Search Results - (Author, Cooperation:T. M. Miller)

2016-03-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Aging/immunology ; Amyotrophic Lateral Sclerosis/genetics/*immunology ; Animals ; Frontotemporal Dementia/genetics/*immunology ; Gene Knockdown Techniques ; Guanine Nucleotide Exchange Factors/genetics/*physiology ; Heterozygote ; Humans ; Lymphatic Diseases/genetics/immunology ; Macrophages/*immunology ; Mice ; Mice, Knockout ; Microglia/*immunology ; Myeloid Cells/*immunology ; Proteins/genetics/*physiology ; Rats ; Splenomegaly/genetics/immunology

2011-09-29

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/analogs & derivatives/chemistry/metabolism ; DEAD-box RNA Helicases/*chemistry/immunology/*metabolism ; Enzyme Activation ; Fluorometry ; Humans ; Immunity, Innate/*immunology ; Models, Molecular ; Nucleic Acid Conformation ; Pliability ; Protein Binding ; Protein Structure, Tertiary ; Proteolysis ; RNA, Double-Stranded/chemistry/*metabolism ; RNA-Binding Proteins/chemistry/immunology/metabolism ; Scattering, Small Angle ; Structure-Activity Relationship ; Substrate Specificity ; Trypsin/metabolism ; X-Ray Diffraction

2014-02-21

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Crystallography, X-Ray ; Disulfides/chemistry ; Hepacivirus/*chemistry/physiology ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Immunoglobulin Fab Fragments/chemistry/metabolism ; Immunoglobulin G/chemistry ; Models, Molecular ; Protein Folding ; Protein Structure, Tertiary ; Scattering, Small Angle ; Surface Properties ; Viral Envelope Proteins/*chemistry/metabolism ; Viral Fusion Proteins ; Viral Hepatitis Vaccines ; Virus Internalization

1089-7550

AIP Digital Archive

Physics

Thin polycrystalline films of perylenetetracarboxylic dianyhydride (PTCDA), an organic molecular solid, exhibits substantial anisotropies in its electronic transport properties. Only electrons transport in the directions along molecular planes, while mainly holes transport in the direction normal to molecular planes. A series of measurements on both field effect transistors with PTCDA active layers and light emitting diodes with PTCDA transport layers documents the anisotropy seen in the electronic transport in thin films of PTCDA. © 1997 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

The important changes produced on the electroluminescence characteristics of organic materials due to planar microcavity effects are examined in detail. The photon density of states is redistributed such that only certain wavelengths, which correspond to allowed cavity modes, are emitted in a given direction. This enables us to realize color selectivity over a large wavelength (and color coordinate) range with broadband emitters such as 8-hydroxyquinoline aluminum (Alq), and intensity enhancement in narrow band emitters. The intensity enhancement in Alq-based cavity light emitting diodes (LEDs) is extensively evaluated both experimentally and theoretically. The design considerations for and device characteristics of a novel multiple emissive layer LED are also described. © 1996 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Microcavity structures containing hydroxyquinoline aluminum and diamine layers commonly used in electroluminescent devices are described. We show that it is possible to obtain emission at red, green, and blue wavelengths by changing the thickness of a polyimide filler layer in the cavity. The angular dependence of the emission wavelength and linewidth are reported and the implications for organic electroluminescent color displays are discussed.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

The range of possibilities in controlling the color of an organic semiconductor based light emitter diode (LED) by incorporating the active layers in a multimode Fabry–Pérot cavity is demonstrated. The combination of carefully designed multimode microcavities and electroluminescent organic semiconductors makes possible the realization of mixed colors such as white, purple, etc. with a single LED. The parameters affecting the color include the total optical thickness of the device and the position of the electromagnetic-field antinodes with respect to the location of the emitting dipoles. The electrical characteristics and quantum efficiency of such devices are also reported. © 1994 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Thin film organic electroluminescent devices are described which employ a blue-emitting species as a layer sandwiched between the hole transporter bis(triphenyl)diamine and the light emitting electron transporter tris(8-hydroxyquinoline)aluminum to obtain bright ((approximately-greater-than)4700 cd/ m2) efficient (0.5 lm/W) white emission. © 1996 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

We have studied the dependence of the electro-optical properties of polymer dispersed liquid crystals (PDLC) on the ultraviolet (UV) cure of the solution of monomer and liquid crystal. The kinetics of UV polymerization and its effect on the morphology of the phase separated droplets of liquid crystal determine the switching voltage, response time, and luminance of the PDLC. Using a series of statistically designed experiments, we have mapped the dependence of these responses on the weight fraction of liquid crystal, the temperature of the cell during cure, and light intensity. Temperature and composition are strongly coupled parameters that influence switching voltage, luminance, and response times. Switching voltages are minimized at 4–5 V for an 8 μm cell gap over a large region of temperature-composition space. An abrupt transition line occurs through that space. On one side of the transition line, voltage increases linearly either as temperature increases or composition decreases, and on the other side of the line, voltage is constant. Analyses of decay times, the slower response time of the PDLC, show that the times peak along a line of points in temperature-composition space that is close to the transition line for increasing switching voltages. We present these results as contours on the same graphs and relate them to our understanding of the phase separation process in the PDLC mixture. © 1997 American Institute of Physics.

Electronic Resource

1573-7330

in vitro fertilization ; oocyte maturity ; cumuluscoronal morphology

Springer Online Journal Archives 1860-2000

Medicine

Results The three participating embryologists had directly evaluated 1304, 75, and 0 oocytes for nuclear maturity and CCM at study initiation and correctly predicted nuclear maturity from CCM in 74, 64, and 47% of oocytes, respectively. Embryologist 1 did not significantly change in predictive ability during the 17-month study period. Embryologist 2 significantly improved in predictive ability during the first 9 months of the study (841 oocytes evaluated) and plateaued thereafter, at a similar percentage of correct predictions as embryologist 1. Embryologist 3 continued to improve in predictive ability throughout the study period, reaching 61% correct predictions at the close of the study after evaluating 223 oocytes. Once embryologists had plateaued in their predictive ability, 72% of oocytes evaluated received the correct nuclear maturity classification based on CCM. Significantly fewer oocytes (54%; 375/690) evaluated by embryologists who had not plateaued in their predictive ability received the correct nuclear maturity classification based on CCM.

Conclusions These results indicate that embryologists' ability to predict oocyte nuclear maturity correctly from CCM continues to change over several months even when pretraining video recordings are used before beginning direct evaluations. After embryologists plateaued in their predictive ability, nuclear maturity still could not be correctly predicted from CCM in 28% of oocytes due to asynchrony between nuclear and CCM maturity. Based upon this, circumstances in which the spreading technique should be used for direct assessment of nuclear maturity as opposed to assessment of CCM only are discussed.

Purpose A majority of in vitro fertilization (IVF) programs continues to evaluate oocyte maturity on the basis of cumulus-coronal morphology (CCM) even though marked asynchrony has been reported between CCM and nuclear maturity. This study was designed to examine changes in embryologists' ability to correctly predict nuclear maturity from CCM as a function of increasing experience. Nuclear maturity was assessed by inverted microscopy with a modified spreading technique at follicular aspiration. A second objective was to determine the percentage of oocytes which displayed asynchrony between CCM and nuclear maturity as assessed by embryologists with extensive experience in oocyte maturity evaluation.

Electronic Resource