Search Results - (Author, Cooperation:V. Chan)
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1Latest Papers from Table of Contents or Articles in PressKunadian, V., Chan, D., Ali, H., Wilkinson, N., Howe, N., McColl, E., Thornton, J., von Wilamowitz-Moellendorff, A., Holstein, E.-M., Burns, G., Fisher, A., Stocken, D., De Soyza, A., On behalf of APPLE COPD-ICON2 Trial Investigators
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-05-27Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Cardiovascular medicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-13Publisher: Wiley-BlackwellPrint ISSN: 0022-3417Electronic ISSN: 1096-9896Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressJane A. Mitchell, Rebecca B. Knowles, Nicholas S. Kirkby, Daniel M. Reed, Matthew L. Edin, William E. White, Melissa V. Chan, Hilary Longhurst, Magdi M. Yaqoob, Ginger L. Milne, Darryl C. Zeldin, Timothy D. Warner
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-02-16Publisher: American Heart Association (AHA)Print ISSN: 0009-7330Electronic ISSN: 1524-4571Topics: MedicineKeywords: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Physiology, Vascular Biology, ThrombosisPublished by: -
4Latest Papers from Table of Contents or Articles in PressTaian Liu; Yujian Shi; Matthew T. V. Chan; Gang Peng; Quan Zhang; Xiao Sun; Zeyao Zhu; Yuxin Xie; Kathy W. Y. Sham; Jianzhen Li; Xiaodong Liu; Idy H. T. Ho; Tony Gin; Zhonghua Lu; William K. K. Wu; Christopher H. K. Cheng
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-10-24Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2158-3188Topics: MedicinePublished by: -
5Latest Papers from Table of Contents or Articles in PressJane A. Mitchell, Rebecca B. Knowles, Nicholas S. Kirkby, Daniel M. Reed, Matthew L. Edin, William E. White, Melissa V. Chan, Hilary Longhurst, Magdi M. Yaqoob, Ginger L. Milne, Darryl C. Zeldin, Timothy D. Warner
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-05-11Publisher: American Heart Association (AHA)Print ISSN: 0009-7330Electronic ISSN: 1524-4571Topics: MedicineKeywords: Biomarkers, Vascular Biology, ThrombosisPublished by: -
6Latest Papers from Table of Contents or Articles in PressJ. Barretina ; G. Caponigro ; N. Stransky ; K. Venkatesan ; A. A. Margolin ; S. Kim ; C. J. Wilson ; J. Lehar ; G. V. Kryukov ; D. Sonkin ; A. Reddy ; M. Liu ; L. Murray ; M. F. Berger ; J. E. Monahan ; P. Morais ; J. Meltzer ; A. Korejwa ; J. Jane-Valbuena ; F. A. Mapa ; J. Thibault ; E. Bric-Furlong ; P. Raman ; A. Shipway ; I. H. Engels ; J. Cheng ; G. K. Yu ; J. Yu ; P. Aspesi, Jr. ; M. de Silva ; K. Jagtap ; M. D. Jones ; L. Wang ; C. Hatton ; E. Palescandolo ; S. Gupta ; S. Mahan ; C. Sougnez ; R. C. Onofrio ; T. Liefeld ; L. MacConaill ; W. Winckler ; M. Reich ; N. Li ; J. P. Mesirov ; S. B. Gabriel ; G. Getz ; K. Ardlie ; V. Chan ; V. E. Myer ; B. L. Weber ; J. Porter ; M. Warmuth ; P. Finan ; J. L. Harris ; M. Meyerson ; T. R. Golub ; M. P. Morrissey ; W. R. Sellers ; R. Schlegel ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Lineage ; Chromosomes, Human/genetics ; Clinical Trials as Topic/methods ; *Databases, Factual ; Drug Screening Assays, Antitumor/*methods ; *Encyclopedias as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; *Models, Biological ; Neoplasms/*drug therapy/genetics/metabolism/*pathology ; Pharmacogenetics ; Plasma Cells/cytology/drug effects/metabolism ; Precision Medicine/methods ; Receptor, IGF Type 1/antagonists & inhibitors/metabolism ; Receptors, Aryl Hydrocarbon/genetics/metabolism ; Sequence Analysis, DNA ; Topoisomerase Inhibitors/pharmacologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-16Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Rehabilitation medicinePublished by: -
8Latest Papers from Table of Contents or Articles in PressP. Chen, Woei Wu Pai, Y.-H. Chan, V. Madhavan, M. Y. Chou, S.-K. Mo, A.-V. Fedorov, and T.-C. Chiang
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-11-10Publisher: American Physical Society (APS)Print ISSN: 0031-9007Electronic ISSN: 1079-7114Topics: PhysicsKeywords: Condensed Matter: Electronic Properties, etc.Published by: -
9Articles: DFG German National LicensesChiu, S. C. ; Chan, V. S. ; Chu, M. S. ; Lin-Liu, Y. R.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The equations of motion of charged particles of a strongly magnetized flowing plasma under the influence of high frequency waves are derived in the guiding center approximation. A quasilinear theory of the interactions of waves with rotating plasmas is formulated. This is applied to investigate the effect of radio frequency waves on a rotating tokamak plasma with a heated minority species. The angular momentum drive is mainly due to the rf-induced radial minority current. The return current by the bulk plasma gives an equal and opposite rotation drive on the bulk. Using moment equations and a small banana width approximation, the J×B drive was evaluated for the bulk plasma. Quite remarkably, although collisions are included, the net rotation drive is due to a term which can be obtained by neglecting collisions. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesChiu, S. C. ; Chan, V. S. ; Lin-Liu, Y. R. ; Omelchenko, Y.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The noncanonical Lagrangian theory of guiding center orbits is applied to the coordinate system of White–Chance–Boozer. The result is a generalized set of equations of motion which eliminates certain approximations of the static field and includes the effects of large rotations and high frequency waves. A quasilinear gyrokinetic theory is shown to readily follow from these equations. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesChan, V. S. ; Chiu, S. C. ; Omelchenko, Y. A.
[S.l.] : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: Plasma rotational shear is potentially important for controlling the formation and positioning of internal transport barriers that could stabilize tokamak microturbulence and improve plasma confinement. A new physical mechanism capable of inducing plasma rotation and rotational shear via the ion cyclotron resonance frequency (ICRF) heating of minority ion species in a tokamak has been proposed [Perkins, White, Bonoli, and Chan, Phys. Plasmas 8, 2181 (2001)]. The present work evaluates the validity of this mechanism under the realistic condition when fast ions are continuously heated and slowed down in a driven system. Ion dynamics are calculated with a Monte Carlo code in which wave-induced diffusion in velocity space is accounted for by a quasilinear operator. The code follows the drift trajectories of test particles in a tokamak geometry under the influence of given rf fields and collisions with the background plasma. When the heating geometry is such that no net toroidal wave momentum is injected, the rotational characteristics described in Perkins et al. are reproduced. A physical picture emerges which ascribes the directionality of the rotation as a consequence of finite drift orbit width. The stochastic nature of the wave-induced diffusion can result in a net toroidal torque on the bulk plasma. A number of predicted features can be experimentally tested as a validation of finite orbit drift physics and radio-frequency-induced orbit diffusion. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesPopov, A. M. ; Chan, V. S. ; Chu, M. S. ; Liu, Y. Q. ; Rice, B. W. ; Turnbull, A. D.
[S.l.] : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: Nonlinear simulations of experimentally observed magnetohydrodynamic (MHD) bursts in DIII-D [J. Luxon and L. G. Davis, Fusion Technol. 8, 441 (1985)] L-mode negative central magnetic shear (NCS) discharges were performed with a full three-dimensional nonlinear MHD code. The effects of plasma rotation in the presence of resistivity and viscosity are included and an effectively implicit numerical scheme allows the transport profile to evolve self-consistently with the nonlinear MHD instabilities and externally applied sources and sinks. The simulations follow the MHD bursts and disruptions through the linear and nonlinear phases and identify the connections between the early MHD bursts and the ultimate disruption phase. Specific predictions of the growth and saturation of the modes are directly compared with experimental diagnostic measurements in DIII-D. The simulations show that the bursts observed in experiments are triggered by MHD instability of a resistive interchange mode and a resistive kink mode that are excited for critical plasma profiles. The critical profiles are determined by the balance between inductive and noninductive sources of current density. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMiller, R. L. ; Lin-Liu, Y. R. ; Turnbull, A. D. ; Chan, V. S.
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: Low aspect ratio tokamaks (LATs) can potentially provide a high ratio of plasma pressure to magnetic pressure β and high plasma current I at a modest size. This opens up the possibility of a high-power density compact fusion power plant. For the concept to be economically feasible, bootstrap current must be a major component of the plasma current, which requires operating at high βp. A high value of the Troyon factor βN and strong shaping is required to allow simultaneous operation at a high-β and high bootstrap fraction. Ideal magnetohydrodynamic stability of a range of equilibria at aspect ratio 1.4 is systematically explored by varying the pressure profile and shape. The pressure and current profiles are constrained in such a way as to assure complete bootstrap current alignment. Both βN and β are defined in terms of the vacuum toroidal field. Equilibria with βN≥8 and β∼35%–55% exist that are stable to n=∞ ballooning modes. The highest β case is shown to be stable to n=0,1,2,3 kink modes with a conducting wall. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesLao, L. L. ; Burrell, K. H. ; Casper, T. S. ; Chan, V. S. ; Chu, M. S. ; DeBoo, J. C. ; Doyle, E. J. ; Durst, R. D. ; Forest, C. B. ; Greenfield, C. M. ; Groebner, R. J. ; Hinton, F. L. ; Kawano, Y. ; Lazarus, E. A. ; Lin-Liu, Y. R. ; Mauel, M. E. ; Meyer, W. H. ; Miller, R. L. ; Navratil, G. A. ; Osborne, T. H. ; Peng, Q. ; Rettig, C. L. ; Rewoldt, G. ; Rhodes, T. L. ; Rice, B. W.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The confinement and the stability properties of the DIII-D tokamak [Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 159] high-performance discharges are evaluated in terms of rotational and magnetic shear, with an emphasis on the recent experimental results obtained from the negative central magnetic shear (NCS) experiments. In NCS discharges, a core transport barrier is often observed to form inside the NCS region accompanied by a reduction in core fluctuation amplitudes. Increasing negative magnetic shear contributes to the formation of this core transport barrier, but by itself is not sufficient to fully stabilize the toroidal drift mode (trapped-electron-ηi mode) to explain this formation. Comparison of the Doppler shift shear rate to the growth rate of the ηi mode suggests that the large core E×B flow shear can stabilize this mode and broaden the region of reduced core transport. Ideal and resistive stability analysis indicates the performance of NCS discharges with strongly peaked pressure profiles is limited by the resistive interchange mode to low βN≤2.3. This mode is insensitive to the details of the rotational and the magnetic shear profiles. A new class of discharges, which has a broad region of weak or slightly negative magnetic shear (WNS), is described. The WNS discharges have broader pressure profiles and higher β values than the NCS discharges, together with high confinement and high fusion reactivity. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesChiu, S. C. ; Chan, V. S. ; Omelchenko, Y. A.
[S.l.] : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The orbits of particles in the core region of a rotating tokamak plasma are analyzed. It is found that the phase space topologies of finite orbits differ significantly from those of thin orbit considerations. Specifically, in the absence of rotations, the trapped-passing boundary of co-moving particles has a finite extent in energies and disappears above a critical energy; and the pitch angle of the boundary has a rather strong energy dependence. Rotation and rotation shear cause significant shifts of this boundary in phase space so that above certain thresholds this boundary disappears. The finite orbit analysis also leads to improved analytic formulas for orbit averaged quantities of interest. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesHarvey, R. W. ; Chan, V. S. ; Chiu, S. C. ; Evans, T. E. ; Rosenbluth, M. N. ; Whyte, D. G.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: Runaway electrons are calculated to be produced during the rapid plasma cooling resulting from "killer pellet" injection experiments, in general agreement with observations in the DIII-D [J. L. Luxon et al., Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. I, p. 159] tokamak. The time-dependent dynamics of the kinetic runaway distributions are obtained with the CQL3D [R. W. Harvey and M. G. McCoy, "The CQL3D Code," in Proceedings of the IAEA Technical Committee Meeting on Numerical Modeling, Montreal, 1992 (International Atomic Energy Agency, Vienna, 1992), p. 489] collisional Fokker–Planck code, including the effect of small and large angle collisions and stochastic magnetic field transport losses. The background density, temperature, and Zeff are evolved according to the KPRAD [D. G. Whyte and T. E. Evans et al., in Proceedings of the 24th European Conference on Controlled Fusion and Plasma Physics, Berchtesgaden, Germany (European Physical Society, Petit-Lancy, 1997), Vol. 21A, p. 1137] deposition and radiation model of pellet–plasma interactions. Three distinct runway mechanisms are apparent: (1) prompt "hot-tail runaways" due to the residual hot electron tail remaining from the pre-cooling phase, (2) "knock-on" runaways produced by large-angle Coulomb collisions on existing high energy electrons, and (3) Dreicer "drizzle" runaway electrons due to diffusion of electrons up to the critical velocity for electron runaway. For electron densities below (approximate)1×1015 cm−3, the hot-tail runaways dominate the early time evolution, and provide the seed population for late time knock-on runaway avalanche. For small enough stochastic magnetic field transport losses, the knock-on production of electrons balances the losses at late times. For losses due to radial magnetic field perturbations in excess of (approximate)0.1% of the background field, i.e., δBr/B≥0.001, the losses prevent late-time electron runaway. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesLao, L. L. ; La Haye, R. J. ; Burrell, K. H. ; Chan, V. S. ; Ferron, J. R. ; Rettig, C. L. ; Rewoldt, G. ; Scoville, J. T. ; Staebler, G. M. ; Strait, E. J. ; Tang, W. M. ; Taylor, T. S. ; Wròblewski, D.
[S.l.] : American Institute of Physics (AIP)
Published 1998Staff ViewISSN: 1089-7674Source: AIP Digital ArchiveTopics: PhysicsNotes: The role of E×B flow shear on confinement enhancement in the DIII-D tokamak [Plasma Physics and Controlled Nuclear Fusion Research, 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 159] high internal inductance discharges with high-confinement edge is investigated experimentally using a nonaxisymmetric poloidal magnetic-field perturbation from an external coil to drag down the plasma toroidal rotation. At similar values of internal inductance, discharges which rotate faster and have a stronger E×B flow shear have better confinement. These results indicate that E×B flow shear likely plays an important role in the confinement enhancement of these discharges. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesChu, X. ; Chan, V. ; Schmidt, L. D. ; Smyrl, W. H.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The microstructures of chemically polymerized polypyrrole films (100–800 A(ring) thick) were studied by transmission electron microscopy, electron diffraction, and x-ray photoelectron spectroscopy. In contrast to previous work where only amorphous polypyrrole was found, crystalline fiber structures were observed in the chemically polymerized thin films. The fibers are embedded in an amorphous matrix which forms a self-reinforced composite. The shape of the fibers ranged from thin rods to ellipsoids depending on the preparation conditions. The density and size of the fibers were affected by the polymerization time and the concentration ratio of pyrrole and oxidants. Polypyrrole fibers were aligned along the thin-film plane and were randomly oriented in the plane. The two-dimensional orientation of the crystalline fibers produced strongly anisotropic electrical properties in the thin films. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesShi, X. ; Chan, V. K. ; Gallup, G. A. ; Burrow, P. D.
College Park, Md. : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Differential cross section measurements for the elastic scattering of electrons from CH3Cl at energies from 0.5 to 9.5 eV are reported for scattering angles of 30° and 100°. The angular scattering dependence is determined at selected energies over this range. At energies below 1.0 eV, the cross sections are in excellent agreement with calculations using the Born dipole approximation. At large angles and higher energies, the scattering is dominated by a 2A1 temporary negative ion state near 3.5 eV. Energy loss data at 3.5, 5.0, and 8.5 eV are reported and the relative contributions of various vibrational modes determined. Differential cross sections for vibrational excitation of the υ3(a1)C–Cl and υ4(e)CH stretching modes have been measured. The latter reveals a broad shape resonance of 2E symmetry peaking near 5.5 eV. Angular distributions for excitation of these same modes are also reported. Using fittings to the vibrational excitation functions, the resonance parameters have been extracted and used in a mixed semiempirical ab initio calculation to compute the relative strengths of the vibrational energy loss peaks. These compare favorably with the results of the experiment. Elastic cross sections integrated over angle are reported for low energies. They are substantially larger than the results from recent measurements of the total cross section. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: