Search Results - (Author, Cooperation:T. M. Allen)
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1Latest Papers from Table of Contents or Articles in PressJ. M. Carlson ; M. Schaefer ; D. C. Monaco ; R. Batorsky ; D. T. Claiborne ; J. Prince ; M. J. Deymier ; Z. S. Ende ; N. R. Klatt ; C. E. DeZiel ; T. H. Lin ; J. Peng ; A. M. Seese ; R. Shapiro ; J. Frater ; T. Ndung'u ; J. Tang ; P. Goepfert ; J. Gilmour ; M. A. Price ; W. Kilembe ; D. Heckerman ; P. J. Goulder ; T. M. Allen ; S. Allen ; E. Hunter
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Consensus Sequence ; DNA Mutational Analysis ; Disease Transmission, Infectious/statistics & numerical data ; Female ; HIV Infections/*transmission ; HIV-1/*genetics ; *Heterosexuality ; High-Throughput Nucleotide Sequencing ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Male ; Models, Statistical ; Molecular Sequence Data ; Point Mutation ; Risk Factors ; *Selection, Genetic ; Viral LoadPublished by: -
2Latest Papers from Table of Contents or Articles in PressG. Alter ; D. Heckerman ; A. Schneidewind ; L. Fadda ; C. M. Kadie ; J. M. Carlson ; C. Oniangue-Ndza ; M. Martin ; B. Li ; S. I. Khakoo ; M. Carrington ; T. M. Allen ; M. Altfeld
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Physiological/genetics/*immunology ; Antibodies, Neutralizing/immunology ; CD4-Positive T-Lymphocytes/immunology/virology ; Decision Trees ; *Evolution, Molecular ; Genotype ; HIV Infections/*immunology/*virology ; HIV-1/genetics/*immunology/physiology ; Host-Pathogen Interactions/immunology ; Human Immunodeficiency Virus Proteins/genetics/immunology/metabolism ; Humans ; Immune Evasion/*immunology ; Killer Cells, Natural/*immunology ; Polymorphism, Genetic ; Receptors, KIR/deficiency/genetics/immunology/metabolism ; Receptors, KIR2DL2/chemistry/deficiency/genetics/immunology ; Viral Regulatory and Accessory Proteins/genetics/immunology/metabolism ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/genetics/immunology/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressP. A. Mudd ; M. A. Martins ; A. J. Ericsen ; D. C. Tully ; K. A. Power ; A. T. Bean ; S. M. Piaskowski ; L. Duan ; A. Seese ; A. D. Gladden ; K. L. Weisgrau ; J. R. Furlott ; Y. I. Kim ; M. G. Veloso de Santana ; E. Rakasz ; S. Capuano, 3rd ; N. A. Wilson ; M. C. Bonaldo ; R. Galler ; D. B. Allison ; M. Piatak, Jr. ; A. T. Haase ; J. D. Lifson ; T. M. Allen ; D. I. Watkins
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/*immunology ; Acquired Immunodeficiency Syndrome/*virology ; Animals ; CD8-Positive T-Lymphocytes/*immunology ; Disease Models, Animal ; Epitopes, T-Lymphocyte/immunology ; Female ; HIV-1/immunology ; HLA-B27 Antigen/immunology ; Humans ; Immunodominant Epitopes/immunology ; Macaca mulatta/immunology/virology ; Male ; SAIDS Vaccines/*immunology ; Simian Acquired Immunodeficiency Syndrome/immunology/*prevention & ; control/virology ; Simian Immunodeficiency Virus/growth & development/*immunology/pathogenicity ; Viral Load ; Viremia/immunology/prevention & control ; Virus Replication/*immunologyPublished by: -
4Articles: DFG German National LicensesAllen, T. M. ; Kelly, P. B. ; Anderson, J. E. ; Taylor, T. N. ; Nogar, N. S.
Springer
Published 1995Staff ViewISSN: 1432-0630Keywords: 78.65 ; 07.75 ; 81.60 ; 82.80Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Abstract In Resonant Laser Ablation (RLA), material is related and selectively ionized by a low-energy pulse from a tunable laser. The selectivity and efficiency allow detection and quantitation at very low concentrations. We demonstrate that RLA has potential use in profiling thin layer and multilayer structures. Quantitative results are reported on the analysis of 20 and 100 Å copper thin films on Si(110) surfaces. Removal rates range from 10−3 to 10−2 Å/shot. Prospects for interrogation of dopants and impurities are also evaluated.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Liposomes containing cortisol palmitate showed greater anti-inflammatory activity than water soluble cortisol succinate, following intravenous injection into rats, as sssessed by inhibition of (a) carrageenan-induced paw swelling, and (b) inflammatory responses in subcutaneous sponge implants impregnated with heat-killedMycobacterium tuberculosis.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesUrvater, J. A. ; McAdam, S. N. ; Loehrke, J. H. ; Allen, T. M. ; Moran, J. L. ; Rowell, T. J. ; Rojo, S. ; López de Castro, J.A. ; Taurog, J. D. ; Watkins, D. I.
Springer
Published 2000Staff ViewISSN: 1432-1211Keywords: Key words Nonhuman primate ; Spondyloarthropathy ; Reactive arthritis ; Autoimmunity ; Major histocompatibility locusSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The human major histocompatibility complex (MHC) class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies. Rodents that express HLA-B27 develop spondyloarthropathies, implicating HLA-B27 in the etiology of these disorders. To determine whether an HLA-B27-like molecule was associated with spondyloarthropathies in nonhuman primates, we analyzed the MHC class I cDNAs expressed in a cohort of rhesus macaques that developed reactive arthritis after an outbreak of shigellosis. We identified several cDNAs with only limited sequence similarity to HLA-B27. Interestingly, one of these MHC molecules had a B pocket identical to that of HLA-B39. Pool sequencing of radiolabeled peptides bound by this molecule demonstrated that, like HLA-B27 and HLA-B39, it could bind peptides with arginine at the second position. However, extensive analysis of the MHC class I molecules in this cohort revealed no statistically significant association between any particular MHC class I allele and susceptibility to reactive arthritis. Furthermore, none of the rhesus MHC class I molecules bore a strong resemblance to HLA-B27, indicating that reactive arthritis can develop in this animal model in the absence of an HLA-B27-like molecule. Surprisingly, there was a statistically significant association between the rhesus macaque MHC A locus allele, Mamu-A*12, and the absence of reactive arthritis following Shigella infection.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1211Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The New World primate, the cotton-top tamarin (Saguinus oedipus), expresses major histocompatibility complex (MHC) class I molecules with limited diversity. The uniqueness of the cotton-top tamarin MHC class I loci may contribute to this species’ unusual susceptibility to viral infections and high incidence of ulcerative colitis. As a prelude to examining the effect of this limited MHC class I diversity on the tamarin CD8+ T-cell receptor (TCR) repertoire, we identified expressed tamarin TCR β chain (TCRB) cDNAs by anchored and inverse polymerase chain reaction. Sequence alignments and phylogenetic comparisons with human and rhesus macaque sequences identified homologues of 21 human variable (V) gene families. Only single variable region genes were identified in each of these tamarin VB families, with the exception of the VB 5, 9, and 13 families which were comprised of two or three distinct members. The multiple genes within these three VB families do not appear to have separate human homologues, but rather aligned equally well to a single human gene from their respective VB families. These genes appear to have arisen, therefore, by duplication of certain VB genes in the tamarin ancestors following their divergence from the lineage leading to Old World primates and hominoids. Homologues of 12 of the 13 human joining (J) region genes were also identified in the tamarin. Comparison of the proportion of nonsynonymous (pN) and synonymous (pS) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions (CDR1 and CDR2). Taken together, these findings illustrate that the TCR β chain-encoding genes of the cotton-top tamarin are similar in structure and degree of complexity compared with their Old World primate and human counterparts.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1573-4927Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Abstract Five types of subunits are postulated to explain the lactate dehydrogenase zymogram patterns of cod tissues. The subunits designated A, B, and C occur predominantly in white skeletal muscle, heart, and liver tissues, respectively. The D subunit is found almost exclusively in the retina. Activity of the E subunit is found in most tissues but does not appear to be predominant in any one tissue. The A subunits are most susceptible to heat treatment. The B subunits are the least reactive when AcPyAD, an NAD analogue, is used in place of NAD. Subbands may be produced in incubating heart or muscle extracts with pyloric caeca extract or with trypsin or chymotrypsin. Subbands normally appearing in tissues zymograms may represent partially synthesized or partially degraded active LDH tetramers normally present in a metabolizing tissue. In a sampling of three Canadian and one European cod populations, four forms of the heart subunit were found. They are designated B, B′, B″, and B‴. Allele frequencies of the heart types for each population sample are compared.Type of Medium: Electronic ResourceURL: