Search Results - (Author, Cooperation:Y. Imai)

2018-01-09

The Company of Biologists

0950-1991

1477-9129

Biology

Chromatin & epigenetics, Musculoskeletal system

2011-11-29

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Acetylglucosamine/*metabolism ; Amino Acid Sequence ; Animals ; Cell Line ; HeLa Cells ; Histones/chemistry/genetics/*metabolism ; Humans ; Models, Molecular ; Mutation ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry/metabolism ; Ubiquitination

2018-09-28

Institute of Physics Publishing (IOP)

1748-0221

Physics

2011-08-27

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

0021-9304

Chemistry ; Polymer and Materials Science

Wiley InterScience Backfile Collection 1832-2000

Medicine

Technology

Various condensation polymers including polyamides, polyesters, polyethers, polysulfonamides, polysulfonate, polyphosphonate, polyimide, polyamide-imides, polyester-amides, etc. have been prepared and evaluated for their biocompatibility by a cell culture method. Cell attachment and cell growth are influenced by the chemical structures of the tested polymers. Aliphatic polyamides exhibited considerably different cell growth behavior than aromatic polyamides.

2 Ill.

Electronic Resource

2018-10-05

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2018-05-31

American Heart Association (AHA)

1942-325X

1942-3268

Medicine

Genetic, Association Studies, Aneurysm, Aortic Dissection

1089-7550

AIP Digital Archive

Physics

The carrier generated by a solid-state laser can be frequency shifted by a significant amount. This fact was exploited to implement a high-resolution optical-fiber fault locator. A resolution of 4 mm was achieved. Compared to the resolution of a frequency-domain reflectometer that shifts the frequency of the AM modulation of the light, the proposed fault locator has a resolution about 1000 times better. The potential of developing the proposed reflectometer into an ultrahigh-resolution integrated optics fault locator is also discussed. UFaipxr

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

The ground and excited states of Ni(CO)4 are studied using the symmetry adapted cluster (SAC)/SAC-configuration interaction (SAC-CI) method. The experimental absorption spectrum is well reproduced by the present calculations. All the peaks observed in the range of 200∼350 nm are assigned to the electronic allowed 1T2 excited states. The third peak is assigned to the 3 1T2 and 4 1T2 states. Next, the potential energy curves of the ground and the low-lying excited states are calculated by the same method and utilized to clarify the mechanism of the photofragmentation reaction of Ni(CO)4 by a XeCl laser (308 nm). A reaction pathway involving several excited states is proposed for the photofragmentation reaction into the excited Ni(CO)3 and CO. The calculated emission energy from the former agrees well with the observed luminescence spectrum. © 1995 American Institute of Physics.

Electronic Resource

1600-0625

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract:  To identify differentially expressed genes which play causal roles in pathogenesis and maintenance for psoriasis, we used BodyMapping and introduced amplified fragment length polymorphism approaches. From the BodyMap database, we selected 2007 genes which specifically expressed in epithelial tissues. Among 2007 genes, we surveyed genes which differentially expressed in involved or uninvolved psoriatic lesional skin samples compared with atopic dermatitis, mycosis fungoides, and normal skin samples. As a result of surveying 2007 genes, 241 genes were differentially expressed only in involved psoriatic skin but not in the other samples. Hierarchical cluster analysis of gene expression profiles showed that 13 independent psoriatic-involved skin samples clustered tightly together, reflecting highly similar expression profiles. Using the same 2007 gene set, we examined gene expression levels in five serial lesions from distal uninvolved psoriatic skin to involved psoriatic plaque. We identified seven genes such as alpha-1-microglobulin/bikunin precursor, calnexin, claudin 1, leucine zipper down-regulated in cancer 1, tyrosinase-related protein 1, Yes-associated protein 1, and unc-13-like protein (Coleonyx elegans) which show high-expression levels only in uninvolved psoriatic lesions. These seven genes, which were reported to be related to apoptosis or antiproliferation, might have causal roles in pathophysiology in psoriasis.

Electronic Resource

1365-2516

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary.  Haemostatic management of intraoral bleeding was investigated in patients with congenital α2-plasmin inhibitor (α2-PI) deficiency or congenital plasminogen activator inhibitor- 1 (PAI-1) deficiency. When extracting teeth from patients with congenital α2-PI deficiency, we advocate that 7.5–10 mg kg−1 of tranexamic acid be administered orally every 6 h, starting 3 h before surgery and continuing for about 7 days. For the treatment of continuous bleeding, such as post-extraction bleeding, 20 mg kg−1 of tranexamic acid should be administered intravenously, and after achieving local haemostasis 7.5 mg kg−1 of tranexamic acid should be administered orally every 6 h for several days. In addition, when treating haematoma caused by labial or gingival laceration or buccal or mandibular contusion, haemostasis should be achieved by administering 7.5–10 mg kg−1 of tranexamic acid every 6 h. Tranexamic acid can also be used for haemostatic management of intraoral bleeding in patients with congenital PAI-1 deficiency, but is less effective when compared with use in patients with congenital α2-PI deficiency. Continuous infusion of 1.5 mg kg−1 h−1 of tranexamic acid is necessary for impacted tooth extraction requiring gingival incision or removal of local bone.

Electronic Resource

1600-0714

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background:  Considerable controversy exists in the literature regarding the clinical course of young patients with oral squamous cell carcinoma (SCC). The purpose of this study was to evaluate the clinico-pathological features of oral SCC among young people.Methods:  From a cohort of 529 patients diagnosed with SCC, 35 (6.6%) were under the age of 40 years. This group was compared to a control group of 110 cases aged over 40 to determine if there were any differences in clinicopathological features between the two groups.Results:  In the young group there were 20 males and 15 females. The site was most frequently the tongue (51.3%), followed by the floor of the mouth, the buccal mucosa, and the upper and lower alveolus and gingiva. The local and regional control rate was 64.8% which was similar to that of older patients in this series.Conclusions:  The prognosis of oral SCC in the young patients does not appear to be different from that of the older population. Univariate analysis showed that clinical stage and the mode of invasion were the most significant prognostic factors in both younger and older patients.

Electronic Resource

0003-2697

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

1365-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Induction of suppressor cells specific for gmmosine in C57BL/6 mice with syngeneic spleen cells coupled with guanosine was demonstrated. Spleen cells from mice that had been tolerized by the injection of guanosine-coupled syngeneic spleen cells (G–SC) were repeatedly stimulated with mitomycin C-treated G-SC (MMC-G-SC) in vitro. These cells effectively suppressed the secondary in vitro response to guanosine–keyhote limpet haemocyanin (G–KLH) but did not suppress the response to sheep erythrocytes (SRBC). From these cell populations a long-term-cultured suppressor T-cell line specific for guanosine was established by using interleukin-2 and MMC-G-SC. This cell line suppressed the response to G-KLH but did not suppress the response to trinitrophenyl–KLH and SRBC. The suppressive effect was completely eliminated by treatment with anti-Thy 1.2 and complement

Electronic Resource

1440-1681

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

1. In anaesthetized, open-chest dogs, 2-nicotinamidoethyl nitrate (SG-75) administered intravenously (0.3–1 mg/kg) or intraduodenally (3 mg/kg) produced decreases in systemic blood pressure, coronary resistance, heart rate and an increase in coronary sinus outflow, but virtually no change in myocardial oxygen consumption and atrioventricular conduction. The effects of SG-75 administered intraduodenally emerged within a few minutes after dosing and lasted over about 1 h.2. In isolated, blood-perfused sino-atrial node preparations of the dog SG-75 administered into the sinus node artery decreased slightly sinus rate at the dose which doubled blood flow through the artery.3. In isolated, blood-perfused atrioventricular node preparations of the dog SG-75 administered into the atrioventricular node artery did not impair atrioventricular conduction even in doses which increased blood flow through the artery to more than twice the basal level.4. In isolated, blood-perfused papillary muscle preparations of the dog SG-75 administered into the anterior septal artery scarcely affected force of contraction of the papillary muscle at the dose which doubled blood flow through the artery, although in further large doses it produced a transient decrease in the force of contraction. In extremely large doses it produced ventricular fibrillation.5. In anaesthetized, open-chest dogs in which cardiac input was kept constant SG-75 (0.01–1 mg/kg) administered into the ascending aorta increased venous return without changing systemic output.6. 2-Nicotinamidoethyl alcohol, a denitrated compound of SG-75, had no vasodilator action in doses comparable to those of the parent compound.7. These results indicate SG-75 to be a potential antianginal drug having no cardiodepressant actions but having properties uncharacteristic of the nitrates.

Electronic Resource

1440-1681

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

〈list xml:id="l1" style="custom"〉1The age-related changes in mean arterial pressure (MAP), heart rate (HR), and baroreflex sensitivity (BRS) were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats from 4 to 20 weeks of age.2Intra-arterial blood pressure (BP) was continuously recorded for 24 h in conscious, freely moving rats. Twenty-four hour MAP and HR were calculated by an online computer. Baroreflex sensitivity was measured by phenylephrine infusion.3In SHR, BRS was significantly lower than in WKY as early as 4-5 weeks, at which time MAP in SHR was only slightly raised. During subsequent weeks, rapid increase in MAP occurred in SHR, in association with progressive bradycardia.4It was concluded that a reduced BRS may be detected in young prehypertensive SHR and this impairment of BRS may be central in origin.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The purpose of this study was to investigate bone dynamics under a denture base, in relation to the intensity of continuous pressure exerted through it to the denture supporting tissue. Two hundred and fifty male rats of Wistar strain were divided into five groups, four of which wore experimental dentures to load continuous pressure of 0·0, 1·0, 10·0 or 20·0 kPa to the molar region of the hard palate. The fifth group was the non-denture-wearing group. Fluorescent labelled palatal bone tissue was stained with Villanueva bone stain and was prepared for the undecalcified grinding section. In the 0·0 kPa group whose mucosa was covered with denture base, although no bone resorption was observed, bone formation was inhibited up to 4 weeks after the denture insertion. Bone dynamics in the 1·0 kPa group was similar to those in the 0·0 kPa group. In the 10·0 and 20·0 kPa groups, bone resorption was observed until 3 and 2 weeks after the denture insertion, and the amount of bone resorption (AoBR) was 24 ± 17 and 35 ± 21 lm, respectively. After bone resorption in these groups, although osteoid formation increased earlier than 0·0 kPa group, mineralization showed a similar time course with 0·0 kPa group. In conclusion, bone dynamics under a denture base caused by continuous pressure exerted through it was revealed to show a time course depending on the intensity of the initial pressure. Amount of bone resorption was also revealed to correspond to the intensity of the initial pressure. Bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The bone dynamics under denture base has not been clarified sufficiently. The purpose of this study was to evaluate histomorphometrically the bone dynamics in denture supporting tissue with relation to the intensity of the masticatory pressure. The removable denture bases, which exerted four different regulated masticatory pressures (0·0, 1·0, 20·0 or 40·0 kPa), were inserted to the hard palate of the molar region of 22-week-old rats. The palatal tissues were excised from 1 to 12 weeks after denture insertion at intervals of 1 week and embedded in methyl-methacrylate. No bone resorption was observed throughout the experimental period in the 0·0 and 1·0 kPa groups. In the 1·0 kPa group compared with the 0·0 kPa group, bone formation parameters except for bone formation rate significantly increased at 4 weeks, but there was no significant difference between these groups in the other experimental periods. In the 20·0 and 40·0 kPa groups, bone resorption was observed until 3 and 5 weeks, respectively, and the amounts of bone resorption (AoBR) were 45 ± 25 and 104 ± 21 μm, respectively. After bone resorption, bone formation parameters in these two groups showed transiently significant decrease compared with the 0·0 kPa group, but were the same time course as the 0·0 kPa group following this decrease. In conclusion, masticatory pressure caused different time courses of the bone dynamics in denture supporting tissue depending on the initial intensity of the pressure. The AoBR responded to the initial intensity of masticatory pressure. Bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption in the present study.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The purpose of this study was to investigate bone dynamics in denture supporting tissue under continuous pressure in the diabetic condition by using bone histomorphometry in relation to initial intensity of continuous pressure exerted through the denture base. The experimental denture base, which was designed to load initial continuous pressure of 0·0, 1·0, 10·0 or 20·0 kPa to the denture supporting tissue, was applied to the molar region of hard palate of streptozotocin-induced diabetic rats. Fluorescent labelled palatal bone tissue was stained with Villanueva bone stain and was prepared for the undecalcified grinding section. In 0·0 kPa group, no bone resorption was observed and bone formation was transiently inhibited after the denture insertion. In 1·0 kPa group, although no bone resorption was observed, the beginning of bone formation after the inhibition of bone formation was later than that in 0·0 kPa group and bone formation dynamics after the resumption of bone formation was similar to that in 0·0 kPa group. In 10·0 and 20·0 kPa groups, bone resorption was observed until 3 and 4 weeks, respectively, and the amount of bone resorption for each group was 60 ± 16 and 87 ± 18 μm, respectively. The resumption of bone formation in 10·0 and 20·0 kPa groups were observed at the same stage with 1·0 kPa group, and the bone formation dynamics after the resumption of bone formation in 10·0 and 20·0 kPa groups were also similar to that in 0·0 kPa group. From the results of this study, it was revealed that bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption in the diabetic condition.

Electronic Resource

1365-2036

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background : The incidence and severity of non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastro-duodenal ulcer have not been extensively studied in Japan.Aim : We performed a prospective study to clarify NSAIDs-induced gastro-duodenal injury, focusing especially on low-dose aspirin (L-A).Methods : Two hundred and thirty-eight patients with bleeding peptic ulcers admitted to our hospital. History of taking NSAIDs and anti-ulcer drugs was obtained from all patients who underwent endoscopic examinations. The lesion scores of patients taking L-A were classified numerically from zero (no lesion) to five (ulcer).Results : The NSAIDs were associated with 28.2% of hemorrhagic ulcers. The rates of patients using L-A, loxoprofen, diclofenac, and combination of two of these drugs were 27, 16, 10 and 9%, respectively. Co-administered anti-ulcer drugs were cytoprotective anti-ulcer drugs (27%), H2 receptor antagonists (16%), PPI (4%), and none (53%). In patients taking L-A, H2 receptor antagonists were used most frequently. The HP was positive in 63% of L-A-induced ulcer cases and in 69% of NSAIDs other than low-dose aspirin-induced ulcer cases. The lesion scores of patients taking L-A with H2 receptor antagonists or PPI were significantly lower than those of patients who were taking only L-A (P 〈 0.05).Conclusions : Approximately one-third of hospitalized patients with NSAIDs-induced hemorrhagic ulcer showed an association with L-A. Prospective randomized controlled trials including H2 receptor antagonists are required to establish preventive efforts aimed at L-A-induced gastro-duodenal injury.

Electronic Resource