords: Chromosome Dynamics and Nuclear ArchitecturePublished by: -
3Staff View
ISSN: 1617-4623Keywords: Key words Adaptive mutation ; DNA repair ; Saccharomyces cerevisiae ; Starvation ; RAD6Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract The accumulation of Ade+ revertants during adenine starvation and Trp+ revertants during tryptophan starvation in haploid polyauxotrophic strains of Saccharomyces cerevisiae occurs in a time-dependent manner. Accumulation of revertants is enhanced in Rad6− strains, suggesting that starvation-induced reversion is influenced by some of the RAD6 gene functions. The higher frequency of adaptive reversions in Rad6− strains is somewhat influenced by, but does not totally depend on, the genetic background. Therefore, the RAD6 gene product is involved in maintaining a low level not only of spontaneous mutation but also of starvation-induced reversion. The starvation-induced Ade+ and Trp+ reversions both appear to be adaptive. The analysis of growth characteristics and the genotype of revertants shows a difference between early and late-appearing revertants. These results support the hypothesis that the adaptivity of starvation-induced reversion is based on the selective fixation of random mutations, and particularly on transcription-enhanced repair and/or mutagenesis processes.Type of Medium: Electronic ResourceURL: