Search Results - (Author, Cooperation:T. Miyamoto)

2018-05-30

The American Society for Microbiology (ASM)

0022-538X

1098-5514

Medicine

2018-03-07

National Academy of Sciences

0027-8424

1091-6490

Biology

Medicine

Natural Sciences in General

2015-09-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Androgen Antagonists/pharmacology/*therapeutic use ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/*genetics ; Humans ; Male ; Mice ; Neoplastic Cells, Circulating/drug effects/*metabolism ; Phenylthiohydantoin/*analogs & derivatives/pharmacology/therapeutic use ; Prostate/drug effects/metabolism/pathology ; Prostatic Neoplasms/*drug therapy/*pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA Splicing ; Receptors, Androgen/*genetics ; Sequence Analysis, RNA/methods ; Signal Transduction ; Single-Cell Analysis/methods ; Transcriptome ; Wnt Proteins/genetics/*metabolism ; Xenograft Model Antitumor Assays

2018-11-29

American Physical Society (APS)

0556-2821

1089-4918

Physics

Strong Interactions

2018-09-27

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2014-04-11

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Action Potentials ; Animals ; Electric Conductivity ; Female ; In Vitro Techniques ; Ion Channels/deficiency/genetics/*metabolism ; Male ; *Mechanotransduction, Cellular/genetics ; Merkel Cells/*metabolism ; Mice ; Mice, Knockout ; Neurites/metabolism ; Neurons, Afferent/metabolism ; Skin/cytology/innervation ; Touch/genetics/*physiology

2015-03-18

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Actomyosin/metabolism ; Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Body Size/*genetics ; Embryo, Nonmammalian/anatomy & histology/embryology/metabolism ; Fish Proteins/genetics/*metabolism ; GTPase-Activating Proteins/metabolism ; Genes, Essential/genetics ; Gravitation ; Humans ; Morphogenesis/*genetics ; Mutation/genetics ; Organ Size/genetics ; Oryzias/*anatomy & histology/*embryology/genetics ; Phenotype ; Protein-Serine-Threonine Kinases/genetics/metabolism ; Signal Transduction ; Spheroids, Cellular/cytology/metabolism

2018-04-19

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2018-06-08

Institute of Physics (IOP)

1367-2630

Physics

2018-12-01

American Association for the Advancement of Science (AAAS)

2375-2548

Natural Sciences in General

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A self-crowbar switch for a gas-puff z-pinch, driven by a pulsed power generator with output voltage 600 kV, pulse width 70 ns, and characteristic impedance of 3 Ω, has been built and tested successfully. Discharges with pulsed gas injection are placed into four groups dependent on the delay between the pulsed power generator trigger time and the gas-puff trigger time. For short delay times (〈2.8 ms), vacuum discharge occurs. For moderate delay times (2.8–3.8 ms), a z-pinch plasma is produced without using the self-crowbar switch, and the plasma exists for a much longer time than the voltage pulse, that is, 700 ns compared to 70 ns. For relatively longer delay times (3.8–6 ms), the self-crowbar switch operates, and the decay time of the current becomes approximately 2.5 μs. Moreover, a z-pinch occurs after self-crowbarring. For long delay times (〉6 ms), a z-pinch does not occur. The self-crowbar switch is believed to operate by photoionization of puffed gas which has reached the switch region.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1089-7550

AIP Digital Archive

Physics

The low temperature growth of highly strained GaInNAs/GaAs quantum wells was investigated by low-pressure metalorganic chemical vapor deposition (MOCVD) using tertiarybutylarsine (TBAs) and dimethylhydrazine. We found that the incorporation behavior of indium in the strained GaInAs layers at low growth temperature was very different from that at high growth temperature. The N content dropped rapidly with increasing In content in the strained GaInNAs layer. It is pointed out that the V/III ratio is an important growth parameter for TBAs based MOCVD. The V/III ratio strongly affected both the photoluminescence intensity and the alloy composition of the GaInNAs. © 1998 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

The capture process of carriers in the pulse-filling measurements is analyzed by including the slow capture on the edge of a depletion layer. An analytical expression is derived to determine the capture cross section of majority carriers from the initial slope of the semilogarithmic plot of capacitance versus capture time in the case of low trap concentration. A method is proposed to determine the fast capture rate in the bulk region from a slow capture process in the edge region when the trap concentration is not negligible compared with the concentration of the shallow dopant. The edge effect is intentionally enhanced to observe the capacitance variation with the capture time. Pulse-filling measurements on Au-doped Si p+n and undoped liquid-encapsulated Czochralski n-GaAs Schottky diodes are made to verify the method.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Nitrogen-containing carbon films where deposited by reactive ion plating under a pure nitrogen ambient. Knoop hardness, microindentation hardness, and microscratch hardness of these films were evaluated. Indentation hardness, such as Knoop hardness and microindentation hardness, is influenced by surface roughness and substrate hardness, so the effect of nitrogen inclusion on the hardness cannot be clearly evaluated. In contrast, an atomic force microscope can clearly evaluate the effect of nitrogen inclusion on scratched wear depth. © 1994 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

We investigate the effect of the sequence of gas flows at heterointerfaces on optical quality of GaInNAs/GaAs quantum wells grown by metalorganic chemical vapor deposition (MOCVD). We point out that the degradation mechanism of photoluminescence of GaInNAs grown by MOCVD method is categorized in two types. One is the formation of a GaNAs layer at the heterointerface which causes both increase of emission wavelength and degradation of crystal quality. The other is generation of nonradiative centers induced by incorporation of nitrogen (N). The insertion of a GaInAs layer to the GaInNAs/GaAs heterointerface is proposed to overcome these degradation mechanisms. A GaInAs intermediate layer is effective to suppress the GaNAs formation and to reduce the total GaInNAs thickness. © 2002 American Institute of Physics.

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

To evaluate the contribution of human lung mast cells (HLMC) to allergic inflammation, we investigated whether or not cytokines, including stem-cell factor (SCF), monocyte chemotactic and activating factor (MCAF), and RANTES, activate HLMC. SCF induced histamine release from dispersed HLMC in a dose-dependent fashion (P〈0.01). The release was 7.8 ± 1.0% at 500 ng/ml SCF (n= 9). This response was also observed in chopped lung tissue. HLMC from which surface IgE molecules had been removed by treatment with lactic acid responded to SCF, while these cells lost their response to anti-IgE. The process was relatively rapid and reached a maximum in 5 min. This response required extracellular calcium, and it was observed at 37°C, but not at 4°C or 20°. A brief preincubation (10 min) with lower concentrations of SCF, which were ineffective in releasing histamine, enhanced anti-IgE-induced histamine release (P〈0.05), while its enhancing effect was lost by the longer preincubation (30 min). SCF did not prime basophils to enhance stimulated-histamine release. Interleukin (IL)-1α, IL-1β, IL-3, IL-4, IL-5, granulocyte/macrophage-colony stimulating factor (GM-CSF), MCAF, and RANTES neither induced histamine release nor enhanced the release stimulated by anti-IgE after a 10- or 30-min preincubation. The combination of IL-3 and IL-4 showed no effect on histamine release from HLMC. Leukotriene (LT)C4/D4/E4 production by SCF was negligible, as compared with anti-IgE-induced LT production. SCF at 1.5 ng/ml augmented anti-IgE-induced LT generation significantly (536+ 117 pg/105 mast cells and 1569 ± 258 pg/105 mast cells; P〈0.01). These results provide further evidence that numerous aspects of the phenotype of mast cells and basophils are heterogeneous, including structure, relevant secretagogues, and pharmacologic control.

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Miyamoto T. Epidemiology of pollution-induced airway disease in Japan.Air pollution has been implicated as one of the factors responsible for the increased incidence of allergic diseases seen over recent years. Epidemiological studies in Japan demonstrate that atopic subjects living in urban areas are more likely to suffer from the effects of air pollution, with increased coughing, sputum production, wheezing and throat irritation. Furthermore, animal studies show that high concentrations of pollutant gases can promote airway sensitization. The incidence of allergic rhinitis and asthma have been shown to be greater in areas where there is heavy traffic and hence high levels of automobile exhaust emissions. Intranasal administration of diesel exhaust particles in mice produces a stimulatory effect on immunoglobulin E production, and a similar finding has also been shown with suspended particulate matter in air. Air pollutants, such as ozone and nitrogen dioxide (NO2), have been shown to stimulate the production of granulocyte-macrophage colony stimulating factor, which may play a vital role in airway hyperreactivity and asthma. In comparative studies of asthma in urban and rural areas, history of airway infection and a younger age of onset were found to be sifificantly greater in urban areas. When the asthmatic patients were divided into two groups according to environmental NO2 levels (group I: NO2 〉30 ppb; group II: NO2 〈30 ppb), no signficant difference regarding the various parameters was noted between the two groups, except for a greater severity of asthma in adults in group I, and a greater severity in children in group 11. These studies imply that air pollution may be one reason for the increase in allergic diseases in Japan, but a definitive conclusion cannot be drawn, and further investigation is warranted.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A case of an anaphylactic shock following topical application of chlorhexidine preparation is reported. Specific skin-sensitizing antibodies against chlorhexidine were demonstrated in the serum from the patient by a passive transfer test. IgE antibodies against chlorhexidine were also detected by radioallergosorbent technique (RAST). Paper discs conjugated with chlorhexidine-HSA (human serum albumin) significantly bound the IgE antibodies. Furthermore, all of the sera from seven other patients with shock reactions following the topical application of chlorhexidine preparation also showed high RAST counts. Both chlorhexidine gluconate and chlorguanide which represents approximately half a molecule of chlorhexidine inhibited the reaction in a dose-dependent fashion. It is suggested that the shock reactions following topical application of chlorhexidine are mediated by IgE antibodies against chlorhexidine and that chlorhexidine and chlorguanide share the same antigenic determinant.

Electronic Resource