Search Results - (Author, Cooperation:Weise)

Stengel, Erich; Weise, Kurt

Unknown

173 S.

Kletts biologisches Unterrichtswerk Bd. 4/5

Kletts Biologisches Unterrichtswerk

German

Weise, Georg

Unknown

267 S.

3801701018

Psychologische Leistungstests Bd. 1

German

Stengel, Erich; Weise, Kurt Otto

Book

249 S.

Kletts Biologisches Unterrichtswerk Bd. 7

German

Stengel, Erich; Weise, Kurt Otto

Book

296 S.

2. Aufl.

Kletts Biologisches Unterrichtswerk 1-3

German

Stengel, Erich; Thieme, Erich; Weise, Kurt Otto

Book

5. Aufl.

Kletts Biologisches Unterrichtswerk Bd. 4

German

Reinhardt, Sibylle; Weise, Elke

Unknown

248 S.

3892717419

Studien zur Schul- und Bildungsforschung Bd. 5

1433-0407

Schlüsselwörter Chorea Huntington ; Intrafamiliäre Variabilität ; Krankheitsbeginn ; Fehldiagnosen ; Key words Huntington’s disease ; Intrafamiliar variability ; Age of onset ; Misdiagnosis

Springer Online Journal Archives 1860-2000

Medicine

Summary Huntington’s disease (HD) may cause considerable diagnostic problems because of the highly variable clinical features, especially at the beginning of the illness. We report the case of a 21-year-old woman with definite HD whose main symptoms were psychopathological changes that were misinterpreted as schizophrenia for 7 years. One reason for this misdiagnosis was the unusual, very early onset and the remarkable earlier age of onset of HD compared with that of other affected relatives. The phenomenon of earlier onset within one affected family is well documented in the literature in cases with the paternally transmitted mutated gene. Diagnostic landmarks were consideration of the initially mild disturbances of movement and the once again repeated detailed examination of the family history.

Zusammenfassung Die Diagnose einer Chorea Huntington kann aufgrund der hohen Variabilität des klinischen Bildes besonders zu Beginn der Erkrankung erhebliche Probleme bereiten. Wir stellen eine 21jährige Patientin mit einer gesicherten Chorea Huntington vor, bei der über 7 Jahre die psychopathologischen Veränderungen die Hauptsymptomatik bildeten und als Schizophrenie fehldiagnostiziert wurden. Außergewöhnlich und somit für die Fehldiagnose maßgeblich verantwortlich waren der sehr frühe Beginn der Erkrankung und die im Vergleich zu anderen erkrankten Familienmitgliedern deutliche Vorverlegung des Krankheitsbeginns. Das Phänomen der Vorverlegung des Krankheitsbeginns ist jedoch für den Fall der Übertragung des mutierten Gens vom Vater in der Literatur gut dokumentiert. Differentialdiagnostisch wegweisend waren die Beachtung der zunächst dezenten Auffälligkeiten des Bewegungsmusters der Patientin und die daraufhin nochmals detaillierte Erhebung der Familienanamnese.

Electronic Resource

2018-07-27

"Der Aufsatz untersucht, welche menschlichen Handlungen als individualethisch bezeichnet werden können und welches Verhalten als durch Institutionen bewirktes ethisches Verhalten gelten könnte. Es wird argumentiert, dass ein ethisches Verhalten im eigentlichen Sinne immer nur individualethisch sein kann. Die als Institutionenethik bezeichnete Koordination des Verhaltens durch Märkte oder Normen lässt keinen Spielraum für individuelles Ermessen und entbindet den Menschen damit von selbstbestimmtem moralischen Verhalten." (Autorenreferat)

"The aim of this paper is twofold. It discusses which behaviour can be viewed as Individual Ethics and in which circumstances one can speak of Institutional Ethics. It is argued that only Individual Ethics can be interpreted as actual ethical behaviour. Institutional Ethics - that is, the coordination of human beings by markets or normative regulations - leaves no room for individual judgements and, therefore, prevents a deliberate moral behaviour. A functioning Individual Ethic has the advantage of having a socially costless consideration for the general well-being. Yet, there are situations, regulated by markets or norms; either because the regulation lies within the logic of the institution (compensation via market prices) or because there seems to be a need to enforce some kind of behaviour (law). In such cases, however, the Individual Ethic's 'natural' propensity for ethical behaviour is endangered and Institutional Ethics can be far more costly to enforce." (author's abstract)

Wirtschaft ; Philosophie ; Economics ; Philosophy ; Allgemeines, spezielle Theorien und Schulen, Methoden, Entwicklung und Geschichte der Wirtschaftswissenschaften ; Philosophie, Theologie ; Basic Research, General Concepts and History of Economics ; Philosophy, Ethics, Religion ; Individuum ; Ethik ; Wirtschaftsethik ; Moral ; Handlung ; Markt ; soziale Norm ; Institution ; Tausch ; Wirtschaftsbeziehungen ; individual ; ethics ; business ethics ; morality ; action ; market ; social norm ; institution ; barter ; economic relations ; Grundlagenforschung ; basic research

Zeitschriftenartikel, journal article

2024-03-15

Der Dialog ist für die einen das Versprechen gelingender Kommunikation, für die anderen ein überholtes Ideal. Der Autor zeigt in einer interdisziplinär angelegten Studie, dass sich die Lücke zwischen Lobpreisungen und Abgesängen schließen lässt. Er setzt bei der Unmöglichkeit des Denkens "nach der Shoah" an und erkundet in exemplarischen Untersuchungen der europäischen Literatur-, Theater- und Theoriegeschichte die Spannungen und Widersprüche im Verhältnis zum "Anderen", ohne die der Dialog nicht zu greifen ist. So macht er zwischenmenschliche, soziale und politische Vorgänge als prinzipiell unabschließbares Sprachgeschehen fassbar und eröffnet einen Spielraum für die Aushandlung und das Aushalten von Dissens und Differenz.

Literatur, Rhetorik, Literaturwissenschaft ; Literature, rhetoric and criticism ; Denkfigur; Dissens; Differenz; Literaturtheorie; Figure of Thought; Difference; Theory of Literature; Theatre Studies ; Literaturwissenschaft, Sprachwissenschaft, Linguistik ; Science of Literature, Linguistics ; Literatur ; Theater ; Philosophie ; Dialog ; Literaturwissenschaft ; Theaterwissenschaft ; literature ; theater ; philosophy ; dialogue ; literature (discipline) ; theater arts and sciences

Dissertation, phd thesis

2020-07-22

Publicly available visualisations play an increasing role in enabling wider audiences to contribute to debates to shape place futures. In this article, we unpack such contributions to consider the conceptualisation, actualisation and deployment of these visualisations as separate entities that each require development and reflection. In doing so we draw on our experiences of using two public engagement tools that utilise visualisations of residents’ comments. Through this we explore the limitations of visualisations in public engagement designed to support differing levels of debate and their abilities to support abstract topics and geographic associations. We discuss how visualisations alone do not produce actions and how they need to be rooted in wider conversations about a place to lead to insights and action. The article calls for the linking of visualisations for place meaning and place action at different stages of much broader public engagement projects to unlock the potentials present in them in the mediatisation of built environment outcomes.

Städtebau, Raumplanung, Landschaftsgestaltung ; Landscaping and area planning ; knowledge exchange ; Raumplanung und Regionalforschung ; Area Development Planning, Regional Research ; Stadtplanung ; Stadtentwicklung ; Digitalisierung ; Visualisierung ; Bürgerbeteiligung ; urban planning ; urban development ; digitalization ; visualization ; citizens' participation

Zeitschriftenartikel, journal article

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: Adult beagle dogs of either sex were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-HCl (2.5 mg/kg, i.v.) alone or after pretreatment with pargyline (5.0 mg/kg, s.c, twice), with pargyline alone, or were unin-jected. Groups were killed 2 h, 3 weeks, or 3 months after injection, and several brain areas were assayed for biogenic amines and their synthetic and degradative enzymes. MPTP caused a massive and permanent loss of striatal dopamine, tyrosine hydroxylase, and 3,4-dihydroxyphenylalanine decarboxylase activities and the loss of cells within the substantia nigra pars compacta. Dopamine and norepinephrine also were depleted to various degrees in cortex, olfactory bulb, and hypothalamus; however, dopamine β-hydroxylase activity in cortex was normal. There was no cell loss in the ventral tegmental area or locus ceruleus. The activities of monoamine oxidase (MAO)-A and MAO-B in cortex and caudate were not affected by MPTP. Despite a permanent loss of the ni-grostriatal system, the dogs exhibited only a transient hypokinesia lasting 1-2 weeks. Pargyline pretreatment prevented the loss of striatal dopamine and cells from the substantia nigra, but did not prevent a prolonged but reversible decrease in the concentration of dopamine metabolites. It is argued that this apparent inhibition of MAO is due not to suicide inactivation of the enzyme by MPTP, but to reversible inhibition by accumulation of the pyridinium metabolite, 1-methyl-4-phenylpyridinium, selectively in aminergic terminals.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: The effects of a single and of repeated immobilization stress on the expression of the final enzyme involved in epinephrine biosynthesis, phenylethanolamine N-methyltransferase (PNMT), are described. A single immobilization (whether lasting 5 or 120 min) caused a severalfold increase of the adrenal PNMT mRNA level as measured 2 h after the beginning of the procedure. This elevation was of a transient nature, peaked 3–6 h after the 2-h immobilization, and returned to control values by 12 h after the stress. When the animals were immobilized for 2 h/day for seven consecutive days, an increase in content of PNMT mRNA of a similar magnitude was observed, which persisted for at least 2 days after the seventh immobilization. The immobilization-induced increase was completely abolished in hypophysectomized animals, whereas adrenal denervation failed to prevent it. These data suggest that the immobilization-induced increase in adrenal PNMT mRNA level depends primarily on pituitary-adrenocortical regulation.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Single toxic doses of l-methyl-4-phenyl-l,2,3,6- tetrahydropyridine (MPTP)-HCI (2.5 mg/kg i.v.) and 4′- amino-MPTP · 2HCI (22.5 mg/kg) induce loss of striatal dopamine (DA) and tyrosine hydroxylase (TH) activity and of nigral DA neurons in the dog. To examine the subacute neurochemical changes induced by low doses of MPTP and 4′- amino-MPTP, dose-response studies of these compounds were carried out in the dog, using 6- and 3-week survival times for these two compounds, respectively. Low single doses of MPTP (1.0, 0.5, and 0.1 mg/kg i.v.) and 4′-amino-MPTP (15, 7.5, and 3.75 mg/kg i.v.) did not cause depletion of canine striatal DA or TH or a loss of nigral neurons. However, levels of the DA metabolites 3,4-dihydroxyphenylacetic acid (DO- PAC) and homovanillic acid (HVA) were decreased in a doserelated fashion, with significant loss of DOPAC being evident 6 weeks after the lowest administered dose of MPTP and 3 weeks after 4′-amino-MPTP. This selective loss of DA metabolites following nontoxic doses of MPTP and 4′-amino- MPTP led to a shift in the ratio of DA to DOPAC or HVA, which was characteristic for each compound. The measurement of striatal l-methyl-4-phenylpyridinium (MPP+) and 4′-amino-MPP+ levels revealed that high concentrations (up to 150 μM) persist in the striatum for weeks following administration of a single nontoxic dose of MPTP or 4′-amino- MPTP. A causal relationship between the striatal concentration of MPP+ or 4-amino-MPP+ and the change in DA metabolism as reflected in the DA/DOPAC ratio is suggested by a significant correlation between these measures. It is suggested that presynaptic sequestration and retention of MPP+ and 4′-amino-MPP+ by striatal DA terminals result in the inhibition of the monoamine oxidase contained within these terminals.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: A rapid method for similarity searches (FASTP program) was used to identify similarities between a protein database and the human basic proteins from myelin [P2 protein and 17.2K, 18.5K, and 21.5K variants of myelin basic protein (MBP)]. From similarity scores, we concluded that none of the presently known proteins are in a family containing the MBPs. No new members were found for the lipid-binding family of which P2 is a member. Sequence similarities deemed relevant to the molecular mimicry hypothesis for virus-induced autoimmunity were identified in FASTP data with the aid of microcomputer programs. Several MBP/viral protein similarities were found that have not been reported previously. Of note because of their association with demyelinating conditions were proteins from visna and vaccinia. Similarity with visna was specific to the 21.5K and 20.2K MBPs. The most interesting new possibility for mimicry involving the P2 protein was between the influenza A NS2 protein and a sequence region of P2 thought to be neuritogenic in animals and mitogenic for lymphocytes from some patients with Guillain-Barre syndrome (GBS). This may have relevance for some cases of GBS associated with the 1976 U.S.A. swine flu vaccination program. Because FASTP reports only the best similarities between proteins, searches with FASTP may not have detected all the examples of mimicry present in the database. Searches might also be more effective if similarities could be scored on immunological rather than structural relatedness.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: In conscious animals, handling and immobilization increase plasma levels of the catecholamines norepinephrine (NE) and epinephrine (EPI). This study examined plasma concentrations of endogenous compounds related to catecholamine synthesis and metabolism during and after exposure to these stressors in conscious rats. Plasma levels of 3,4-dihydroxyphenylalanine (DOPA). NE, EPI, and dopamine (DA), the deaminated catechol metabolites 3,4-dihydroxyphenylglycol (DHPG) and 3,4-dihydroxyphenylacetic acid (DOPAC), and their O-methylated derivatives methoxyhydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were measured using liquid chromatography with electrochemical detection at 1,3, 5, 20, 60, and 120 min of immobilization. By 1 min of immobilization, plasma NE and EPI levels had already reached peak values, and plasma levels of DOPA, DHPG, DOPAC, and MHPG were increased significantly from baseline, whereas plasma DA and HVA levels were unchanged. During the remainder of the immobilization period, the increased levels of DOPA, NE, and EPI were maintained, whereas levels of the metabolites progressively increased. In animals immobilized briefly (5 min), elevated concentrations of the metabolites persisted after release from the restraint, whereas DOPA and catecholamine levels returned to baseline. Gentle handling for 1 min also significantly increased plasma levels of DOPA, NE. EPI, and the NE metabolites DHPG and MHPG, without increasing levels of DA or HVA. The results show that in conscious rats, immobilization or even gentle handling rapidly increases plasma levels of catecholamines, the catecholamine precursor DOPA, and metabolites of NE and DA, indicating rapid increases in the synthesis, release, reuptake, and metabolism of catecholamines.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: Cysteine sulfinate decarboxylase (CSD), the putative biosynthetic enzyme for taurine, has been shown to exist in two forms in rat brain, respectively CSDI and CSDII, one of which (CSDII) is considered to be in fact glutamate decarboxylase (GAD). CSDI assay after immunotrapping was made possible by using an anti-CSD antiserum raised in sheep immunized with a partially purified CSD fraction from liver. This antiserum immunoprecipitated both liver CSD and brain CSDI activities with the same affinity but did not inhibit their enzymatic activities. The immunotrapping of CSDI was selective without any contamination by GAD/CSDII activity. The immunotrapped CSD activity, which corresponded exactly to the amount of CSD not precipitated by a GAD/CSDII antiserum, was not inhibited by a specific irreversible GAD inhibitor. A quantitative, selective and sensitive assay was thus developed by measuring CSD activity on the solid phase after immunotrapping. Kinetic parameters of the immunotrapped enzyme remained unchanged. CSDI activity represented only a fraction, around 20% with saturating concentration of substrate, of the total CSD activity in rat brain homogenate. This indicates that most studies on total CSD activity dealt essentially with CSDII activity that is indeed GAD. Regional and subcellular distributions of CSDI have been determined. CSDI activity was about threefold higher in the richest (cerebellum) compared to the poorest (striatum) region without any correlation with GAD/CSDII distribution. Subcellular distribution showed a fourfold enrichment of CSDI activity in the synaptosomal fraction. The precise role of CSDI and CSDII in the biosynthesis of taurine in vivo remains to be elucidated.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: Adrenal catecholamines are known to mediate many of the physiological consequences of the “fight or flight” response to stress. However, the mechanisms by which the long-term responses to repeated stress are mediated are less well understood and possibly involve alterations in gene expression. In this study the effects of a single and repeated immobilization stress on mRNA levels of the adrenal catecholamine biosynthetic enzymes, tyrosine hydroxylase and dopamine β-hydroxylase, were examined. A repeated 2-hr daily immobilization for 7 consecutive days markedly elevated both tyrosine hydroxylase and dopamine β-hydroxylase mRNA levels (about six- and fourfold, respectively). In contrast, tyrosine hydroxylase but not dopamine β-hydroxylase mRNA levels were elevated immediately following a single immobilization. The elevation in tyrosine hydroxylase mRNA with a single immobilization was as high as with seven daily repeated immobilizations. This elevation was not sustained and returned toward control values 24 hr later. Both tyrosine hydroxylase and dopamine β-hydroxylase mRNA levels were elevated immediately following two daily immobilizations to levels similar to those observed after seven immobilizations and were maintained 24 hr later. The results indicate that both tyrosine hydroxylase and dopamine β-hydroxylase mRNA levels are elevated by stress; however, the mechanism and/or timing of their regulation are not identical.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: P2 protein is a minor component of the myelin membrane. We have crystallized this protein for high-resolution crystallographic study. Three crystal morphologies are available. Two of them are from ammonium sulfate, and one is from polyethyleneglycol (PEG). The unit cell of the most suitable crystals from PEG 4000 has the dimensions a= 91.3 Å, b= 99.8 Å, c= 56.0 Å; is of space group P212121; and contains up to four molecules per asymmetric unit. The limit of resolution is 2.7 Å.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Computer-generated “hydropathic’ profiles were constructed for graphic comparison of the amino acid sequences for P2 protein, 18.5 kilodalton (kDa) myelin basic protein (BP), and myelin proteolipid protein (PLP). Profiles were also obtained for cytochrome b5, a membrane protein known to be capable of reversible association with lipid bilayers and of a size comparable to that of the myelin BPs. Analysis of the PLP sequence produced profiles generally compatible with the suggestions that PLP has three transbilayer and two bilayer intercalating segments. Profiles for P2 and 18.5 kDa BP were found to contain hydrophilic segments separated by relatively short hydrophobic regions. Whereas hydropathic indices in hydrophobic regions of P2, 18.5 kDa BP, and PLP fall in the value ranges recently reported for cores of globular proteins and intrabilayer domains of membrane proteins, hydrophobic sections of P2 and 18.5 kDa BP have hydropathic indices similar to those in the hydrophobic core (transprotein) regions of globular proteins. None of them are comparable to the region of cytochrome b5 known to anchor that protein in its membrane or to the segments of PLP sequence proposed as intrabilayer domains. This comparison suggests that neither BP has structural characteristics compatible with insertion into the hydrocarbon core of the myelin lipid bilayer, a conclusion that is consistent with a recently published study that identified the bilayer penetrating proteins of myelin with a hydrophobic probe. The above findings suggest an enhancement for some details of myelin architecture and a cautious approach to interpreting data for BP intercalation into bilayers.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: Proteins in peripheral nervous system and central nervous system myelin and homogenates of sciatic nerve and brain from young and adult mice and rats were characterized with affinity-purified anti-P2 and anti-myelin basic protein sera after electrophoretic transfer from sodium dodecyl sulfate-polyacrylamide gels to nitrocellulose sheets. Using this method we have identified a component of rodent peripheral nervous system myelin as P2 protein. Peripheral nervous system myelin also showed the presence of four basic proteins in addition to P2 protein. These were found to be analogous to the 14, 17, 18.5, and 21.5K species found in the central nervous system myelin. A number of high-molecular-weight proteins were also detected with anti-myelin basic protein serum in peripheral nervous system, as well as central nervous system myelin. In addition, we report the presence of a high-molecular-weight P2 cross-reactive protein in rodent brain stem homogenates, but not in central nervous system myelin.

Electronic Resource