Search Results - (Author, Cooperation:U. Pastorino)

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  1. 1
    J. George ; J. S. Lim ; S. J. Jang ; Y. Cun ; L. Ozretic ; G. Kong ; F. Leenders ; X. Lu ; L. Fernandez-Cuesta ; G. Bosco ; C. Muller ; I. Dahmen ; N. S. Jahchan ; K. S. Park ; D. Yang ; A. N. Karnezis ; D. Vaka ; A. Torres ; M. S. Wang ; J. O. Korbel ; R. Menon ; S. M. Chun ; D. Kim ; M. Wilkerson ; N. Hayes ; D. Engelmann ; B. Putzer ; M. Bos ; S. Michels ; I. Vlasic ; D. Seidel ; B. Pinther ; P. Schaub ; C. Becker ; J. Altmuller ; J. Yokota ; T. Kohno ; R. Iwakawa ; K. Tsuta ; M. Noguchi ; T. Muley ; H. Hoffmann ; P. A. Schnabel ; I. Petersen ; Y. Chen ; A. Soltermann ; V. Tischler ; C. M. Choi ; Y. H. Kim ; P. P. Massion ; Y. Zou ; D. Jovanovic ; M. Kontic ; G. M. Wright ; P. A. Russell ; B. Solomon ; I. Koch ; M. Lindner ; L. A. Muscarella ; A. la Torre ; J. K. Field ; M. Jakopovic ; J. Knezevic ; E. Castanos-Velez ; L. Roz ; U. Pastorino ; O. T. Brustugun ; M. Lund-Iversen ; E. Thunnissen ; J. Kohler ; M. Schuler ; J. Botling ; M. Sandelin ; M. Sanchez-Cespedes ; H. B. Salvesen ; V. Achter ; U. Lang ; M. Bogus ; P. M. Schneider ; T. Zander ; S. Ansen ; M. Hallek ; J. Wolf ; M. Vingron ; Y. Yatabe ; W. D. Travis ; P. Nurnberg ; C. Reinhardt ; S. Perner ; L. Heukamp ; R. Buttner ; S. A. Haas ; E. Brambilla ; M. Peifer ; J. Sage ; R. K. Thomas
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-07-15
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Nadav, Y ; Pastorino, U ; Nicholson, A G

    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Published 1998
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    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We report a patient with Li–Fraumeni syndrome who developed multiple synchronous primary lung cancers together with atypical adenomatous hyperplasia, and discuss the pathogenesis of the lesions.〈section xml:id="abs1-2"〉〈title type="main"〉Case detailsA 57-year-old woman with Li–Fraumeni syndrome and a history of smoking was diagnosed as having multiple synchronous primary lung tumours, all of which were treated by surgical excision. Histological examination showed three separate well-differentiated adenocarcinomas and a single focus of atypical adenomatous hyperplasia. A constitutional mutation of the p53 gene had been identified, both in this patient and other members of her family.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionMultiple synchronous primary lung tumours have not been reported before in association with this syndrome. With both smoking and Li–Fraumeni syndrome known to be associated with mutations in the p53 gene, a cumulative effect is suggested in this patient.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2559.1998.00439.x

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1569-8041
    Keywords:
    lung metastases ; testicular cancer ; thoracic metastasectomies
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background: This study evaluated the results of thoracic metastasectomy for germ cell tumours to assess long term survival and identify prognostic factors. Patients and methods: A series of 141 consecutive patients who underwent resection of thoracic metastases at Royal Brompton Hospital were retrospectively reviewed. Kaplan–Meier estimates of survival were calculated for clinical variables related to primary tumour and thoracic metastases, using the Cox model for multivariate analysis. Results: Complete resection was achieved in 123 cases (87%); pathology showed viable malignant elements in 46 (32%), necrosis or fibrosis in 32, differentiated teratoma in 63. The overall survival was 77% at five years and 65% at 15 years, being significantly shorter in patients with malignant teratomatous elements (51% at five years, P = 0.0001) or incomplete resection (64% at five years, P = 0.019). At multivariate analysis these factors retained their prognostic value, with a relative risk of death of 5.7 for malignant teratomatous elements and 4.0 for incomplete resection. In addition, the Cox model revealed a 3.2 times higher risk of relapse in patients with malignant teratomatuos elements at the time of thoracic metastasectomy. Conclusions: These data confirm the value of thoracic metastasectomy to asses pathological response and achieve permanent cure of chemoresistant disease.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008491807858

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0165-4608
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-4608(92)90534-F

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0165-4608
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-4608(91)90500-T

    Articles: DFG German National Licenses