Search Results - (Author, Cooperation:W. Koenig)

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  1. 1
    D. Shungin ; T. W. Winkler ; D. C. Croteau-Chonka ; T. Ferreira ; A. E. Locke ; R. Magi ; R. J. Strawbridge ; T. H. Pers ; K. Fischer ; A. E. Justice ; T. Workalemahu ; J. M. Wu ; M. L. Buchkovich ; N. L. Heard-Costa ; T. S. Roman ; A. W. Drong ; C. Song ; S. Gustafsson ; F. R. Day ; T. Esko ; T. Fall ; Z. Kutalik ; J. Luan ; J. C. Randall ; A. Scherag ; S. Vedantam ; A. R. Wood ; J. Chen ; R. Fehrmann ; J. Karjalainen ; B. Kahali ; C. T. Liu ; E. M. Schmidt ; D. Absher ; N. Amin ; D. Anderson ; M. Beekman ; J. L. Bragg-Gresham ; S. Buyske ; A. Demirkan ; G. B. Ehret ; M. F. Feitosa ; A. Goel ; A. U. Jackson ; T. Johnson ; M. E. Kleber ; K. Kristiansson ; M. Mangino ; I. Mateo Leach ; C. Medina-Gomez ; C. D. Palmer ; D. Pasko ; S. Pechlivanis ; M. J. Peters ; I. Prokopenko ; A. Stancakova ; Y. Ju Sung ; T. Tanaka ; A. Teumer ; J. V. Van Vliet-Ostaptchouk ; L. Yengo ; W. Zhang ; E. Albrecht ; J. Arnlov ; G. M. Arscott ; S. Bandinelli ; A. Barrett ; C. Bellis ; A. J. Bennett ; C. Berne ; M. Bluher ; S. Bohringer ; F. Bonnet ; Y. Bottcher ; M. Bruinenberg ; D. B. Carba ; I. H. Caspersen ; R. Clarke ; E. W. Daw ; J. Deelen ; E. Deelman ; G. Delgado ; A. S. Doney ; N. Eklund ; M. R. Erdos ; K. Estrada ; E. Eury ; N. Friedrich ; M. E. Garcia ; V. Giedraitis ; B. Gigante ; A. S. Go ; A. Golay ; H. Grallert ; T. B. Grammer ; J. Grassler ; J. Grewal ; C. J. Groves ; T. Haller ; G. Hallmans ; C. A. Hartman ; M. Hassinen ; C. Hayward ; K. Heikkila ; K. H. Herzig ; Q. Helmer ; H. L. Hillege ; O. Holmen ; S. C. Hunt ; A. Isaacs ; T. Ittermann ; A. L. James ; I. Johansson ; T. Juliusdottir ; I. P. Kalafati ; L. Kinnunen ; W. Koenig ; I. K. Kooner ; W. Kratzer ; C. Lamina ; K. Leander ; N. R. Lee ; P. Lichtner ; L. Lind ; J. Lindstrom ; S. Lobbens ; M. Lorentzon ; F. Mach ; P. K. Magnusson ; A. Mahajan ; W. L. McArdle ; C. Menni ; S. Merger ; E. Mihailov ; L. Milani ; R. Mills ; A. Moayyeri ; K. L. Monda ; S. P. Mooijaart ; T. W. Muhleisen ; A. Mulas ; G. Muller ; M. Muller-Nurasyid ; R. Nagaraja ; M. A. Nalls ; N. Narisu ; N. Glorioso ; I. M. Nolte ; M. Olden ; N. W. Rayner ; F. Renstrom ; J. S. Ried ; N. R. Robertson ; L. M. Rose ; S. Sanna ; H. Scharnagl ; S. Scholtens ; B. Sennblad ; T. Seufferlein ; C. M. Sitlani ; A. Vernon Smith ; K. Stirrups ; H. M. Stringham ; J. Sundstrom ; M. A. Swertz ; A. J. Swift ; A. C. Syvanen ; B. O. Tayo ; B. Thorand ; G. Thorleifsson ; A. Tomaschitz ; C. Troffa ; F. V. van Oort ; N. Verweij ; J. M. Vonk ; L. L. Waite ; R. Wennauer ; T. Wilsgaard ; M. K. Wojczynski ; A. Wong ; Q. Zhang ; J. Hua Zhao ; E. P. Brennan ; M. Choi ; P. Eriksson ; L. Folkersen ; A. Franco-Cereceda ; A. G. Gharavi ; A. K. Hedman ; M. F. Hivert ; J. Huang ; S. Kanoni ; F. Karpe ; S. Keildson ; K. Kiryluk ; L. Liang ; R. P. Lifton ; B. Ma ; A. J. McKnight ; R. McPherson ; A. Metspalu ; J. L. Min ; M. F. Moffatt ; G. W. Montgomery ; J. M. Murabito ; G. Nicholson ; D. R. Nyholt ; C. Olsson ; J. R. Perry ; E. Reinmaa ; R. M. Salem ; N. Sandholm ; E. E. Schadt ; R. A. Scott ; L. Stolk ; E. E. Vallejo ; H. J. Westra ; K. T. Zondervan ; P. Amouyel ; D. Arveiler ; S. J. Bakker ; J. Beilby ; R. N. Bergman ; J. Blangero ; M. J. Brown ; M. Burnier ; H. Campbell ; A. Chakravarti ; P. S. Chines ; S. Claudi-Boehm ; F. S. Collins ; D. C. Crawford ; J. Danesh ; U. de Faire ; E. J. de Geus ; M. Dorr ; R. Erbel ; J. G. Eriksson ; M. Farrall ; E. Ferrannini ; J. Ferrieres ; N. G. Forouhi ; T. Forrester ; O. H. Franco ; R. T. Gansevoort ; C. Gieger ; V. Gudnason ; C. A. Haiman ; T. B. Harris ; A. T. Hattersley ; M. Heliovaara ; A. A. Hicks ; A. D. Hingorani ; W. Hoffmann ; A. Hofman ; G. Homuth ; S. E. Humphries ; E. Hypponen ; T. Illig ; M. R. Jarvelin ; B. Johansen ; P. Jousilahti ; A. M. Jula ; J. Kaprio ; F. Kee ; S. M. Keinanen-Kiukaanniemi ; J. S. Kooner ; C. Kooperberg ; P. Kovacs ; A. T. Kraja ; M. Kumari ; K. Kuulasmaa ; J. Kuusisto ; T. A. Lakka ; C. Langenberg ; L. Le Marchand ; T. Lehtimaki ; V. Lyssenko ; S. Mannisto ; A. Marette ; T. C. Matise ; C. A. McKenzie ; B. McKnight ; A. W. Musk ; S. Mohlenkamp ; A. D. Morris ; M. Nelis ; C. Ohlsson ; A. J. Oldehinkel ; K. K. Ong ; L. J. Palmer ; B. W. Penninx ; A. Peters ; P. P. Pramstaller ; O. T. Raitakari ; T. Rankinen ; D. C. Rao ; T. K. Rice ; P. M. Ridker ; M. D. Ritchie ; I. Rudan ; V. Salomaa ; N. J. Samani ; J. Saramies ; M. A. Sarzynski ; P. E. Schwarz ; A. R. Shuldiner ; J. A. Staessen ; V. Steinthorsdottir ; R. P. Stolk ; K. Strauch ; A. Tonjes ; A. Tremblay ; E. Tremoli ; M. C. Vohl ; U. Volker ; P. Vollenweider ; J. F. Wilson ; J. C. Witteman ; L. S. Adair ; M. Bochud ; B. O. Boehm ; S. R. Bornstein ; C. Bouchard ; S. Cauchi ; M. J. Caulfield ; J. C. Chambers ; D. I. Chasman ; R. S. Cooper ; G. Dedoussis ; L. Ferrucci ; P. Froguel ; H. J. Grabe ; A. Hamsten ; J. Hui ; K. Hveem ; K. H. Jockel ; M. Kivimaki ; D. Kuh ; M. Laakso ; Y. Liu ; W. Marz ; P. B. Munroe ; I. Njolstad ; B. A. Oostra ; C. N. Palmer ; N. L. Pedersen ; M. Perola ; L. Perusse ; U. Peters ; C. Power ; T. Quertermous ; R. Rauramaa ; F. Rivadeneira ; T. E. Saaristo ; D. Saleheen ; J. Sinisalo ; P. E. Slagboom ; H. Snieder ; T. D. Spector ; U. Thorsteinsdottir ; M. Stumvoll ; J. Tuomilehto ; A. G. Uitterlinden ; M. Uusitupa ; P. van der Harst ; G. Veronesi ; M. Walker ; N. J. Wareham ; H. Watkins ; H. E. Wichmann ; G. R. Abecasis ; T. L. Assimes ; S. I. Berndt ; M. Boehnke ; I. B. Borecki ; P. Deloukas ; L. Franke ; T. M. Frayling ; L. C. Groop ; D. J. Hunter ; R. C. Kaplan ; J. R. O'Connell ; L. Qi ; D. Schlessinger ; D. P. Strachan ; K. Stefansson ; C. M. van Duijn ; C. J. Willer ; P. M. Visscher ; J. Yang ; J. N. Hirschhorn ; M. C. Zillikens ; M. I. McCarthy ; E. K. Speliotes ; K. E. North ; C. S. Fox ; I. Barroso ; P. W. Franks ; E. Ingelsson ; I. M. Heid ; R. J. Loos ; L. A. Cupples ; A. P. Morris ; C. M. Lindgren ; K. L. Mohlke
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/metabolism ; Adipogenesis/genetics ; Adipose Tissue/*metabolism ; Age Factors ; *Body Fat Distribution ; Body Mass Index ; Continental Population Groups/genetics ; Epigenesis, Genetic ; Europe/ethnology ; Female ; Genome, Human/genetics ; *Genome-Wide Association Study ; Humans ; Insulin/*metabolism ; Insulin Resistance/genetics ; Male ; Models, Biological ; Neovascularization, Physiologic/genetics ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Sex Characteristics ; Transcription, Genetic/genetics ; Waist-Hip Ratio
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. E. Locke ; B. Kahali ; S. I. Berndt ; A. E. Justice ; T. H. Pers ; F. R. Day ; C. Powell ; S. Vedantam ; M. L. Buchkovich ; J. Yang ; D. C. Croteau-Chonka ; T. Esko ; T. Fall ; T. Ferreira ; S. Gustafsson ; Z. Kutalik ; J. Luan ; R. Magi ; J. C. Randall ; T. W. Winkler ; A. R. Wood ; T. Workalemahu ; J. D. Faul ; J. A. Smith ; J. Hua Zhao ; W. Zhao ; J. Chen ; R. Fehrmann ; A. K. Hedman ; J. Karjalainen ; E. M. Schmidt ; D. Absher ; N. Amin ; D. Anderson ; M. Beekman ; J. L. Bolton ; J. L. Bragg-Gresham ; S. Buyske ; A. Demirkan ; G. Deng ; G. B. Ehret ; B. Feenstra ; M. F. Feitosa ; K. Fischer ; A. Goel ; J. Gong ; A. U. Jackson ; S. Kanoni ; M. E. Kleber ; K. Kristiansson ; U. Lim ; V. Lotay ; M. Mangino ; I. Mateo Leach ; C. Medina-Gomez ; S. E. Medland ; M. A. Nalls ; C. D. Palmer ; D. Pasko ; S. Pechlivanis ; M. J. Peters ; I. Prokopenko ; D. Shungin ; A. Stancakova ; R. J. Strawbridge ; Y. Ju Sung ; T. Tanaka ; A. Teumer ; S. Trompet ; S. W. van der Laan ; J. van Setten ; J. V. Van Vliet-Ostaptchouk ; Z. Wang ; L. Yengo ; W. Zhang ; A. Isaacs ; E. Albrecht ; J. Arnlov ; G. M. Arscott ; A. P. Attwood ; S. Bandinelli ; A. Barrett ; I. N. Bas ; C. Bellis ; A. J. Bennett ; C. Berne ; R. Blagieva ; M. Bluher ; S. Bohringer ; L. L. Bonnycastle ; Y. Bottcher ; H. A. Boyd ; M. Bruinenberg ; I. H. Caspersen ; Y. D. Ida Chen ; R. Clarke ; E. W. Daw ; A. J. de Craen ; G. Delgado ; M. Dimitriou ; A. S. Doney ; N. Eklund ; K. Estrada ; E. Eury ; L. Folkersen ; R. M. Fraser ; M. E. Garcia ; F. Geller ; V. Giedraitis ; B. Gigante ; A. S. Go ; A. Golay ; A. H. Goodall ; S. D. Gordon ; M. Gorski ; H. J. Grabe ; H. Grallert ; T. B. Grammer ; J. Grassler ; H. Gronberg ; C. J. Groves ; G. Gusto ; J. Haessler ; P. Hall ; T. Haller ; G. Hallmans ; C. A. Hartman ; M. Hassinen ; C. Hayward ; N. L. Heard-Costa ; Q. Helmer ; C. Hengstenberg ; O. Holmen ; J. J. Hottenga ; A. L. James ; J. M. Jeff ; A. Johansson ; J. Jolley ; T. Juliusdottir ; L. Kinnunen ; W. Koenig ; M. Koskenvuo ; W. Kratzer ; J. Laitinen ; C. Lamina ; K. Leander ; N. R. Lee ; P. Lichtner ; L. Lind ; J. Lindstrom ; K. Sin Lo ; S. Lobbens ; R. Lorbeer ; Y. Lu ; F. Mach ; P. K. Magnusson ; A. Mahajan ; W. L. McArdle ; S. McLachlan ; C. Menni ; S. Merger ; E. Mihailov ; L. Milani ; A. Moayyeri ; K. L. Monda ; M. A. Morken ; A. Mulas ; G. Muller ; M. Muller-Nurasyid ; A. W. Musk ; R. Nagaraja ; M. M. Nothen ; I. M. Nolte ; S. Pilz ; N. W. Rayner ; F. Renstrom ; R. Rettig ; J. S. Ried ; S. Ripke ; N. R. Robertson ; L. M. Rose ; S. Sanna ; H. Scharnagl ; S. Scholtens ; F. R. Schumacher ; W. R. Scott ; T. Seufferlein ; J. Shi ; A. Vernon Smith ; J. Smolonska ; A. V. Stanton ; V. Steinthorsdottir ; K. Stirrups ; H. M. Stringham ; J. Sundstrom ; M. A. Swertz ; A. J. Swift ; A. C. Syvanen ; S. T. Tan ; B. O. Tayo ; B. Thorand ; G. Thorleifsson ; J. P. Tyrer ; H. W. Uh ; L. Vandenput ; F. C. Verhulst ; S. H. Vermeulen ; N. Verweij ; J. M. Vonk ; L. L. Waite ; H. R. Warren ; D. Waterworth ; M. N. Weedon ; L. R. Wilkens ; C. Willenborg ; T. Wilsgaard ; M. K. Wojczynski ; A. Wong ; A. F. Wright ; Q. Zhang ; E. P. Brennan ; M. Choi ; Z. Dastani ; A. W. Drong ; P. Eriksson ; A. Franco-Cereceda ; J. R. Gadin ; A. G. Gharavi ; M. E. Goddard ; R. E. Handsaker ; J. Huang ; F. Karpe ; S. Kathiresan ; S. Keildson ; K. Kiryluk ; M. Kubo ; J. Y. Lee ; L. Liang ; R. P. Lifton ; B. Ma ; S. A. McCarroll ; A. J. McKnight ; J. L. Min ; M. F. Moffatt ; G. W. Montgomery ; J. M. Murabito ; G. Nicholson ; D. R. Nyholt ; Y. Okada ; J. R. Perry ; R. Dorajoo ; E. Reinmaa ; R. M. Salem ; N. Sandholm ; R. A. Scott ; L. Stolk ; A. Takahashi ; F. M. Van't Hooft ; A. A. Vinkhuyzen ; H. J. Westra ; W. Zheng ; K. T. Zondervan ; A. C. Heath ; D. Arveiler ; S. J. Bakker ; J. Beilby ; R. N. Bergman ; J. Blangero ; P. Bovet ; H. Campbell ; M. J. Caulfield ; G. Cesana ; A. Chakravarti ; D. I. Chasman ; P. S. Chines ; F. S. Collins ; D. C. Crawford ; L. A. Cupples ; D. Cusi ; J. Danesh ; U. de Faire ; H. M. den Ruijter ; A. F. Dominiczak ; R. Erbel ; J. Erdmann ; J. G. Eriksson ; M. Farrall ; S. B. Felix ; E. Ferrannini ; J. Ferrieres ; I. Ford ; N. G. Forouhi ; T. Forrester ; O. H. Franco ; R. T. Gansevoort ; P. V. Gejman ; C. Gieger ; O. Gottesman ; V. Gudnason ; U. Gyllensten ; A. S. Hall ; T. B. Harris ; A. T. Hattersley ; A. A. Hicks ; L. A. Hindorff ; A. D. Hingorani ; A. Hofman ; G. Homuth ; G. K. Hovingh ; S. E. Humphries ; S. C. Hunt ; E. Hypponen ; T. Illig ; K. B. Jacobs ; M. R. Jarvelin ; K. H. Jockel ; B. Johansen ; P. Jousilahti ; J. W. Jukema ; A. M. Jula ; J. Kaprio ; J. J. Kastelein ; S. M. Keinanen-Kiukaanniemi ; L. A. Kiemeney ; P. Knekt ; J. S. Kooner ; C. Kooperberg ; P. Kovacs ; A. T. Kraja ; M. Kumari ; J. Kuusisto ; T. A. Lakka ; C. Langenberg ; L. Le Marchand ; T. Lehtimaki ; V. Lyssenko ; S. Mannisto ; A. Marette ; T. C. Matise ; C. A. McKenzie ; B. McKnight ; F. L. Moll ; A. D. Morris ; A. P. Morris ; J. C. Murray ; M. Nelis ; C. Ohlsson ; A. J. Oldehinkel ; K. K. Ong ; P. A. Madden ; G. Pasterkamp ; J. F. Peden ; A. Peters ; D. S. Postma ; P. P. Pramstaller ; J. F. Price ; L. Qi ; O. T. Raitakari ; T. Rankinen ; D. C. Rao ; T. K. Rice ; P. M. Ridker ; J. D. Rioux ; M. D. Ritchie ; I. Rudan ; V. Salomaa ; N. J. Samani ; J. Saramies ; M. A. Sarzynski ; H. Schunkert ; P. E. Schwarz ; P. Sever ; A. R. Shuldiner ; J. Sinisalo ; R. P. Stolk ; K. Strauch ; A. Tonjes ; D. A. Tregouet ; A. Tremblay ; E. Tremoli ; J. Virtamo ; M. C. Vohl ; U. Volker ; G. Waeber ; G. Willemsen ; J. C. Witteman ; M. C. Zillikens ; L. S. Adair ; P. Amouyel ; F. W. Asselbergs ; T. L. Assimes ; M. Bochud ; B. O. Boehm ; E. Boerwinkle ; S. R. Bornstein ; E. P. Bottinger ; C. Bouchard ; S. Cauchi ; J. C. Chambers ; S. J. Chanock ; R. S. Cooper ; P. I. de Bakker ; G. Dedoussis ; L. Ferrucci ; P. W. Franks ; P. Froguel ; L. C. Groop ; C. A. Haiman ; A. Hamsten ; J. Hui ; D. J. Hunter ; K. Hveem ; R. C. Kaplan ; M. Kivimaki ; D. Kuh ; M. Laakso ; Y. Liu ; N. G. Martin ; W. Marz ; M. Melbye ; A. Metspalu ; S. Moebus ; P. B. Munroe ; I. Njolstad ; B. A. Oostra ; C. N. Palmer ; N. L. Pedersen ; M. Perola ; L. Perusse ; U. Peters ; C. Power ; T. Quertermous ; R. Rauramaa ; F. Rivadeneira ; T. E. Saaristo ; D. Saleheen ; N. Sattar ; E. E. Schadt ; D. Schlessinger ; P. E. Slagboom ; H. Snieder ; T. D. Spector ; U. Thorsteinsdottir ; M. Stumvoll ; J. Tuomilehto ; A. G. Uitterlinden ; M. Uusitupa ; P. van der Harst ; M. Walker ; H. Wallaschofski ; N. J. Wareham ; H. Watkins ; D. R. Weir ; H. E. Wichmann ; J. F. Wilson ; P. Zanen ; I. B. Borecki ; P. Deloukas ; C. S. Fox ; I. M. Heid ; J. R. O'Connell ; D. P. Strachan ; K. Stefansson ; C. M. van Duijn ; G. R. Abecasis ; L. Franke ; T. M. Frayling ; M. I. McCarthy ; P. M. Visscher ; A. Scherag ; C. J. Willer ; M. Boehnke ; K. L. Mohlke ; C. M. Lindgren ; J. S. Beckmann ; I. Barroso ; K. E. North ; E. Ingelsson ; J. N. Hirschhorn ; R. J. Loos ; E. K. Speliotes
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipogenesis/genetics ; Adiposity/genetics ; Age Factors ; *Body Mass Index ; Continental Population Groups/genetics ; Energy Metabolism/genetics ; Europe/ethnology ; Female ; Genetic Predisposition to Disease/genetics ; *Genome-Wide Association Study ; Glutamic Acid/metabolism ; Humans ; Insulin/metabolism/secretion ; Male ; Obesity/*genetics/*metabolism ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Synapses/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Type of Medium:
    article
    Publication Date:
    1992
    Keywords:
    Gedicht ; Maria ; Stalingrad
    In:
    Katechetische Blätter, Bd. 117 (1992) H. 11, S. 753-754, 0341-0013
    0342-5517
    0342-5541
    0342-555X
    Language:
    German

    FIS Bildung Literaturdatenbank
  4. 4
    Ward-Caviness, C. K., Huffman, J. E., Everett, K., Germain, M., van Dongen, J., Hill, W. D., Jhun, M. A., Brody, J. A., Ghanbari, M., Du, L., Roetker, N. S., de Vries, P. S., Waldenberger, M., Gieger, C., Wolf, P., Prokisch, H., Koenig, W., ODonnell, C. J., Levy, D., Liu, C., Truong, V., Wells, P. S., Tregouët, D.-A., Tang, W., Morrison, A. C., Boerwinkle, E., Wiggins, K. L., McKnight, B., Guo, X., Psaty, B. M., Sotoodenia, N., Boomsma, D. I., Willemsen, G., Ligthart, L., Deary, I. J., Zhao, W., Ware, E. B., Kardia, S. L. R., Van Meurs, J. B. J., Uitterlinden, A. G., Franco, O. H., Eriksson, P., Franco-Cereceda, A., Pankow, J. S., Johnson, A. D., Gagnon, F., Morange, P.-E., de Geus, E. J. C., Starr, J. M., Smith, J. A., Dehghan, A., Björck, H. M., Smith, N. L., Peters, A.
    American Society of Hematology (ASH)
    Published 2018
    Staff View
    Publication Date:
    2018-10-26
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Thrombosis and Hemostasis
    Published by:
    http://www.hematology.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Belkacem, A. ; Faibis, A. ; Kanter, E. P. ; Koenig, W. ; Mitchell, R. E. ; Vager, Z. ; Zabransky, B. J.

    [S.l.] : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    The foil-induced dissociation of molecular ions can provide a direct image of the stereochemical structures of small molecules. Such experiments require high-resolution measurements of the relative momenta of all dissociation fragments. In order to improve and extend previous studies of this type to a larger variety of molecules and clusters, we have developed a new type of low-pressure multiwire proportional counter. The novel feature of this large-area (25×50 cm2 ) multiparticle detector is that all the signals are recorded from a single two-level printed circuit board which serves as the anode. This segmented anode consists of three families of nonintersecting "wires'' which are interwoven on the rear surface of the board. By redundantly determining positions and arrival times, the new segmented anode multiparticle detector provides good time resolution (100–200 ps) and high spatial resolution (0.2 mm) for detecting as many as six simultaneous particles.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1141447

    Articles: DFG German National Licenses
  6. 6
    Lobentanzer, H. ; König, W. ; Stolz, W. ; Ploog, K. ; Elsaesser, T. ; Bäuerle, R. J.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1988
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    We observe strong intersubband absorption at a wavelength of 8.4 μm in an n-type modulation-doped Ga0.47In0.53As/Al0.48In0.52As multiple quantum well structure with a well thickness of 8.2 nm. An oscillator strength of the corresponding dipole transition of 21.0 is measured. The dependence of the intersubband absorption on the polarization of the incident light and on lattice temperature is investigated in detail.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.99860

    Articles: DFG German National Licenses
  7. 7
    Hausen, B. M. ; Milbrodt, M. ; Koenig, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin layers of nail polish that had been painted onto glass plates and allowed to dry for 3 days. Comparing the isolated fractions and compounds with known nail polish ingredients revealed that the water-soluble substances are para- and ortho-toluenesulfonamide. Dihuty1 phthalate and 3 constituents of toluenesulfonamide-formaldehyde resin (TS-F-R), which is the basic material of almost all nail polishes sold worldwide. 12 female patients with proven nail polish allergy were patch tested with 21 nail polish components, including those isolated. Only 2 fractions were positive. These contained a monomer and a dimer created during condensation of TS-F-R. Their structures were elucidated. The 3rd compound, a trimer, remained negative, except in 1 case.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1995.tb00537.x

    Articles: DFG German National Licenses
  8. 8
    Hausen, B. M. ; Hettsch, H. ; Borrman, B. ; Koch, D. ; Rathmann, R. ; Richter, B. ; König, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Primin (2-methoxy-6-pentyl-1,4-benzoquinone)is a naturally-occurring strong sensitizer from Primula obconica (Primulaceae), To determine the effect of side-chain length on senstizing potency 15 analogues with linear side chains from to from C1, to C15 and 4 C6- analogues with branched side chains were prepared synthetically and devoted to experimental sensitization in guinea pigs The results showed an increase of the sensitizing capacity with increasing length of the alkyl side chain from C1 to C10, reaching a maximum at C11 and C12. On further elongation the senstizing potency decreased beyond C13 reaching values which finally were as low as those of the C1 and C3 derivatives. The results mirror finding which finally were as low as those of the C1 and C3 derivatives. The results mirror findings which formerly have been obtained with other non-quinonoid compounds like catechols, phenols hydroquinones and gallates. In the plant kingdom. Compound approximating an “ideal allergen” consisting of a quinonoid ring with a 10 or 11 carbon-remarkably strong sensitizer found in Wigandia caracasana (Hydrophyllaceae)
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1995.tb00440.x

    Articles: DFG German National Licenses
  9. 9
    Hausen, B. M. ; Bruhn, G. ; Koenig, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A 15-year-old girl developed perioral dermatitis and swelling of the lips, having played a flute made of cocus wood for 2 years. Patch tests with wood shavings, as well as with subsequently isolated constituents named focus 1 and focus II. were Strongly positive. Alter complete purification, boltContact allergens were identified as isoflavan derivatives, While Cocus 1 was shown to be 7,8-dihydroxy-2,4,5trmethoxyisoflava, the structure of focus II could not be elucidated exactly. It could have been Either 7,8,3′-trihydroxy 2,4 dimethoxyisoflavan or 7,8,2-trihydroxy-3′,4-dime-thoxyoflavan The exact position of the hydroxy and methoxy group in C-2 and C-3 can be determined only by complete synthesis Of both compounds or by isolation of greater amounts of focus II for further oxidation experiments. Due t0 the stronger patch lest reaction and the higher yield cocus I in the wood, this hydroxyisoflavan must be recognized as the main contact allergen.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1991.tb01820.x

    Articles: DFG German National Licenses
  10. 10
    Hausen, B. M. ; Krueger, A. ; Mohnert, J. ; Hahn, H. ; König, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    7 resin acids, 3 symbolically prepared derivatives and the neutral fraction of Chinese colophony were studied by experimental sensitization using a modified FCA method. 4 resin acids, laevopimaric. abietic. podocarpic and tetrahydroabietic. proved to be weak sensitizers Neoabietic, dehydroabietic, isopimarie acid and larixol remained negative. However, the derivative, methyl abietate and calcium abietate. were shown to be moderate sensitizers. and the maleic-modified adduct to be a moderate to strong sensitizer. As laevopimaric acid plays only a minor rote in colophony, abietic acid must he considered a major, even if weak, allergen in non-modified colophony. The neutral fraction of colophony is also partially involved in colophony allergy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1989.tb03094.x

    Articles: DFG German National Licenses
  11. 11
    RAULF, M. ; KÖNIG, W. ; KÖLLER, M. ; STÜNING, M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Polymorphonuclear leucocytes released LTD4-dipeptidase activity in a time-, calcium-, and cell number-dependent fashion. The LTD4-dipeptidase released from polymorphonuclear leucocytes (PMN) by incubation with calcium (0.91 mm) was detectable up to a cell concentration of 1 × 106/ml and increased with higher concentrations. Maximal LTD4-dipeptidase activity within the extracellular environment was detected after 15 min of incubation (2x107/ml) in the presence of 2–4.5 mm calcium or after 30 min, when stimulation was carried out with 0.91 mm calcium. The activity of the released LTD4-dipeptidase was modulated by various metal ions and other compounds. The addition of Mn2+ Co2+, and Zn2+ (final concentration 1 mm) enhanced the LTD4-dipeptidase activity, while Cu2+ led to a complete inhibition. In the absence of exogenoas calcium EDTA inhibited LTD4-dipeptidase. Calcium up to a concentration of 5 and 10mm decreased the dipeptidase activity. The LTD4-dipeptidase is not affected by bestatin, leupeptin. or N-ethyl-maleinimide (NEM). The Km of LTD4-dipeptidase for LTD4 was 0.95±0.2μm and vmax was 737.5±112.5 pmol/min × mg protein (n = 3±SEM). The highest LTD4dipeptidase activity was obtained at physiological pH values. LTD4-dipeptidase activity can also be released from other cell types, but the enzyme activity from human PMN exceeded that of other cells (e.g. human lymphocytes/monocytes and basophils (LMB) and human lung cell suspension).
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1987.tb01076.x

    Articles: DFG German National Licenses
  12. 12
    PFEIFFER, P. ; RAUSCHEN, I. ; BUJANOWSKI, J. ; KÖNIG, W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Modulation of de novo IgE synthesis in vitro was studied using the parasitic infection of mice with the nematode Nippostrongylus brasiliensis. Cell-derived factors were generated by stimulation of splenic and mesenteric lymph node cells of BALB/c mice with monoclonal IgE in vitro. High molecular weight (〉50,000) and low molecular weight (〈50,000) culture superna-tants were prepared. De novo IgE synthesis of BALB/c lymphocytes-obtained from N. brasiliensis-reinfected mice that secreted pronounced quantities of IgE in vitro-was markedly reduced by the addition of high molecular weight supernatants. A dose-dependent suppression of IgE synthesis was obtained, whereas IgG synthesis, viability, and cell proliferation were not inhibited. After fractionation of low molecular weight supernatants with IgE-Sepharose the glycine/HCl eluate fractions markedly inhibited the in vitro IgE synthesis. Low molecular weight factors which suppressed IgE synthesis without modulating IgG production were obtained from IgE high responder B6D2F1 normal mouse cells. Thus, our results demonstrate the generation of IgE-specific suppressor factors in vitro upon stimulation with IgE. The suppression of IgE synthesis by eluate fractions of low molecular weight supernatants absorbed with IgE-Sepharose suggest a potential role for IgE binding factors on de novo IgE synthesis in vitro.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1986.tb02168.x

    Articles: DFG German National Licenses
  13. 13
    König, W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2222.1991.tb01707.x

    Articles: DFG German National Licenses
  14. 14
    Arnold, R. ; Rihoux, J.-P. ; König, W.

    Oxford BSL : Blackwell Science Ltd
    Published 1999
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Cetirizine, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities. In particular epithelial cells activated in the presence of cetirizine showed a reduced ICAM-1 cell surface expression and a diminished release of sICAM-1.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveWe wondered whether cetirizine might influence the release of interleukin-8 (IL-8) from human epithelial cells activated with agonists distinct from histamine.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsWe used the human lung epithelial cell line A549 for our in vitro studies. IL-8 release was determined by IL-8 enzyme immunoassay, the intracellular staining for IL-8 and NF-kB was analysed by FACS analysis and IL-8 mRNA steady state level was studied by Northern blot analysis. Confluent epithelial cell monolayer were pre-incubated with cetirizine (0.01 −1.0 μmol/L) for 30 min and afterwards activated with pro-inflammatory cytokines (TNF-α IL-1β, IL-6, IFN-γ) or different agonists (PMA, NaF, respiratory syncytial virus [RSV]) for 24 h.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsEpithelial cells stimulated with TNF-α IL-1β, PMA and RSV, respectively, showed a significantly increased release of IL-8. Pre-incubation with cetirizine diminished the IL-8 release from cells activated with TNF-α or PMA in a significant manner. The reduced IL-8 release coincided with a diminished percentage of cells expressing IL-8. Northern blot analysis revealed a reduced steady state level of IL-8 mRNA in cells pretreated with cetirizine and stimulated with TNF-α. Furthermore, a decreased amount of accessible DNA-binding sites of the nuclear factor kappa B (NF-kB) was determined by FACS analysis.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsThese results suggest that cetirizine reduced the release of IL-8 from A549 cells stimulated with PMA and TNF-α, respectively, by lowering IL-8 gene expression. Therefore, cetirizine might exert anti-inflammatory effects beyond its H1-receptor antagonistic activity in the course of inflammatory respiratory tract disorders such as bronchial asthma and allergic rhinitis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2222.1999.00630.x

    Articles: DFG German National Licenses
  15. 15
    ARNOLD, R. ; KöNIG, B. ; KöNIG, W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1997
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2222.1997.tb02576.x

    Articles: DFG German National Licenses
  16. 16
    Hausen, B. M. ; Evers, P. ; Stüwe, H -T. ; König, W. A. ; Wollenweber, E.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    26 different compounds have been investigated experimentally for their sensitizing capacity in guinea pigs. 19 of these occur in propolis as well as in poplar bud exudates, and 14 of them are also found in balsam of Peru. 4 caffeates and benzyl isoferulate were found to be strong Sensitizers. 7 compounds were moderate, and 13 compounds showed only weak sensitizing potency. Methyl cinnamate was negative. Patch tests in 11 propolis-sensitive patients once more revealed 3-methyi-2-butenyl caffeate and phenylethyl caffeate as the major sensitizers. In addition to the 8 compounds already known to occur in propolis as well as in balsam of Peru, we detected 5 further substances that both materials have in common. Among these, benzyl isoferulate is considered a noteworthy sensitizer. Coniferyl benzoate, which was shown to be a moderate sensitizer, is present in fresh samples of balsam of Peru, while in propolis it has been detected only once so far. The flavonoid aglycones occurring in poplar bud exudates, and hence also in propolis, are weak sensitizers which play only a minor role m propolis hypersensitivity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1992.tb00865.x

    Articles: DFG German National Licenses
  17. 17
    Hausen, B. M. ; Faasch, H. ; König, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1987.tb01490.x

    Articles: DFG German National Licenses
  18. 18
    Hausen, B. M. ; Bröhas, J. ; König, W. A. ; Faasch, H. ; Hahn, H. ; Bruhn, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Experimental and chemical investigations revealed that common ivy (Hedera helix susp. Helix) contains 3 compounds which are powerful irritants and moderate sensitizers. Only 2 of these constituents, falcarinol and didehydrofalcarinol, are present in the plant during the whole year. Besides Panax ginseng and Schefflera arboricala, this is the third species of the Araliaceae in which these polyacetylenic sensitizers have been found. Falcarinol and didehydrofalcarinol also occur in Hedera helix subsp. canariensis. 4 patients have been patch tested. Even in low concentrations (0.03%). the main allergen falcarinol elicited strong reactions in all of them. One of the authors became sensitized during the investigations.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1987.tb02634.x

    Articles: DFG German National Licenses
  19. 19
    Gude, M. ; Hausen, B. M. ; Heitsch, H. ; König, W. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Irritancy of daffodil flowers and bulbs was assessed using various fresh plant preparations, solvent extracts and some of the known Amaryllidaceae alkaloids on guinea pigs. Sensitization was also carried out on guinea pigs using these plant preparations. solvent extracts and 7 fractions obtained after preparative chromatography of the bulb ether extract. Only 1 fraction, containing 2 alkaloids, was capable of inducing delayed hypersensitivity in the animals: the sensitivity achieved, however, was weak. The substances were identified as masonin and homolycorin, which acted as elicitors. but masonin may also be a sensitizer. While homolycorin is a known daffodil constituent, masonin has not been found previously in Narcissus pseudonarcissus. 3 other alkaloids as well as chelidonic acid and isorhamnetin were non-elicitors in the sensitized guinea pigs.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0536.1988.tb02860.x

    Articles: DFG German National Licenses
  20. 20
    TESCH, H. ; KÖNIG, W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1980
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    An eosinophil chemotactic factor (ECF) of low molecular weight can be generated and released from human polymorphonuclear neutrophils by the calcium ionophore, phagocytosis of zymosan particles, arachidonic acid, and phospholipase A2. Since the activation of cells by the ionophore and during the phagocytic event leads to phospholipid turnover, with the subsequent generation of arachidonic acid, it is reasonable that phospholipase A2 represents the common link for ECF production. The kinetics of ECF release by phospholipase A2 is similar to the pattern observed with the various stimuli. After a rapid rise in activity a decline occurred at later times of secretion, suggesting a mechanism of inactivation. During subcellular fractionation of cells an ECF-generating component was enriched in the 200,000 g supernatant fraction, which represents the cytosol. Addition of arachidonic acid or phospholipase A2 induced ECF generation. On gel filtration analysis the ECF-generating component revealed a molecular weight of about 80,000 daltons. It is suggested that this component represents a lipoxygenase.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1980.tb00007.x

    Articles: DFG German National Licenses