Search Results - (Author, Cooperation:T. W. Kuijpers)
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1Latest Papers from Table of Contents or Articles in PressB. Chaigne-Delalande ; F. Y. Li ; G. M. O'Connor ; M. J. Lukacs ; P. Jiang ; L. Zheng ; A. Shatzer ; M. Biancalana ; S. Pittaluga ; H. F. Matthews ; T. J. Jancel ; J. J. Bleesing ; R. A. Marsh ; T. W. Kuijpers ; K. E. Nichols ; C. L. Lucas ; S. Nagpal ; H. Mehmet ; H. C. Su ; J. I. Cohen ; G. Uzel ; M. J. Lenardo
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-13Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: CD8-Positive T-Lymphocytes/*immunology ; Cation Transport Proteins/genetics/metabolism ; *Cytotoxicity, Immunologic ; Epstein-Barr Virus Infections/*immunology ; Humans ; Killer Cells, Natural/*immunology ; Magnesium/*immunology ; Magnesium Deficiency/*immunology ; NK Cell Lectin-Like Receptor Subfamily K/genetics/*metabolism ; X-Linked Combined Immunodeficiency Diseases/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressDe Boer, M., Gavrieli, R., van Leeuwen, K., Wolf, H. R., Dushnitzki, M., Bar-Yosef, Y., Bar-Ziv, A., Behar, D., Lipitz, S., Miller, T. E., Tool, A. T. J., Kuijpers, T. W., van den Berg, T. K., Wolach, B., Roos, D., Pras, E.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-02-23Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressBranch, D. R., Hellberg, A., Bruggeman, C. W., Storry, J. R., Sakac, D., Blacquiere, M., Tong, T. N., Burke-Murphy, E., Binnington, B., Parmar, N., Riden, L. S., Willie, K., Armali, C., Aziz, J., Lieberman, L., Laroche, V., Callum, J., Lin, Y., Shehata, N., Pavenski, K., Lau, W., Hannach, B., Kuijpers, T. W., Olsson, M. L., Cserti-Gazdewich, C., Pendergrast, J.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-02-16Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Transfusion MedicinePublished by: -
4Articles: DFG German National LicensesLie, W. J. ; Homburg, C. H. E. ; Kuijpers, T. W. ; Knol, E. F. ; Mul, F. P. J. ; Roos, D. ; Tool, A. T. J.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Allergic disease is the result of an interplay of many different cell types, including basophils and mast cells, in combination with various inflammatory lipid mediators, such as platelet-activating factor (PAF) and leukotrienes (LT). LTC4 synthesis by human basophils has been studied quite extensively. However, not much is known about the synthesis of PAF by human basophils.Objective In this study, we have made a comprehensive comparison between the kinetics of PAF and LTC4 synthesis, in highly purified basophils, activated with different stimuli or with combinations of stimuli.Methods Synthesis of PAF and LTC4 by human basophils was determined with commercially available assay kits. The basophils were activated with C5a, fMLP, PMA, allergen or anti-IgE, in the absence and presence of IL-3 and/or in combination with elevation of cytosolic free Ca2+ by the sarcoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin.Results Most stimuli were found to induce both PAF and LTC4 synthesis. PAF synthesis and LTC4 release were enhanced by preincubation of the basophils with IL-3 or by elevation of cytosolic free Ca2+ by thapsigargin. Incubation of human basophils with IL-3 alone or thapsigargin alone did not result in detectable synthesis of PAF and LTC4, whereas the combination of the two resulted in high amounts of PAF and LTC4 synthesis. Depending on the stimulus used, LTC4 release was 5–100-fold higher than PAF synthesis. In addition, PAF, but not LTC4, was transiently detected, probably due to PAF degradation.LTC4 and PAF synthesis was strongly blocked by inhibitors of cytosolic phospholipase A2, indicating that this enzyme is involved in PAF and LTC4 synthesis by activated human basophils.Conclusion This study provides a first comprehensive comparison of PAF and LTC4 synthesis in highly purified human basophils, stimulated with a variety of stimuli.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National Licensesvan Kooyk, Y. ; van de Wiel-van Kemenade, P. ; Weder, P. ; Kuijpers, T. W. ; Figdor, C. G.
[s.l.] : Nature Publishing Group
Published 1989Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] LFA-1, CR3 and p!50, 95 comprise a group of heterodimeric adhesion receptors with a unique a-chain and a common /3-chain. They mediate adhesion among leukocytes and of FIG. 1 Photomicrographs of homotypic cell adhesion and its inhibition by anti-LFA-1 antibodies. JS-136 cells were incubated ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Keywords: Key words Kawasaki disease ; Cardiac tamponade ; Polyserositis ; Intravenous immunoglobulin ; MethylprednisoloneSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We describe a boy with Kawasaki disease (KD) whose clinical course was marked by a rapid improvement upon treatment with intravenous immunoglobulin (IVIG) and oral aspirin, which – within 14 days – was followed by the development of a large pericardial effusion with symptoms of impending cardiac tamponade as part of a polyserositis syndrome (pleural effusions, ascites). Upon treatment with pulsed methylprednisolone, the pericardial and pleural effusions and ascites rapidly disappeared within 48 h. This is the first case reported with a polyserositis syndrome and impending cardiac tamponade during KD.Type of Medium: Electronic ResourceURL: