Search Results - (Author, Cooperation:T. Kuner)

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  1. 1
    Staff View
    Publication Date:
    2015-11-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Astrocytoma/metabolism/*pathology/radiotherapy ; Brain Neoplasms/metabolism/*pathology/radiotherapy ; Cell Communication/radiation effects ; Cell Death/radiation effects ; Cell Proliferation/radiation effects ; Cell Surface Extensions/metabolism/radiation effects ; Cell Survival/radiation effects ; Connexin 43/metabolism ; Disease Progression ; GAP-43 Protein/metabolism ; Gap Junctions/*metabolism/radiation effects ; Glioma/metabolism/pathology/radiotherapy ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Radiation Tolerance/drug effects
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Korpi, E. R. ; Kuner, T. ; Kristo, P. ; Köhler, M. ; Herb, A. ; Lüddens, H. ; Seeburg, P. H.

    Oxford, UK : Blackwell Science Ltd
    Published 1994
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Sequence variation was found in cDNA coding for the extracellular domain of the rat γ-aminobutyric acid type A (GABAA) receptor α6 subunit. About 20% of polymerase chain reaction (PCR)-amplified α6 cDNA prepared from rat cerebellar mRNA lacked nucleotides 226–255 as estimated by counting single-stranded phage plaques hybridized specifically to the short (α6S) and long (wild-type) forms of the α6 mRNA. Genomic PCR revealed an intron located upstream of the 30-nucleotide sequence. Both splice forms were detected in the cerebellum by in situ hybridization. Recombinant receptors, resulting from coexpression of the α6S subunit with the GABAA receptor β2 and γ2 subunits in human embryonic kidney 293 cells, were inactive at binding [3H]muscimol and [3H]Ro 15-4513. In agreement, injection of complementary RNAs encoding the same subunits into Xenopus oocytes produced only weak GABA-induced currents, indistinguishable from those produced by β2γ2 receptors. Therefore, the 10 amino acids encoded by the 30-nucleotide fragment may be essential for the correct assembly or folding of the α6 subunit-containing receptors.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.1994.63031167.x

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Argiotoxin ; NMDA receptor ; Recombinant ; Site-directed mutagenesis
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)81533-6

    Articles: DFG German National Licenses