Search Results - (Author, Cooperation:Y. Uchiyama)

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  1. 1
    M. Ackermann ; M. Ajello ; A. Allafort ; L. Baldini ; J. Ballet ; G. Barbiellini ; M. G. Baring ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; E. Bottacini ; T. J. Brandt ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; G. Busetto ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; J. M. Casandjian ; C. Cecchi ; O. Celik ; E. Charles ; S. Chaty ; R. C. Chaves ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; G. Chiaro ; A. N. Cillis ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; L. R. Cominsky ; J. Conrad ; S. Corbel ; S. Cutini ; F. D'Ammando ; A. de Angelis ; F. de Palma ; C. D. Dermer ; E. do Couto e Silva ; P. S. Drell ; A. Drlica-Wagner ; L. Falletti ; C. Favuzzi ; E. C. Ferrara ; A. Franckowiak ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; S. Germani ; N. Giglietto ; P. Giommi ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; M. H. Grondin ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; K. Hayashi ; E. Hays ; J. W. Hewitt ; A. B. Hill ; R. E. Hughes ; M. S. Jackson ; T. Jogler ; G. Johannesson ; A. S. Johnson ; T. Kamae ; J. Kataoka ; J. Katsuta ; J. Knodlseder ; M. Kuss ; J. Lande ; S. Larsson ; L. Latronico ; M. Lemoine-Goumard ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; G. M. Madejski ; F. Massaro ; M. Mayer ; M. N. Mazziotta ; J. E. McEnery ; J. Mehault ; P. F. Michelson ; R. P. Mignani ; W. Mitthumsiri ; T. Mizuno ; A. A. Moiseev ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; R. Nemmen ; E. Nuss ; M. Ohno ; T. Ohsugi ; N. Omodei ; M. Orienti ; E. Orlando ; J. F. Ormes ; D. Paneque ; J. S. Perkins ; M. Pesce-Rollins ; F. Piron ; G. Pivato ; S. Raino ; R. Rando ; M. Razzano ; S. Razzaque ; A. Reimer ; O. Reimer ; S. Ritz ; C. Romoli ; M. Sanchez-Conde ; A. Schulz ; C. Sgro ; P. E. Simeon ; E. J. Siskind ; D. A. Smith ; G. Spandre ; P. Spinelli ; F. W. Stecker ; A. W. Strong ; D. J. Suson ; H. Tajima ; H. Takahashi ; T. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; S. E. Thorsett ; L. Tibaldo ; O. Tibolla ; M. Tinivella ; E. Troja ; Y. Uchiyama ; T. L. Usher ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; A. P. Waite ; M. Werner ; B. L. Winer ; K. S. Wood ; M. Wood ; R. Yamazaki ; Z. Yang ; S. Zimmer
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-02-16
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    L. A. T. C. Fermi ; M. Ackermann ; M. Ajello ; J. Ballet ; G. Barbiellini ; D. Bastieri ; A. Belfiore ; R. Bellazzini ; B. Berenji ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; E. Cavazzuti ; C. Cecchi ; O. Celik ; E. Charles ; S. Chaty ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; S. Corbel ; R. H. Corbet ; S. Cutini ; A. de Luca ; P. R. den Hartog ; F. de Palma ; C. D. Dermer ; S. W. Digel ; E. do Couto e Silva ; D. Donato ; P. S. Drell ; A. Drlica-Wagner ; R. Dubois ; G. Dubus ; C. Favuzzi ; S. J. Fegan ; E. C. Ferrara ; W. B. Focke ; P. Fortin ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; D. Gasparrini ; N. Gehrels ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; E. Hays ; A. B. Hill ; R. E. Hughes ; G. Johannesson ; A. S. Johnson ; T. J. Johnson ; T. Kamae ; H. Katagiri ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; M. N. Mazziotta ; J. E. McEnery ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; C. Monte ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; M. Naumann-Godo ; J. P. Norris ; E. Nuss ; M. Ohno ; T. Ohsugi ; A. Okumura ; N. Omodei ; E. Orlando ; M. Ozaki ; D. Paneque ; D. Parent ; M. Pesce-Rollins ; M. Pierbattista ; F. Piron ; G. Pivato ; T. A. Porter ; S. Raino ; R. Rando ; M. Razzano ; A. Reimer ; O. Reimer ; S. Ritz ; R. W. Romani ; M. Roth ; P. M. Saz Parkinson ; C. Sgro ; E. J. Siskind ; G. Spandre ; P. Spinelli ; D. J. Suson ; H. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; M. Tinivella ; D. F. Torres ; G. Tosti ; E. Troja ; Y. Uchiyama ; T. L. Usher ; J. Vandenbroucke ; G. Vianello ; V. Vitale ; A. P. Waite ; B. L. Winer ; K. S. Wood ; M. Wood ; Z. Yang ; S. Zimmer ; M. J. Coe ; F. Di Mille ; P. G. Edwards ; M. D. Filipovic ; J. L. Payne ; J. Stevens ; M. A. Torres
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-01-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    A. A. Abdo ; M. Ackermann ; M. Ajello ; A. Allafort ; L. Baldini ; J. Ballet ; G. Barbiellini ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; B. Berenji ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; A. Bouvier ; T. J. Brandt ; J. Bregeon ; A. Brez ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; A. Cannon ; P. A. Caraveo ; J. M. Casandjian ; O. Celik ; E. Charles ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; L. Costamante ; S. Cutini ; F. D'Ammando ; C. D. Dermer ; A. de Angelis ; A. de Luca ; F. de Palma ; S. W. Digel ; E. do Couto e Silva ; P. S. Drell ; A. Drlica-Wagner ; R. Dubois ; D. Dumora ; C. Favuzzi ; S. J. Fegan ; E. C. Ferrara ; W. B. Focke ; P. Fortin ; M. Frailis ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; D. Gasparrini ; N. Gehrels ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; M. H. Grondin ; J. E. Grove ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; K. Hayashi ; M. Hayashida ; E. Hays ; D. Horan ; R. Itoh ; G. Johannesson ; A. S. Johnson ; T. J. Johnson ; D. Khangulyan ; T. Kamae ; H. Katagiri ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; L. Latronico ; S. H. Lee ; M. Lemoine-Goumard ; F. Longo ; F. Loparco ; P. Lubrano ; G. M. Madejski ; A. Makeev ; M. Marelli ; M. N. Mazziotta ; J. E. McEnery ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; A. A. Moiseev ; C. Monte ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; T. Nakamori ; M. Naumann-Godo ; P. L. Nolan ; J. P. Norris ; E. Nuss ; T. Ohsugi ; A. Okumura ; N. Omodei ; J. F. Ormes ; M. Ozaki ; D. Paneque ; D. Parent ; V. Pelassa ; M. Pepe ; M. Pesce-Rollins ; M. Pierbattista ; F. Piron ; T. A. Porter ; S. Raino ; R. Rando ; P. S. Ray ; M. Razzano ; A. Reimer ; O. Reimer ; T. Reposeur ; S. Ritz ; R. W. Romani ; H. F. Sadrozinski ; D. Sanchez ; P. M. Saz Parkinson ; J. D. Scargle ; T. L. Schalk ; C. Sgro ; E. J. Siskind ; P. D. Smith ; G. Spandre ; P. Spinelli ; M. S. Strickman ; D. J. Suson ; H. Takahashi ; T. Takahashi ; T. Tanaka ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; D. F. Torres ; G. Tosti ; A. Tramacere ; E. Troja ; Y. Uchiyama ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; P. Wang ; K. S. Wood ; Z. Yang ; M. Ziegler
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-01-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    M. Ackermann ; M. Ajello ; A. Allafort ; L. Baldini ; J. Ballet ; G. Barbiellini ; D. Bastieri ; A. Belfiore ; R. Bellazzini ; B. Berenji ; R. D. Blandford ; E. D. Bloom ; E. Bonamente ; A. W. Borgland ; E. Bottacini ; M. Brigida ; P. Bruel ; R. Buehler ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; J. M. Casandjian ; C. Cecchi ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; S. Ciprini ; R. Claus ; J. Cohen-Tanugi ; A. de Angelis ; F. de Palma ; C. D. Dermer ; E. S. E. do Couto ; P. S. Drell ; D. Dumora ; C. Favuzzi ; S. J. Fegan ; W. B. Focke ; P. Fortin ; Y. Fukazawa ; P. Fusco ; F. Gargano ; S. Germani ; N. Giglietto ; F. Giordano ; M. Giroletti ; T. Glanzman ; G. Godfrey ; I. A. Grenier ; L. Guillemot ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; K. Hayashi ; E. Hays ; G. Johannesson ; A. S. Johnson ; T. Kamae ; H. Katagiri ; J. Kataoka ; M. Kerr ; J. Knodlseder ; M. Kuss ; J. Lande ; L. Latronico ; S. H. Lee ; F. Longo ; F. Loparco ; B. Lott ; M. N. Lovellette ; P. Lubrano ; P. Martin ; M. N. Mazziotta ; J. E. McEnery ; J. Mehault ; P. F. Michelson ; W. Mitthumsiri ; T. Mizuno ; C. Monte ; M. E. Monzani ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; M. Naumann-Godo ; P. L. Nolan ; J. P. Norris ; E. Nuss ; T. Ohsugi ; A. Okumura ; E. Orlando ; J. F. Ormes ; M. Ozaki ; D. Paneque ; D. Parent ; M. Pesce-Rollins ; M. Pierbattista ; F. Piron ; M. Pohl ; D. Prokhorov ; S. Raino ; R. Rando ; M. Razzano ; T. Reposeur ; S. Ritz ; P. M. Parkinson ; C. Sgro ; E. J. Siskind ; P. D. Smith ; P. Spinelli ; A. W. Strong ; H. Takahashi ; T. Tanaka ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; D. F. Torres ; G. Tosti ; A. Tramacere ; E. Troja ; Y. Uchiyama ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; A. P. Waite ; P. Wang ; B. L. Winer ; K. S. Wood ; Z. Yang ; S. Zimmer ; S. Bontemps
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-11-26
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-06-08
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    0031-9007
    Electronic ISSN:
    1079-7114
    Topics:
    Physics
    Keywords:
    Condensed Matter: Structure, etc.
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Ishibashi, K. ; Uchiyama, Y. ; Hwang, U. ; Suzuki, T.

    [S.l.] : American Institute of Physics (AIP)
    Published 1988
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The tilt angle of the c axis from the film normal in Co-Cr flexible media fabricated by continuous sputter deposition is determined by analyzing torque curves, and is compared with that obtained by x-ray diffraction. A discussion is given concerning the perpendicular anisotropy constant obtained from torque curves with and without considering such a tilt angle of the c axis.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Suzuki, T. ; Yoshida, N. ; Hwang, U. ; Uchiyama, Y. ; Ishibashi, K.

    [S.l.] : American Institute of Physics (AIP)
    Published 1988
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The effect of Pr on both the magnetic properties and microstructure of Co-Cr alloys is discussed. The saturation magnetization Ms and perpendicular magnetic anisotropy Ku at room temperature is found to increase with Pr, becoming maximum at about 0.5 wt. % Pr, and then decreases monotonously. The microstructure is also changed with Pr, leading to a less-defined columnar structure. However, no significant change is found in the Auger spectra for various contents.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Asai, T. ; Uchiyama, Y. ; Yamamoto, K. ; Johmura, S. ; Shingu, K.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The Vital View™ laryngoscope (Vital Signs, NJ, USA) consists of a plastic disposable blade containing a fibrelight and a non-disposable handle; there is therefore no need to sterilise the blade and no concern about disintegration of the fibrelight. In a random cross-over design, we compared the Vital View laryngoscope with a conventional metal fibrelight laryngoscope (Welch Allyn, NY, USA) in 100 patients. The Vital View laryngoscope produced a brighter field than the metal laryngoscope (p 〈 0.001), whereas there was no significant difference in the view of the glottis or the success rate of tracheal intubation. In no patient did any problem occur, such as damage to the laryngoscope blade or loss of light during laryngoscopy. In another 10 patients, prevention of light emission from the side of the laryngoscope blade reduced the brightness (p 〈 0. 01). This indicated that the brightness of the Vital View laryngoscope is produced by light emission not only from the tip of the blade but also from the side of the blade. Therefore, the disposable Vital View laryngoscope can be used as effectively as a conventional non-disposable laryngoscope.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Yamazaki, Y. ; Uchiyama, Y. ; Ito, K. ; Akimoto, M. ; Terada, N.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0197-3975
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geography
    Sociology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    0009-8981
    Keywords:
    Complex III ; Electron transport chain ; Mitochondrial DNA ; Mitochondrial myopathy ; Respiratory chain ; Ubiquinol-cytochrome c reductase
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Sato, N. ; Ishidoh, K. ; Uchiyama, Y. ; Kominami, E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0378-1119
    Keywords:
    Cysteine proteinase inhibitor ; exon ; genomic library ; intron ; recombinant DNA
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    0014-5793
    Keywords:
    DNA-linked enzyme ; Kinetic study ; RNase H ; Site specificity
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    0022-2836
    Keywords:
    [abr] A"m; 2'-O-methyladenosine ; [abr] ATp; adenosine 5'-triphosphate ; [abr] C"m; 2'-O-methylcytidine ; [abr] CPG; controlled-pore glass ; [abr] G"M; 2'-O-methylguanosine ; [abr] HIV; human immunodeficiency virus ; [abr] HPLC; high-pressure liquid chromatography ; [abr] NMR; nuclear magnetic resonance ; [abr] PAGE; polyacrylamide gel electrophoresis ; [abr] RNase; ribonuclease ; [abr] TEAA; triethylammonium acetate (pH 7.0) ; [abr] U"m; 2'-O-methyluridine ; [abr] d^P^hU; 5-phenyl-2'-deoxyuridine ; kinetic analysis ; minor groove binding ; modified oligonucleotide ; phosphorothioate ; ribonuclease H
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Yagi, T. ; Uchiyama, Y. ; Akaogi, M. ; Ito, E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0031-9201
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geosciences
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Mato, M. ; Uchiyama, Y.
    Springer
    Published 1974
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Zusammenfassung Nachweis, dass durch Gaben von β-Aminopropionitril die Bildung von Membransystemen in den Purkinje-Zellen des Kleinhirns induziert wird.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-0827
    Keywords:
    Key words: Serum osteocalcin — Histomorphometry — Mechanical test — Inflammation — Secondary osteoporosis.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Physics
    Notes:
    Abstract. To assess the reductions in bone mass, strength, and turnover in adjuvant-induced arthritic rats and to examine the effect of a new benzamide compound, DU-6712, on these parameters, a 28-day dosing experiment was performed using 8-week-old female Lewis rats. Arthritis was induced by injecting the adjuvant into the hind paw. The age-dependent increases in the body weight, lumbar bone mineral content and density (BMC and BMD) and compressive strength were disturbed in the arthritic rats. At 14 days, the histomorphometric parameters of bone formation (BFR/BS and BFR/BV) and the serum osteocalcin levels were significantly reduced compared with the baseline controls. However, the BMC values corrected for body weight did not differ significantly between the arthritic and normal rats, and the bone minerals were not reduced compared with the baseline controls. At 28 days, the parameters of bone minerals and strength of the lumbar body in the arthritic rats, both with and without correction for body weight, were significantly reduced compared with the baseline controls. The trabecular mineralizing surface remained significantly reduced and the osteoclast numbers were increased. DU-6712 at the doses of 5, 15, and 45 mg/kg, orally administered daily from the start of the experiment, significantly prevented the development of the chronic paw edema at 28 days. The reductions in the parameters of bone minerals, strength, and trabecular bone formation, and the increase in osteoclast number were alleviated by this agent. Age-dependent increases in the lumbar height, disturbed by the adjuvant injection, were also maintained. These data indicated that a 28-day period is necessary to obtain sufficient reductions in the bone mass and strength of the lumbar body concerning the model of secondary osteoporosis in adjuvant arthritic rats. DU-6712 was able to prevent these reductions by modulating the bone turnover in this arthritis model.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Hwang, U. ; Uchiyama, Y. ; Ishibashi, K. ; Suzuki, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0040-6090
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses