Search Results - (Author, Cooperation:T. Lumley)

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  1. 1
    P. K. Joshi ; T. Esko ; H. Mattsson ; N. Eklund ; I. Gandin ; T. Nutile ; A. U. Jackson ; C. Schurmann ; A. V. Smith ; W. Zhang ; Y. Okada ; A. Stancakova ; J. D. Faul ; W. Zhao ; T. M. Bartz ; M. P. Concas ; N. Franceschini ; S. Enroth ; V. Vitart ; S. Trompet ; X. Guo ; D. I. Chasman ; J. R. O'Connel ; T. Corre ; S. S. Nongmaithem ; Y. Chen ; M. Mangino ; D. Ruggiero ; M. Traglia ; A. E. Farmaki ; T. Kacprowski ; A. Bjonnes ; A. van der Spek ; Y. Wu ; A. K. Giri ; L. R. Yanek ; L. Wang ; E. Hofer ; C. A. Rietveld ; O. McLeod ; M. C. Cornelis ; C. Pattaro ; N. Verweij ; C. Baumbach ; A. Abdellaoui ; H. R. Warren ; D. Vuckovic ; H. Mei ; C. Bouchard ; J. R. Perry ; S. Cappellani ; S. S. Mirza ; M. C. Benton ; U. Broeckel ; S. E. Medland ; P. A. Lind ; G. Malerba ; A. Drong ; L. Yengo ; L. F. Bielak ; D. Zhi ; P. J. van der Most ; D. Shriner ; R. Magi ; G. Hemani ; T. Karaderi ; Z. Wang ; T. Liu ; I. Demuth ; J. H. Zhao ; W. Meng ; L. Lataniotis ; S. W. van der Laan ; J. P. Bradfield ; A. R. Wood ; A. Bonnefond ; T. S. Ahluwalia ; L. M. Hall ; E. Salvi ; S. Yazar ; L. Carstensen ; H. G. de Haan ; M. Abney ; U. Afzal ; M. A. Allison ; N. Amin ; F. W. Asselbergs ; S. J. Bakker ; R. G. Barr ; S. E. Baumeister ; D. J. Benjamin ; S. Bergmann ; E. Boerwinkle ; E. P. Bottinger ; A. Campbell ; A. Chakravarti ; Y. Chan ; S. J. Chanock ; C. Chen ; Y. D. Chen ; F. S. Collins ; J. Connell ; A. Correa ; L. A. Cupples ; G. D. Smith ; G. Davies ; M. Dorr ; G. Ehret ; S. B. Ellis ; B. Feenstra ; M. F. Feitosa ; I. Ford ; C. S. Fox ; T. M. Frayling ; N. Friedrich ; F. Geller ; G. Scotland ; I. Gillham-Nasenya ; O. Gottesman ; M. Graff ; F. Grodstein ; C. Gu ; C. Haley ; C. J. Hammond ; S. E. Harris ; T. B. Harris ; N. D. Hastie ; N. L. Heard-Costa ; K. Heikkila ; L. J. Hocking ; G. Homuth ; J. J. Hottenga ; J. Huang ; J. E. Huffman ; P. G. Hysi ; M. A. Ikram ; E. Ingelsson ; A. Joensuu ; A. Johansson ; P. Jousilahti ; J. W. Jukema ; M. Kahonen ; Y. Kamatani ; S. Kanoni ; S. M. Kerr ; N. M. Khan ; P. Koellinger ; H. A. Koistinen ; M. K. Kooner ; M. Kubo ; J. Kuusisto ; J. Lahti ; L. J. Launer ; R. A. Lea ; B. Lehne ; T. Lehtimaki ; D. C. Liewald ; L. Lind ; M. Loh ; M. L. Lokki ; S. J. London ; S. J. Loomis ; A. Loukola ; Y. Lu ; T. Lumley ; A. Lundqvist ; S. Mannisto ; P. Marques-Vidal ; C. Masciullo ; A. Matchan ; R. A. Mathias ; K. Matsuda ; J. B. Meigs ; C. Meisinger ; T. Meitinger ; C. Menni ; F. D. Mentch ; E. Mihailov ; L. Milani ; M. E. Montasser ; G. W. Montgomery ; A. Morrison ; R. H. Myers ; R. Nadukuru ; P. Navarro ; M. Nelis ; M. S. Nieminen ; I. M. Nolte ; G. T. O'Connor ; A. Ogunniyi ; S. Padmanabhan ; W. R. Palmas ; J. S. Pankow ; I. Patarcic ; F. Pavani ; P. A. Peyser ; K. Pietilainen ; N. Poulter ; I. Prokopenko ; S. Ralhan ; P. Redmond ; S. S. Rich ; H. Rissanen ; A. Robino ; L. M. Rose ; R. Rose ; C. Sala ; B. Salako ; V. Salomaa ; A. P. Sarin ; R. Saxena ; H. Schmidt ; L. J. Scott ; W. R. Scott ; B. Sennblad ; S. Seshadri ; P. Sever ; S. Shrestha ; B. H. Smith ; J. A. Smith ; N. Soranzo ; N. Sotoodehnia ; L. Southam ; A. V. Stanton ; M. G. Stathopoulou ; K. Strauch ; R. J. Strawbridge ; M. J. Suderman ; N. Tandon ; S. T. Tang ; K. D. Taylor ; B. O. Tayo ; A. M. Toglhofer ; M. Tomaszewski ; N. Tsernikova ; J. Tuomilehto ; A. G. Uitterlinden ; D. Vaidya ; A. van Hylckama Vlieg ; J. van Setten ; T. Vasankari ; S. Vedantam ; E. Vlachopoulou ; D. Vozzi ; E. Vuoksimaa ; M. Waldenberger ; E. B. Ware ; W. Wentworth-Shields ; J. B. Whitfield ; S. Wild ; G. Willemsen ; C. S. Yajnik ; J. Yao ; G. Zaza ; X. Zhu ; R. M. Salem ; M. Melbye ; H. Bisgaard ; N. J. Samani ; D. Cusi ; D. A. Mackey ; R. S. Cooper ; P. Froguel ; G. Pasterkamp ; S. F. Grant ; H. Hakonarson ; L. Ferrucci ; R. A. Scott ; A. D. Morris ; C. N. Palmer ; G. Dedoussis ; P. Deloukas ; L. Bertram ; U. Lindenberger ; S. I. Berndt ; C. M. Lindgren ; N. J. Timpson ; A. Tonjes ; P. B. Munroe ; T. I. Sorensen ; C. N. Rotimi ; D. K. Arnett ; A. J. Oldehinkel ; S. L. Kardia ; B. Balkau ; G. Gambaro ; A. P. Morris ; J. G. Eriksson ; M. J. Wright ; N. G. Martin ; S. C. Hunt ; J. M. Starr ; I. J. Deary ; L. R. Griffiths ; H. Tiemeier ; N. Pirastu ; J. Kaprio ; N. J. Wareham ; L. Perusse ; J. G. Wilson ; G. Girotto ; M. J. Caulfield ; O. Raitakari ; D. I. Boomsma ; C. Gieger ; P. van der Harst ; A. A. Hicks ; P. Kraft ; J. Sinisalo ; P. Knekt ; M. Johannesson ; P. K. Magnusson ; A. Hamsten ; R. Schmidt ; I. B. Borecki ; E. Vartiainen ; D. M. Becker ; D. Bharadwaj ; K. L. Mohlke ; M. Boehnke ; C. M. van Duijn ; D. K. Sanghera ; A. Teumer ; E. Zeggini ; A. Metspalu ; P. Gasparini ; S. Ulivi ; C. Ober ; D. Toniolo ; I. Rudan ; D. J. Porteous ; M. Ciullo ; T. D. Spector ; C. Hayward ; J. Dupuis ; R. J. Loos ; A. F. Wright ; G. R. Chandak ; P. Vollenweider ; A. R. Shuldiner ; P. M. Ridker ; J. I. Rotter ; N. Sattar ; U. Gyllensten ; K. E. North ; M. Pirastu ; B. M. Psaty ; D. R. Weir ; M. Laakso ; V. Gudnason ; A. Takahashi ; J. C. Chambers ; J. S. Kooner ; D. P. Strachan ; H. Campbell ; J. N. Hirschhorn ; M. Perola ; O. Polasek ; J. F. Wilson
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-07-02
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Biological Evolution ; Blood Pressure/genetics ; Body Height/*genetics ; Cholesterol, LDL/genetics ; *Cognition ; Cohort Studies ; Educational Status ; Female ; Forced Expiratory Volume/genetics ; Genome, Human/genetics ; *Homozygote ; Humans ; Lung Volume Measurements ; Male ; Phenotype
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    C. Gieger ; A. Radhakrishnan ; A. Cvejic ; W. Tang ; E. Porcu ; G. Pistis ; J. Serbanovic-Canic ; U. Elling ; A. H. Goodall ; Y. Labrune ; L. M. Lopez ; R. Magi ; S. Meacham ; Y. Okada ; N. Pirastu ; R. Sorice ; A. Teumer ; K. Voss ; W. Zhang ; R. Ramirez-Solis ; J. C. Bis ; D. Ellinghaus ; M. Gogele ; J. J. Hottenga ; C. Langenberg ; P. Kovacs ; P. F. O'Reilly ; S. Y. Shin ; T. Esko ; J. Hartiala ; S. Kanoni ; F. Murgia ; A. Parsa ; J. Stephens ; P. van der Harst ; C. Ellen van der Schoot ; H. Allayee ; A. Attwood ; B. Balkau ; F. Bastardot ; S. Basu ; S. E. Baumeister ; G. Biino ; L. Bomba ; A. Bonnefond ; F. Cambien ; J. C. Chambers ; F. Cucca ; P. D'Adamo ; G. Davies ; R. A. de Boer ; E. J. de Geus ; A. Doring ; P. Elliott ; J. Erdmann ; D. M. Evans ; M. Falchi ; W. Feng ; A. R. Folsom ; I. H. Frazer ; Q. D. Gibson ; N. L. Glazer ; C. Hammond ; A. L. Hartikainen ; S. R. Heckbert ; C. Hengstenberg ; M. Hersch ; T. Illig ; R. J. Loos ; J. Jolley ; K. T. Khaw ; B. Kuhnel ; M. C. Kyrtsonis ; V. Lagou ; H. Lloyd-Jones ; T. Lumley ; M. Mangino ; A. Maschio ; I. Mateo Leach ; B. McKnight ; Y. Memari ; B. D. Mitchell ; G. W. Montgomery ; Y. Nakamura ; M. Nauck ; G. Navis ; U. Nothlings ; I. M. Nolte ; D. J. Porteous ; A. Pouta ; P. P. Pramstaller ; J. Pullat ; S. M. Ring ; J. I. Rotter ; D. Ruggiero ; A. Ruokonen ; C. Sala ; N. J. Samani ; J. Sambrook ; D. Schlessinger ; S. Schreiber ; H. Schunkert ; J. Scott ; N. L. Smith ; H. Snieder ; J. M. Starr ; M. Stumvoll ; A. Takahashi ; W. H. Tang ; K. Taylor ; A. Tenesa ; S. Lay Thein ; A. Tonjes ; M. Uda ; S. Ulivi ; D. J. van Veldhuisen ; P. M. Visscher ; U. Volker ; H. E. Wichmann ; K. L. Wiggins ; G. Willemsen ; T. P. Yang ; J. Hua Zhao ; P. Zitting ; J. R. Bradley ; G. V. Dedoussis ; P. Gasparini ; S. L. Hazen ; A. Metspalu ; M. Pirastu ; A. R. Shuldiner ; L. Joost van Pelt ; J. J. Zwaginga ; D. I. Boomsma ; I. J. Deary ; A. Franke ; P. Froguel ; S. K. Ganesh ; M. R. Jarvelin ; N. G. Martin ; C. Meisinger ; B. M. Psaty ; T. D. Spector ; N. J. Wareham ; J. W. Akkerman ; M. Ciullo ; P. Deloukas ; A. Greinacher ; S. Jupe ; N. Kamatani ; J. Khadake ; J. S. Kooner ; J. Penninger ; I. Prokopenko ; D. Stemple ; D. Toniolo ; L. Wernisch ; S. Sanna ; A. A. Hicks ; A. Rendon ; M. A. Ferreira ; W. H. Ouwehand ; N. Soranzo
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-12-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blood Platelets/*cytology/metabolism ; Cell Size ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Europe ; Gene Expression Profiling ; Gene Silencing ; Genome, Human/genetics ; Genome-Wide Association Study ; Hematopoiesis/*genetics ; Humans ; Megakaryocytes/*cytology/metabolism ; Platelet Count ; Protein Interaction Maps ; Transcription, Genetic/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Macri, V., Brody, J. A., Arking, D. E., Hucker, W. J., Yin, X., Lin, H., Mills, R. W., Sinner, M. F., Lubitz, S. A., Liu, C.-T., Morrison, A. C., Alonso, A., Li, N., Fedorov, V. V., Janssen, P. M., Bis, J. C., Heckbert, S. R., Dolmatova, E. V., Lumley, T., Sitlani, C. M., Cupples, L. A., Pulit, S. L., Newton-Cheh, C., Barnard, J., Smith, J. D., Van Wagoner, D. R., Chung, M. K., Vlahakes, G. J., ODonnell, C. J., Rotter, J. I., Margulies, K. B., Morley, M. P., Cappola, T. P., Benjamin, E. J., Muzny, D., Gibbs, R. A., Jackson, R. D., Magnani, J. W., Herndon, C. N., Rich, S. S., Psaty, B. M., Milan, D. J., Boerwinkle, E., Mohler, P. J., Sotoodehnia, N., Ellinor, P. T., Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Sequencing Project, NHLBI Exome Sequencing Project
    American Heart Association (AHA)
    Published 2018
    Staff View
    Publication Date:
    2018-05-16
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    1942-325X
    Electronic ISSN:
    1942-3268
    Topics:
    Medicine
    Keywords:
    Electrophysiology, Atrial Fibrillation, Ion Channels/Membrane Transport, Functional Genomics
    Published by:
    http://www.americanheart.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Lumley, T. C. ; Farquhar, M. L. ; Peterson, R. L.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-1890
    Keywords:
    Key words Pseudotsuga ; Douglas fir ; Laccaria ; Monokaryons ; Genotypes ; Ectomycorrhizas ; Anatomy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract  Seedling roots of Pseudotsuga menziesii were colonized with three monokaryotic isolates and one dikaryotic isolate of Laccaria bicolor to assess the effect of fungal genotype on ectomycorrhiza formation. Ectomycorrhizas resulting from colonization by the dikaryotic isolate had a multilayered mantle and a cortical Hartig net. One monokaryotic isolate (ss7) formed ectomycorrhizas comparable in anatomy to those induced by the dikaryotic isolate. Two other monokaryotic isolates (ss5, ss1) failed to form mantles or Hartig nets. Roots colonized by these isolates developed characteristics indicating an incompatible reaction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00204956

    Articles: DFG German National Licenses
  5. 5
    Lumley, T. C. ; Farquhar, M. L. ; Peterson, R. L.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-1890
    Keywords:
    Pseudotsuga ; Douglas fir ; Laccaria Monokaryons ; Genotypes ; Ectomycorrhizas Anatomy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract Seedling roots of Pseudotsuga menziesii were colonized with three monokaryotic isolates and one dikaryotic isolate of Laccaria bicolor to assess the effect of fungal genotype on ectomycorrhiza formation. Ectomycorrhizas resulting from colonization by the dikaryotic isolate had a multilayered mantle and a cortical Hartig net. One monokaryotic isolate (ss7) formed ectomycorrhizas comparable in anatomy to those induced by the dikaryotic isolate. Two other monokaryotic isolates (ss5, ss1) failed to form mantles or Hartig nets. Roots colonized by these isolates developed characteristics indicating an incompatible reaction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00204956

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1569-8041
    Keywords:
    cachexia ; megestrol acetate ; quality of life
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Purpose: To investigate the effect of two doses of megestrol acetate(MA) compared with placebo on quality of life (QoL) and nutritional status(NS) in patients with advanced endocrine-insensitive cancer. Patients and methods: Two hundred forty patients were randomised todouble-blind MA 480 mg/day, MA 160 mg/day, or matching placebo for 12 weeks.Nutritional status (including weight, skinfold thickness and midarmcircumference) and QoL (using 6 linear analogue self-assessment (LASA) scales)were assessed at randomisation and after four, eight and 12 weeks. A QoLranking incorporating QoL and death was also used ranging from 1 = dead to 5= much better QoL. Results: One hundred seventy-four patients were assessable at weekfour, 136 at week eight and 103 patients at week 12. Patients receiving MAreported substantially better appetite (P = 0.001), mood (P =0.001) and overall quality of life ( P 〈 0.001), and possibly lessnausea and vomiting (P = 0.08) than patients receiving placebo, basedon a test for trend. A larger benefit was seen with the higher dose which(unlike the lower dose) was significantly better in pairwise comparisons withplacebo for appetite, mood and overall QoL (each P≤ 0.001). Despitesome missing data on QoL scores, QoL ranking was available on 227 (95%)of patients with significantly higher QoL ranking associated with MA (P= 0.002). Improvements in QoL occurred early within four weeks and weresustained. No statistically significant differences were observed in NSmeasurements, including weight (P = 0.29). Side effects of therapy wereminor and did not differ significantly across treatments. Conclusion: Megestrol acetate given at 480 mg/day is usefulpalliation in patients with endocrine-insensitive advanced cancer. It improvesappetite, mood and overall quality of life in these patients, although notthrough a direct effect on nutritional status.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008291825695

    Articles: DFG German National Licenses
  7. 7
    Martin, A. J. ; Glasziou, P. P. ; Simes, R. J. ; Lumley, T.
    Springer
    Published 1998
    Staff View
    ISSN:
    1573-2649
    Keywords:
    UBQ-H ; quality of life ; utilities ; scoring system.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The Utility-based Quality of Life – Heart Questionnaire (UBQ-H) is a cardiovascular extension of the Health Measurement Questionnaire. It is a multidimensional instrument that can be scored to yield a utility estimate using the Rosser Index and a classification algorithm developed for the Health Measurement Questionnaire. The aim of this study was to employ a statistical modelling approach to devise an improved scoring system. A sample of 201 cardiovascular patients completed the UBQ-H and assessed the utility of their own health state using standard gamble and time trade-off questions in an interview. Two new scoring methods were devised by regressing the UBQ-H data against patients' self-assessed utilities. The new methods gave utility estimates that correlated with angina/dyspnoea grades, life satisfaction scores and General Health Questionnaire (GHQ) scores. In a second sample of 1,112 cardiovascular patients, the UBQ-H utilities were able to distinguish between patients who had/had not experienced an adverse event (e.g. myocardial infarction) and were responsive to changes in health over time. The new scoring methods were not particularly more sensitive to quality of life effects than the original method based on the Rosser Index. However, they produced significantly lower estimates and more accurately reflected patients' self-assessed utilities.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008857131564

    Articles: DFG German National Licenses