Search Results - (Author, Cooperation:V. K. Kuchroo)
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1Latest Papers from Table of Contents or Articles in PressK. K. Farh ; A. Marson ; J. Zhu ; M. Kleinewietfeld ; W. J. Housley ; S. Beik ; N. Shoresh ; H. Whitton ; R. J. Ryan ; A. A. Shishkin ; M. Hatan ; M. J. Carrasco-Alfonso ; D. Mayer ; C. J. Luckey ; N. A. Patsopoulos ; P. L. De Jager ; V. K. Kuchroo ; C. B. Epstein ; M. J. Daly ; D. A. Hafler ; B. E. Bernstein
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Autoimmune Diseases/*genetics/immunology/pathology ; Base Sequence ; Chromatin/genetics ; Consensus Sequence/genetics ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Genome-Wide Association Study ; Humans ; Nucleotide Motifs ; Organ Specificity ; Polymorphism, Single Nucleotide/*genetics ; T-Lymphocytes/immunology/metabolism ; Transcription Factors/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressY. H. Huang ; C. Zhu ; Y. Kondo ; A. C. Anderson ; A. Gandhi ; A. Russell ; S. K. Dougan ; B. S. Petersen ; E. Melum ; T. Pertel ; K. L. Clayton ; M. Raab ; Q. Chen ; N. Beauchemin ; P. J. Yazaki ; M. Pyzik ; M. A. Ostrowski ; J. N. Glickman ; C. E. Rudd ; H. L. Ploegh ; A. Franke ; G. A. Petsko ; V. K. Kuchroo ; R. S. Blumberg
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD/chemistry/immunology/*metabolism ; Autoimmunity/immunology ; Cell Adhesion Molecules/chemistry/immunology/*metabolism ; Cell Line ; Colorectal Neoplasms/immunology ; Disease Models, Animal ; Female ; Humans ; Immune Tolerance/*immunology ; Inflammation/immunology/pathology ; Ligands ; Male ; Membrane Proteins/chemistry/immunology/*metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Models, Molecular ; Mucous Membrane/immunology/pathology ; Protein Conformation ; Protein Multimerization ; Receptors, Virus/chemistry/immunology/*metabolism ; T-Lymphocytes/*immunology/*metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressE. Esplugues ; S. Huber ; N. Gagliani ; A. E. Hauser ; T. Town ; Y. Y. Wan ; W. O'Connor, Jr. ; A. Rongvaux ; N. Van Rooijen ; A. M. Haberman ; Y. Iwakura ; V. K. Kuchroo ; J. K. Kolls ; J. A. Bluestone ; K. C. Herold ; R. A. Flavell
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies/immunology/pharmacology ; Antigens, CD3/immunology ; CD4-Positive T-Lymphocytes/immunology/transplantation ; Cell Movement/drug effects ; Chemokine CCL20/immunology ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Gene Expression Profiling ; Gene Expression Regulation/immunology ; Influenza A virus/immunology ; Interleukin-17/immunology ; Intestine, Small/cytology/*immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Orthomyxoviridae Infections/immunology ; Receptors, CCR6/immunology ; Sepsis/immunology ; Staphylococcal Infections/immunology ; Th17 Cells/*immunologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressY. H. Huang ; C. Zhu ; Y. Kondo ; A. C. Anderson ; A. Gandhi ; A. Russell ; S. K. Dougan ; B. S. Petersen ; E. Melum ; T. Pertel ; K. L. Clayton ; M. Raab ; Q. Chen ; N. Beauchemin ; P. J. Yazaki ; M. Pyzik ; M. A. Ostrowski ; J. N. Glickman ; C. E. Rudd ; H. L. Ploegh ; A. Franke ; G. A. Petsko ; V. K. Kuchroo ; R. S. Blumberg
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressM. A. Czuczman ; R. Fattouh ; J. M. van Rijn ; V. Canadien ; S. Osborne ; A. M. Muise ; V. K. Kuchroo ; D. E. Higgins ; J. H. Brumell
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Actins/metabolism ; Animals ; Bacterial Toxins/metabolism ; Cell Membrane/metabolism/microbiology/pathology ; Cell Surface Extensions/metabolism/*microbiology ; Cytoplasm/metabolism/microbiology ; Female ; HeLa Cells ; Heat-Shock Proteins/metabolism ; Hemolysin Proteins/metabolism ; Humans ; Listeria monocytogenes/pathogenicity/*physiology ; Macrophages/cytology/metabolism/microbiology ; Membrane Proteins/metabolism ; Mice ; *Phagocytosis ; Phagosomes/metabolism/microbiology ; Phosphatidylserines/metabolism ; Type C Phospholipases/metabolism ; Vacuoles/metabolism/microbiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressC. Wu ; N. Yosef ; T. Thalhamer ; C. Zhu ; S. Xiao ; Y. Kishi ; A. Regev ; V. K. Kuchroo
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Differentiation/*drug effects ; Encephalomyelitis, Autoimmune, Experimental/chemically ; induced/immunology/metabolism/pathology ; Forkhead Transcription Factors/metabolism ; HEK293 Cells ; Humans ; Immediate-Early Proteins/deficiency/genetics/*metabolism ; Interferon-gamma/biosynthesis/immunology ; Interleukin-17/biosynthesis/immunology/*metabolism ; Mice ; Phenotype ; Phosphorylation/drug effects ; Protein-Serine-Threonine Kinases/deficiency/genetics/*metabolism ; Receptors, Interleukin/biosynthesis/immunology ; Sodium Chloride/*pharmacology ; Sodium Chloride, Dietary/pharmacology ; Th17 Cells/*drug effects/enzymology/immunology/*pathologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressN. Yosef ; A. K. Shalek ; J. T. Gaublomme ; H. Jin ; Y. Lee ; A. Awasthi ; C. Wu ; K. Karwacz ; S. Xiao ; M. Jorgolli ; D. Gennert ; R. Satija ; A. Shakya ; D. Y. Lu ; J. J. Trombetta ; M. R. Pillai ; P. J. Ratcliffe ; M. L. Coleman ; M. Bix ; D. Tantin ; H. Park ; V. K. Kuchroo ; A. Regev
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD95/metabolism ; Cell Differentiation/*genetics ; Cells, Cultured ; DNA/genetics/metabolism ; Forkhead Transcription Factors/metabolism ; Gene Knockdown Techniques ; Gene Regulatory Networks/*genetics ; Genome/genetics ; Interferon-gamma/biosynthesis ; Interleukin-2/genetics ; Mice ; Mice, Inbred C57BL ; Nanowires ; Neoplasm Proteins/metabolism ; Nuclear Proteins/metabolism ; RNA, Messenger/genetics/metabolism ; Reproducibility of Results ; Silicon ; Th17 Cells/*cytology/immunology/*metabolism ; Time Factors ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcription, Genetic/geneticsPublished by: -
8Latest Papers from Table of Contents or Articles in PressSage, P. T., Schildberg, F. A., Sobel, R. A., Kuchroo, V. K., Freeman, G. J., Sharpe, A. H.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-04-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
9Latest Papers from Table of Contents or Articles in PressDixon, K. O., Schorer, M., Nevin, J., Etminan, Y., Amoozgar, Z., Kondo, T., Kurtulus, S., Kassam, N., Sobel, R. A., Fukumura, D., Jain, R. K., Anderson, A. C., Kuchroo, V. K., Joller, N.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-04-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
10Articles: DFG German National LicensesOttosson, L. ; Salomonsson, S. ; Hennig, J. ; Sonesson, S.-E. ; Dörner, T. ; Raats, J. ; Kuchroo, V. K. ; Sunnerhagen, M. ; Wahren-Herlenius, M.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Congenital heart block is a passively transferred autoimmune condition, which affects the children of mothers with Ro/SSA autoantibodies. During pregnancy, the antibodies are transported across the placenta and affect the fetus. We have previously demonstrated that antibodies directed to the 200–239 amino acid (aa) stretch of the Ro52 component of the Ro/SSA antigen correlate with the development of congenital heart block. In this report, we investigated the antibody–antigen interaction of this target epitope in detail at a molecular and structural level. Peptides representing aa 200–239 (p200) with structurally derived mutations were synthesized to define the epitopes recognized by two Ro52 human monoclonal antibodies, S3A8 and M4H1, isolated from patient-derived phage display libraries. Analyses by ELISA, circular dichroism and MALDI-TOF-MS demonstrate that the antibody recognition is dependent on a partly α-helical fold within the putative leucine zipper of the 200–239 aa stretch and that the two human anti-p200 monoclonal antibodies, M4H1 and S3A8, recognize different epitopic structures within the p200 peptide. In addition, we investigated the representation of each fine specificity within the sera of mothers with children born with congenital heart block, and in such sera, antibodies of the S3A8 idiotype were more commonly detected and at higher levels than M4H1-like antibodies.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesNelson, Margaret ; Nelson, D. S. ; Kuchroo, V. K. ; Spradbrow, P. B. ; Jennings, P. A.
Springer
Published 1987Staff ViewISSN: 1432-0851Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Tumours produce substances that inhibit the expression of cell-mediated immunity, in the form of delayed-type hypersensitivity in mice. Phenol-saline extracts of bovine ocular squamous cell carcinoma (BOSCC) which have immunotherapeutic activity in cattle were able to immunize mice against this depressive effect. Such immunization was effective against products of BOSCC, a spontaneous rat tumour, three of four human tumour cell lines and (in other experiments) mouse tumours. Phenol-saline extracts of mouse tumour cell lines were immunogenic (protective against depression of delayed-type hypersensitivity) in mice. Fractions of BOSCC phenol-saline extracts which were immunotherapeutically active in cattle were generally also protective in mice. The protective activity was lost after treatment with proteinase K, and was present in the supernatant after precipitation with 55% ammonium sulphate. It was not affected by treatment with RNase or DNase or by heating to 50 °C for 2 h. It was present in gel filtration fractions with an apparent molecular weight of 10,000–37,000 daltons. The immunogenic factor in mice and the immunotherapeutic factor in cattle may be related to each other.Type of Medium: Electronic ResourceURL: