Search Results - (Author, Cooperation:Y. Maehara)

2015-03-04

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adaptor Proteins, Signal Transducing/*metabolism ; Animals ; Body Weight ; Cell Differentiation ; Cell Proliferation ; Cytokine Receptor gp130/*metabolism ; Disease Models, Animal ; Enzyme Activation ; Epithelial Cells/*cytology/metabolism/pathology ; HEK293 Cells ; Homeostasis ; Humans ; Inflammation/*metabolism/pathology ; Inflammatory Bowel Diseases/metabolism/pathology ; Intestinal Mucosa/*cytology/metabolism/pathology ; Mice ; Phosphoproteins/*metabolism ; Proto-Oncogene Proteins c-yes/metabolism ; Proto-Oncogene Proteins pp60(c-src)/*metabolism ; Receptors, Notch/metabolism ; *Regeneration ; Signal Transduction ; Up-Regulation

1089-7550

AIP Digital Archive

Physics

Nano-structures on the surface of graphite based carbon particles have been investigated by means of high resolution transmission electron microscopy. The surfaces consist of "closed-edge" structures in a similar manner as carbon nano-tube. That is, they are composed of coaxial carbon tubes consisting of adequate coupling of graphite layer edges. These graphite particles are chemically stable and, therefore, applicable for lithium-ion secondary battery anodes. Molecular dynamics simulations based on the Tersoff potential reveal that the vibrations of the graphite layers at the free edges play an important role in the formation of the closed-edge structures. In lithium-ion secondary batteries, Li ions can intrude into bulk carbon anodes through these closed-edge structures. In order to clarify this intrusion mechanism, we have studied the barrier potentials of Li intrusion through these closed edges using the first-principles cluster calculations. From electrochemical measurements, the carbon anodes composed of these closed-edge structures show actually high battery performance with a large discharge capacity and a small irreversible capacity. This article also implies that we can control these surface structures by choosing some suitable heat treatment conditions and/or pulverization conditions before the final heat treatment process. © 2000 American Institute of Physics.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Aims : To evaluate the relationship between phenotypic expression and tumour progression as represented by macroscopic features, submucosal invasion and lymph node metastasis in early differentiated gastric adenocarcinoma.Methods : One hundred and fifty-five cases of early gastric differentiated adenocarcinoma without any poorly differentiated components were studied. The mucosal and submucosal components of carcinomas and lymph node metastatic lesions were classified into four categories, gastric type (G-type), incomplete intestinal type (I-type), complete intestinal type (C-type) and unclassified type (U-type), based on the combination of the phenotypic expression of HGM (gastric foveolar epithelium), MUC6 (gastric pyloric glands), MUC2 (intestinal goblet cells) and CD10 (small intestinal brush border). In addition, a new classification representing a phenotypic shift from mucosa to submucosa or from primary lesion to lymph node metastasis was established with the categories of preserved group (P-group), loss group (L-group) and acquired group (A-group).Results : (1) In submucosal carcinoma, U-type was more common in the submucosa (39%) than in the mucosa (9%). (2) U-type was more common in the metastatic lesions (42%) than in the primary lesions (5%). (3) The submucosal component and lymph node metastatic lesions were classified as P-group in 48% and 43% of cases, respectively, and as L-group in 50% and 52% of cases, respectively. (4) Lymph node metastatic lesions comprising undifferentiated carcinoma were classified as L-group in 100% of cases.Conclusion : During the course of tumour progression, early differentiated adenocarcinoma at first tends to lose its phenotypic expression despite preserving its morphology, but subsequently morphological dedifferentiation occurs.

Electronic Resource

0008-6215

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0167-4781

(Rat ascites hepatoma) ; Gene expression ; Poly(A)^+ RNA ; RNA ; Repetitive sequence ; cDNA library

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0009-8981

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0009-8981

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0006-291X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

1049-0078

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Economics

Electronic Resource

1572-8838

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Electrical Engineering, Measurement and Control Technology

Abstract Electrodeposited Fe−P amorphous alloy has been characterized in terms of magnetic properties and the microstructure. The Fe−P electrodeposits show amorphous structure with phosphorus contents of about 20 at%. The formation of the amorphous structure depends mainly on the phosphorus content. The amorphous Fe−P alloy shows typical soft magnetic properties such as low coercive force and high permeability. The coercive force (Hc) decreases with the low temperature annealing, and the lowestHc is about 0.05 oersted. This reduction inHc can be attributed to structural relaxation. The amorphous phase is crystallized at temperatures above 300°C accompanying a drastic increase inHc. The stable crystalline phase is Fe3P.

Electronic Resource

1432-0843

Springer Online Journal Archives 1860-2000

Medicine

Summary Relationships between in vitro chemosensitivity and cell nuclear DNA content were investigated in malignant cells from 41 patients exhibiting advanced gastric carcinoma. The chemosensitivity was evaluated by measuring the succinate dehydrogenase (SD) activity in drug-exposed cancer cells and the DNA content was microspectrophotometrically determined. Following exposure of malignant tissue to carboquone (CQ) and cisplatin (DDP), the mean SD activity in cells displaying a relatively regular DNA distribution (type II) was significantly higher than that in those exhibiting a widely scattered DNA distribution (type IV;P〈0.01 in CQ,P〈0.05 in DDP). A similar tendency was recognized in cells that were treated with aclacinomycin A (ACR), Adriamycin (ADM), and mitomycin C (MMC). Such a decrease in SD activity in cells exhibiting a type IV pattern was remarkable, especially in cases undifferentiated adenocarcinoma. Mitotic counting analysis revealed a significantly higher value for DNA pattern type IV as compared with the findings for type II (P〈0.01). These results demonstrate that gastric carcinoma displaying a high malignant potentiality shows a better response to antitumor drugs. Adjuvant chemotherapy prescribed following drug-sensitivity testing should be effective against such tumors.

Electronic Resource

1432-0843

Springer Online Journal Archives 1860-2000

Medicine

Abstract The effects of heat on intracellular accumulation of anthracyclines were investigated by laser flow cytometry analysis. Sarcoma-180 cells were exposed to Adriamycin (ADM), epirubicin (EPIR), daunomycin (DM), THP-Adriamycin (THP), ME-2303 (ME) and KRN-8602 (KRN) at 37°C and at higher temperatures. There was a dose-dependent increase in the fluorescence intensity of all drugs at 37°C, but heat varied the fluorescence intensity of each drug. At 43°C the cellular fluorescence of ADM and EPIR increased by approximately 200%, but for DM the increase was 110–130%. The cellular fluorescence of THP and ME was little affected by heat, and heat reduced that of KRN to 80–90%. Each drug showed was unique in the relationship between drug exposure time and the fluorescence intensity at 37°C and 43°C. Cytotoxicity determined by the MTT assay was enhanced with heat in the cases of ADM and EPIR, but not with DM, THP, ME, or KRN. Thus, ADM and EPIR are expected to show enhanced antitumor activities when given in combination with hyperthermia.

Electronic Resource

1432-0843

Springer Online Journal Archives 1860-2000

Medicine

Abstract. The effects of heat on intracellular accumulation of anthracyclines were investigated by laser flow cytometry analysis. Sarcoma-180 cells were exposed to Adriamycin (ADM), epirubicin (EPIR), daunomycin (DM), THP-Adriamycin (THP), ME-2303 (ME) and KRN-8602 (KRN) at 37° C and at higher temperatures. There was a dose-dependent increase in the fluorescence intensity of all drugs at 37° C, but heat varied the fluorescence intensity of each drug. At 43° C the cellular fluorescence of ADM and EPIR increased by approximately 200%, but for DM the increase was 110 – 130%. The cellular fluorescence of THP and ME was little affected by heat, and heat reduced that of KRN to 80 – 90%. Each drug showed was unique in the relationship between drug exposure time and the fluorescence intensity at 37° C and 43° C. Cytotoxicity determined by the MTT assay was enhanced with heat in the cases of ADM and EPIR, but not with DM, THP, ME, or KRN. Thus, ADM and EPIR are expected to show enhanced antitumor activities when given in combination with hyperthermia.

Electronic Resource

1432-1262

Springer Online Journal Archives 1860-2000

Medicine

Abstract The succinate dehydrogenase inhibition (SDI) test was used to examine eight pairs of samples obtained simultaneously from primary colorectal cancers and metastatic liver lesions. The chemosensitivity of the metastatic lesions to six antitumour drugs, carboquone (CQ), adriamycin (ADM), mitomycin C (MMC), aclacinomycin A (ACR), cisplatin (DDP), and 5-fluorouracil (5-FU), differed from that of the primary lesions-the metastatic lesions were less sensitive to all these drugs. There were no correlations of chemosensitivities between the primary and the metastatic lesions (r=-0.4331∼0.4857). Thus, in patients with liver metastasis from a primary colorectal cancer, treatment with these drugs may not be so effective. When selecting antitumour drugs for metastatic liver lesions of colorectal cancer, the chemosensitivity of the primary tumour should first be assessed.

Electronic Resource