Search Results - (Author, Cooperation:T. Nomura)

2018-09-15

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

2018-05-09

American Physical Society (APS)

1098-0121

1095-3795

Physics

Magnetism

2018-01-26

Wiley-Blackwell

0007-0963

1365-2133

Medicine

2018-09-22

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2014-10-18

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Arthritis, Rheumatoid/genetics/*immunology ; Autoantigens/*immunology ; Autoimmunity/*immunology ; DNA-Binding Proteins/genetics ; Gene Expression Regulation ; Genes, T-Cell Receptor beta ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Mutant Strains ; Receptors, Antigen, T-Cell/*immunology ; Ribosomal Proteins/genetics/*immunology ; T-Lymphocytes/*immunology

2018-04-26

The Company of Biologists

0950-1991

1477-9129

Biology

Neural development

2018-02-17

American Physical Society (APS)

0556-2813

1089-490X

Physics

Nuclear Structure

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A small size electron cyclotron resonance ion source to be operating in a pulsed mode has been designed. The main static magnetic field for the confinement is formed by permanent magnets. In addition to these magnets, two small coils are introduced for controlling the magnetic field with a repetition rate synchronized with the pulsed operation of microwave power feeding. One is installed in the middle of the plasma chamber, the other is near the anode electrode. © 2000 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

Beam extraction tests were carried out using a new compact Ku-band electron cyclotron resonance (ECR) ion source. In the case of a single rf frequency operation, a B2 zone can contribute for increase of single and low charged state ion beams when the gas flow rate is relatively higher than that for the basic ECR mode. The scheme seems, however, not so effective for the production of multicharged state ion beams. A double frequency heating (12 and 14 GHz) is, on the other hand, effective for increase of extracted ion current when the rf power is injected into the chamber from both the axial and the radial ports, as succeeded at the LBL experiment. © 2000 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

For the construction of an electron cyclotron resonance (ECR) charge breeder at the KEK-JAERI radioactive nuclear beam facility, we have made and tested a pilot charge breeding system consisting of two compact-sized ECR ion sources. Using a simulation code, we have investigated the geometrical beam acceptance of the present system for the external injection of ions of interest into ECR plasma. Following discussions on the ECR plasma influenced by a deceleration potential for the external injection, the charge breeding efficiency for Ar ions is presented and discussed. © 2002 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A single stage 6.4 GHz ECR ion source for an isotope separator on-line based radioactive nuclear beam facility at KEK-Tanashi, is under an on-line test for the effective production of 19Ne2+ ions by using alpha beams from a cyclotron. Synchronized with the pulsed operation of heavy ion linacs, the millisecond beam bunching is now being performed to reduce the loss of radioactive ions in acceleration by using a pulsed-gating potential method. The highest beam intensity at 100 Hz and 20% duty factor reaches 60% of that obtained in a continuous-wave mode. © 1998 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

For an isotope separator on-line based radioactive nuclear beam facility at KEK-Tanashi, two different types of ion sources are currently employed: a single stage 6.4 GHz electron cyclotron resonance ion source for 18Ne2+ and 19Ne2+ ions and a surface ionization-type ion source for 8Li1+ ions. The production target for Ne radioisotopes is LiF powder. Enclosed in a water-cooled Cu target cell, the target can sustain proton beam power of 120 W for a long term. The methods to suppress unwanted isotopes, like 19F in 19Ne and 18O in 18Ne, are discussed. For the production of 8Li1+ with the surface ionization-type ion source, a recoil-catcher method is adopted. The feasibility is discussed, comparing to a thick target method. © 2000 American Institute of Physics.

Electronic Resource

1439-0523

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Effectivness of the hybrid-weakness caused by a complementary interaction of two dominant genes Hwc1 and Hwc2 to suppress the spread of the red-grain gene into ordinary white-grained rice cultivars was investigated using the Monte Carlo computer simulation method. It was shown that the weakness genes, as far as being capable of reducing the fitness of the carrier by 80 percent or more, work quite effectively to suppress the genetic contamination of white-grained cultivars due to inflow of pollen from red-grained cultivars due to inflow of pollen from red-grain gene once the gene has been incorporated in to the population in the form of red-grained progeny produced as a result of the imperfect lethality of the initial hybrid between red-and white-grained cultivars. The weakness genes have little or no effect cultivars. The weakness genes have little or no effect either, when the contamination is initiated by an inflow of seeds or seedlings from ed-grained cultivars in these situations, removal (selection)of red grained plants Is the only countermeasure to exterminate the red-grain gene. The removal of red grained plants need not be intensive if carried out continuously. The spread of the red-grain gene after initial contamination is suppressed if the red-grain gene and weakness genes are linked. The suppressing effect of the linkage, however, is not substantial when the outcrossing rate is around or smaller than 0.01 as can be assumed in most rice cultivars.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

We have simulated the trajectories of ions injected into an ECR plasma, by taking into account explicitly the cumulative small angle scattering of charged ions as well as the confinement magnetic field of the ECR source. Assuming homogeneous and uniform plasma in a given volume, the stopping efficiency, defined as a probability that the injected ions are alive in the plasma volume until their initial directional motions become at random, has been extracted and discussed. © 2002 American Institute of Physics.

Electronic Resource

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A 48-year-old Japanese woman with angiolymphoid hyperplasia with eosinophilia (ALHE) was successfully treated with a flashlamp pulsed dye laser (585 nm, 450 µs pulse duration). The lesion was severely pruritic and had been enlarging slowly for 2 years but was resistant to conventional therapies, including topical, intralesional, and systemic corticosteroid, and cryotherapy. The severe pruritus immediately improved after the first treatment using the pulsed dye laser. The erythema and papules gradually improved without scarring and this was followed by further five treatments over approximately a 4-month interval. No clinical recurrences have been observed 1 year after completion of the treatment. We think that pulsed dye laser therapy is an effective treatment for ALHE in both Japanese as well as Caucasian patients. Pulsed dye laser therapy is also helpful in reducing the pruritus in ALHE patients.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Formaldehyde is associated with sick building syndrome (SBS), a set of diffuse and irritative symptoms predominantly involving the eyes and the respiratory tract. However, its pathophysiological mechanism in SBS has not yet been clarified.Objective In this study we investigated the effect of formaldehyde on the expression of adhesion molecules on human mucosal microvascular endothelial cells (HMMECs). Furthermore, we investigated the effect of formaldehyde on adhesiveness of HMMECs to eosinophils.Materials and methods HMMECs were incubated with various concentrations of formaldehyde (1 ng/mL−1 µg/mL) for 24 h, and the expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) on HMMECs were evaluated by flow cytometry. The change in the expression of ICAM-1 and VCAM-1 mRNA was then evaluated by reverse transcriptase polymerase chain reaction. To understand the role of formaldehyde in eosinophilic inflammation of the nasal mucosa, we examined the effects of formaldehyde on the adhesiveness between HMMECs and eosinophils by eosinophil adhesion assay.Results Formaldehyde increased the surface expressions of ICAM-1 and VCAM-1 on HMMECs. Formaldehyde also induced ICAM-1 and VCAM-1 mRNA. In addition, the adhesiveness between HMMECs and eosinophils was also increased by formaldehyde.Conclusion These in vitro studies suggest that formaldehyde may play a role as the irritant of the nasal mucosa by increasing the expressions of adhesion molecules on HMMECs and by enhancing the adhesiveness between HMMECs and eosinophils.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Although interleukin (IL)-4 and IL-5 have been demonstrated to play a critical role in the pathophysiology of allergic diseases such as allergic rhinitis, the mechanism that causes the predominance of Th2 lymphocytes has yet to be clarified. Thymus and activation-regulated chemokine (TARC) has been known to facilitate the recruitment, activation and development of Th2 polarized cells, leading investigators to suggest a role for TARC in the development of Th2 responses.Objective To gain a better understanding of the role of TARC in the pathogenesis of allergic rhinitis we investigated the cellular sources of this chemokine in nasal mucosa. In addition, the effect of cytokines on TARC production has been investigated.Methods The expression of TARC in human nasal mucosa was assessed by immunohistochemistry. To study the effect of cytokines on TARC production, epithelial cells, endothelial cells and fibroblasts, isolated from inferior nasal mucosa samples, were stimulated by a variety of cytokines including IL-4, IL-13, tumour necrosis factor (TNF)-α and interferon (IFN)-γ.Results Epithelial cells in nasal mucosa in subjects with allergic rhinitis expressed higher signal level than those in non-allergy patients. Combined stimulation with IL-4 and TNF-α, as well as IL-13 and TNF-α, synergistically induced TARC expression in epithelial cells. Furthermore, the amount of TARC induced by these cytokines was higher in epithelial cells obtained from patients with allergic rhinitis than in those from non-allergic patients.Conclusion These results demonstrate a crucial role of nasal epithelial cells in the expression of TARC, and that Th2 cytokine IL-4 and IL-13 may promote Th2 responses by inducing TARC production from epithelial cells.

Electronic Resource

0003-2670

Adsorption ; Metal ions ; Piezoelectric sensors

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

1440-1797

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1440-1797

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource