Search Results - (Author, Cooperation:T. R. Insel)
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1Latest Papers from Table of Contents or Articles in PressT. R. Insel ; S. C. Landis ; F. S. Collins
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-05-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Brain/*physiology ; Brain Mapping ; Humans ; Magnetic Resonance Imaging ; *National Institutes of Health (U.S.) ; Neurosciences/*trends ; United StatesPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. R. Insel ; B. N. Cuthbert
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-05-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Brain/metabolism ; Brain Diseases/*complications ; Humans ; Mental Disorders/*diagnosis/*etiology ; National Institute of Mental Health (U.S.) ; Psychiatry/*trends ; United StatesPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-03-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Clinical Trials as Topic/methods/trends ; Cognitive Therapy ; Disease Models, Animal ; Drug Industry/statistics & numerical data ; Humans ; Impulsive Behavior/drug therapy ; *Mental Disorders/drug therapy/economics/genetics/prevention & control ; Molecular Targeted Therapy/trends ; Neurosciences/manpower/*trends ; Translational Medical Research/manpower/*trendsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-11-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biology/history ; Birds/anatomy & histology/*physiology ; History, 20th Century ; History, 21st Century ; Humans ; Models, Neurological ; Neurosciences/*history ; Psychiatry/history ; Speech/*physiology ; Vocalization, Animal/*physiologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressP. Y. Collins ; V. Patel ; S. S. Joestl ; D. March ; T. R. Insel ; A. S. Daar ; W. Anderson ; M. A. Dhansay ; A. Phillips ; S. Shurin ; M. Walport ; W. Ewart ; S. J. Savill ; I. A. Bordin ; E. J. Costello ; M. Durkin ; C. Fairburn ; R. I. Glass ; W. Hall ; Y. Huang ; S. E. Hyman ; K. Jamison ; S. Kaaya ; S. Kapur ; A. Kleinman ; A. Ogunniyi ; A. Otero-Ojeda ; M. M. Poo ; V. Ravindranath ; B. J. Sahakian ; S. Saxena ; P. A. Singer ; D. J. Stein
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Global Health ; Humans ; Mental Disorders/economics/epidemiology/prevention & control ; Mental Health/*statistics & numerical data ; Substance-Related Disorders/economics/epidemiology ; World Health OrganizationPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesFERRIS, C. F. ; FOOTE, K. B. ; MELTSER, H. M. ; PLENBY, M. G. ; SMITH, K. L. ; INSEL, T. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesFrancis, D. D. ; Young, L. J. ; Meaney, M. J. ; Insel, T. R.
Oxford, UK : Blackwell Science, Ltd
Published 2002Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Variations in maternal care have been associated with long-term changes in neurochemistry and behaviour in adult rats. Rats receiving high levels of licking and grooming as pups are less fearful and more maternal than rats receiving low levels of maternal licking and grooming. Central pathways for oxytocin and vasopressin have been implicated in the neurobiology of anxiety and social behaviours. We assessed whether variations in maternal care were associated with differences in oxytocin receptors (OTR) or vasopressin (V1a) receptors in the brains of adult offspring. In the central nucleus of the amygdala and bed nucleus of the stria terminalis, OTR binding was increased in adult females, but not adult males, that had received high levels of maternal licking and grooming as pups. Conversely, amygdala V1a receptor binding was increased in males, but not females, that had received high levels of maternal licking and grooming. These findings suggest that variations in maternal care may influence the expression of oxytocin and vasopressin receptors in a gender-specific manner.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesWang, Z. X. ; Liu, Y. ; Young, L. J. ; Insel, T. R.
Oxford, UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In previous studies, the closely related neuropeptide hormones oxytocin and vasopressin have been implicated in the central mediation of parental behaviour. Several studies in rats and sheep have demonstrated a role for oxytocin in the initiation of maternal behaviour. Recently, a few studies in a biparental species, the prairie vole (Microxytocinus ochrogaster) have suggested that vasopressin is important for paternal care. The present study investigated this latter possibility by measuring changes in vasopressin and oxytocin hypothalamic gene expression 1 day and 6 days following parturition in prairie voles which show paternal care and in montane voles (M. montanus) which lack paternal care. In prairie voles, vasopressin gene expression increased in both males and females postpartum, relative to sexually naive controls. In the non-paternal montane vole, no change in vasopressin gene expression was observed in either sex. In contrast to this species difference in vasopressin gene expression, hypothalamic oxytocin gene expression increased in both prairie and montane vole females, but not in males of either species. To augment measures of gene expression, we assessed vasopressin (V1a) and oxytocin receptor binding in both species. Although forebrain vasopressin V1a receptor binding was not altered following parturition in either species, oxytocin receptor binding increased in the ventromedial nucleus of the hypothalamus in females, but not males, in both prairie and montane voles. In summary, vasopressin gene expression increases in both males and females postpartum in a biparental species and oxytocin gene expression and receptor binding increase selectively in females. These results are consistent with earlier reports of a role for vasopressin in paternal care and for oxytocin in maternal behaviour.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Neuroendocrine systems play a key role not only in the maintenance of whole-body homeostasis but also as the link between behavioural, endocrine and autonomic responses to environmental stimuli. It is becoming increasingly clear that neuroendocrine regulatory mechanisms are under the control of a combination of factors including genetic background, environment and early-life programming. Patterns of gene expression are increasingly being used to provide information on the genotypes associated with particular behaviours, and modulation of specific parts of the genome allow investigation of the contribution of particular genes. The sequencing of the genome provides a unique opportunity to elucidate the genetic contribution to neuroendocrine and behavioural processes, and to investigate the interactions between genetic and environmental factors. Although drugs can be used to activate or inhibit neurotransmitters and receptors, they lack specificity. New technologies now permit the activation or inactivation of both neurotransmitters and receptors in specific areas of the brain for defined periods, including crucially important developmental windows when activation appears to have long-term consequences. The future challenges are to define the critical mechanisms through which the genetic constitution of an individual human or experimental animal interacts with environmental cues to result in altered physiological or even pathological behaviour and endocrine function.Type of Medium: Electronic ResourceURL: