Search Results - (Author, Cooperation:W. Sweeney)
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1Latest Papers from Table of Contents or Articles in PressM. Nicholl ; S. J. Smartt ; A. Jerkstrand ; C. Inserra ; M. McCrum ; R. Kotak ; M. Fraser ; D. Wright ; T. W. Chen ; K. Smith ; D. R. Young ; S. A. Sim ; S. Valenti ; D. A. Howell ; F. Bresolin ; R. P. Kudritzki ; J. L. Tonry ; M. E. Huber ; A. Rest ; A. Pastorello ; L. Tomasella ; E. Cappellaro ; S. Benetti ; S. Mattila ; E. Kankare ; T. Kangas ; G. Leloudas ; J. Sollerman ; F. Taddia ; E. Berger ; R. Chornock ; G. Narayan ; C. W. Stubbs ; R. J. Foley ; R. Lunnan ; A. Soderberg ; N. Sanders ; D. Milisavljevic ; R. Margutti ; R. P. Kirshner ; N. Elias-Rosa ; A. Morales-Garoffolo ; S. Taubenberger ; M. T. Botticella ; S. Gezari ; Y. Urata ; S. Rodney ; A. G. Riess ; D. Scolnic ; W. M. Wood-Vasey ; W. S. Burgett ; K. Chambers ; H. A. Flewelling ; E. A. Magnier ; N. Kaiser ; N. Metcalfe ; J. Morgan ; P. A. Price ; W. Sweeney ; C. Waters
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-10-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralNotes: Vulvovaginitis in childhood has been defined and a working classification devised. The diagnosis is made by a thorough history, physical examination, and the use of appropriate laboratory aids. Adequate examination of the vagina and cervix and the taking of cultures are absolutely necessary in all cases. Treatment should be individualized on the basis of the etiologic agent involved. The importance of personal cleanliness cannot be overemphasized, as it is probably the most important factor in the treatment.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesPalakanis, Kerry C. ; DeNobile, John W. ; Sweeney, W. Brian ; Blankenship, Charles L.
Springer
Published 1994Staff ViewISSN: 1530-0358Keywords: Flexible sigmoidoscopy ; Colorectal cancer screening ; Music therapySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract PURPOSE: Patient anxiety related to flexible sigmoidoscopy can negatively affect acceptability and compliance with screening protocol, complicate and prolong procedure time, and potentially result in prematurely aborted procedures. Music has been recognized through research as a safe, inexpensive, and effective nonpharmaceutical anxiolitic agent. METHODS: An experimental study was performed on 50 adults scheduled for outpatient sigmoidoscopy. The control group received standard sigmoidoscopy protocol. Subjects in the experimental group received the standard protocol with the addition of listening to music throughout the procedure. State-Trait Anxiety Inventory (STAI) measurements were performed on all subjects before and postsigmoidoscopy. Physiologic recordings of heart rate and mean arterial pressure were recorded before and during the procedure. RESULTS: Patients who listened to self-selected music tapes during the procedure had significantly decreased STAI scores (P 〈0.002), heart rates (P 〈0.03), and mean arterial pressures (P 〈0.001) in comparison to the control subjects. CONCLUSION: The results of the study indicate that music is an effective anxiolitic adjunct to flexible sigmoidoscopy.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1530-0358Keywords: Rectal cancer ; Local excision ; Surgical techniqueSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Transanal local excision is a management option for patients with rectal tumors. An important final step in this operation is specimen orientation. A simple technique is described for specimen preparation, ideally performed by the surgeon in the operating room. This technique is recommended as the concluding step, for it can be as important as the local excision itself in regard to the determination of adequacy of resection and the need for additional treatment.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1530-0358Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1530-0358Keywords: Rectal prolapse ; Bulimia nervosa ; Eating disorders ; Laxative abuseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract PURPOSE: Rectal prolapse is a condition in which, when complete, the full thickness of the rectal wall protrudes through the anus. Bulimia nervosa is an eating disorder characterized by periodic food binges, which are followed by purging. Purging usually takes the form of self-induced vomiting, laxative abuse, and/or diuretic abuse. We report seven cases of rectal prolapse associated with bulimia nervosa. METHODS: The case histories of seven women with rectal prolapse and bulimia nervosa, average age 29 (range 21–42) years, seen over a period of 11 years (1987–1997) were reviewed. An analysis of the clinical data, including history, presenting physical examination, surgical treatment, and outcome was performed. RESULTS: All seven patients had a diagnosis of bulimia nervosa, made either before or with a diagnosis of rectal prolapse. Rectal prolapse was confirmed in each patient at anorectal examination. Five patients underwent sigmoid resection with proctopexy, one died before operative therapy, and one awaits further treatment. One of the five surgical patients had a recurrence that was managed by a perineal rectosigmoidectomy. CONCLUSION: To our knowledge, despite extensive review of both bulimia nervosa and rectal prolapse as seen in the medical literature, an association between the two has not been described previously. Several aspects of bulimia nervosa, including constipation, laxative use, overzealous exercise, and increased intra-abdominal pressure from forced vomiting are likely causes for the probable relationship with rectal prolapse. The possibility that an atypically young female presenting with rectal prolapse may also have bulimia nervosa should be taken into account by clinicians. This may assist the diagnosis of bulimia nervosa, a disease with multiple morbidities. Conversely, a patient being treated for bulimia nervosa who develops anorectal symptoms may come to earlier diagnosis and treatment for rectal prolapse.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesRicciardi, Rocco ; Counihan, Timothy C. ; Banner, Barbara F. ; Brian Sweeney, W.
Springer
Published 1999Staff ViewISSN: 1530-0358Keywords: Hirschsprung's disease ; Meissner's plexus ; Auerbach's plexus ; Anal Canal ; CadaverSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract INTRODUCTION: Ultrashort-segment Hirschsprung's disease as a cause of obstructed defecation is controversial because of a lack of knowledge regarding the normal aganglionic zone of the distal rectum. The intent of this study was to define the normal aganglionic zone of the distal rectum through histologic review of cadaveric dissections. METHODS: Cadavers were obtained from the anatomic pathology laboratory at the University of Massachusetts Medical School. Strip myectomy with overlying mucosa was performed from distal to the dentate line to at least 3 cm into the anal canal and rectum after the pelvis was hemisected. Specimens were fixed in 10 percent buffered formalin. Specimens were sectioned serially every 3 mm and embedded in paraffin. Four-micron slices were then stained with hematoxylin and eosin. Each section was examined by a gastrointestinal pathologist. The presence or absence of nerves and ganglion cells was recorded. RESULTS: Thiry cadavers were obtained for analysis. Mean age at time of death was 79 (range, 65–97) years. There were 13 men. The mean distance of aganglionic bowel from the dentate line was 6.6 (range, 0–21) mm in Meissner's plexus and 5.1 (range, 0–15) mm in Auerbach's plexus. CONCLUSION: The normal distance of aganglionic bowel wall is 2 cm or less from the dentate line. The absence of ganglion cells proximal to this normal aganglionic zone in the patient with clinical findings of lifelong obstructed defecation defines ultrashort-segment Hirschsprung's disease.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 μg/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basic mechanisms underlying renal tubular cystic changes, as well as the mechanisms by which nephrotoxins may mediate renal tubular injury.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Polycystic kidney disease ; organ cultureSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary A new experimental model of glucocortocoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4×10−5 M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis. The model isolates the role of glucocorticoids in experimental cyst formation.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-2218Keywords: Continent ileostomy ; Kock pouch ; Pregnancy and ileostomySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The Kock continent ileostomy is a surgical alternative to a Brooke ileostomy after total proctocolectomy. Complications resulting from an improperly functioning nipple valve are not infrequent and when they occur most often require surgical revision. A 19-year-old female with a functioning Kock pouch of 4 years presented at 6 months of pregnancy with complete bowel obstruction due to nipple valve dysfunction. Operative management was avoided and her bowel obstruction was relieved by endoscopic placement of a stent through the nipple valve and into the abdominal reservoir. The stent was removed at 1 week postpartum with immediate return to normal function of her Kock pouch nipple value. Temporary malfunction of the Kock pouch nipple valve can occur during pregnancy, probably due to distortion of the valve mechanism by the enlarging uterus. The endoscopic placement of a stent can maintain proper bowel evacuation until delivery and normal Kock pouch function can be expected after stent removal.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-2218Keywords: Key words: Large bowel obstruction — Colonic stent — Endoprosthesis — Diverticular strictureSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. We report a case of complete descending colon obstruction due to diverticular disease that was initially managed by endoscopic stent placement followed by single-stage left colectomy with primary anastomosis. Traditional management of complete large bowel obstruction, whether due to benign or malignant disease, most often requires a temporary colostomy because of unprepared colon. In this case, preparation of the colon was accomplished by successful stenting of the benign colonic obstruction. We believe that endoscopic colonic stenting is an effective way of avoiding a temporary colostomy in patients with complete large bowel obstruction.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesRugh, R. ; Duhamel, L. ; Osborne, A. W. ; Sweeney, W. A.
New York, NY [u.a.] : Wiley-Blackwell
Published 1969Staff ViewISSN: 0002-9106Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: CF1 mice were exposed to x-rays during development at various intervals from 0.5 day after conception to 18 days. The levels of x-irradiation were previously established for each gestation day so that half of the exposed fetuses would survive for at least 30 days after birth. Those that survived to two months were radiographed (1,174 mice including 150 controls of the two sexes) and seven bone measurements were taken from each mouse. From conception through gestation day 10 there appeared to be no significant reduction in bone measurements as a result of embryonic or fetal x-irradiation even though the exposures ranged from 100 R to 400 R. The greatest decrements followed exposure of the fetuses at days 15 and 16, although there was some reduction on days 13 and 14 also. The spine measurements were first reduced when x-irradiation was done on day 11. In both the controls and those x-rayed the average bone measurements were slightly greater for the males than for the females. Embryologically those days most radiosensitive with respect to skeletal growth were those when osteogenesis was the most active. There is no evidence that ionizing radiations prior to chondrogenesis has any effect on later skeletal development.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesBacskai, R. ; Lindeman, L. P. ; Ransley, D. L. ; Sweeney, W. A.
New York : Wiley-Blackwell
Published 1969Staff ViewISSN: 0449-296XKeywords: Physics ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The 100 MHz proton magnetic resonance (PMR) spectra of free radical alternating ω-alkyl-α-olefin/SO2 copolymers has been investigated. The data obtained from the quantitative evaluation of the spectra are consistent with a copolymer structure containing unrearranged olefinic monomer units. The 4-methyl-1-pentene/SO2 copolymer shows a quadruplet resonance in the CH3 proton region. This multiplicity, observed also in the analogous 1,2-dichloro-4-methylpentane and 1,2-dibromo-4-methylpentane, arises from the presence of magnetically nonequivalent CH3 protons located in the vicinity of the asymmetric carbon atoms of the main chain. There is no detectable nonequivalency of CH3 protons in the 5-methyl-1-hexene/SO2 copolymer, probably because the center of asymmetry is further removed from the isopropyl group. In poly-4-methyl-1-pentene, prepared with Ziegler-Natta catalyst, the polymer structure around the main chain tertiary carbons is fairly symmetrical; and, as expected, the CH3 protons of the isopropyl group are magnetically equivalent.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: