Search Results - (Author, Cooperation:T. Schoofs)
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1Latest Papers from Table of Contents or Articles in PressC. L. Lu ; D. K. Murakowski ; S. Bournazos ; T. Schoofs ; D. Sarkar ; A. Halper-Stromberg ; J. A. Horwitz ; L. Nogueira ; J. Golijanin ; A. Gazumyan ; J. V. Ravetch ; M. Caskey ; A. K. Chakraborty ; M. C. Nussenzweig
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. Schoofs ; F. Klein ; M. Braunschweig ; E. F. Kreider ; A. Feldmann ; L. Nogueira ; T. Oliveira ; J. C. Lorenzi ; E. H. Parrish ; G. H. Learn ; A. P. West, Jr. ; P. J. Bjorkman ; S. J. Schlesinger ; M. S. Seaman ; J. Czartoski ; M. J. McElrath ; N. Pfeifer ; B. H. Hahn ; M. Caskey ; M. C. Nussenzweig
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressCohen, Y. Z., Lorenzi, J. C. C., Seaman, M. S., Nogueira, L., Schoofs, T., Krassnig, L., Butler, A., Millard, K., Fitzsimons, T., Daniell, X., Dizon, J. P., Shimeliovich, I., Montefiori, D. C., Caskey, M., Nussenzweig, M. C.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-02-14Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
4Articles: DFG German National LicensesGötting, N. ; Fritz, H. ; Maier, M. ; von Stamm, J. ; Schoofs, T. ; Bayer, E.
Springer
Published 1999Staff ViewISSN: 1435-1536Keywords: Key words Nanoparticles ; Drug carrier ; Colloidal stability ; Oligonucleotides ; Zeta potentialSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Cationic polystyrene nanoparticles, as a model drug carrier system for nucleic acids, are capable of binding negatively charged oligonucleotides by multiple electrostatic interactions. The effect of the adsorption of phosphorothioate oligonucleotides on the physicochemical properties of the carrier system was investigated for uncoated and sterically stabilized latex particles. Turbidity measurements and photon-correlation spectroscopy indicate that the colloidal stability of the nanoparticle-oligonucleotide conjugates is influenced by the number of oligonucleotides adsorbed on the carrier. Especially in the case of the uncoated material, a destabilizing effect has been observed up to oligonucleotide concentrations of 2.7 μmol/g polymer. Strikingly, at higher concentrations the latexes exhibit colloidal stability similar to the oligonucleotide-free samples. These results were correlated to zeta-potential measurements demonstrating a reversal from positive to negative values of the zeta potential with increasing oligonucleotide concentration. The points of zero charge of the particles are in the region of maximum coagulation. These findings were compared to adsorption studies and calculations based on the random sequential adsorption model. It appears that at first the colloidal stability of the carrier systems is diminished with increasing oligonucleotide adsorption, while higher surface coverages lead to a significant reduction in coagulation. At the saturation level the surface coverage can be considered as a monolayer of “side-on” adsorbed molecules and the conjugates exhibit colloidal stability similar to the bare particles without adsorbed molecules.Type of Medium: Electronic ResourceURL: