Search Results - (Author, Cooperation:W. I. Weis)
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1Latest Papers from Table of Contents or Articles in PressS. Granier ; A. Manglik ; A. C. Kruse ; T. S. Kobilka ; F. S. Thian ; W. I. Weis ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Binding Sites ; Conserved Sequence ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Molecular Sequence Data ; Naltrexone/*analogs & derivatives/chemistry/metabolism/pharmacology ; Protein Structure, Tertiary ; Receptors, Opioid, delta/antagonists & inhibitors/*chemistry/metabolism ; Reproducibility of Results ; Structure-Activity Relationship ; Substrate SpecificityPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. Manglik ; A. C. Kruse ; T. S. Kobilka ; F. S. Thian ; J. M. Mathiesen ; R. K. Sunahara ; L. Pardo ; W. I. Weis ; B. K. Kobilka ; S. Granier
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites ; Crystallography, X-Ray ; Ligands ; Mice ; Models, Molecular ; Morphinans/*chemistry/metabolism/pharmacology ; Protein Conformation ; Protein Multimerization ; Receptors, Opioid, mu/*antagonists & inhibitors/*chemistry/metabolism ; Solvents/chemistryPublished by: -
3Latest Papers from Table of Contents or Articles in PressC. D. Buckley ; J. Tan ; K. L. Anderson ; D. Hanein ; N. Volkmann ; W. I. Weis ; W. J. Nelson ; A. R. Dunn
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-11-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Actin Cytoskeleton/*metabolism ; Actins/*metabolism ; Adherens Junctions/*metabolism ; Caco-2 Cells ; Cadherins/*metabolism ; Catenins/*metabolism ; Cell Adhesion ; Humans ; *Mechanotransduction, Cellular ; Protein BindingPublished by: -
4Latest Papers from Table of Contents or Articles in PressQ. Zhou ; Y. Lai ; T. Bacaj ; M. Zhao ; A. Y. Lyubimov ; M. Uervirojnangkoorn ; O. B. Zeldin ; A. S. Brewster ; N. K. Sauter ; A. E. Cohen ; S. M. Soltis ; R. Alonso-Mori ; M. Chollet ; H. T. Lemke ; R. A. Pfuetzner ; U. B. Choi ; W. I. Weis ; J. Diao ; T. C. Sudhof ; A. T. Brunger
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites/genetics ; Calcium/chemistry/metabolism ; Cell Membrane/metabolism ; Crystallography, X-Ray ; Electrons ; *Exocytosis ; Hippocampus/cytology ; Lasers ; Magnesium/chemistry/metabolism ; Membrane Fusion ; Mice ; Models, Biological ; Models, Molecular ; Mutation/genetics ; Neurons/chemistry/cytology/*metabolism/secretion ; SNARE Proteins/*chemistry/genetics/*metabolism ; Synaptic Transmission ; Synaptic Vesicles/chemistry/metabolism/secretion ; Synaptotagmins/*chemistry/genetics/*metabolismPublished by: -
5Latest Papers from Table of Contents or Articles in PressC. Zhang ; Y. Srinivasan ; D. H. Arlow ; J. J. Fung ; D. Palmer ; Y. Zheng ; H. F. Green ; A. Pandey ; R. O. Dror ; D. E. Shaw ; W. I. Weis ; S. R. Coughlin ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Motifs ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Enzyme Activation/genetics ; Humans ; Hydrolysis ; Lactones/chemistry/pharmacology ; Ligands ; Models, Molecular ; Molecular Dynamics Simulation ; Myocardial Infarction/prevention & control ; Protein Conformation ; Pyridines/chemistry/pharmacology ; Receptor, PAR-1/agonists/antagonists & inhibitors/*chemistry/metabolism ; Receptors, G-Protein-Coupled/chemistry/classification ; Receptors, ThrombinPublished by: -
6Latest Papers from Table of Contents or Articles in PressA. M. Ring ; A. Manglik ; A. C. Kruse ; M. D. Enos ; W. I. Weis ; K. C. Garcia ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-2 Receptor Agonists/*pharmacology ; Benzoxazines/pharmacology ; Binding Sites/drug effects ; Crystallography, X-Ray ; Directed Molecular Evolution ; Epinephrine/*pharmacology ; Humans ; Hydrogen Bonding/drug effects ; Isoproterenol/analogs & derivatives/pharmacology ; Ligands ; Models, Molecular ; *Protein Engineering ; Protein Stability/drug effects ; Receptors, Adrenergic, beta-2/*chemistry/drug effects/*metabolism ; Single-Chain Antibodies/genetics/*pharmacology ; Tyrosine/chemistry/metabolism ; Water/chemistry/pharmacologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressA. C. Kruse ; A. M. Ring ; A. Manglik ; J. Hu ; K. Hu ; K. Eitel ; H. Hubner ; E. Pardon ; C. Valant ; P. M. Sexton ; A. Christopoulos ; C. C. Felder ; P. Gmeiner ; J. Steyaert ; W. I. Weis ; K. C. Garcia ; J. Wess ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Binding Sites ; Cytoplasm/metabolism ; Humans ; Isoxazoles/chemistry/metabolism ; *Models, Molecular ; Protein Binding ; Protein Structure, Tertiary ; Quaternary Ammonium Compounds/chemistry/metabolism ; Receptors, Muscarinic/*chemistry/*metabolismPublished by: -
8Latest Papers from Table of Contents or Articles in PressD. M. Thal ; B. Sun ; D. Feng ; V. Nawaratne ; K. Leach ; C. C. Felder ; M. G. Bures ; D. A. Evans ; W. I. Weis ; P. Bachhawat ; T. S. Kobilka ; P. M. Sexton ; B. K. Kobilka ; A. Christopoulos
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylcholine/metabolism ; Allosteric Regulation/drug effects ; Allosteric Site/drug effects ; Alzheimer Disease ; Crystallization ; Crystallography, X-Ray ; Drug Inverse Agonism ; Humans ; Models, Molecular ; Nicotinic Acids/metabolism/pharmacology ; Receptor, Muscarinic M1/*chemistry/metabolism ; Receptor, Muscarinic M4/*chemistry/metabolism ; Schizophrenia ; Static Electricity ; Substrate Specificity ; Surface Properties ; Thiophenes/metabolism/pharmacology ; Tiotropium Bromide/pharmacologyPublished by: -
9Latest Papers from Table of Contents or Articles in PressA. K. Shukla ; A. Manglik ; A. C. Kruse ; K. Xiao ; R. I. Reis ; W. C. Tseng ; D. P. Staus ; D. Hilger ; S. Uysal ; L. Y. Huang ; M. Paduch ; P. Tripathi-Shukla ; A. Koide ; S. Koide ; W. I. Weis ; A. A. Kossiakoff ; B. K. Kobilka ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/*chemistry/immunology/*metabolism ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/chemistry/immunology/metabolism ; Models, Molecular ; Phosphopeptides/*chemistry/*metabolism ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Stability ; Rats ; Receptors, Vasopressin/*chemistry ; RotationPublished by: -
10Latest Papers from Table of Contents or Articles in PressW. Huang ; A. Manglik ; A. J. Venkatakrishnan ; T. Laeremans ; E. N. Feinberg ; A. L. Sanborn ; H. E. Kato ; K. E. Livingston ; T. S. Thorsen ; R. C. Kling ; S. Granier ; P. Gmeiner ; S. M. Husbands ; J. R. Traynor ; W. I. Weis ; J. Steyaert ; R. O. Dror ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Animals ; Binding Sites ; Crystallography, X-Ray ; Heterotrimeric GTP-Binding Proteins/chemistry/metabolism ; Mice ; Models, Molecular ; Molecular Dynamics Simulation ; Morphinans/chemistry/metabolism/pharmacology ; Protein Stability/drug effects ; Protein Structure, Tertiary ; Pyrroles/chemistry/metabolism/pharmacology ; Receptor, Muscarinic M2/chemistry ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Opioid, mu/agonists/*chemistry/*metabolism ; Single-Chain Antibodies/chemistry/pharmacology ; Structure-Activity RelationshipPublished by: -
11Latest Papers from Table of Contents or Articles in PressS. G. Rasmussen ; H. J. Choi ; J. J. Fung ; E. Pardon ; P. Casarosa ; P. S. Chae ; B. T. Devree ; D. M. Rosenbaum ; F. S. Thian ; T. S. Kobilka ; A. Schnapp ; I. Konetzki ; R. K. Sunahara ; S. H. Gellman ; A. Pautsch ; J. Steyaert ; W. I. Weis ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-01-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-2 Receptor ; Agonists/*chemistry/immunology/metabolism/*pharmacology ; Animals ; Binding Sites ; Camelids, New World ; Crystallography, X-Ray ; Drug Inverse Agonism ; Humans ; Immunoglobulin Fragments/*chemistry/*immunology/metabolism/pharmacology ; Ligands ; Models, Molecular ; Movement/drug effects ; Nanostructures/*chemistry ; Opsins/agonists/chemistry/metabolism ; Propanolamines/chemistry/metabolism/pharmacology ; Protein Conformation/drug effects ; Protein Stability/drug effects ; Receptors, Adrenergic, beta-2/*chemistry/*metabolism ; Viral Proteins/chemistry/metabolismPublished by: -
12Latest Papers from Table of Contents or Articles in PressK. Haga ; A. C. Kruse ; H. Asada ; T. Yurugi-Kobayashi ; M. Shiroishi ; C. Zhang ; W. I. Weis ; T. Okada ; B. K. Kobilka ; T. Haga ; T. Kobayashi
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylcholine/analogs & derivatives/chemistry/metabolism ; Acetylcholinesterase/chemistry/metabolism ; Allosteric Regulation ; Binding Sites ; Carrier Proteins/chemistry/metabolism ; Cholinergic Antagonists/*chemistry/metabolism/*pharmacology ; Crystallography, X-Ray ; Evolution, Molecular ; Humans ; Ligands ; Models, Molecular ; Protein Conformation ; Quinuclidinyl Benzilate/*analogs & ; derivatives/*chemistry/metabolism/*pharmacology ; Receptor, Muscarinic M2/*antagonists & inhibitors/*chemistry/genetics/metabolism ; Tyrosine/chemistry/metabolismPublished by: -
13Latest Papers from Table of Contents or Articles in PressS. G. Rasmussen ; B. T. DeVree ; Y. Zou ; A. C. Kruse ; K. Y. Chung ; T. S. Kobilka ; F. S. Thian ; P. S. Chae ; E. Pardon ; D. Calinski ; J. M. Mathiesen ; S. T. Shah ; J. A. Lyons ; M. Caffrey ; S. H. Gellman ; J. Steyaert ; G. Skiniotis ; W. I. Weis ; R. K. Sunahara ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-2 Receptor Agonists/chemistry/metabolism ; Animals ; Catalytic Domain ; Cattle ; Crystallization ; Crystallography, X-Ray ; Enzyme Activation ; GTP-Binding Protein alpha Subunits, Gs/*chemistry/*metabolism ; Models, Molecular ; Multiprotein Complexes/chemistry/metabolism ; Protein Binding ; Rats ; Receptors, Adrenergic, beta-2/*chemistry/*metabolismPublished by: -
14Latest Papers from Table of Contents or Articles in PressD. M. Rosenbaum ; C. Zhang ; J. A. Lyons ; R. Holl ; D. Aragao ; D. H. Arlow ; S. G. Rasmussen ; H. J. Choi ; B. T. Devree ; R. K. Sunahara ; P. S. Chae ; S. H. Gellman ; R. O. Dror ; D. E. Shaw ; W. I. Weis ; M. Caffrey ; P. Gmeiner ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-01-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-2 Receptor Agonists/*chemistry/*metabolism ; Crystallization ; Crystallography, X-Ray ; Disulfides/chemistry/metabolism ; Drug Inverse Agonism ; Heterotrimeric GTP-Binding Proteins/metabolism ; Humans ; Lipid Bilayers/chemistry/metabolism ; Models, Molecular ; Molecular Dynamics Simulation ; Procaterol/chemistry/metabolism ; Propanolamines/chemistry/metabolism ; Protein Conformation ; Receptors, Adrenergic, beta-2/*chemistry/*metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Viral Proteins/chemistry/metabolismPublished by: -
15Latest Papers from Table of Contents or Articles in PressA. C. Kruse ; J. Hu ; A. C. Pan ; D. H. Arlow ; D. M. Rosenbaum ; E. Rosemond ; H. F. Green ; T. Liu ; P. S. Chae ; R. O. Dror ; D. E. Shaw ; W. I. Weis ; J. Wess ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylcholine/chemistry/metabolism ; Allosteric Site ; Animals ; COS Cells ; Crystallization ; Crystallography, X-Ray ; Kinetics ; Ligands ; Models, Molecular ; Molecular Dynamics Simulation ; Radioligand Assay ; Rats ; Receptor, Muscarinic M3/*chemistry/*metabolism ; Scopolamine Derivatives/chemistry/metabolism ; Substrate Specificity ; Tiotropium BromidePublished by: -
16Latest Papers from Table of Contents or Articles in PressD. J. Dickinson ; W. J. Nelson ; W. I. Weis
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-03-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Actin Cytoskeleton/metabolism ; Cadherins/metabolism ; *Cell Polarity ; Cellulose/metabolism ; Dictyostelium/cytology/growth & development/*physiology/ultrastructure ; Epithelial Cells/*physiology/ultrastructure ; Epithelium/*physiology ; Intercellular Junctions/metabolism ; Morphogenesis ; Protozoan Proteins/chemistry/genetics/*metabolism ; RNA Interference ; alpha Catenin/chemistry/genetics/*metabolism ; beta Catenin/*metabolismPublished by: