Search Results - (Author, Cooperation:Y. M. Lee)
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1Latest Papers from Table of Contents or Articles in PressC. H. Park ; S. Y. Lee ; D. S. Hwang ; D. W. Shin ; D. H. Cho ; K. H. Lee ; T. W. Kim ; M. Lee ; D. S. Kim ; C. M. Doherty ; A. W. Thornton ; A. J. Hill ; M. D. Guiver ; Y. M. Lee
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-04-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biomimetic Materials/chemistry ; Biomimetics ; Cactaceae/metabolism ; Desiccation ; Dialysis ; Electrochemistry ; Humidity ; Hydrophobic and Hydrophilic Interactions ; *Membranes, Artificial ; *Nanotechnology ; Plant Stomata/metabolism ; Polymers/*chemistry ; Protons ; Surface Properties ; Temperature ; Water/*analysisPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-01-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressA. M. Schieber ; Y. M. Lee ; M. W. Chang ; M. Leblanc ; B. Collins ; M. Downes ; R. M. Evans ; J. S. Ayres
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apoptosis Regulatory Proteins/metabolism ; Biosynthetic Pathways ; Burkholderia ; Burkholderia Infections/complications ; Calcium-Binding Proteins/metabolism ; Escherichia coli/*immunology ; Inflammasomes/*immunology ; Insulin-Like Growth Factor I/*metabolism ; Intestines/*microbiology ; Mice ; Mice, Inbred C57BL ; *Microbiota ; Muscle, Skeletal/*metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Salmonella Infections/complications ; Salmonella typhimurium ; Wasting Syndrome/etiology/*immunology/*microbiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressLee, J. S., Choi, S. H., Yun, S. J., Kim, Y. I., Boandoh, S., Park, J.-H., Shin, B. G., Ko, H., Lee, S. H., Kim, Y.-M., Lee, Y. H., Kim, K. K., Kim, S. M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-11-16Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Materials SciencePublished by: -
5Latest Papers from Table of Contents or Articles in PressKim, M.-Y., Lee, S., Myong, Y. H., Lee, Y. J., Kim, M.-R., Shin, J.-S., Lee, J., Ha, I.-H.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-06-15Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, EpidemiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressHang Yin, Qiaoxian Huang, Wenwen Zhao, David Bardelang, Didier Siri, Xiuping Chen, Simon M. Y. Lee, Ruibing Wang
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-04-07Publisher: American Chemical Society (ACS)Print ISSN: 0022-3263Electronic ISSN: 1520-6904Topics: Chemistry and PharmacologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressRizwan S. Akhtar, Joseph P. Licata, Kelvin C. Luk, Leslie M. Shaw, John Q. Trojanowski, Virginia M.-Y. Lee
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-03-13Publisher: Wiley-BlackwellPrint ISSN: 0022-3042Electronic ISSN: 1471-4159Topics: MedicinePublished by: -
8Latest Papers from Table of Contents or Articles in PressCheng Gao; Qiaoxian Huang; Qingping Lan; Yu Feng; Fan Tang; Maggie P. M. Hoi; Jianxiang Zhang; Simon M. Y. Lee; Ruibing Wang
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-07-28Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
9Latest Papers from Table of Contents or Articles in PressAnson T. H. Ma; Alice S. Y. Chow; Lewis T. O. Cheung; Karen M. Y. Lee; Shuwen Liu
MDPI Publishing
Published 2018Staff ViewPublication Date: 2018-09-23Publisher: MDPI PublishingElectronic ISSN: 2071-1050Topics: Energy, Environment Protection, Nuclear Power EngineeringPublished by: -
10Latest Papers from Table of Contents or Articles in PressA. Van Keymeulen ; M. Y. Lee ; M. Ousset ; S. Brohee ; S. Rorive ; R. R. Giraddi ; A. Wuidart ; G. Bouvencourt ; C. Dubois ; I. Salmon ; C. Sotiriou ; W. A. Phillips ; C. Blanpain
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Breast Neoplasms/*genetics/metabolism/*pathology ; Cell Differentiation/genetics ; Cell Division ; Cell Lineage ; Cell Transformation, Neoplastic ; Female ; Genes, p53/genetics ; Humans ; Mammary Neoplasms, Animal/*genetics/metabolism/*pathology ; Mice ; Mutation/genetics ; Neoplasm Invasiveness/genetics ; Phenotype ; Phosphatidylinositol 3-Kinases/*genetics/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolismPublished by: -
11Latest Papers from Table of Contents or Articles in PressSílvia Porta; Yan Xu; Clark R. Restrepo; Linda K. Kwong; Bin Zhang; Hannah J. Brown; Edward B. Lee; John Q. Trojanowski; Virginia M.-Y. Lee
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-10-12Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
12Latest Papers from Table of Contents or Articles in PressChia-Yu Chung; Amit Berson; Jason R. Kennerdell; Ashley Sartoris; Travis Unger; Sílvia Porta; Hyung-Jun Kim; Edwin R. Smith; Ali Shilatifard; Vivianna Van Deerlin; Virginia M.-Y. Lee; Alice Chen-Plotkin; Nancy M. Bonini
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-10-24Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
13Latest Papers from Table of Contents or Articles in PressA. C. Straub ; A. W. Lohman ; M. Billaud ; S. R. Johnstone ; S. T. Dwyer ; M. Y. Lee ; P. S. Bortz ; A. K. Best ; L. Columbus ; B. Gaston ; B. E. Isakson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-11-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic alpha-1 Receptor Agonists/pharmacology ; Animals ; Cells, Cultured ; Diffusion ; Endothelial Cells/drug effects/enzymology/*metabolism ; Gene Expression Profiling ; *Gene Expression Regulation/drug effects ; Hemoglobins/genetics/*metabolism ; Humans ; Iron/chemistry ; Mice ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase/metabolism ; Oxidation-Reduction ; Peptide Fragments/genetics/*metabolism ; Phenylephrine/pharmacology ; *Signal TransductionPublished by: -
14Articles: DFG German National LicensesKOPIN, A. S. ; BEINBORN, M. ; LEE, Y.-M. ; McBride, E. W. ; QUINN, S. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesPyon, H. S. ; Ha-Lee, Y. M. ; Song, G. G. ; Sohn, J.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Sequence analysis of antibody variable (V) regions can provide an insight regarding whether B cells have gone through an antigen-driven process of affinity maturation. In this study, we analyzed 16 V-regions of immunoglobulin (Ig) κ light chain genes obtained from a cDNA library of a rheumatoid arthritis (RA) synovial tissue. A salient feature of our results is the high frequency utilization of germline VκI family genes, especially the O2/O12 gene (38%). All κ V-regions showed extensive somatic hypermutation with 5.4% of an average mutation rate. Replacement to silent mutation (R/S) ratio in the complementarity determining region (CDR) was 〉 2.9 in 12 out of 16 clones, indicating that the majority of the RA synovial B cells had undergone affinity maturation. However, the four other clones showed R/S ratios of 〈 2.9 in the CDR despite a high mutation rate. In contrast to the previous reports, long CDR3 was not a characteristic feature of these clones. In summary, these data show the high frequency utilization of the germline O2/O12 gene and a high rate of mutation with an evidence of antigen selection in most of the Ig κ genes expressed in the RA synovium.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesLim, L. L. ; Wai, C. T. ; Lee, Y. M. ; Kong, H. L. ; Lim, R. ; Koay, E. ; Lim, S. G.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Chronic hepatitis B virus carriers receiving chemotherapy develop a high hepatitis B virus reactivation rate (38–53%) with a high mortality (37–60%). Few studies have characterized the efficacy of lamivudine in the treatment of chemotherapy-induced hepatitis B virus reactivation.Aim : To determine whether lamivudine prophylaxis reduces chemotherapy-induced hepatitis B virus reactivation and mortality.Methods : The medical records of all hepatitis B surface antigen-positive patients with malignancy treated with chemotherapy since 1995 at the National University Hospital of Singapore were identified, and divided into those who received lamivudine prophylaxis before chemotherapy (P) and those who did not (NP).The parameters examined included gender, age, malignancy type, steroid usage, number of chemotherapy courses and regimens, follow-up duration and hepatitis B virus status. The outcome measures were hepatitis B virus reactivation (abrupt rise of serum alanine aminotransferase to 〉 200 IU/L) and reactivation death. Patients with primary hepatoma or liver metastasis were excluded.Results : Thirty-five patients were identified: 16 in the P group and 19 in the NP group. The baseline characteristics of the two groups were similar. Seven of the 19 patients in the NP group and none of the 16 patients in the P group developed reactivation (36.8% vs. 0%, P=0.009). Six of the seven patients in the NP group who developed reactivation received lamivudine at that time, but five died (mortality, 71.4%), whilst no patient in the P group died from reactivation (P=0.064).Conclusions : Prophylactic lamivudine appears to prevent hepatitis B virus reactivation and its associated mortality in patients treated with chemotherapy. This should be confirmed with prospective studies.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Keywords: M13 ; Sau3AI-BamHI ; self-ligation ; sequencing strategy ; subcloningSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0167-0115Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesHwu, W.-L. ; Wang, P.-J. ; Hsiao, K.-J. ; Wang, T.-R. ; Chiou, Y.-W. ; Lee, Y.-M.
Springer
Published 1999Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. GTP cyclohydrolase I (GTPCH) catalyzes the rate-limiting step of tetrahydrobiopterin (BH4) biosynthesis. GTPCH has been associated with two clinically distinct human diseases: the recessive hyperphenylalaninemia (HPA) and the dominant dopa-responsive dystonia (DRD). We found a recessive GTPCH mutation (R249 S, 747C→G) in a dystonia patient. Her PHA-stimulated mononuclear blood cells had a normal amount of GTPCH mRNA, but low GTPCH activity. Arginine 249 is located at the C-terminus of GTPCH, outside the catalytic site. E. coli expressed recombinant R249 S mutant protein possessed normal enzyme activity and kinetics. However, in transfected eukaryotic cells, R249 S mutant protein expression level was lower than the wild-type protein. Therefore, this is suspected to be a destabilizing mutation. Our data suggest that DRD could be either dominantly or recessively inherited, and the inheritance might be determined by the mechanism of mutation.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1573-4838Source: Springer Online Journal Archives 1860-2000Topics: MedicineTechnologyNotes: Abstract Semi-interpenetrating polymer network (semi-IPN) hydrogels composed of β-chitosan and poly(ethylene glycol) diacrylate macromer (PEGM) were synthesized and characterized for the application as potential biomedical materials. The mixture of PEGM and β-chitosan, dissolved in water including a small amount of acetic acid, was cast to prepare hydrogel films, followed by a subsequent crosslinking with 2,2-dimethoxy-2-phenylacetophenone as a non-toxic photoinitiator by ultraviolet irradiation. Photocrosslinked hydrogels exhibited relatively high equilibrium water content in the range 77–83% which is mainly attributed to the free water content rather than to the bound water, hydrogen bonded with components in semi-IPN hydrogels. The crystallinity, thermal properties and mechanical properties of semi-IPN hydrogels were studied. All the photocrosslinked hydrogels revealed a remarkable decrease in crystallinity. The glass transition temperatures, Tg, of crosslinked PEGM segment in semi-IPNs increased compared with poly(ethylene glycol) itself. However, with increasing β-chitosan content their Tg decreased owing to the higher degree of crosslinking. The tensile strengths of semi-IPNs in dry state were rather high, but those of hydrogels in wet state decreased drastically.Type of Medium: Electronic ResourceURL: