Search Results - (Author, Cooperation:V. Anelli)
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1Latest Papers from Table of Contents or Articles in PressS. Francia ; F. Michelini ; A. Saxena ; D. Tang ; M. de Hoon ; V. Anelli ; M. Mione ; P. Carninci ; F. d'Adda di Fagagna
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle Proteins/metabolism ; Cell Line ; DNA Breaks, Double-Stranded ; DNA Damage/*genetics ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/metabolism ; Enzyme Activation ; HEK293 Cells ; HeLa Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Nuclear Proteins/metabolism ; RNA Interference ; RNA, Untranslated/biosynthesis/*genetics ; Ribonuclease III/*genetics ; Ribonuclease, Pancreatic/metabolism ; Sequence Analysis, RNA ; Substrate Specificity/genetics ; Zebrafish/*geneticsPublished by: -
2Articles: DFG German National LicensesRiboni, L. ; Anelli, V. ; Bassi, R. ; Giussani, P. ; Viani, P. ; Tettamanti, G.
Oxford, UK : Blackwell Publishing Ltd
Published 2003Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Over the past decade, ceramide and sphingosine-1-phosphate have emerged as crucial mediators in many cells including those from the nervous system. In brain cells various stimuli, ranging from growth factors and differentiating agents, to oxidative stress and cytotoxic drugs, regulate one or more of the enzymes of sphingolipid metabolism. This results in the variation of cell sphingoids, which in turn act as mediators in regulating growth, differentiation and fate. Emerging data also indicate that sphingosine-1-phosphate can be released from brain cells and acts as intercellular mediator, after interaction with specific EDG receptors. The importance of sphingoid mediators in brain has been reinforced by recent findings implicating them in physiological processes as well as in the pathogenesis of brain diseases, including degenerative disorders and cancers. Evidence is accumulating that the manipulation of sphingolipid metabolism in brain cells will offer novel potential targets for therapeutic intervention in brain dysfunctions.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0001-9046Topics: ArchaeologyNotes: Recensioni e bibliografiaURL: -
4Articles: DFG German National LicensesPacella, C. M. ; Papini, E. ; Bizzarri, G. ; Fabbrini, R. ; Anelli, V. ; Rinaldi, R. ; Valle, D. ; Nardi, F.
Springer
Published 1995Staff ViewISSN: 1432-1084Keywords: Hyperthyroidism ; Thyroidnodule ; Alcohol-ethyl ; Doppler sonography ; Ultrasonography ; Ultrasonography interventionalSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Percutaneous ethanol injection (PEI) is an effective treatment for autonomously functioning thyroid nodules (AFTNs). The aims of this study were to assess: (1) the ultrasound (US) and colour-coded duplex sonography (CCDS) baseline and post-therapy patterns of AFTN, and (2) the contribution of CCDS in determining the efficacy and optimum duration of PEI. Forty AFTNs were evaluated by US and CCDS before, during and 6 and 12 months after PEI. Four grades of increasing vascularity were arbitrarily identified at CCDS (0-1-2-3). These data were compared with thyroid scintiscan and hormonal findings. All nodules showed a striking volume decrease. After treatment a hypoechoic pattern and blurred outlines on US were associated with a higher percentage volume reduction. Soon after PEI a reduction in the vascularity score was noticed in 29 of 40 of AFTNs. Pre- and post-treatment vascular score distributions were significantly different. It is concluded that a vascular score decrease to grade 0–1 at the end of PEI is an index of successful treatment.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesPacella, C. M. ; Bizzarri, G. ; Anelli, V. ; Valle, D. ; Fabbrini, R. ; Bianchini, A. ; Fenderico, P. ; Rossi, Z.
Springer
Published 1998Staff ViewISSN: 1432-1084Keywords: Key words: Liver neoplasm ; Dynamic CT ; Helical CTSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. The aim of this work was to study the vascularization of hepatocellular carcinoma (HCC) by means of dynamic CT and to demonstrate the existence of optimal temporal windows for visualization of HCC in order to develop new protocols for helical CT of the liver. We studied, by means of dynamic CT, 42 histologically proved HCCs in 30 patients after injecting contrast medium (100 ml, 3 ml/s). We performed a time–density analysis of the aorta, liver, portal vein, spleen and lesion. We identified three temporal curves of attenuation of the neoplastic tissue. Curve 1 was three-phasic: hyperattenuation, isoattenuation and hypoattenuation; curve 2 was two-phasic: hyperattenuation and isoattenuation; curve 3 was two-phasic: isoattenuation and hypoattenuation. Thirty-two lesions were homogeneous (curve 1 in 22 cases, 68.7 %; curve 2 in 7 cases, 21.8 %; curve 3 in 3 cases, 9.4 %), whereas 10 lesions were non-homogeneous. Two optimal temporal windows were identified: the first, with predominantly hyperattenuating lesions (range 29–65 s, 90.4 % sensitivity); the second, with predominantly hypoattenuating lesions (range 132.1–360 s, 76.1 %). There is an interposed time range of reduced visualization (range 62–127 s, 54.7 %) in which lesions are isoattenuating. Combined CT study during the first and second temporal windows improves the detection of HCCs especially for homogeneous and small lesions. The intermediate isoattenuation time range does not increase lesion detection rate.Type of Medium: Electronic ResourceURL: