Search Results - (Author, Cooperation:T. Miyagaki)

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  1. 1
    Staff View
    Publication Date:
    2012-10-16
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antigens, CD19/genetics/metabolism ; Antigens, CD40/immunology/metabolism ; Antigens, CD5/metabolism ; Autoimmunity/*immunology ; B-Lymphocytes, Regulatory/cytology/*immunology/metabolism/secretion ; Cell Division ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/immunology/pathology ; Female ; Histocompatibility Antigens Class II/immunology ; Humans ; Interleukin-10/biosynthesis/immunology/secretion ; Interleukins/*immunology ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/immunology/pathology ; Receptors, Interleukin-21/immunology/metabolism ; T-Lymphocytes/*immunology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-11-02
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Immunobiology and Immunotherapy, Lymphoid Neoplasia
    Published by:
    http://www.hematology.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1432-0851
    Keywords:
    Monoclonal antibody ; Drug modifier ; Cancer chemotherapy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract An anticancer antibiotic, neocarzinostatin (NCS), was covalently conjugated to the murine monoclonal antibody A7 (mAb A7), which recognizes the glycoprotein on the cell surface of human colon cancer. The biological and pharmacological properties of the conjugate (A7-NCS) were examined and compared with those of unconjugated NCS. A7-NCS exhibited a strong binding and cytotoxicity to the cell and an antigen-specific tumor accumulation. Significant tumoricidal effects in vivo were observed in the antigen-positive tumor-bearing mice treated with A7-NCS, whereas NCS mixed with mAb A7 and NCS alone were relatively ineffective. In the antigennegative tumor, the tumoricidal effect of A7-NCS was lower than in the antigen-positive tumor. The NCS concentration in blood and tumor were significantly elevated by conjugation to mAb A7. The NCS localization in tumor was higher in the antigen-positive tumor than in the antigen-negative tumor. Death due to acute toxicity was observed at a dose of 20 units (U) NCS in mice treated with unconjugated NCS, whereas toxicity was seen with a much higher dose of NCS (100 U) if the drug was conjugated to the mAb. These findings show that mAb A7 confers more favorable pharmacological properties on an anticancer drug, making it potentially more useful for cancer chemotherapy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01741089

    Articles: DFG German National Licenses