Search Results - (Author, Cooperation:U. Hesse)
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1Latest Papers from Table of Contents or Articles in PressC. T. Amemiya ; J. Alfoldi ; A. P. Lee ; S. Fan ; H. Philippe ; I. Maccallum ; I. Braasch ; T. Manousaki ; I. Schneider ; N. Rohner ; C. Organ ; D. Chalopin ; J. J. Smith ; M. Robinson ; R. A. Dorrington ; M. Gerdol ; B. Aken ; M. A. Biscotti ; M. Barucca ; D. Baurain ; A. M. Berlin ; G. L. Blatch ; F. Buonocore ; T. Burmester ; M. S. Campbell ; A. Canapa ; J. P. Cannon ; A. Christoffels ; G. De Moro ; A. L. Edkins ; L. Fan ; A. M. Fausto ; N. Feiner ; M. Forconi ; J. Gamieldien ; S. Gnerre ; A. Gnirke ; J. V. Goldstone ; W. Haerty ; M. E. Hahn ; U. Hesse ; S. Hoffmann ; J. Johnson ; S. I. Karchner ; S. Kuraku ; M. Lara ; J. Z. Levin ; G. W. Litman ; E. Mauceli ; T. Miyake ; M. G. Mueller ; D. R. Nelson ; A. Nitsche ; E. Olmo ; T. Ota ; A. Pallavicini ; S. Panji ; B. Picone ; C. P. Ponting ; S. J. Prohaska ; D. Przybylski ; N. R. Saha ; V. Ravi ; F. J. Ribeiro ; T. Sauka-Spengler ; G. Scapigliati ; S. M. Searle ; T. Sharpe ; O. Simakov ; P. F. Stadler ; J. J. Stegeman ; K. Sumiyama ; D. Tabbaa ; H. Tafer ; J. Turner-Maier ; P. van Heusden ; S. White ; L. Williams ; M. Yandell ; H. Brinkmann ; J. N. Volff ; C. J. Tabin ; N. Shubin ; M. Schartl ; D. B. Jaffe ; J. H. Postlethwait ; B. Venkatesh ; F. Di Palma ; E. S. Lander ; A. Meyer ; K. Lindblad-Toh
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Animals, Genetically Modified ; *Biological Evolution ; Chick Embryo ; Conserved Sequence/genetics ; Enhancer Elements, Genetic/genetics ; Evolution, Molecular ; Extremities/anatomy & histology/growth & development ; Fishes/anatomy & histology/*classification/*genetics/physiology ; Genes, Homeobox/genetics ; Genome/*genetics ; Genomics ; Immunoglobulin M/genetics ; Mice ; Molecular Sequence Annotation ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA ; Vertebrates/anatomy & histology/genetics/physiologyPublished by: -
2Articles: DFG German National LicensesHesse, U. ; Schöberlein, W. ; Wittenmayer, L. ; Förster, K. ; Warnstorff, K. ; Diepenbrock, W. ; Merbach, W.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Three Lolium perenne L. genotypes collected from different natural habitats were tested for the effects of their fungal endophyte Neotyphodium spp. on plant growth and seed yield. Half the clones of the originally infected plants were subjected to fungicide treatment to eradicate the endophytes. In an experiment, the clones were planted separately into pots and were either watered adequately or subjected to drought stress. In the genotype collected from a dry site, the endophyte infection reduced plant growth at an adequate water supply, but increased regrowth under drought. In the genotype from a periodically either flooded or dry site, endophyte infection significantly promoted the development of reproductive tillers and seed production (effects which are associated with adaptation to drought). In contrast, the genotype that originated from a wet site showed higher sensitivity to drought stress when endophyte infection was present. The results suggest that environmental conditions in the original habitat of the plants may influence the symbiotic interaction between plant and fungus, probably through natural selection. However, endophyte-induced increases in root dry weight and root/shoot ratio were recorded for all three genotypes. These features could be beneficial for plant persistence, especially on sites where water is the growth-limiting factor.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesSøsted, H. ; Hesse, U. ; Menné, T. ; Andersen, K.E. ; Johansen, J.D.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Contact allergy to hair dye ingredients is a well-known entity seen both in consumers using hair dyes and among hairdressers with occupational contact dermatitis. Surveys show that consumers with even severe adverse skin reactions to hair dyes only rarely contact the healthcare services. The frequency of hair dye-induced skin reactions in the consumer population is unknown.Objectives An epidemiological investigation with the aim of establishing the proportion of hair dye-induced skin reactions was performed in a population-based sample.Methods A representative random sample (n = 4000) was taken of the Danish adult population. Personal interview questions were asked regarding adverse skin reactions to hair dyes, either compatible with a classical allergic eczematous reaction with redness, scaling and itching or a severe allergic reaction with oedema of the forehead and face. The response rate was 65·2%.Results A total of 18·4% of the male respondents and 74·9% of the female respondents had at some point dyed their hair. The median age at first hair dyeing was 16 years (range 1–80). Adverse skin reactions to hair dyes compatible with an allergic reaction were reported in 5·3% of individuals who had ever used hair dye. Of these, only 15·6% had been in contact with healthcare services after the hair dye reaction. Having had a temporary tattoo was not a significant risk factor for an adverse reaction to hair dyes.Conclusions The rate of adverse allergic skin reactions to hair dyes was higher than expected from patch-test studies. Only by studying the clinical types of adverse reactions to hair dyes will it be possible to gather a complete epidemiological picture of the nature and extent of the problems related to hair dye ingredients.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0011-2240Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Cyclosporin ; Conventional immunosuppression ; Long-term renal functionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary In a prospective randomized trial 50 renal transplant patients (group A) received a sequential course of 14 days conventional immunosuppression (Lymphocytoglobuline (ALG), azathioprine, steroids) and cyclosporin and steroids thereafter, while 50 patients (group B) received the conventional immunosuppression for 7 days followed by cyclosporin and steroids. In the latter group ALG was tolerated for the whole period while in the first group conversion from conventional to cyclosporin A therapy had to be performed after a mean of 11 days, due to ALG intolerance. Actual patient survival rates 1 year posttransplant were 100% in both groups and graft survival rates 96% in group A and 86% in group B (P〈0.05). There was a mean dialysis frequency per patient of 0.7±2.0 in group A and 1.8±3.4 in group B (P=0.064). Serum creatinine 1 year posttransplant was 1.8±0.8 mg/dl in group A and 2.2±1.4 in group B. A total of 58 patients had a serum creatinine of less than 2 mg/dl at the time of conversion to cyclosporin. These patients had a significantly better graft survival rate (98.3%) and serum creatinine 1 year posttransplant (1.6±0.5 mg/dl) than the 40 patients with a serum creatinine of more than 2 mg/dl at the time of conversion (85%; 2.4±1.4 mg/dl), indicating that a delayed onset of cyclosporin therapy might benefit the kidney in the immediate posttransplant period when it is susceptible to nephrotoxicity due to the damage from hypothermic storage.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung 1. 1. Der Padtest und der klinische Streßtest sind gut reproduzierbar. 2. Der Padtest berücksichtigt die täglichen Inkontinenzsituationen mit den individuellen Kompensationsmechanismen. 3. Ergebnis des Padtests ist abhängig vom Blasenvolumen. 4. Der Provokationstest beurteilt den Blasenverschlußmechanismus. 5. Der Provokationstest ist kürzer und erlaubt den Harnverlust bei Belastung unter standardisierten Bedingungen direkt zu beurteilen.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung 1. Die subjektive und objektive Beurteilung des Therapieerfolges von SUI-Operationen unterscheiden sich deutlich. 2. Durch Die subjektive Beurteilung werden Therapieergebnisse “geschönt”. 3. Die subjektive Einschätzung mag dabei durchaus die persönliche Situation der Patientin wiedergeben, sie erlaubt aber nicht die Beurteilung eines Operationsergebnissesfür den Therapeuten.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Die EMG-Ableitung mit unipolaren Drahtelektroden ermöglicht eine schmerzlose, objektive und kontinuierliche Anleitung der beiden Levatorenseiten. In 4 von 8 stressin-kontinenten Para lagen im Vergleich zu den Nullipara nicht nur Veränderungen der maximalen Beckenbodenwillküraktivierungsdauer vor, sondern zeigten ein intermittierendes Aktivierungsmuster, welches wahrscheinlich für ein wiederholtes Hochstoßen des Konus, der nach unten zu fallen droht, spricht. Durch den Konus werden nicht nur Beckenbodenmuskeln gestärkt, sondern er führt zu einer Art „Lerneffekt“ in Hinblick auf eine koordinierte Aktivierung der beiden Levatorenseiten.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHesse, U. ; v.Obernitz, N. ; Römisch, M. ; Konecny, G. ; Anthuber, S. ; Schüßler, B.
Springer
Published 1993Staff ViewISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0030-4018Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1433-3023Keywords: Continent nulliparous women ; Holding time difference ; Learning effect of vaginal cones ; Pelvic floor coordination disturbance ; Urinary stress incontinent parous women ; Vaginal cone therapySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Simultaneous electromyographic (EMG) recordings with intramuscular wire electrodes from the left and right pubococcygeal muscles were performed to elucidate the neurophysiological effect of vaginal cones on the pelvic floor muscles. Ten continent nulliparous women (aged 22–32 years) and 20 stress urinary incontinent parous women (aged 27–60 years, average 2–4 deliveries) were examined before, during holding and after removal of the cone. All the continent nulliparous women could retain the cone in the vagina (mean weight 83.5 g (range 70–85 g). In the incontinent parous group 7 women could not hold any cone, 9 women could hold the 45 g cone, 1 the 32.5 g cone and 3 women the 57.5g cone. There was a significant voluntary holding time difference between continent nulliparous and incontinent parous women. The study reveals that vaginal cones may induce both strengthening of muscles as well as a learning effect leading towards a better coordinated muscle activation.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesHesse, U. J. ; Troisi, R. ; Mortier, E. ; Decruyenaere, J. ; de Hemptinne, B.
Springer
Published 1997Staff ViewISSN: 1433-0385Keywords: Key words: Domino liver transplantation ; Familial amyloid polyneuropathy. ; Schlüsselwörter: Dominolebertransplantation ; familiäre amyloidotische Polyneuropathie.Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung. Die familiäre amyloidotische Polyneuropathie (FAP) ist eine seltene Indikation zur Lebertransplantation. Die excidierte Leber des FAP-Patienten kann einem ausgewählten Patienten transplantiert werden. Im folgenden wird über eine sequentielle Lebertransplantation berichtet, die bei einer 34 jährigen FAP-Patientin mit der Leber eines hirntoten Organspenders durchgeführt wurde. Die excidierte Leber der Patientin wurde einem 60 jährigen Patienten mit hepatocellulärem Carcinom bei Cirrhose nach Hepatitis-C-Infektion implantiert.Notes: Summary. Familial amyloid polyneuropathy (FAP) is a rare indication for liver transplantation. The excised liver of the FAP patient can be transplanted into a selected patient. In the following report, sequential liver transplantation is described where a 34-year-old female FAP patient received a cadaver donor liver. The excised native liver was transplanted to a 60-year-old male patient suffering from hepatocellular carcinoma in cirrhosis due to hepatitis C.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesSitges-Serra, A. ; Gores, P. ; Hesse, U. ; Fryd, D. S. ; Najarian, J. S. ; Sutherland, D. E. R.
Springer
Published 1986Staff ViewISSN: 1432-2323Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Résumé Dans le but de déterminer les risques de complications chez un groupe de malades ayant présenté un hyperparathyroïdisme après transplantation rénale les auteurs ont comparé une série de 14 cas où le taux de calcium avait été au moins une fois supérieure à 12 mg/100 ml et une série de 11 receveurs où le taux de calcium était normal et ce 6 et 30±8 mois après allogreffe rénale. Au bout de 6 mois le taux de calcium fut supérieur à 12 mg/100 ml chez 13 des 14 malades qui avaient subi une transplantation rénale. Des différences significatives furent constatées entre les transplantés et les sujets appartenant au groupe de contrôle aussi bien en ce qui concerne le calcium sérique (11.6 contre 9.2 mg/100 ml) et la phosphatase alcaline (228 contre 120 U/l). Au terme de 30±8 mois des différences furent également constatées pour le calcium (10.2 contre 9.4 mg/100 ml), pour le phosphore (2.8 contre 4.8 mg/100 ml) et pour la phosphatase alcaline (180 contre 88 U/l). Les taux de créatinine sérique étaient identiques dans les 2 groupes. Une corrélation significative fut constatée entre les déterminations précoces et tardives de la phosphatase alcaline chez les 25 sujets rassemblés en un seul groupe (r=0.72, p〈0.001). La douleur osseuse et/ou des signes radiologiques évidents d'atteinte osseuse d'origine hyperparathyroïdienne allaient de pair significativement chez les transplantés (8 contre 1 et 7 contre 0 respectivement). Chez ceux-ci fut constatée une fréquence supérieure mais non significative de calcifications vasculaires (5 contre 1) et de pancréatite aiguë (2 contre 0). Les opérés qui ont développé un hyperparathyroïdisme modéré ou intense (un taux supérieur à 12 mg/100 ml, au moins une fois) au cours des 6 mois qui suivirent la transplantation rénale, en particulier lorsqu'ils présentèrent une atteinte du squelette, devraient bénéficier d'une parathyroïdectomie subtotale.Abstract: Resumen Con el propósito de determinar si el grupo particular de pacientes con hiperparatiroidismo después de transplante renal (HTR) posee riesgo de desarrollar complicaciones, se realizó la evaluación de 14 casos definidos de HTR no tratados y que presentaban por lo menos un valor de calcio sérico ≥ 12 mg/100 ml, los cuales fueron comparados con 11 recipientes normocalcémicos de transplante renal a los 6 y 30 ±8 meses después de un aloinjerto renal exitoso. El calcio sérico apareció en ≥ 12 mg/100 ml dentro de los primeros 6 meses de efectuado el transplante en 13 de 14 pacientes con HTR. A los 6 meses se hallaron diferencias significativas entre los pacientes con HTR y los controles en el valor promedio del calcio sérico (11.6 vs. 9.2 mg/100 ml) y de la fosfatasa alcalina (228 vs. 120 U/l). A los 30±8 meses se hallaron diferencias en el calcio sérico (10.2 vs. 9.4 mg/100 ml), fosfato (2.8 vs. 4.8 mg/100 ml) y fosfatasa alcalina (180 vs. 88 U/l). Los niveles de creatinina sérica aparecieron similares en los 2 grupos. Se encontró una correlación significativa entre las determinaciones tempranas y las tardías de la fosfatasa alcalina cuando la totalidad de los 25 pacientes fue estudiada como grupo único (r= 0.72, p〈0.001). El dolor óseo y/o la evidencia radiológica de enfermedad ósea paratiroidea aparecieron en asociación significativa con el HTR (8 vs. 1 y 7 vs. 0, respectivamente). Una incidencia mayor, aunque no significativa, de calcificaciones vasculares (5 vs. 1) y de pancreatitis aguda (2 vs. 0) fue hallada en el HTR. Los pacientes con HTR severo definido como el hallazgo de por lo menos una determinación de calcio sérico ≥ 12 mg/100 ml, lo desarrollan dentro de los 6 meses siguientes al transplante renal, presentan morbilidad aumentada, especialmente con afección esquelética, y es posible que se beneficien de paratiroidectomía subtotal.Notes: Abstract In an attempt to find out if a particular group of patients with hyperparathyroidism after renal transplantation (HRT) are at risk of developing complications, 14 patients with overt untreated HRT who had at least 1 serum calcium determination ≥ 12 mg/100 ml were evaluated and compared retrospectively with 11 normocalcemic transplant recipients at 6 and 30± 8 months after successful renal allografting. Serum calcium was ≥ 12 mg/100 ml within 6 months of transplantation in 13 of the 14 HRT patients. At 6 months significant differences were found between HRT and controls in mean serum calcium (11.6 versus 9.2 mg/100 ml) and alkaline phosphatase (228 versus 120 U/l). At 30±8 months differences were found in serum calcium (10.2 versus 9.4 mg/100 ml), phosphate (2.8 versus 4.8 mg/100 ml), and alkaline phosphatase (180 versus 88 U/l). Serum creatinine levels were similar in the 2 groups. A significant correlation was found between early and late determinations of alkaline phosphatase when all 25 patients were studied as a single group (r=0.72, p〈0.001). Bone pain and/or radiological evidence of hyperparathyroid bone disease were significantly associated with HRT (8 versus 1 and 7 versus 0, respectively). A higher but not significant incidence of vascular calcifications (5 versus 1) and acute pancreatitis (2 versus 0) was found in HRT. Patients who develop moderate to severe HRT as defined by at least 1 serum calcium determination ≥ 12 mg/100 ml do so within 6 months of renal transplantation, have increased morbidity, particularly involving the skeleton, and might benefit from early subtotal parathyroidectomy.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesDefreyne, L. ; König, K. ; Lerch, M. M. ; Hesse, U. J. ; Rottiers, R. ; Feifel, G. ; de Hemptinne, B. ; Kramann, B. ; Kunnen, M.
Springer
Published 1998Staff ViewISSN: 1432-0509Keywords: Key words: Pancreas angiography—Pancreas neoplasms—Venous blood sampling—Hormones.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Background: To determine the accuracy and safety of a modified intra-arterial calcium stimulation with the venous sampling test (ASVS) for preoperative localization of insulinomas. Modification included stimulation with a fixed low dose of calcium gluconate, additional stimulation in the distal splenic artery, and no insulin sampling in the left hepatic vein. Methods: In 10 patients showing biochemical evidence of organic hyperinsulinemia, 0.45 mmol of Ca2+ was injected into the gastroduodenal, superior mesenteric, proper hepatic, proximal, and distal splenic arteries during angiography. Insulin levels were measured in samples taken from the right hepatic vein before and 30, 60, 90, 120, 180, and 300 s after Ca2+ injection. Results: Insulin gradients with an increase of more than fourfold indicated direct tumor supply, two- to fourfold correlated with collateral supply, and less than twofold correlated with normal tissue vascularization. ASVS localized all the adenomas of the pancreatic head (n = 3) and body (n = 2) and two of four adenomas of the tail correctly, as confirmed by surgery. Two adenomas of the proximal pancreatic tail were erroneously localized to the body segment, but the fault was rectified by angiography. In one patient with a negative ASVS and without exploration, the diagnosis of an insulinoma was revised. Conclusion: ASVS with a fixed low dose of calcium gluconate is a highly accurate and safe method for preoperative localization of insulinomas. Sampling in the left hepatic vein can be routinely omitted. Additional stimulation in the distal splenic artery seems helpful in surgical decision making, but additional experience is needed.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Wir konnten zeigen, daß ein Prolaps in situ den Verschlußdruck bei Belastung verbessert. Bedingt durch die suburethrale Unterpolsterung, die in Folge des erhöhten intraurethralen Druckes bei Belastung forciert wird. Eine urodynamische Aussage über den Harnröhrenverschlußdruck durch den Prolaps, insbesondere bei Patientinnen mit klinisch gesicherter larvierter Streßinkontinenz, ist nur bei Wiederholung der Urethromanometrie mit Reposition zu treffen.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Eine individuelle Miktionseinleitung und BT ist sinnvoll bei Pat. mit langdauernden BES, zumal die Pat. das Gefühl haben sollten, nicht mit ihren Problemen alleingelassen zu werden. Wertheim-Pat. miktieren postop. schneller als Pat. nach SIK-Operationen mit einer deutlichen Erhöhung des Blasenauslaßwiderstandes. Langdauernde BES sind mit differenzierter Diagnostik, dem Einsatz von Medikamenten, evtl. intermittierendem Selbstkatheterismus und Geduld des Gynäkologen zu beherrschen.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesHesse, U. ; Troisi, R. ; Pattyn, P. ; Mortier, E. ; Decruyenaere, J. ; de Hemptinne, B.
Springer
Published 1997Staff ViewISSN: 1432-2277Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesTroisi, R. ; Meester, D. ; Regaert, B. ; Jacobs, B. ; Van den Broucke, C. ; Cuvelier, Claude ; de Hemptinne, B. ; Hesse, U. J.
Springer
Published 2000Staff ViewISSN: 1432-2277Keywords: Key words Pancreas preservation ; HTK-solution ; Segmental porcine pancreatic autotransplantation ; Delayed endocrine graft functionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Delayed graft function (DEGF) remains an obscure phenomenon in organ transplantation. For the optimal washing of the compounds of the different organ flush solutions, adequate temperature and equilibrium of electrolytes have to be provided. A total of 29 landrace pigs weighing 37.3–5.4 kg were included in this study. According to the model, the left hemipancreas was perfused with Histidine-Tryptophan-Ketoglutarate (HTK)-solution and autotransplanted after 24 h (G1, n = 13) and 48 h (G2, n = 4) of cold storage (CS). Results were compared with grafts perfused with UW-solution and autotransplanted after 24 h (G3, n = 8) and 48 h (G4, n = 4) CS respectively. Daily measurements of glycemia, glucosuria, amylase and lipase were carried out. HTK perfusion resulted in an increase in wet weight of the grafts after 24 h and 48 h CS (P = 0.031 vs UW). Postoperative glycemia levels in pancreases flushed with HTK-solution were higher after 48 h than after 24 h CS until the 6th postoperative day, when the glycemia returned to normal range (P = 0.02), suggesting a delayed endocrine graft function. The mean IVGTT values attained after full function were comparable in G1 and in G3 (–1.22 ± 0.23 vs. –1.5 ± 0.65). The rises in serum amylase and lipase levels were more pronounced after 48 h CS in both HTK and UW groups, (P = n.s.). Appearance of interstitial and intracellular edema after CS and reperfusion did not influence the function.¶Conclusion: HTK-solution is suitable for 24 h pancreatic preservation in vivo; the perfusion requires at least 4 min for electrolyte equilibration. Long preservation time (48 h) resulted in a transitory DEGF.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-2277Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: