Search Results - (Author, Cooperation:X. Zeng)
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1Latest Papers from Table of Contents or Articles in PressEhlerding, E. B., Sun, L., Lan, X., Zeng, D., Cai, W.
The Society of Nuclear Medicine (SNM)
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: The Society of Nuclear Medicine (SNM)Print ISSN: 0022-3123Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressZhong, Q., Liu, Z.-H., Lin, Z.-R., Hu, Z.-D., Yuan, L., Liu, Y.-m., Zhou, A.-J., Xu, L.-H., Hu, L.-J., Wang, Z.-F., Guan, X.-Y., Hao, J.-J., Lui, V. W. Y., Guo, L., Mai, H.-Q., Chen, M.-Y., Han, F., Xia, Y.-F., Grandis, J. R., Zhang, X., Zeng, M.-S.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-02-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressChen, S., Hu, M., Shen, M., Wang, S., Wang, C., Chen, F., Tang, Y., Wang, X., Zeng, H., Chen, M., Gao, J., Wang, F., Su, Y., Xu, Y., Wang, J.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-07-13Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Platelets and ThrombopoiesisPublished by: -
4Latest Papers from Table of Contents or Articles in PressQ. Zhang ; J. Shi ; G. Deng ; J. Guo ; X. Zeng ; X. He ; H. Kong ; C. Gu ; X. Li ; J. Liu ; G. Wang ; Y. Chen ; L. Liu ; L. Liang ; Y. Li ; J. Fan ; J. Wang ; W. Li ; L. Guan ; Q. Li ; H. Yang ; P. Chen ; L. Jiang ; Y. Guan ; X. Xin ; Y. Jiang ; G. Tian ; X. Wang ; C. Qiao ; C. Li ; Z. Bu ; H. Chen
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chickens/virology ; Columbidae/virology ; Ducks/virology ; Ferrets/*virology ; Genes, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/genetics/metabolism ; Humans ; Influenza A virus/genetics/isolation & purification/*pathogenicity/physiology ; Influenza in Birds/virology ; Influenza, Human/*transmission/*virology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Mutation ; Orthomyxoviridae Infections/*transmission/*virology ; Receptors, Cell Surface/metabolism ; Receptors, Virus/metabolism ; Respiratory System/*virology ; Virus ReplicationPublished by: -
5Latest Papers from Table of Contents or Articles in PressR. Apps ; Y. Qi ; J. M. Carlson ; H. Chen ; X. Gao ; R. Thomas ; Y. Yuki ; G. Q. Del Prete ; P. Goulder ; Z. L. Brumme ; C. J. Brumme ; M. John ; S. Mallal ; G. Nelson ; R. Bosch ; D. Heckerman ; J. L. Stein ; K. A. Soderberg ; M. A. Moody ; T. N. Denny ; X. Zeng ; J. Fang ; A. Moffett ; J. D. Lifson ; J. J. Goedert ; S. Buchbinder ; G. D. Kirk ; J. Fellay ; P. McLaren ; S. G. Deeks ; F. Pereyra ; B. Walker ; N. L. Michael ; A. Weintrob ; S. Wolinsky ; W. Liao ; M. Carrington
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-04-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Alleles ; Amino Acid Sequence ; Anti-Retroviral Agents/therapeutic use ; Crohn Disease/genetics/immunology ; *Gene Expression Regulation ; HIV/genetics/*immunology ; HIV Infections/drug therapy/*genetics/*immunology ; HLA-C Antigens/*genetics ; Humans ; Immunodominant Epitopes/genetics ; Molecular Sequence Data ; Mutation ; Peptide Fragments/immunology ; Polymorphism, Single Nucleotide ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Load/geneticsPublished by: -
6Latest Papers from Table of Contents or Articles in PressL. Sun ; X. Zeng ; C. Yan ; X. Sun ; X. Gong ; Y. Rao ; N. Yan
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biological Transport ; Crystallography, X-Ray ; Deoxyglucose/analogs & derivatives/chemistry/metabolism ; Escherichia coli/*chemistry ; Escherichia coli Proteins/*chemistry/metabolism ; Glucose/chemistry/metabolism ; Glucose Transport Proteins, Facilitative/*chemistry/metabolism ; Glucose Transporter Type 1/chemistry ; Humans ; Hydrogen Bonding ; Models, Molecular ; Protein Conformation ; Structural Homology, Protein ; Structure-Activity Relationship ; Substrate Specificity ; Symporters/*chemistry/metabolism ; Xylose/chemistry/metabolismPublished by: -
7Latest Papers from Table of Contents or Articles in PressX. Zeng ; R. Kieffer ; B. Glettner ; C. Nurnberger ; F. Liu ; K. Pelz ; M. Prehm ; U. Baumeister ; H. Hahn ; H. Lang ; G. A. Gehring ; C. H. Weber ; J. K. Hobbs ; C. Tschierske ; G. Ungar
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-03-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
8Latest Papers from Table of Contents or Articles in PressK. L. Sackton ; N. Dimova ; X. Zeng ; W. Tian ; M. Zhang ; T. B. Sackton ; J. Meaders ; K. L. Pfaff ; F. Sigoillot ; H. Yu ; X. Luo ; R. W. King
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Anaphase-Promoting Complex-Cyclosome/*chemistry/*metabolism ; Binding Sites/drug effects ; Carbamates/*pharmacology ; Cdc20 Proteins/chemistry/metabolism ; Cell Death/drug effects ; Crystallography, X-Ray ; Diamines/*pharmacology ; Drug Synergism ; Mitosis/*drug effects ; Protein Binding/drug effects ; Proteolysis/drug effects ; Tosylarginine Methyl Ester/*pharmacology ; Ubiquitination/drug effectsPublished by: -
9Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We have employed density functional theory to study gas–liquid nucleation in binary fluids. Effects of surface enrichment and curvature are naturally included in this novel statistical mechanical approach, allowing the classical capillarity approximation to be tested. In this paper we apply the theory to mixtures of Lennard-Jones fluids (modeled on argon and krypton). For these nearly ideal mixtures, the magnitude of nonclassical effects tend to be small, but systematic deviations do appear, with the ratio of the classical to nonclassical rate showing a maximum at intermediate compositions.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesZeng, X. C. ; Oxtoby, David W.
College Park, Md. : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Our recently proposed effective liquid free energy model (ELFEM) density functional theory is extended to nonuniform binary systems. The theory is based on mapping the excess free energy of a nonuniform binary system onto that of an effective binary liquid. In the uniform density limit, the theory is required to reproduce the known properties of the liquid. The present theory is applied to the freezing of a binary hard sphere liquid into a substitutionally disordered fcc solid. Comparisons with previous density functional investigations and recent computer simulations are made.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We propose a relation among the crystal–melt surface tension τsl, the compressibility KT, and the thickness wsl of the crystal–melt interface for simple liquids, based on the density-functional approach of Moore and Raveche.1 Combining this with a similar relation in note I by Mon and Stroud, we obtain a formula connecting the surface tension ratio τsl/τlv, and ratio of surface width wsl/wlv. A new empirical law of freezing is conjectured.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesZeng, X. C. ; Oxtoby, David W. ; Tang, Hai ; Freed, Karl F.
College Park, Md. : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: A study is conducted on the square−gradient theories of polymer blend interfaces.Polymer blend exhibits a phase transition at a critical value of the interaction parameter. (AIP)Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesZeng, X. C. ; Oxtoby, David W.
College Park, Md. : American Institute of Physics (AIP)
Published 1991Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We have applied a nonclassical density functional theory of nucleation to the gas–liquid and liquid–gas transitions of a Lennard-Jones fluid. For the liquid-to-gas transition (cavitation) deviations from classical theory are extremely large: 15 orders of magnitude in rates. For the gas-to-liquid transition (condensation) the deviations are smaller in magnitude but still systematic. Our nonclassical theory agrees with classical theory in its prediction of the dependence of nucleation rates on supersaturation, but it differs in its prediction of temperature dependence. Good agreement is found between our theory and experiments on condensation nucleation of nonane.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesZeng, X. C. ; Oxtoby, David W.
College Park, Md. : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: A new formulation of the weighted density approximation, the so-called modified weighted density approximation (MWDA), has been developed recently by Denton and Ashcroft [Phys. Rev. A39, 4701 (1989)]. In the present article, the MWDA theory is examined by applying it to the freezing of simple liquids in low dimensions such as one-dimensional hard rods and two-dimensional hard disks, and also applying it to three-dimensional adhesive hard spheres and classical one-component plasma systems. Comparisons with previous density functional investigations and computer simulations are also presented.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesZeng, X. C. ; Liu, A. G. ; Kwok, T. K. ; Chu, P. K. ; Tang, B. Y.
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The temporal evolution of the plasma sheath in a small cylindrical bore with an auxiliary electrode is calculated for zero-rise-time voltage pulses. The ion density, flux, dose, ion energy distribu-tion, and electric field are determined by solving Poisson's equation and the equations of ion motion and continuity using finite difference methods. Our results indicate that the implantation time is about halved and slightly more than 50% of the ions possess impact energy higher than the maximum achieved when an auxiliary electrode is absent. The resulting ion flux, ion current, as well as ion energy distribution, are also determined. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesZeng, X. H. ; Zhang, Y. ; Chesca, B. ; Barthel, K. ; Greenberg, Ya. S. ; Braginski, A. I.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We measured the amplitude–frequency characteristics of radio frequency superconducting quantum interference devices (rf SQUIDs) over a temperature range between 65 and 79 K. Using the expressions derived from the recently developed rf SQUID theory, valid also at large thermal fluctuations, we determined from these data the basic parameters of high-transition-temperature superconductor (HTS) rf SQUIDs. These parameters were: (a) the high-frequency coupling coefficient between the rf SQUID and the tank circuit resonator, k, (b) the SQUIDs hysteretic parameter, β, (c) the critical current of the Josephson junction, Ic, (d) its normal resistance, Rn, and (e) its noise parameter, Γ. We found a good agreement with the values of β(Ic) and Rn determined directly after destructively opening the SQUID loop. In accordance with the theoretical predictions, our experimental results show that at large thermal fluctuation levels (T≅77 K), rf SQUIDs with large loop inductance operate in nonhysteretic mode up to β values exceeding 3. Furthermore, we have shown that the optimal energy sensitivity is attained in the nonhysteretic mode at a value of β distinctly higher than 1. A quantitative comparison of white noise predicted by the theory with that obtained from the experiment showed a reasonable agreement. We also discussed the contribution of the phase information to the SQUID's signal and noise at optimum operation conditions, when a mixer was used as a signal detector. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesYi, H. R. ; Zhang, Y. ; Schubert, J. ; Zander, W. ; Zeng, X. H. ; Klein, N.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: This article describes three planar layouts of superconducting multiturn flux transformers integrated with a coplanar resonator for radio frequency (rf) superconducting quantum interference device (SQUID) magnetometers. The best magnetic field noise values of 22 and 11.5 fT/Hz1/2 in the white noise regime were obtained for the layout with two input coils and the layout with the labyrinth resonator, respectively. Excess low-frequency noise (about 200 fT/Hz1/2 at 10 Hz) was present. Computer simulation showed that the loss in this trilayer system was dominated by the high loss tangent of the dielectric film used for the separation of the upper and lower superconducting films. The rf coupling coefficient krf between the resonator and the flip-chip-coupled SQUID was also estimated. The values krf2(approximate)14×10−3 obtained for the layout with two input coils, and krf2(approximate)45×10−3 for the layout with the labyrinth resonator were considerably higher than the typical value of krf2(approximate)7×10−3 for the single-layer coplanar resonator. These high coupling coefficients have compensated the somewhat degraded unloaded quality factor of the resonator, thus securing the optimum operation of the rf SQUID. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modulate GABAR function in CA1 pyramidal cells, the present study assessed whether GABAR dysfunction is associated with changes in PKA activity. Two days after 1-week FZP treatment, there were significant decreases in basal (− 30%) and total (− 25%) PKA activity, and a 40% reduction in PKA RIIβ protein in the insoluble fraction of CA1 hippocampus. The soluble component of CA1 showed a significant increase in basal (100%) but not total PKA activity. Whole-cell recording in vitro showed a 50% reduction in mIPSC amplitude in CA1 pyramidal cells, with altered sensitivity to PKA modulators. Neurons from FZP-treated rats responded to 8-bromo-cAMP with a significant increase (31%) in mIPSC amplitude. Likewise, vasoactive intestinal polypeptide (VIP), an endogenous PKA activator, caused a significant 36% increase in mIPSC amplitude in FZP-treated cells. Neither agent had a significant effect on mIPSC amplitude in control cells. This study supports a role for PKA in GABAR dysfunction after chronic FZP treatment.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesYagyu, K. ; Kitagawa, K. ; Irie, T. ; Wu, B. ; Zeng, X. T. ; Hattori, N. ; Inagaki, C.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Cl−-ATPase in the CNS is a candidate for an outwardly directed neuronal Cl− transporter requiring phosphatidylinositol-4-phosphate (PI4P) for its optimal activity. To test its pathophysiological changes in a phosphatidylinositol (PI) metabolism disorder, the effects of neurotoxic factors in Alzheimer's disease (AD), amyloid β proteins (Aβs), on the Cl−-ATPase activity were examined using primary cultured rat hippocampal neurons. Amyloid β proteins (1–40, 1–42 and 25–35) concentration-dependently (1–100 nm) and time-dependently (from 1 h to 6 day) decreased Cl−-ATPase activity and elevated intracellular Cl− concentrations ([Cl−]i), Aβ25–35 being the most potent. Addition of inositol or 8-Br-cyclic GMP completely reversed these Aβ-induced changes. The recoveries in enzyme activity were attenuated by an inhibitor of PI 4-kinase, 10 µm wortmannin or 20 µm quercetin, but not by a PI 3-kinase inhibitor, 50 nm wortmannin or 10 µm LY294002. The PI, PIP and PIP2 levels of the plasma membrane-rich fraction were lower in the Aβ-treated cells as compared with each control. In the Aβ-exposed culture, but not in control, stimulation by 10 µm glutamate for 10 min significantly increased fragmentation of DNA and decreased cell viability. Addition of inositol or 8-Br-cyclic GMP prevented the effect of Aβ-treatment on the neurotoxicity of glutamate. Thus, Aβs reduce neuronal Cl−-ATPase activity, resulting in an increase in [Cl−]i probably by lowering PI4P levels, and this may reflect a pre-apoptotic condition in early pathophysiological profiles of AD.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Giant magnetoresistance (GMR) effect in magnetic multilayered thin films is strongly affected by interface roughness. We prepared [Ag/Ni]60 superlattices on Corning's 7059 glass substrates using a novel facing-target sputtering method and observed that the interface roughness can be controlled by varying the discharge pressure (PAr). The samples prepared at PAr≈10 mTorr exhibit sharpest interfaces, good (111) texture, and largest GMR effects (Δρ/ρs=9% at room temperature). Lower PAr promotes interface mixing while higher PAr results in much rougher interfaces and emergence of structural defects. Both cases weaken the antiferromagnetic coupling strength and thus reduce the MR effect. When PAr≥30 mTorr, we observed a further degradation of the multilayered structure. The GMR effects in these samples disappeared. Low-temperature annealing can improve the flatness of the interfaces and film structure, while higher-temperature annealing ((approximately-greater-than)300 °C) decomposes the multilayer structures. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: