Search Results - (Author, Cooperation:T. M. Hyde)
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1Latest Papers from Table of Contents or Articles in PressC. Colantuoni ; B. K. Lipska ; T. Ye ; T. M. Hyde ; R. Tao ; J. T. Leek ; E. A. Colantuoni ; A. G. Elkahloun ; M. M. Herman ; D. R. Weinberger ; J. E. Kleinman
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/*genetics ; Autopsy ; Continental Population Groups/genetics ; Fetus/metabolism ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/*genetics ; Genome, Human/genetics ; Humans ; Polymorphism, Single Nucleotide/genetics ; Prefrontal Cortex/embryology/*growth & development/*metabolism ; Time Factors ; Transcriptome/*geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressH. J. Kang ; Y. I. Kawasawa ; F. Cheng ; Y. Zhu ; X. Xu ; M. Li ; A. M. Sousa ; M. Pletikos ; K. A. Meyer ; G. Sedmak ; T. Guennel ; Y. Shin ; M. B. Johnson ; Z. Krsnik ; S. Mayer ; S. Fertuzinhos ; S. Umlauf ; S. N. Lisgo ; A. Vortmeyer ; D. R. Weinberger ; S. Mane ; T. M. Hyde ; A. Huttner ; M. Reimers ; J. E. Kleinman ; N. Sestan
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/*genetics ; Brain/embryology/*growth & development/*metabolism ; Child ; Child, Preschool ; Exons/genetics ; Female ; Fetus/metabolism ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/*genetics ; Gene Regulatory Networks/genetics ; Humans ; Infant ; Male ; Middle Aged ; Quality Control ; Quantitative Trait Loci/genetics ; Sex Characteristics ; Time Factors ; Transcriptome/*genetics ; Young AdultPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Neuroscience, Online OnlyPublished by: -
4Articles: DFG German National LicensesHyde, T. M. ; Weinberger, D. R. ; Kleinman, J. E. ; Egan, M. F. ; Wing, L. L. ; Wyatt, R. J.
Springer
Published 1995Staff ViewISSN: 1432-2072Keywords: Catalepsy ; Vacuous chewing movements ; Parkinsonism ; Tardive dyskinesia ; HaloperidolSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (VCMs). VCMs were measured every 3 weeks for 33 weeks while rats received injections of haloperidol decanoate. Catalepsy was measured after the second through the seventh injections of the depot neuroleptic. There were no correlations between the severity of catalepsy scores after the second or third injections of haloperidol and the severity of the overall VCM syndrome. However, the severity of the catalepsy score following the third through seventh injections of haloperidol strongly correlated with the concurrent number of VCMs. Persistent high catalepsy scores across the six catalepsy rating sessions were strongly associated with the development of persistent severe VCMs. These findings suggest that, to the extent that persistent parkinsonian signs in humans are associated with a propensity towards the development of TD, the VCM syndrome in rats is at least a partially faithful animal model of this relationship.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesWolf, S. S. ; Hyde, T. M. ; Saunders, R. C. ; Herman, M. M. ; Weinberger, D. R. ; Kleinman, J. E.
Springer
Published 1995Staff ViewISSN: 1435-1463Keywords: Autoradiography ; neurotensin ; schizophreniaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Neurotensin, an endogenous peptide and putative neurotransmitter, exhibits a wide range of interactions with dopaminergic neurons and displays some actions akin to neuroleptics. Moreover, neurotensin receptors are abundant in specific layers of the entorhinal cortex where cytoarchitectural abnormalites have been reported in schizophrenia. We therefore examined the entorhinal cortex from postmortem specimens of five control patients and six schizophrenic patients for alterations in neurotensin receptor quantitation and distribution using receptor autoradiography. Specific125I-neurotensin binding was concentrated in layer II cell clusters, with a 40% reduction in binding in the schizophrenic group (p〈0.05). Moderate binding was observed in both cohorts in deep layers V/VI, with negligible binding in the hippocampus. There was no statistical difference in quantitative neurotensin binding in other lamina of the entorhinal cortex of schizophrenics compared with controls. The characteristic laminar pattern of binding did not differ between cohorts. The reduction in neurotensin binding in schizophrenics is consistent with an increasing number of reports of structural abnormalities in the medial temporal lobe of schizophrenics in general and the entorhinal cortex in particular. Further studies are required to examine the evidence for neuroanatomic and neurochemical pathology in the entorhinal cortex.Type of Medium: Electronic ResourceURL: