Search Results - (Author, Cooperation:W. H. Miller)
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1Latest Papers from Table of Contents or Articles in PressM. T. McCabe ; H. M. Ott ; G. Ganji ; S. Korenchuk ; C. Thompson ; G. S. Van Aller ; Y. Liu ; A. P. Graves ; A. Della Pietra, 3rd ; E. Diaz ; L. V. LaFrance ; M. Mellinger ; C. Duquenne ; X. Tian ; R. G. Kruger ; C. F. McHugh ; M. Brandt ; W. H. Miller ; D. Dhanak ; S. K. Verma ; P. J. Tummino ; C. L. Creasy
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors/genetics/metabolism ; Histones/chemistry/metabolism ; Humans ; Indoles/*pharmacology/*therapeutic use ; Lymphoma, Follicular/*drug therapy/enzymology/genetics/pathology ; Lymphoma, Large B-Cell, Diffuse/*drug therapy/enzymology/genetics/pathology ; Methylation/drug effects ; Mice ; Mutation/*genetics ; Neoplasm Transplantation ; Polycomb Repressive Complex 2/*antagonists & inhibitors/genetics/metabolism ; Pyridones/*pharmacology/*therapeutic use ; Repressor Proteins/chemistry/metabolism ; Transcriptional Activation/drug effects ; Transplantation, HeterologousPublished by: -
2Latest Papers from Table of Contents or Articles in PressH. A. Zahreddine ; B. Culjkovic-Kraljacic ; S. Assouline ; P. Gendron ; A. A. Romeo ; S. J. Morris ; G. Cormack ; J. B. Jaquith ; L. Cerchietti ; E. Cocolakis ; A. Amri ; J. Bergeron ; B. Leber ; M. W. Becker ; S. Pei ; C. T. Jordan ; W. H. Miller ; K. L. Borden
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Line, Tumor ; Cytarabine/metabolism/pharmacology ; *Drug Resistance, Neoplasm/drug effects/genetics ; Gene Deletion ; Glucuronic Acid/*metabolism ; Glucuronosyltransferase/biosynthesis/*metabolism ; Hedgehog Proteins/*metabolism ; Humans ; Leukemia, Myeloid, Acute/*drug therapy/enzymology/*metabolism/pathology ; Ribavirin/metabolism/pharmacology ; Signal Transduction ; Transcription Factors/antagonists & inhibitors/genetics/*metabolismPublished by: -
3Articles: DFG German National LicensesHarris, R. A. ; Grayce, C. J. ; Makri, N. ; Miller, W. H.
College Park, Md. : American Institute of Physics (AIP)
Published 1991Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: In a previous study (Bernal & Miller, 1970), striking differences were found between schizophrenic and normal children in the magnitude of their galvanic skin responses (GSRs) to simple sensory stimuli. However, the Lang and Hnatiow (1962) measure of cardiac response failed to demonstrate these GSR group differences. The present paper is a followup of the Bernal and Miller study and its purpose was to evaluate the use of various measures of heart rate (HR) in discriminating between clinical and normal groups of children.The cardiac data were converted to measures that were (1) independent of and dependent upon prestimulus HR level, and (2) based upon individually and group derived decelerative trough in HR. The main results of the analyses of variance for repeated measurements were: (1) no single HR measure was found to delineate the cardiac response reliably across stimulus conditions or between groups of Ss, and (2) individually-determined HR deceleration, especially when corrected via covariance analysis for prestimulus level, was superior to a group-determined decelerative HR measure in demonstrating both habituation and group effects.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-1017Keywords: Phototransduction ; Cyclic GMP ; Rods ; Response kineticsSource: Springer Online Journal Archives 1860-2000Topics: BiologyPhysicsNotes: Abstract Pulsatile injections of cyclic GMP into rod outer segments of the isolated toad retina cause transient depolarizations that are reduced in amplitude in proportion with the receptor potential by low Na+ Ringer's. This reduction in the amplitude of the cyclic GMP depolarization may be due to the direct effect of external Na+ concentration on dark current and an indirect effect resulting from the inactivation of a sodium-calcium exchange mechanism raising the intracellular Ca2+ concentration. By comparison the reduction in cyclic GMP response amplitude effected by illumination is accompanied by faster kinetics. This difference suggests that the reduced amplitude and speedier response reflect a light induced increase in phosphodiesterase (PDE) activity rather than the effects of Ca2+. Large doses of cyclic GMP can distort the kinetics of both the light response and the recovery from a depolarization caused by a pulse of cyclic GMP by similarly slowing both types of responses. This similarity in the kinetics of the cyclic GMP response and the initial hyperpolarizing phase of the receptor potential suggests that the kinetics of the initial phase of the receptor potential are controlled by light-mediated cyclic GMP hydrolysis.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesMiller, W. H. ; Reyno, L. M. ; Loewen, G. R. ; Huan, S. ; Winquist, E. ; Moore, M. ; Cato, A. ; Jaunakais, D. ; Truglia, J. A. ; Matthews, S. ; Dancey, J. ; Eisenhauer, E.
Springer
Published 2000Staff ViewISSN: 1569-8041Keywords: interferon-α ; pharmacokinetics ; renal carcinoma ; retinoidsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Although advanced renal-cell carcinoma (RCC) responds poorly to standardtherapies, phase I–II trials have shown activity for combinations ofinterferon-α2b (IFN) with a retinoid. Alitretinoin (9-cis RA) isan endogenous retinoid with high binding affinity for both RAR and RXRreceptor families. This phase I–II study enrolled 38 patients with RCCin a dose-escalation study of tolerability, pharmacokinetics (PK), andefficacy of twice daily oral 9-cis RA with subcutaneous IFN. Incontrast to studies with similar doses of daily 9-cis RA, PK studiesfound a consistent reduction in 9-cis RA concentrations of about50% after multiple b.i.d. doses of 30 or 50 mg/m2,independent of cotreatment with IFN. In the phase I portion, toxicitiesincluded systemic symptoms typical of IFN and biochemical abnormalitiespreviously associated with retinoids. Two patients experienced dose-limitingtoxicity at 50 mg/m2 b.i.d. of 9-cis RA, thus therecommended phase II dose was 30 mg/m2 b.i.d. One of twenty-sixevaluable patients achieved a durable objective partial remission, andrepeated dosing with this regimen was poorly tolerated. This combination ofretinoid and interferon is not recommended for further study in RCC.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0075-4617Keywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: