Search Results - (Author, Cooperation:Z. Harris)
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1Latest Papers from Table of Contents or Articles in PressOnuchic, V., Lurie, E., Carrero, I., Pawliczek, P., Patel, R. Y., Rozowsky, J., Galeev, T., Huang, Z., Altshuler, R. C., Zhang, Z., Harris, R. A., Coarfa, C., Ashmore, L., Bertol, J. W., Fakhouri, W. D., Yu, F., Kellis, M., Gerstein, M., Milosavljevic, A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Online OnlyPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. F. Mackay ; S. Richards ; E. A. Stone ; A. Barbadilla ; J. F. Ayroles ; D. Zhu ; S. Casillas ; Y. Han ; M. M. Magwire ; J. M. Cridland ; M. F. Richardson ; R. R. Anholt ; M. Barron ; C. Bess ; K. P. Blankenburg ; M. A. Carbone ; D. Castellano ; L. Chaboub ; L. Duncan ; Z. Harris ; M. Javaid ; J. C. Jayaseelan ; S. N. Jhangiani ; K. W. Jordan ; F. Lara ; F. Lawrence ; S. L. Lee ; P. Librado ; R. S. Linheiro ; R. F. Lyman ; A. J. Mackey ; M. Munidasa ; D. M. Muzny ; L. Nazareth ; I. Newsham ; L. Perales ; L. L. Pu ; C. Qu ; M. Ramia ; J. G. Reid ; S. M. Rollmann ; J. Rozas ; N. Saada ; L. Turlapati ; K. C. Worley ; Y. Q. Wu ; A. Yamamoto ; Y. Zhu ; C. M. Bergman ; K. R. Thornton ; D. Mittelman ; R. A. Gibbs
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Centromere/genetics ; Chromosomes, Insect/genetics ; Drosophila melanogaster/*genetics ; *Genome-Wide Association Study ; *Genomics ; Genotype ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Selection, Genetic/genetics ; Starvation/genetics ; Telomere/genetics ; X Chromosome/geneticsPublished by: -
3Articles: DFG German National LicensesChamnongpol, Sangpen ; Dodson, Walter ; Cromie, Michael J. ; Harris, Z. Leah ; Groisman, Eduardo A.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Because it can undergo reversible changes in oxidation state, iron is an excellent biocatalyst but also a potentially deleterious metal. Iron-mediated toxicity has been ascribed to Fe(II), which reacts with oxygen to generate free radicals that damage macromolecules and cause cell death. However, we now report that Fe(III) exhibits microbicidal activity towards strains of Salmonella enterica, Escherichia coli and Klebsiella pneumoniae defective in the Fe(III)-responding PmrA/PmrB signal transduction system. Fe(III) bound to a pmrA Salmonella mutant more effectively than to the isogenic wild-type strain and exerted its microbicidal activity even under anaerobic conditions. Moreover, Fe(III) permeabilized the outer membrane of the pmrA mutant, rendering it susceptible to vancomycin, which is normally non-toxic to Gram-negative species. On the other hand, Fe(III) did not affect the viability of a mutant defective in Fur, the major regulator of cytosolic iron homeostasis, which is hypersensitive to Fe(II)-mediated toxicity. A functional pmrA gene was necessary for bacterial survival in soil. Our results indicate that Fe(III) exerts its microbicidal activity by a mechanism that is oxygen independent and different from that mediated by Fe(II).Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0149-7189Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologySociologyType of Medium: Electronic ResourceURL: