Search Results - (Author, Cooperation:W. L. Lee)

2018-09-26

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2012-09-21

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antigen Presentation ; Antigens, CD/metabolism ; Antigens, CD8/immunology/metabolism ; Basic-Leucine Zipper Transcription ; Factors/chemistry/deficiency/genetics/*metabolism ; CD4-Positive T-Lymphocytes/cytology/immunology ; CTLA-4 Antigen/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Cell Lineage ; Dendritic Cells/*cytology/immunology/*metabolism ; Female ; Fibrosarcoma/immunology/metabolism/pathology ; Gene Expression Regulation ; Integrin alpha Chains/metabolism ; Interferon Regulatory Factors/deficiency/genetics/*metabolism ; Interleukin-10/metabolism ; Interleukin-12/immunology/metabolism ; Leucine Zippers ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Oncogene Protein p65(gag-jun)/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Repressor Proteins/deficiency/genetics ; T-Lymphocytes, Helper-Inducer/cytology/immunology/metabolism ; Toxoplasma/immunology

1077-3118

AIP Digital Archive

Physics

The photoluminescence (PL) response of porous silicon is usually in the form of a single broad peak. Recently, however, PL response with two peaks has been reported. Here we report the observation of multiple peaks in the PL spectrum of porous silicon. A simple modeling of the line shape indicates that four peaks exist within the response curve, and analysis suggests that the PL of porous silicon is derived from quantum confinement in the silicon crystallites. The line shapes can be due to either minibands within the conduction and valence bands or crystallite size variation or a combination of the two.

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Naftifine (NF), a topical antimycotic agent, is highly active in vitro and in vivo against a wide range of pathogenic fungi. NF inhibits human polymorphonuclear leucocyte (PMN) chemotaxis. Following stimulation with zymosan-activated serum. 85–97% of the PMNs exhibited detectable membrane ruffling and polarity. In contrast, NF-treated PMNs did not exhibit such chemotactic factor-induced shape changes. We also analysed the effect of NF on PMN superoxide anion (O2−) and chemiluminescence (CL) production, as a measure of respiratory burst activity. Stimulation of PMNs pre-incubated with NF (37°C for 30 min at 1–150 μg/ml) hy FMLP, PMA and zymosan resulted in a dose-dependent inhibition in PMN CL. Doses of NF which depressed chemotaxis, inhibited CL and diminished O2− production in a statistically significant manner (P〈0.05–0.001). In conclusion, NF alters membrane-related responses in PMNs, and this alteration may be associated with a change in PMN morphology. Binding of NF to PMN membrane sterol, with a subsequent alteration in membrane configuration, is the most likely cause of the inhibition of PMN function. The data collectively document biochemical and morphological differences between control and NF-treated PMNs as determined by stimulus-specific CL and O2− generation and membrane shape change. Such differences may account, in part, for its efficacy in inflammatory fungal skin diseases.

Electronic Resource

0003-9861

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

0003-9861

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

1572-8145

Neural simulation ; keyboards ; SIMAN ; assembly ; control

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

This paper describes the integration of a feedforward neural network with a real-time adaptive control technique to model an assembly cell for computer keyboards. The simulation model is able to undertake real-time forecasting of the expected behaviour of the cell, and also able to display in real time the current status of the assembly cell. The potential of integrating artificial neural networks into simulation together with an on-line real-time interface between the simulation model and the real-world system is investigated in this study. A simulation model was built in SIMAN with a neural network written in NeuralWork Professional II Plus embedded in the model to allow training and testing of the network. The control of the cell was achieved through a third-party program written in C that interfaces directly to the cell.

Electronic Resource

1432-1793

Springer Online Journal Archives 1860-2000

Biology

Abstract We assessed the utility of separated carotenoid mixtures for sponge systematics. Carotenoids were extracted from 29 species of 22 genera of 6 families for the demosponge order Poecilosclerida. Mixtures were separated (by thinlayer chromatography on silica gel) without chemical modification and after alteration by saponification, reduction or acetylation or a combination thereof. This approach allowed analysis of individual colonies of less than 1 g wet weight. Relationships among taxa were determined through use of Lawson's similarity index and discriminative analysis. Analysis of multiple runs of fractions from one individual of Ophlitaspongia pennata showed the method to be consistent and reliable. Comparison of specimens of species collected at different localities and times showed high correspondence of carotenoid patterns except in those species suspected of representing species complexes. Analysis of members of the family Clathriidae and of relationships within the order Poecilosclerida suggest that fatty acids esterified to carotenoids may be family-specific and of more taxonomic value than carotenoids. The importance of testing for seasonal, geographic and habitat variability in biochemical patterns is stressed. We discuss the significance of these methods to sponge systematics and their use in comparative studies.

Electronic Resource

1432-1238

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1238

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1920

Key words Temporal lobe epilepsy ; Limbic system ; Hippocampus ; Magnetic resonance imaging

Springer Online Journal Archives 1860-2000

Medicine

Abstract We performed MRI on 27 patients with clinically proven temporal lobe epilepsy (TLE), all with prior EEG lateralisation, and 10 volunteers, studied to evaluate disparity in size arising from biological variation (group 1). Three-dimensional spoiled GRASS (3DSPGR) sequences provided 2-mm contiguous sections of the limbic system, enabling assessment of the hippocampus (HC), fornix (FN) and mamillary body (MB). Measurements of FN and MB width were made from a workstation. Any percentage difference in size was computed. In 19 cases there was unilateral abnormality in the HC (group 2); in 18 and 19 cases respectively there was a smaller FN and MB on the same side as the abnormal HC. This percentage difference in size was significantly greater than that in group 1 in the FN and MB in 17 and 17 cases respectively. Comparison of percentage difference computations for FN and MB between groups 1 and 2 showed high statistical significance (P 〈 0.0002). In 5 patients with clinical TLE the HC was normal on MRI (group 3). Unequal FN and MB sizes were found in 4, significant in 2. Comparison of percentage difference computations for FN and MB showed statistical significance (P 〈 0.0005 and P 〈 0.0003 respectively). There was no case of discordance between the sides of hippocampal abnormality and the smaller FN or MB or between the sides of smaller FN and MB. The strong concordance between the changes in the HC and those in the FN and MB suggests that this combination will play an important role in the assessment of TLE and limbic system abnormality.

Electronic Resource

1573-4811

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Electronic Resource