Search Results - (Author, Cooperation:T. Terada)
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1Latest Papers from Table of Contents or Articles in PressH. Tanabe ; Y. Fujii ; M. Okada-Iwabu ; M. Iwabu ; Y. Nakamura ; T. Hosaka ; K. Motoyama ; M. Ikeda ; M. Wakiyama ; T. Terada ; N. Ohsawa ; M. Hato ; S. Ogasawara ; T. Hino ; T. Murata ; S. Iwata ; K. Hirata ; Y. Kawano ; M. Yamamoto ; T. Kimura-Someya ; M. Shirouzu ; T. Yamauchi ; T. Kadowaki ; S. Yokoyama
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Histidine/chemistry/metabolism ; Humans ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Receptors, Adiponectin/*chemistry/metabolism ; Structure-Activity Relationship ; Zinc/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Arai ; S. Saijo ; K. Suzuki ; K. Mizutani ; Y. Kakinuma ; Y. Ishizuka-Katsura ; N. Ohsawa ; T. Terada ; M. Shirouzu ; S. Yokoyama ; S. Iwata ; I. Yamato ; T. Murata
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Binding Sites ; Crystallization ; Enterococcus/*enzymology/genetics ; *Models, Molecular ; Mutation ; Nucleotides/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Protein Subunits ; Rotation ; Vacuolar Proton-Translocating ATPases/*chemistry/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressF. Inagaki ; K. U. Hinrichs ; Y. Kubo ; M. W. Bowles ; V. B. Heuer ; W. L. Hong ; T. Hoshino ; A. Ijiri ; H. Imachi ; M. Ito ; M. Kaneko ; M. A. Lever ; Y. S. Lin ; B. A. Methe ; S. Morita ; Y. Morono ; W. Tanikawa ; M. Bihan ; S. A. Bowden ; M. Elvert ; C. Glombitza ; D. Gross ; G. J. Harrington ; T. Hori ; K. Li ; D. Limmer ; C. H. Liu ; M. Murayama ; N. Ohkouchi ; S. Ono ; Y. S. Park ; S. C. Phillips ; X. Prieto-Mollar ; M. Purkey ; N. Riedinger ; Y. Sanada ; J. Sauvage ; G. Snyder ; R. Susilawati ; Y. Takano ; E. Tasumi ; T. Terada ; H. Tomaru ; E. Trembath-Reichert ; D. T. Wang ; Y. Yamada
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-07-25Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Aquatic Organisms/*classification/genetics/metabolism ; Archaea/*classification/genetics/metabolism ; Bacteria/*classification/genetics/metabolism ; Biomarkers/metabolism ; Carbon Dioxide/metabolism ; Coal/*microbiology ; Geologic Sediments/*microbiology ; Japan ; Methane/metabolism ; Methanococcus/classification/genetics/metabolism ; Methanosarcina barkeri/classification/genetics/metabolism ; *Microbial Consortia ; Pacific Ocean ; Seawater/*microbiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressIjiri, A., Inagaki, F., Kubo, Y., Adhikari, R. R., Hattori, S., Hoshino, T., Imachi, H., Kawagucci, S., Morono, Y., Ohtomo, Y., Ono, S., Sakai, S., Takai, K., Toki, T., Wang, D. T., Yoshinaga, M. Y., Arnold, G. L., Ashi, J., Case, D. H., Feseker, T., Hinrichs, K.-U., Ikegawa, Y., Ikehara, M., Kallmeyer, J., Kumagai, H., Lever, M. A., Morita, S., Nakamura, K.-i., Nakamura, Y., Nishizawa, M., Orphan, V. J., Roy, H., Schmidt, F., Tani, A., Tanikawa, W., Terada, T., Tomaru, H., Tsuji, T., Tsunogai, U., Yamaguchi, Y. T., Yoshida, N.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-06-14Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
5Latest Papers from Table of Contents or Articles in PressR. Terada, T. Takeshita, H. Itoh and I. Kanzaki
Institute of Physics Publishing (IOP)
Published 2018Staff ViewPublication Date: 2018-02-27Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
6Articles: DFG German National LicensesKoyanagi, M. ; Terada, T. ; Nakashima, K.
College Park, Md. : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Using a heat-pulse modulation technique, phosphorescence spectra of 9-xanthone have been studied in n-pentane at 77 and 2.1 K. The three legitimate phosphorescent levels with different lifetimes are detected at 25 751, 25 766, and 25 774 cm−1 above the zero-vibrational level of the ground state. The origin of these multiple levels is explained in terms of spin–orbit interaction superimposed on environmental electrostatic coupling between T1(ππ*) and T2(nπ*). The two coupling constants obtained are: (for the spin–orbit coupling) ||〈1ξ||Hso||2η〉|| =15.70 cm−1 (ξ=x, η=y or vice versa); (for environmental direct coupling) 〈1ζ||Henv||2ζ〉 =3.14 cm−1 (ζ=x, y, or z). For comparison, the T←S phosphorescence excitation spectrum, measured in the same matrix, are in good agreement with the calculated ones.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesTERADA, T. ; NAKANUMA, Y. ; OHTA, T. ; NAGAKAWA, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Neoplastic transformation occurs in the intrahepatic biliary tree in hepatolithiasis. The present study aimed to clarify the neoplastic processes by correlating the histological features of the bile duct lesions with counts of interphase argyrophilic nucleolar organizer regions (AgNORs), which reflect cell proliferative activity. We studied 55 cases of hepatolithiasis and 25 normal autopsy livers. The biliary epithelial lesions in hepatolithiasis were divisible into hyperplasia, dysplasia and neoplasia. These lesions were found in bile ducts containing calculi. All cases of hepatolithiasis showed a varied degree of hyperplasia. Additionally, eight cases showed dysplasia, five non-invasive intraductal adenocarcinoma and 10 invasive adenocarcinoma. Cases of non-invasive and invasive carcinoma frequently harboured areas of dysplasia, and areas of dysplasia and non-invasive carcinoma, respectively. The mean and standard deviation of the number of interphase AgNORs in the normal and abnormal biliary epithelium showed a step-wise increase in the following order: normal (1.32±0.36), hyperplasia (1.52±0.37), dysplasia (2.28±0.56), non-invasive carcinoma (3.23±1.00), and invasive carcinoma (3.72±0.77). These histological and cell kinetic observations suggest that, in hepatolithiasis, carcinogenesis in bile duct epithelial cells progresses in a multi-step manner, through hyperplasia, dysplasia, non-invasive adenocarcinoma and invasive adenocarcinoma.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesNAKANUMA, Y. ; TERADA, T. ; TERASAKI, S. ; UEDA, K. ; NONOMURA, A. ; KAWAHARA, E. ; MATSUI, O.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically, Ninety-seven nodules of adenomatous hyperplasia were ained from 47 cirrhotic livers and were divided into ‘ordinary’ (44 nodules) and ‘atypical’ (53 nodules) types. The former consisted of hepatocytes similar to those of the surrounding liver, and showed regularly distributed portal tracts. The latter type was composed of hepatocytes showing nuclear atypia, relative to the surrounding liver, and showed irregular or sparse portal tracts. Atypical nodules were histologically heterogen, possessing areas of normo-trabecular, compact, pseudoglandular and/or scirrhous patterns. Several cytological changes, such as clear cell change, small or large cell change and fatty change, were intermingled variably within a given nodule. Atypical nodules showed expansive and/or replacing growth into the surrounding liver. Atypical hepatocytes also infiltrated into the fibrous septa and portal tracts. Foci of overt hepatocellular carcinoma were found in 11 of the 53 atypical nodules. These findings suggest that ordinary adenomatous hyperplasia may be a large-sized regenerative nodule, while atypical adenomatous hyperplasia may be a hepatocellular neoplasm, a peculiar form of low-grade hepatocellular carcinoma or borderline lesion, in which overt hepatocellular carcinoma is likely to evolve through multiple steps.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchyme at 10–14 weeks of gestation. Tenascin was also expressed in the mesenchyme around newly formed hilar bile ducts at 15-20 weeks of gestation, but its expression disappeared after 21 weeks of gestation. Type IV collagen and laminin were expressed around the ductal plate, around epithelial cells migrating from the ductal plate into the mesenchyme, and around newly formed hilar bile ducts, and their expression was present throughout fetal life. By contrast, in the development of peripheral bile ducts, tenascin expression was not found. Type IV collagen and laminin were identified around the ductal plate, migrating epithelial cells and peripheral bile ducts. In cholangiocarcinoma, tenascin and type IV collagen were expressed in the stroma, but laminin was not identified. These findings suggest that tenascin may play a role in hilar bile duct development and that type IV collagen and laminin may play a role in both hilar and peripheral bile duct development. Expression of tenascin and type IV collagen in the stroma of cholangiocarcinoma may be the result of malignant transformation of intrahepatic biliary epithelium; tenascin in peritumoral stroma may stimulate carcinoma cell proliferation and growth in cholangiocarcinoma.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesTERADA, T. ; HIRATA, K. ; HISADA, Y. ; HOSHII, Y. ; NAKANUMA, Y.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Obstructive jaundice has rarely been reported in liver amyloidosis. We report here an autopsy of a 55-year-old woman with multiple myeloma and obstructive jaundice due to the deposition of amyloid-like substances in the walls and lumina of the extrahepatic bile duct and intrahepatic large bile ducts, resulting in obstruction and narrowing of the bile ducts. The amyloid-like deposits were negative with Congo red stain, and were negative immunohistochemically for IgG, IgA, IgM, kappa chain, beta-2-microglobulin, and amyloid A and P components. However, they were positive for lambda chain, and ultrastructurally composed of non-branching filaments with a diameter of 7–10 nm. This is the first case of obstructive jaundice due to histologically confirmed amyloid-like deposits in the biliary system.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesTerada, T. ; Kaneko, H. ; Fukao, T. ; Teramoto, T. ; Asano, T. ; Li, A. L. ; Kasahara, K. ; Kondo, N.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Common variable immunodeficiency (CVID) is a primary antibody deficiency syndrome characterized by defective B-cell maturation and antibody formation resulting in low serum antibody levels of all immunoglobulin (Ig) isotypes. To investigate the pathogenesis of CVID, we developed a set of competitive polymerase chain reaction for membrane-bound Ig heavy chain (mHC) mRNAs for IgM, IgG and IgA. Data on three children with CVID in group A of Bryant's classification were analysed. All the three mHC mRNA levels in Patient 1 were almost same as those in healthy controls. In Patient 2, mHC mRNA for IgM was detected at a level similar to that in controls, but mHC mRNAs for IgG and IgA heavy chains were not detected. In Patient 3, all the three mHC mRNAs were undetectable. Our data suggest that a different molecular basis exists in these patients with CVID even though all belong to group A of Bryant's classification. Use of our method facilitates a better understanding of molecular events in CVID patients and may be useful for precise classifications of CVID.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A few previous studies have demonstrated the expression or mutations of oncogenes and anti-oncogenes as well as that of oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. In this study, we have investigated the immunohistochemical expression of oncogene (ras and c-erbB-2) and anti-oncogene (p53 and retinoblastoma [Rb]) products and oncofetal antigens (CEA, CA19-9 and DUPAN-2) in nine such tumours of the pancreas. In normal pancreas (5 cases), the Rb gene product and CA19-9 were expressed in all cases, while ras and c-erbB-2 gene products, p53 protein, CEA and DUPAN-2 were not expressed. In intraductal papillary-mucinous tumours (n = 9), ras, c-erbB-2, p53 and Rb gene products were present in 4/9 (44%), 7/9 (78%), 0.9 (0%) and 6/9 (67%) cases, respectively. CEA, CA19-9 and DUPAN-2 were expressed in 8/9 (89%), 9/9 (100%) and 2/9 (22%) cases respectively. In invasive ductal adenocarcinoma of the pancrease (7 cases), ras, c-erbB-2, p53 and Rb gene products were expressed in 3/7 (43%), 6/7 (86%), 2/7 (29%) and 3/ & (43%) cases respectively. CEA, CA19-9 and DUPAN-2 were expressed in 7/7 (100%), 7/7 (100%) and 6/7 (86%) cases, respectively. The extent and intensity of the expression of these antigens was greater in invasive ductal adenocarcinomas. These data suggest that activation of ras and c-erbB-2 oncogenes and inactivation of Rb anti-oncogene may contribute to the development and progression of intraductal papillary-mucinous tumours of the pancreas and that there is neo-expression of CEA and DUPAN-2 during the development and progression of these tumours.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Borderline hepatocellular nodule in the human cirrhotic liver is considered a preneoplastic lesion of hepatocellular carcinoma (HCC). However, the angiogenetic process and changes in perisinusoidal cells (fat-storing cells or Ito cells) during the borderline nodule-HCC sequence have not been investigated. We have investigated intraparenchymal arterial elements and perisinusoidal cells in normal livers, chronic hepatitis, borderline nodules and small HCC, using an immunohistochemical staining for α-smooth muscle actin. In normal livers, chronic hepatitis, cirrhotic nodules and large regenerative nodules, no or few arterial elements were present in the parenchyma, and α-smooth muscle actin-positive perisinusoidal cells were not increased. In borderline nodules, however, there were many intranodular arterial elements, and perisinusoidal cells were significantly increased. In small HCC, there were much more arterial elements, and perisinusoidal cells were increased further. These data suggest that angiogenesis first occurs in borderline hepatocellular nodules and it gradually proceeds during the nodule to HCC sequence along with an increase in perisinusoidal cells. The demonstration of arterial elements and perisinusoidal cells may be useful for the differential diagnosis of large regenerative nodule, borderline hepatocellular nodule and small HCC.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The expression of alpha-amylase isoenzymes (pancreatic and salivary) and trypsin by the epithelium of large intrahepatic bile ducts and peribiliary glands was examined immunohistochemically in hepatolithiasis (n= 22), extrahepatic biliary obstruction (n= 20) and normal liver (n= 22). Hepatolithiasis was associated with marked proliferation of bile duct cells and peribiliary glands. Expression of pancreatic and salivary amylase was observed in the proliferating bile duct cells and peribiliary glands of all livers, and trypsin was found in 68% of the livers. In extrahepatic biliary obstruction, proliferation of the biliary epithelium was less marked, but expression of amylase isoenzymes was observed in all livers and trypsin was found in 50%. All normal livers showed expression of amylase isoenzymes in large intrahepatic bile ducts, septal bile ducts and peribiliary glands, and trypsin was found in 73%. The density of enzyme-containing acini was highest in hepatolithiasis, intermediate in extrahepatic biliary obstruction and lowest in normal liver. These results show that the proliferating biliary epithelium in hepatolithiasis contains amylase isoenzymes and trypsin and that biliary epithelium retains the ability to produce these enzymes after proliferation, suggesting that a large amount of amylase isoenzymes and trypsin may be secreted into the bile ducts in hepatolithiasis. These enzymes may play an important role in the pathophysiology of hepatolithiasis.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesAzuma, H. ; Niimi, Y. ; Terada, T. ; Hamasaki, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. We compared endothelial regeneration and intimal thickening after endothelial denudation between normal and sclerotic carotid arteries (CA). Endothelial denudation of the right CA of rabbits formed intimal thickening covered with regenerated endothelial cells (EC) in 6 weeks, which was considered as the sclerosis model. Both CA were then denuded. Morphological and immunohistochemical studies using antibodies for proliferating cell nuclear antigen (PCNA), von Willebrand factor and macrophages were performed.2. Regeneration of EC were observed 24h after denudation on both CA, but completed earlier in the double-denuded right CA. The density of EC in both CA increased after regeneration and gradually decreased afterwards.3. After a single denudation on the left CA, PCNA-positive cells clearly appeared in 24h, markedly increased in 72h both in the intima and media, then greatly decreased in 4 and 6 weeks.4. After a double denudation of the right CA, enhancement of the intimal hyperplasia was observed. PCNA-positive cells markedly increased in 1 week and remained significantly increased in 6 weeks both in the intima and the media.5. We concluded from these results that the repeated endothelial denudation caused more sustained proliferation of smooth muscle cells which led to an enhancement of the intimal hyperplasia.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1460-2695Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: The influence of a notch and a water environment on the quasi-static and fatigue fracture behaviour was investigated in single crystal silicon microelements. The tests were conducted in smooth and notched microcantilever beam samples. Smooth specimens were prepared by micromachining (photo-etching) of (110) silicon wafers. For some specimens, a nanometre-sized notch was machined 100 μm away from the sample root by using a focused ion beam system. A machining condition was optimized, and the V-shaped notch was successfully introduced. The radius of curvature of the notch, measured by an atomic force microscope (AFM), decreased with an increase in notch depth, and ranged from about 20 to 100 nm. Single-crystal Si microelements deformed elastically until final failure, which was of a brittle nature. The maximum fracture strength of a smooth microcantilever specimen reached about 7.7 GPa, which was higher than that obtained in millimetre-sized single crystal Si samples. However, the fracture strength decreased with an increase in notch depth, even though the notch depth was of the order of a nanometre. This means that a nanometre deep notch, which is often regarded as surface roughness in ordinary-sized mechanical components, caused a decrease in the fracture strength of Si microelements. The fracture initiated at the notch, and then the {111} crack propagated in the direction normal to the sample surface. Fatigue tests were also conducted in laboratory air and in pure water at a stress cycle frequency of 0.1 Hz and a stress ratio of 0.1. In laboratory air, no fatigue damage was observed even though the surface was nanoscopically examined by an AFM. However, when the fatigue tests were conducted in pure water, the fatigue lives in water were decreased. Crack formation on the {111} plane was promoted by a synergistic effect of the dynamic loading and the water environment. Atomic force microscopy was capable of imaging the nanoscopic cracks, which caused failure in water.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesHOSO, M. ; TERADA, T. ; NAKANUMA, Y.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesTERAYAMA, N. ; TERADA, T. ; NAKANUMA, Y.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: To elucidate the phenotype of the blood vessels and the expression of the growth factors involved in angiogenesis in metastatic liver cancers, we carried out an immunohistochemical study of 57 surgically resected livers with metastatic cancer. Blood vessels in the metastatic liver cancers frequently expressed von Willebrand factor (vWF), Ulex europaeus agglutinin I (UEA I)-binding sites, α-smooth muscle actin (α-SMA), type IV collagen and laminin. Sinusoidal endothelial cells around the metastatic liver cancers were positive for vWF in 33.3% of the specimens examined and for UEA I in 28.1%. α-SMA-positive perisinusoidal cells accumulated in the vicinity of the metastatic liver cancers in 68.4% of the specimens. Type IV collagen was detected in the perisinusoidal space close to the metastatic cancers as well as distant from them (91.2%). Laminin was detected in the perisinusoidal space in only one specimen (1.8%). Tumour cells of the metastatic liver cancers were positive for vascular endothelial growth factor, basic fibroblast growth factor (bFGF), and acidic fibroblast growth factor (aFGF) in 78.9%, 38.4% and 7.0% of the specimens, respectively. Hepatocytes close to the metastatic liver cancers expressed bFGF more strongly than those distant from the metastatic liver cancers, and their expression of bFGF was more intense than that in the tumour cells. These results suggest that: (1) tumour vessels in metastatic liver cancers consist of endothelium, basement membrane and pericytes, (2) the sinusoids adjacent to tumours undergo capillarization, and (3) vascular endothelial growth factor may contribute to angiogenesis in metastatic liver cancer. Basic fibroblast growth factor may be responsible for the sinusoidal capillarization and the peritumoral fibrosis.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesMINATO, H. ; NAKANUMA, Y. ; TERADA, T.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The abnormal expression of blood group related antigens has been reported in many malignant tumours; however, such expression in cholangiocarcinoma has not been examined systematically. The expression of blood group-related antigens (A, B, H, Lewisa, Lewisb, Lewisx, Lewisy, carbohydrate antigen 19-9 and carcinoembryonic antigen) was investigated immunohistochemically in 75 cases of cholangiocarcinoma (31 peripheral type and 44 hilar type). In non-neoplastic bile ducts, A, B, and H antigens were expressed in large bile ducts, while Lewisa,b,y and carbohydrate antigen 19-9 were variably expressed in both large and small bile ducts. Lewisx and carcinoembryonic antigen was not found in non-neoplastic bile ducts. In cholangiocarcinomas, A, B, and H, antigens were more frequent in the hilar type than in the peripheral type, although the difference was not significant. The expression of the blood-group related antigens, particularly A, Lewisa,b,y, carcinoembryonic antigen, and carbohydrate antigen 19-9, was frequent in the tumour cells in well differentiated adenocarcinomas, while their immunoreactivity was less frequent in poorly differentiated adenocarcinomas. The superanuclear and luminal expression of these antigens in carcinoma cells was frequent in well differentiated adenocarcinomas, and the diffuse, cell membranous and stromal expression of these antigens was relatively frequent in poorly differentiated adenocarcinomas and adenosquamous carcinoma. The A, B, and H immunoreactivity of both non-neoplastic bile ducts and cholangiocarcinomas was consistent with the host blood group type. These findings suggest that both the expression and intracellular distribution of blood group-related antigens in cholangiocarcinoma are related to the differentiation of cholangiocarcinoma and, possibly, to the parent structure.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesNAKANUMA, Y. ; HOSO, M. ; SASAKI, M. ; TERADA, T. ; KATAYANAGI, K. ; NONOMURA, A. ; KURUMAYA, H. ; HARADA, A. ; OBATA, H.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Non-cirrhotic, long-standing portal hypertension of unknown aetiology is being re-evaluated histopathologically and clinically. In this study, we examined 107 livers with this condition (92 wedge biopsy and 15 autopsy specimens) from five institutions in Japan. These cases were histologically categorized into four groups: idiopathic portal hypertension (66 cases), nodular regenerative hyperplasia (14 cases), partial nodular transformation (two cases), and incomplete septal cirrhosis (25 cases). These four groups shared several histological features: dense portal fibrosis with portal venous obliteration and intralobular slender fibrosis. In addition, the histopathological features characteristic of one group were also found to a mild degree in other groups. The histopathological lesions preceding portal venous obliteration remain speculative. However, the portal venous obliteration may be responsible for the occurrence of sustained portal hypertension and several of the pathological changes in these livers. It seems likely that idiopathic portal hypertension, nodular regenerative hyperplasia, partial nodular transformation and incomplete septal cirrhosis comprise a family of non-cirrhotic, long-standing portal hypertension in Japan, and the histological differences between them may reflect chronological progression of a single disease.Type of Medium: Electronic ResourceURL: