Search Results - (Author, Cooperation:W. C. Tseng)
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1A. K. Shukla ; A. Manglik ; A. C. Kruse ; K. Xiao ; R. I. Reis ; W. C. Tseng ; D. P. Staus ; D. Hilger ; S. Uysal ; L. Y. Huang ; M. Paduch ; P. Tripathi-Shukla ; A. Koide ; S. Koide ; W. I. Weis ; A. A. Kossiakoff ; B. K. Kobilka ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/*chemistry/immunology/*metabolism ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/chemistry/immunology/metabolism ; Models, Molecular ; Phosphopeptides/*chemistry/*metabolism ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Stability ; Rats ; Receptors, Vasopressin/*chemistry ; RotationPublished by: -
2C. N. Kuo, W. T. Chen, C. W. Tseng, C. J. Hsu, R. Y. Huang, F. C. Chou, Y. K. Kuo, and C. S. Lue
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-03-07Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Structure, structural phase transitions, mechanical properties, defectsPublished by: -
3Staff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1432-1912Keywords: Contracture ; Spontaneous Contractions ; Cations ; Procaine ; TetrodotoxinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary 1. Scorpion toxin II is potent in inducing contracture and spontaneous contractions of the chick biventer cervicis muscle. In addition, this toxin induces membrane depolarization and blockade of neuromuscular transmission in this muscle preparation. The purpose of the present study is to explore the possible mechanism of actions of toxin II. 2. The muscle contracture induced by toxin II is moderately accelerated by Ca2+-free Krebs solution, delayed by high Ca2+ (10 mM), high Mg2+ (10 mM) and low Na+ (60 mM) Krebs solution. Moreover, this action is inhibited slightly by d-tubocurarine and completely by either procaine or tetrodotoxin, but unaffected by β-bungarotoxin. All these findings suggest that toxin II induces contracture mainly by increasing the Na+ permeability of the muscle membrane. 3. Spontaneous contractions induced by toxin II are abolished by Ca2+-free Krebs solution, inhibited partially by either d-tubocurarine or β-bungarotoxin and completely by tetrodotoxin or procaine. These results suggest that toxin II induces spontaneous contractions partially by releasing acetylcholine from nerve endings and partially by increasing the Na+ permeability of the muscle membraneType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1432-1912Keywords: Direct Hemolysis ; Contracture ; Local Irritation ; Anticholinesterase ; MitochondriaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The actions of cardiotoxin (CTX), melittin and prymnesin were compared on dog erythrocytes, chicken biventer, chicken biventer cervicis muscle, rabbit conjunctiva, acetylcholinesterase, succinate-cytochrome c reductase and turbidity of the rat liver mitochondrial suspension. 1. CTX and melittin were approximately equipotent in the various biological activities, while prymnesin was not. 2. The rate of direct hemolysis induced by CTX was slow, while that induced by either melittin or prymnesin was fast. 3. Phosphate ions, 10mM Ca++, as well as 1 mM reduced glutathione, considerably inhibited the CTX-induced hemolysis, but only slightly inhibited that induced by melittin or prymnesin. 4. CTX, melittin and prymnesin caused contracture of the chicken biventer cervicis muscle. Prymnesin was much less active in this preparation as compared with its hemolytic potency. The CTX contracture was completely inhibited by high Ca++ (10 mM) medium, while the melittin contracture was not. 5. The rate of CTX contracture to reach the peak tension was increased when the concentration of CTX was increased, while the rate of melittin contracture did not change very much as the concentrations varied. 6. All three toxins caused a local irritation of the conjunctival sac of the rabbit eye. 7. Both CTX and melittin inhibited acetylcholinesterase and succinate-cytochrome c reductase activities, and also increased the turbidity of the rat liver mitochondrial suspension, while prymnesin was totally inactive in these respects. It is concluded that the mechanism of actions of these toxins may be different at the molecular level. The role of the detergent properties of these toxins in their biological activities is discussed.Type of Medium: Electronic ResourceURL: