Search Results - (Author, Cooperation:T. Schaller)
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1T. Schaller ; C. Goujon ; M. H. Malim
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-03-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptive Immunity ; Animals ; Autoimmune Diseases of the Nervous System/genetics ; DNA, Complementary/metabolism ; Genes, Viral ; HIV Infections/immunology/*virology ; HIV-1/*immunology/pathogenicity/*physiology ; HIV-2/pathogenicity ; Humans ; Immunity, Innate ; Monomeric GTP-Binding Proteins/chemistry/genetics/*metabolism ; Mutation ; Myeloid Cells/*virology ; Nervous System Malformations/genetics ; Nucleotides/metabolism ; Simian Immunodeficiency Virus/pathogenicity ; Viral Regulatory and Accessory Proteins/genetics/metabolism ; Virus ReplicationPublished by: -
2C. Goujon ; O. Moncorge ; H. Bauby ; T. Doyle ; C. C. Ward ; T. Schaller ; S. Hue ; W. S. Barclay ; R. Schulz ; M. H. Malim
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Line ; Cell Nucleus/genetics/virology ; Cells, Cultured ; HIV Infections/immunology/metabolism/*prevention & control/*virology ; HIV-1/classification/enzymology/genetics/*physiology ; Humans ; Interferons/*immunology ; Myxovirus Resistance Proteins/deficiency/genetics/*metabolism ; RNA, Viral/biosynthesis/genetics/metabolism ; Reverse Transcription/genetics ; Species Specificity ; Substrate Specificity ; Virus Integration ; Virus ReplicationPublished by: -
3Gedeon, P. C., Schaller, T. H., Chitneni, S. K., Choi, B. D., Kuan, C.-T., Suryadevara, C. M., Snyder, D. J., Schmittling, R. J., Szafranski, S. E., Cui, X., Healy, P. N., Herndon, J. E., McLendon, R. E., Keir, S. T., Archer, G. E., Reap, E. A., Sanchez-Perez, L., Bigner, D. D., Sampson, J. H.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-08-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Staff View
ISSN: 0022-2364Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1420-9055Keywords: Key words: Annually laminated lake sediments, eutrophication, phosphorus, nitrogen, oxygen, alkalinity, meromixis.Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract. This introduction to a series of high-resolution varve studies in Baldeggersee provides both an overview of the different subprojects as well as background information on relevant limnologial trends. The project was based on a new method of in-situ freezing of unconsolidated surficial sediments in deep lakes. With this freeze-core technique a detailed, high-resolution stratigraphy of the varved sediments at the deepest point of Baldeggersee has been established for the period of 1885-1993. Annual and seasonal sediment samples were analyzed. Concentrations of redox active metals in sediments were calibrated as proxy indicators for the reconstruction of hypolimnetic oxygen conditions. Particle size analysis and varve measurements were used to discriminate between the influence of nutrients and climate on sediment formation and accumulation. Baldeggersee is an ideal system for calibrating indicators of deep-water oxygen concentrations because it underwent dramatic changes in nutrient loading and redox conditions during this century. The hypolimnion has been seasonally anoxic for the last 100 years and phosphorus content decreased by a factor of five in the last 20 years. Meromixis was observed between 1960 and 1980. Since 1983 the deep water has been artificially oxygenated. This well documented change in deep-water oxygen concentration represents a unique whole-lake experiment that can be used to analyze the geochemical response of the sediments.Type of Medium: Electronic ResourceURL: -
6Fahrenberg, J. ; Schaller, T. ; Bacher, W. ; El-Kholi, A. ; Schomburg, W. K.
Springer
Published 1996Staff ViewISSN: 1432-1858Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyTechnologyNotes: Abstract Complex microstructures can be fabricated in large quantities by thermoplastic molding processes. The shape of the microstructures is determined mainly by the mold insert. Until now, multi-level mold inserts have been fabricated either by deep etch X-ray lithography and electroforming, Harmening et al. (1992), or by milling of a brass substrate, Schaller et al. (1995). In both cases there are limitations on structuring either by the fabrication effort or by the sizes of the smallest available milling heads. To avoid these limitations on structuring, a new process for manufacturing multi-level mold inserts has been developed at Forschungszentrum Karlsruhe. Milling, drilling, deep etch X-ray lithography and electroforming have been combined to manufacture a mold insert which is characterized by high aspect ratios with small lateral dimensions and various level heights. Samples with two levels and an aspect ratio of 15 have been manufactured. Much higher aspect ratios seem to be achievable. This paper covers the fabrication process, first tests, and experimental results of manufacturing a multi-level mold insert for molding three-dimensional components of a microvalve system.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1432-1858Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyTechnologyNotes: Abstract The advantage of thermoplastic molding as a convenient method for fabricating large quantities of microstructures is restricted by the possibilities and the necessary efforts for structuring the required molding tools. In order to increase the complexity of mold inserts without significantly increasing the fabrication expenditure a new process combining LIGA techniques and precision mechanics had been suggested by Research Center Karlsruhe. Recent work on the optimization of this process made it possible to manufacture multi-leveled mold inserts with which different three-dimensional microcomponents have successfully been molded. The two- and three-level structures feature among other details integrated alignment aids which worked very well during the assembly of the valve system the components were designed for. This paper deals with the process optimization, the manufacturing of the mold inserts, the fabrication of the three-dimensional microstructures by hot embossing in PMMA as well as in polymers with high thermal resistance and the application in a microvalve system.Type of Medium: Electronic ResourceURL: