Search Results - (Author, Cooperation:Z. Storchova)

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  1. 1
    M. Raschle ; G. Smeenk ; R. K. Hansen ; T. Temu ; Y. Oka ; M. Y. Hein ; N. Nagaraj ; D. T. Long ; J. C. Walter ; K. Hofmann ; Z. Storchova ; J. Cox ; S. Bekker-Jensen ; N. Mailand ; M. Mann
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-05-02
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Chromatin/chemistry/metabolism ; *DNA Damage ; *DNA Repair ; DNA Repair Enzymes/*metabolism ; *DNA Replication ; DNA-Binding Proteins/metabolism ; Mass Spectrometry/methods ; Proteomics/methods ; RNA-Binding Proteins/metabolism ; Xenopus
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Storchova, Z.
    Cold Spring Harbor Laboratory Press
    Published 2018
    Staff View
    Publication Date:
    2018-12-04
    Publisher:
    Cold Spring Harbor Laboratory Press
    Print ISSN:
    0890-9369
    Topics:
    Biology
    Keywords:
    Chromosome Dynamics and Nuclear Architecture
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1617-4623
    Keywords:
    Key words Adaptive mutation ; DNA repair ; Saccharomyces cerevisiae ; Starvation ; RAD6
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract The accumulation of Ade+ revertants during adenine starvation and Trp+ revertants during tryptophan starvation in haploid polyauxotrophic strains of Saccharomyces cerevisiae occurs in a time-dependent manner. Accumulation of revertants is enhanced in Rad6− strains, suggesting that starvation-induced reversion is influenced by some of the RAD6 gene functions. The higher frequency of adaptive reversions in Rad6− strains is somewhat influenced by, but does not totally depend on, the genetic background. Therefore, the RAD6 gene product is involved in maintaining a low level not only of spontaneous mutation but also of starvation-induced reversion. The starvation-induced Ade+ and Trp+ reversions both appear to be adaptive. The analysis of growth characteristics and the genotype of revertants shows a difference between early and late-appearing revertants. These results support the hypothesis that the adaptivity of starvation-induced reversion is based on the selective fixation of random mutations, and particularly on transcription-enhanced repair and/or mutagenesis processes.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses