Search Results - (Author, Cooperation:Y. Tu)
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1Latest Papers from Table of Contents or Articles in PressHong, Y.-P., Wang, Y.-W., Huang, I.-H., Liao, Y.-C., Kuo, H.-C., Liu, Y.-Y., Tu, Y.-H., Chen, B.-H., Liao, Y.-S., Chiou, C.-S.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-04-27Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-04Publisher: Wiley-BlackwellPrint ISSN: 0148-0227Topics: GeosciencesPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-06Publisher: Wiley-BlackwellPrint ISSN: 0148-0227Topics: GeosciencesPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressTang, Y., Tu, H., Liu, G., Zheng, G., Wang, M., Li, L., Zhao, X., Lin, X.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-06-05Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-10-31Publisher: Institute of Physics (IOP)Print ISSN: 1755-1307Electronic ISSN: 1755-1315Topics: GeographyGeosciencesPhysicsPublished by: -
6Latest Papers from Table of Contents or Articles in PressColt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-10-17Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
7Latest Papers from Table of Contents or Articles in PressJ. H. Sun ; D. R. O'Boyle, 2nd ; R. A. Fridell ; D. R. Langley ; C. Wang ; S. B. Roberts ; P. Nower ; B. M. Johnson ; F. Moulin ; M. J. Nophsker ; Y. K. Wang ; M. Liu ; K. Rigat ; Y. Tu ; P. Hewawasam ; J. Kadow ; N. A. Meanwell ; M. Cockett ; J. A. Lemm ; M. Kramer ; M. Belema ; M. Gao
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation/drug effects ; Animals ; Antiviral Agents/*pharmacology ; Biphenyl Compounds/*pharmacology ; Cell Line ; Drug Resistance, Viral/*drug effects ; Drug Synergism ; Drug Therapy, Combination ; Hepacivirus/*drug effects/*genetics/metabolism ; Hepatitis C/virology ; Hepatocytes/transplantation ; Humans ; Imidazoles/*pharmacology ; Mice ; Models, Molecular ; Protein Conformation/drug effects ; Protein Multimerization/drug effects ; Protein Structure, Quaternary/drug effects ; Reproducibility of Results ; Viral Nonstructural Proteins/chemistry/genetics/*metabolism ; Virus Replication/drug effectsPublished by: -
8Latest Papers from Table of Contents or Articles in PressTu, Y.-H., Cooper, A. J., Teng, B., Chang, R. B., Artiga, D. J., Turner, H. N., Mulhall, E. M., Ye, W., Smith, A. D., Liman, E. R.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Biochemistry, NeurosciencePublished by: -
9Latest Papers from Table of Contents or Articles in PressLuo, D., Yang, W., Wang, Z., Sadhanala, A., Hu, Q., Su, R., Shivanna, R., Trindade, G. F., Watts, J. F., Xu, Z., Liu, T., Chen, K., Ye, F., Wu, P., Zhao, L., Wu, J., Tu, Y., Zhang, Y., Yang, X., Zhang, W., Friend, R. H., Gong, Q., Snaith, H. J., Zhu, R.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-06-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Materials Science, PhysicsPublished by: -
10Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-07-31Publisher: Institute of Physics (IOP)Print ISSN: 1755-1307Electronic ISSN: 1755-1315Topics: GeographyGeosciencesPhysicsPublished by: -
11Articles: DFG German National LicensesLiu, D. C. ; Lee, C. P. ; Tsai, C. M. ; Lei, T. F. ; Tsang, J. S. ; Chiang, W. H. ; Tu, Y. K.
[S.l.] : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The influences of cladding layer thicknesses on the performance of strained-layer InGaAs/GaAs graded-index separated confinement heterostructure quantum well lasers have been studied. The waveguiding property of the laser structure was analyzed using the transfer matrix method. In this work, experimental results and the calculated results showed that threshold current densities and external quantum efficiencies both were crucially dependent on the thicknesses of cladding layer for both single and multiple quantum well lasers. The minimum cladding layer thicknesses needed to maintain low threshold current densities and low internal total loss for both single and multiple quantum well devices were determined experimentally and theoretically.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesLiou, D. C. ; Chiang, W. H. ; Lee, C. P. ; Chang, K. H. ; Liu, D. G. ; Wu, J. S. ; Tu, Y. K.
[S.l.] : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: A novel fabrication technique has been developed for InGaAs/GaAs strained-layer buried heterostructure lasers. Dielectric masks and Zn diffusion are not required in this technique. This novel fabrication process is much easier than the conventional approach and yields excellent laser results. A low threshold of 3 mA and high-power operation for lasing wavelength of 9800±20 A(ring) have been achieved with graded index separate confinement heterostructure devices using this novel technique.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesLee, J. Y.-Y. ; Tsai, Y.-M. ; Chao, S.-C. ; Tu, Y.-F.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Infantile systemic hyalinosis (ISH) is a very rare infantile stiff-skin syndrome characterized by extensive deposits of hyaline material in various organs, especially the skin and gingiva. Recent studies identified pathogenic mutations in the capillary morphogenesis gene 2 (CMG2) in both ISH and juvenile hyaline fibromatosis (JHF). Capillary morphogenesis protein-2 is an integrin-like cell surface receptor for laminins and type IV collagen, and may play a key role in cell–matrix or cell–cell interactions. We report a case of ISH in a 13-month-old Taiwanese girl who manifested progressive joint contractures, recurrent chest infections, chronic diarrhoea with severe hypoalbuminemia and ascites, gum hypertrophy, and violaceous papules and nodules over the occipital area, neck, lumbosacral and anogenital areas since birth. Skin biopsy revealed a thickened and hyalinized papillary dermis. Electron microscopy showed abundant extracellular fibrillogranular material and active fibroblasts with conspicuous Golgi complex filled with fibrillar material. Mutation analysis identified a homozygous 1073–1074insC mutation of CMG2 which had been reported in four other families and may represent a mutation hot spot.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesXu, Shi ; Tay, B. K. ; Tan, H. S. ; Zhong, Li ; Tu, Y. Q. ; Silva, S. R. P. ; Milne, W. I.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Ion energy, controlled by the substrate bias, is an important parameter in determining properties of films deposited by the filtered cathodic vacuum arc technique. The substrate bias determines the ion energy distribution of the growth species. The ion energy is varied, while keeping the other deposition conditions constant, in order to study the effect of ion energy on the film properties. The films were characterized by their optical and mechanical parameters using an ellipsometer, surface profilometer, optical spectrometer, and nanoindenter. Electron energy-loss spectroscopy and Raman spectroscopy were used for structural analysis of the films. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesMicroencapsulation Protects Immunoglobulin in Yolk (IgY) Specific against Helicobacter pylori UreaseChang, H.-M. ; Lee, Y.-C. ; Chen, C.C. ; Tu, Y.-Y.
Oxford, UK : Blackwell Publishing Ltd
Published 2002Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : Hens were intramuscularly (im) immunized on thighs by using urease (E.C. 3.5.1.5) from Helicobactor pylori as antigen. The specificity of IgY against urease of H. pylori increased gradually after initial immunization. The collected yolk was microencapsulated with 10% or 20%β-cyclodextrin (β-CD) and gum arabic by a spray-drier. Microencapsulation was effective in protecting the IgY activity against pepsin. Liposome prepared at the lecithin/ cholesterol ratio of 1/0.25 (mole/mole) displayed satisfactory encapsulation efficiency (69%) of IgY. Increase in cholesterol content in the liposomal structure exhibited a stronger protection effect of IgY against pepsin and acid.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesTu, Y.-Y. ; Chen, C.-C. ; Chang, J-H. ; Chang, H-M.
Oxford, UK : Blackwell Publishing Ltd
Published 2002Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : Lactoferrin (LF) in colostral whey was isolated by anti-LF immunoglobulin in yolk (IgY)-Sepharose 4B immunoaffinity chromatography, and parameters such as binding capacity (qm) and dissociation constant (Kd, × 10−6 M) of this immunoaffinity gel for LF were discussed. Purification folds for colostral whey I (from colostrum collected within 6 d of postpartum) and colostral whey II (from colostrum collected within 1 d of postpartum) by anti-LF IgY-immunoaffinity chromatography were 135.80 and 103.60, respectively. The recovery for LF in the same colostral whey sample by anti-LF IgY-immunoaffinity chromatography was 82 to 99 %. qm of anti-LF IgY-immunoaffinity gel for LF in colostral whey I and whey II were 0.372 and 0.272 mg LF/mL wet gel, respectively. Kd of anti-LF IgY-immunoaffinity gel for LF in colostral whey I was 1.594 × 10−6 M and II was 1.587 × 10−6 M.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: D and z values and some thermodynamic parameters of immunoglobulin G (IgG) in phosphate buffer solution (PBS) (0.15 M NaCl/0.01 M phosphate buffer, pH 7.0) and colostral whey, with or without the presence of thermal protectants, were calculated in model systems. The D and z values for separated IgG in PBS were much lower than those for separated IgG in 20% glycerol, whey, and whey with 20% glycerol. IgG in colostral whey showed larger D and z values with the protectants. The heat denaturing rate constants at 70-82°C for separated IgG in PBS were larger than those of IgG in colostral whey; and the energies of activation for separated IgG in PBS, 0.2% glutamic acid, 10% whole milk, 20% maltose and 20% glycerol were also larger.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesSakaki, N. ; Kozawa, H. ; Egawa, N. ; Tu, Y. ; Sanaka, M.
Oxford UK : Blackwell Science Ltd.
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: To ascertain the progression of atrophic gastritis due to Helicobacter pylori infection, we conducted a 10-year prospective follow-up study with annual endoscopy of the stomach.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Prospective endoscopic observation was started in 53 subjects in 1989 and 1990 after informed consent was obtained. The progression of atrophic gastritis was evaluated mainly by the endoscopic pattern of atrophy. Histological assessment was performed on biopsy specimens taken from the lesser curvature of the lower corpus. By 2000, 43 patients (20 males, 23 females, mean age 56.7 years at entry) had completed at least 10 years of endoscopic follow-up.〈section xml:id="abs1-3"〉〈title type="main"〉Results:Eight H. pylori-negative patients with normal fundic mucosa showed no change endoscopically or histologically. In 35 H. pylori-positive patients, the progression of histological atrophy was observed in 46% and intestinal metaplasia was observed in 49%. Fifteen of 35 H. pylori-positive cases exhibited a cephaloid shift of the endoscopic atrophic border. The cephaloid shift of the atrophic area occured suddenly. The cumulative progression rate of atrophic patterns was 6% after 2 years, 22% after 4 years, 34% after 6 years and 43% after 10 years. These atrophic changes were related to neutrophil infiltration.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:The progression of atrophic gastritis is a result of chronic active gastritis caused by H. pylori infection.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesTao, J. ; Tu, Y-T. ; Huang, C-Z. ; Feng, A-P. ; Wu, Q. ; Lian, Y-J. ; Zhang, L-X. ; Zhang, X-P. ; Shen, G-X.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Vascular endothelial growth factor (VEGF) is overexpressed in malignant melanoma (MM).Objectives To develop an RNA interference approach that specifically targets VEGF by constructing a eukaryotic expression plasmid containing short interfering RNA (siRNA), and to evaluate the effects of this vector on the proliferation and apoptosis of MM in vitro and in vivo.Methods pU-VEGF-siRNA plasmid was transfected into MM cell line A375 and colorectal carcinoma cell line Lovo by electroporation. Expression of VEGF mRNA and protein in A375 and Lovo cells after gene transfer was detected by reverse transcription–polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Proliferation of pU-VEGF-siRNA-transfected A375 and Lovo cells and control cells was observed by cell counting through the microscope. The proliferation of human umbilical vein endothelial cells (ECV-304) cultured in medium containing supernatants of transfected and control A375 cells was measured by the cell counting method. Flow cytometry (FCM) was used to analyse the apoptosis of transfected and control groups. In a mouse model, tumorigenicity and tumour growth of transfected cells were studied in vivo. VEGF expression and microvessel density (MVD) in tumour tissue were measured by immunohistochemistry. Apoptosis in tumours was detected by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling.Results Expression of VEGF mRNA and protein in pU-VEGF-siRNA-transfected A375 and Lovo cells was significantly decreased on days 3, 10, 17 and 24 post-transfection, compared with controls. The greatest suppression occurred on days 3 and 10 post-transfection. The proliferation of transfected A375 cells and ECV-304 cocultured with supernatants of transfected A375 cells was inhibited. FCM analysis showed that a hypodiploidy peak was found only in A375 cells transfected by pU-VEGF-siRNA. After subcutaneous inoculation with pU-VEGF-siRNA-transfected A375 cells, tumour growth in mice was inhibited, VEGF expression and MVD were decreased, and tumour apoptosis was increased significantly, in comparison with mice inoculated with untransfected A375 cells.Conclusions The delivery of siRNA directed against VEGF was shown not only to give efficient and specific downregulation of the expression of VEGF, inhibit proliferation of A375 and ECV-304 cells and induce apoptosis of A375 cells in vitro, but also to suppress growth of MM in vivo. These results suggest that a strategy based on siRNA targeting of VEGF may build the foundation to the clinical management of MM.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesLiu, H-J. ; Moroi, Y. ; Yasumoto, S. ; Koga, T. ; Masuda, T. ; Chen, Q-J. ; Tu, Y-T. ; Furue, M. ; Aburatani, H. ; Urabe, K.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: