Search Results - (Author, Cooperation:X. J. Zhu)

2018-04-12

BMJ Publishing

2044-6055

Medicine

Open access, Public health

2015-09-26

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

2018-10-31

Institute of Physics (IOP)

1755-1307

1755-1315

Geography

Geosciences

Physics

2018-10-31

Institute of Physics (IOP)

1755-1307

1755-1315

Geography

Geosciences

Physics

2018-05-09

American Physical Society (APS)

2160-3308

Physics

2018-02-10

American Physical Society (APS)

0031-9007

1079-7114

Physics

Condensed Matter: Electronic Properties, etc.

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P 〈 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background  Familial benign chronic pemphigus or Hailey–Hailey disease (HHD; OMIM 169600) is an autosomal dominant blistering disease. Pathogenic mutations in ATP2C1 encoding a novel Ca2+ pump have recently been identified.Objectives  To identify mutations in ATP2C1 in Chinese patients with HHD.Methods  Eleven unrelated Chinese patients with HHD were subjected to mutation detection in ATP2C1. Eight of them had a family history of HHD. The 27 coding exons and their flanking sequences were amplified and sequenced.Results  Five of the 11 patients were identified to have heterozygous mutations including three nonsense mutations and two splicing mutations in ATP2C1.Conclusions  Four novel mutations, nonsense mutations S887X and W795X and splicing mutations 118−1 g→a and 1890+1del(gtgag)ins53, were found in this series of Chinese patients with HHD.

Electronic Resource

1468-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Aim To compare the efficacy, safety and tolerability of adapalene gel 0.1% vs. tretinoin gel 0.025% in a Chinese patient population.Background Although acne vulgaris is a common problem among Asians and Asian-Americans, little has been published on the specific manifestations, sequelae, and treatment-responsiveness of this disorder in Asian skin types. Since Asian skin types tend to be more highly pigmented than those of white people of European descent, many Asians share the predisposition toward postinflammatory hyperpigmentation seen in Africans, African-Americans and other dark-skinned peoples. It is generally assumed that the efficacy and safety of topical retinoids is the same in Asians as in white people. Tretinoin has been available in China for decades; adapalene became available in 1998.Methods A total of 150 patients with grade II–III acne vulgaris seen at three dermatology clinics were randomized to 8 weeks of daily treatment with either adapalene gel 0.1% or tretinoin gel 0.025%. Counts of total lesions, inflammatory lesions and non-inflammatory lesions were made at baseline and again at treatment weeks 2, 4, 6 and 8. Global assessment ratings, based on percent lesion reduction from baseline were also made. Erythema, burning, pruritus, scaling and dryness were rated on a 0–3 severity scale.Results A total of 139 patients completed the efficacy evaluation, and 144 patients completed the safety evaluation. Both adapalene and tretinoin produce dramatic reductions in total, inflammatory and non-inflammatory lesion counts, in the range of 69–74% on average. More than 70% of patients in both groups had complete clearance or marked improvement. In general, irritation was mild, but was both more common and more severe in the tretinoin group vs. the adapalene group. No systemic side effects were seen.Conclusions Adapalene offers comparable efficacy to tretinoin, but is less irritating. It represents a good alternative for the treatment of mild to moderate acne vulgaris in Chinese patients.

Electronic Resource

1573-7586

Springer Online Journal Archives 1860-2000

Computer Science

Mathematics

Abstract In [2], L. Chihara proved that many infinite families of classical distance-regular graphs have no nontrivial perfect codes, including the Grassman graphs and the bilinear forms graphs. Here, we present a new proof of her result for these two families using Delsarte's anticode condition[3]. The technique is an extension of an approach taken by C. Roos [6] in the study of perfect codes in the Johnson graphs.

Electronic Resource