Search Results - (Author, Cooperation:Y. C. Kim)

2018-09-05

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2018-02-17

American Heart Association (AHA)

1942-325X

1942-3268

Medicine

Inflammation, Pediatrics, Genetic, Association Studies, Coronary Artery Disease

2015-01-07

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2018-01-22

Wiley-Blackwell

0007-0963

1365-2133

Medicine

2015-01-09

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

ADP-Ribosylation Factor 1/genetics/metabolism ; Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Enzyme Activation ; Gene Knockdown Techniques ; Glutamine/*metabolism ; HEK293 Cells ; Humans ; Leucine/*metabolism ; Lysosomes/*enzymology ; Mice ; Mice, Knockout ; Monomeric GTP-Binding Proteins/genetics/*metabolism ; Multiprotein Complexes/*metabolism ; Protein Transport ; TOR Serine-Threonine Kinases/*metabolism

2015-05-23

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

2018-04-09

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2012-03-06

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

*Biocatalysis ; Biological Products/chemistry/metabolism ; Crystallography, X-Ray ; Cyclization ; Epoxide Hydrolases/*chemistry/genetics/*metabolism ; Ethers/*chemistry/*metabolism ; Hydrogen Bonding ; Lasalocid/analogs & derivatives/*biosynthesis/*chemistry/metabolism ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Streptomyces/genetics ; Structure-Activity Relationship

2018-08-21

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Ecthyma gangrenosum is a well recognized cutaneous manifestation of Pseudomonas aeruginosa infections in immunocompromised patients. Most cases of ecthyma gangrenosum have been associated with concomitant septicaemia. However, ecthyma gangrenosum rarely develops due to Ps. aeruginosa in the absence of bacteraemia. We report a rare case of a nonsepticaemic form of ecthyma gangrenosum presenting as a large solitary necrotic ulcer in a patient with acute myelogenous leukaemia. A culture from the lesion revealed the presence of Ps. aeruginosa, but the results of repeated blood cultures were negative. Histological examination revealed numerous tiny eosinophilic bacilli in the dermis and panniculus with Gram's stain.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Glandular schwannoma is a rare variant of schwannoma characterized by the presence of glands in an otherwise typical schwannoma. We report a patient with benign glandular schwannoma occurring on the scalp, a site not previously reported. Histologically, a well-defined, encapsulated oval nodule was observed in the subcutaneous tissue. The nodule was composed of a spindle cell component and glandular structures. The spindle cell component stained positively for S-100 protein. All of the glandular epithelium stained with CAM 5.2 and epithelial membrane antigen but not with S-100 protein. The glandular epithelium was focally positive for carcinoembryonic antigen. The histogenesis of the glandular elements in these tumours is still debated. The variable size of the glandular structures in our case was evidence against an entrapped normal sweat gland origin. The glandular epithelium did not stain with S-100 protein at all, but stained with CAM 5.2, which did not support a direct metaplastic origin of the epithelial elements from the schwannian component. A few scattered CAM 5.2-positive cells and microglandular structures in our case may be the initial differentiating epithelial elements possibly derived from pluripotential neural crest cells.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

The molecular dynamics and ordering of polymer-dispersed liquid-crystal displays are studied using the technique of paramagnetic resonance of spin probes. A complex spectrum is observed in which components are identified from probes dissolved in the droplet, binder, and interfacial regions of the display. In particular, the liquid-crystal curing, phase separation, and structure of displays with both thermoplastic and epoxy binders are investigated. Observations are also performed as the liquid-crystal droplet size is varied. Among the more interesting results is the demonstrated ability to observe the interfacial region. It appears to be quite fluid and has little or no average order. It is also observed that the compatibility between the binder and liquid crystal, seen from some of the formulations studied, correlates with the reported electro-optical properties. These include the magnitude and hysteresis of switching voltages and the magnitudes of switching times. © 1995 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Low-energy (1–1.5 kV) nitrogen-ion bombardment of sharply pointed Fe-3 at. % Mo tips is performed, at room temperature and 473 K, by applying a negative voltage to the tip in the presence of nitrogen gas (10−3–10−5 Torr) in an ultrahigh vacuum atom-probe field-ion microscope (APFIM). Tip sharpening, as a consequence of sputtering, is observed directly in situ via APFIM. This sharpening phenomenon can be explained by the inertia effect on the trajectories of the field-emitted electrons and nitrogen ions that results in sputtering of the shank of the tip. We also observe that the implanted low-energy (1–1.5 kV) nitrogen ions react with the molybdenum atoms in solid solution in this Fe(Mo) alloy to produce immobile molecular diameter nitrides at room temperature and 473 K. The measured range profile of the implanted 1.5 kV nitrogen species is compared with results calculated using the TRIM.SP Monte Carlo code. This comparison implies that the ionized nitrogen molecules (N21+), generated by the field-emitted electrons, obtain the full potential energy of the tip before bombarding the tip's surface and then dissociating into nitrogen ions (N1+) at or near the surface. The experimental nitrogen range profile is quantitatively fitted to the Edgeworth expansion of the normal distribution function. © 1997 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A novel in situ sample cleavage technique has been developed for fabricating specimens for cross-sectional scanning tunneling microscopy applications. This technique can be easily adapted to any ultrahigh vacuum scanning tunneling microscope that has coarse motion and tip ex- change capabilities. A 90° bent diamond tip attached to a tip holder is used to make micron long scratches on GaAs(001) surfaces along a 〈110〉 direction. The sample is then fractured and the cross-sectional surface is scanned in the conventional way. Atomic resolution images of {110}-type GaAs surfaces are readily and reproducibly obtained. © 1996 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

Digital complex demodulation techniques are used to generate time-varying auto- and cross-power spectra which, in turn, are useful in characterizing the time-frequency characteristics of nonstationary plasma fluctuation data. The approach is illustrated with fluctuation data measured with a heavy-ion beam probe on the TMX experiment.

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

This study was performed to evaluate the effects of cryoanalgesia combined with thoracic epidural analgesia on pain and respiratory complications in patients undergoing thoracotomy. Ninety patients were prospectively randomised to epidural analgesia alone (n = 45) or epidural analgesia and cryoanalgesia combined (n = 45). We monitored the use of rescue pain medication and changes in forced vital capacity and forced expired volume in 1 s, and recorded pain and opioid-related side-effects during the immediate postoperative period. The incidence of post-thoracotomy pain and numbness were also assessed up to the sixth month after surgery. Cryoanalgesia combined with thoracic epidural analgesia was associated with earlier recovery in pulmonary function, less pain during movement and a lower daily requirement for rescue analgesia one week after surgery. However, the combination of cryoanalgesia and epidural analgesia failed to decrease the incidence of long-term pain and numbness. In view of its associated long-term morbidity, cryoanalgesia combined with thoracic epidural analgesia is not recommended for patients undergoing thoracotomy.

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

This study was performed to determine how the use of an introducer affects the extent to which a needle deflects during a spinal or combined spinal-epidural injection. A polystyrene block was used to simulate the paraspinal area of the back. A line was drawn perpendicular to the edge of the block to use as a guide and to measure the deflection. The use of an introducer needle decreased the deflection in all the bevelled needles (p 〈 0.001). Depending on the direction of both the bevels, the deflection decreased as the introducer bevel was changed from the same direction, to right-angles to bevel direction and then to a direction opposite to that of the spinal needle (p 〈 0.05). Deflection was decreased when a thick introducer was used (p 〈 0.001). The use of an introducer increased the deflection of the pencil-point needle only in the deflection direction of the introducer (p 〈 0.001). The 18-gauge Tuohy needle with a ‘backhole’ deflected more than the corresponding needle without a backhole (p 〈 0.001), and the spinal needle inserted through the Tuohy needle with a backhole deflected more (p = 0.002). Besides the tip type and gauge, the deflection of a spinal needle depends upon the use of introducer, its gauge and bevel direction. The deflection of a Tuohy needle depends upon its design, gauge and the presence of a backhole.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Aims : To evaluate the caveolin-1 status of invasive ductal carcinoma and its correlation with other important parameters of breast carcinogenesis. Caveolin-1, the main structural protein of caveolae, is involved in the regulation of several intracellular signalling pathways and also functions as a tumour suppressor in breast carcinogenesis.Methods and results : One hundred and thirty cases of invasive ductal carcinomas with matched normal breast tissue were evaluated immunohistochemically for caveolin-1 expression. Using a tissue microarray, caveolin-1 expression was also correlated with the expression of other antigens such as eostrogen receptor, progesterone receptor, epidermal growth factor receptor (EGFR), HER2, β-catenin, E-cadherin, p53, Ki67 and with clinicopathological parameters. Immunohistochemical results showed strong expression of caveolin-1 in all normal breast epithelial cells, but a reduction of caveolin-1 expression in 56 cases (43.1%) of invasive ductal carcinoma. Furthermore, a statistically significant inverse correlation between caveolin-1 and EGFR and HER2 was noted (P 〈 0.001).Conclusions : Our results indicate a reduction in caveolin-1 expression in invasive ductal carcinoma of the breast, which supports in vitro studies of its role as a tumour suppressor. Caveolin-1 also shows an inverse correlation with EGFR and HER2, which fits with its function as a negative regulator of signal transduction.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource