Search Results - (Author, Cooperation:W. K. Cavenee)
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1Latest Papers from Table of Contents or Articles in PressD. A. Nathanson ; B. Gini ; J. Mottahedeh ; K. Visnyei ; T. Koga ; G. Gomez ; A. Eskin ; K. Hwang ; J. Wang ; K. Masui ; A. Paucar ; H. Yang ; M. Ohashi ; S. Zhu ; J. Wykosky ; R. Reed ; S. F. Nelson ; T. F. Cloughesy ; C. D. James ; P. N. Rao ; H. I. Kornblum ; J. R. Heath ; W. K. Cavenee ; F. B. Furnari ; P. S. Mischel
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/*therapeutic use ; Central Nervous System Neoplasms/*drug therapy/genetics ; DNA/genetics ; Drug Resistance, Neoplasm/*genetics ; Erlotinib Hydrochloride ; Glioblastoma/*drug therapy/genetics ; Humans ; Mice ; *Molecular Targeted Therapy ; Mutation ; Neoplasm Transplantation ; Protein Kinase Inhibitors/*therapeutic use ; Quinazolines/therapeutic use ; Receptor, Epidermal Growth Factor/antagonists & inhibitors/*genetics ; Single-Cell Analysis ; Tumor Cells, Cultured ; Withholding TreatmentPublished by: -
2Latest Papers from Table of Contents or Articles in PressAlexander, B. M., Ba, S., Berger, M. S., Berry, D. A., Cavenee, W. K., Chang, S. M., Cloughesy, T. F., Jiang, T., Khasraw, M., Li, W., Mittman, R., Poste, G. H., Wen, P. Y., Yung, W. K. A., Barker, A. D., on behalf of the GBM AGILE Network
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-02-16Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Articles: DFG German National LicensesKoufos, A. ; Hansen, M. F. ; Lampkin, B. C. ; Workman, M. L. ; Copeland, N. G. ; Jenkins, N. A. ; Cavenee, W. K.
[s.l.] : Nature Publishing Group
Published 1984Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Wilms' tumour, the most common abdominal neoplasm in children, occurs in both hereditary and nonhereditary forms2, and so may be a member of a group of paediatric tumours, including retinoblastoma, neuroblastoma and medulloblastoma, which have a significant genetic component in their aetiology. The ...Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Molecular genetics ; Cancer predisposition ; Cancer progression ; Oncogenes ; Tumor suppressor genesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The development of human cancer is a multistep process that entails a progressively more malignant phenotype through the evolution of cellular subsets with increasing numbers of genetic alterations. Here we review the molecular genetics of human cancer predisposition and progression and describe paradigmatic cancer types and cancer syndromes. We also briefly consider the future impact of molecular biology on cancer diagnosis and treatment.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesNishikawa, R. ; Matsutani, Masao ; Cheng, Shi-Yuan ; Huang, H. J. S. ; Cavenee, W. K.
Springer
Published 1999Staff ViewISSN: 1432-0533Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-069XKeywords: TP53 locus ; Cutaneous malignant melanoma ; Point mutations ; Allelic lossSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesCavenee, W. K. ; Dryja, T. P. ; Phillips, R. A. ; Benedict, W. F. ; Godbout, R. ; Gallie, B. L. ; Murphree, A. L. ; Strong, L. C. ; White, R. L.
[s.l.] : Nature Publishing Group
Published 1983Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Inheritance of a mutation at the Rb-1 locus, which has been mapped to band q14 of human chromosome 13, results in predisposition to retinoblastoma. Cloned DNA segments homologous to arbitrary loci of human chromosome 13 and which reveal polymorphic restriction endonuclease recognition sequences, ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesScrable, H. J. ; Witte, D. P. ; Lampkin, B. C. ; Cavenee, W. K.
[s.l.] : Nature Publishing Group
Published 1987Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] A model has been proposed6 in which predisposing recessive mutations are revealed by chromosomal mechanisms and result in homozygous defects at the tumour locus9. These mechanisms include mitotic nondisjunction and loss (with or without reduplication of the remaining homologue), localized gene ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The development of Wilms' tumor has been associated with two genetic loci on chromosome 11: WT1 in 11p13 and WT2 in 11p15.5. Here, we have used loss of heterozygosity (LOH) in Wilms' tumors to narrow the WT2 locus distal to the D11S988 locus. A similar region was apparent for the clinically associated tumor, embryonal rhabdomyosarcoma. We have also demonstrated that a constitutional chromosome translocation breakpoint associated with Beckwith-Wiedemann syndrome and an acquired somatic chromosome translocation breakpoint in a rhabdoid tumor each occur in the same chromosomal interval as the smallest region of LOH in Wilms' tumors and embryonal rhabdomyosarcoma. Finally, we report the first Wilms' tumor without a cytogenetic deletion that shows targeted LOH for 11p15 and 11p13 while maintaining germline status for 11p14.Type of Medium: Electronic ResourceURL: