Search Results - (Author, Cooperation:T. Klaus)

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  1. 1
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    POKELA, MARJA-LEENA ; ANTTILA, EIJA ; SEPPÄLÄ, TIMO ; OLKKOLA, KLAUS T.

    Oxford, UK : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1460-9592
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : The pharmacokinetics of oxycodone (13-hydroxy-7,8-dihydrocodeinone) has been studied in adults and in children who are older than 6 months but there is no information on the disposition of oxycodone in neonates and young infants. The aim of this study was to study the pharmacokinetics of oxycodone in infants varying in age from 0 to 6 months.Methods : Twenty-two infants undergoing surgery were given postoperatively an intravenous bolus of 0.1 mg·kg−1 of oxycodone hydrochloride. Ten of the patients were younger than 1 week (group 1), six from 1 week to 2 months (group 2) and six from 2 to 6 months (group 3). Plasma samples were collected for the analysis of oxycodone concentrations up to 24 h. Pharmacokinetics were characterized by noncompartmental methods.Results : The median (range) values for the clearance (Cl) were 9.9 (2.3–17.2), 20.1 (3.7–40.4) and 15.4 (14.8–80.2) ml·min−1·kg−1 in the above three groups. The values for volume of distribution at steady-state were 3.3 (1.9–4.7), 5.6 (1.3–8.5) and 3.2 (1.8–6.0) l·kg−1 and for elimination half-life (t1/2) 4.4 (2.4–14.1), 3.6 (1.6–11.6) and 2.0 (0.8–3.9) h, respectively. Both Cl (r = 0.46) and half-life (r = −0.46) were correlated to the age of the patient (P 〈 0.05). There were 13 patients who were on mechanical ventilation at the time of oxycodone administration. None of the spontaneously breathing infants had hypoventilation which required assistance during the study.Conclusions : The values for Cl and t1/2 varied greatly between the subjects. This variability was most pronounced in the two youngest groups. Routine dosing of oxycodone in young infants may be dangerous. The dose of oxycodone must be titrated individually.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-9592.2005.01571.x

    Articles: DFG German National Licenses
  3. 3
    KYLLÖNEN, MATTI ; OLKKOLA, KLAUS T. ; SEPPÄLÄ, TIMO ; RYHÄNEN, PAULI

    Oxford, UK : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1460-9592
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : Ibuprofen is a nonsteroidal anti-inflammatory drug which has both peripheral and central analgesic effects. Ibuprofen has been shown to be an effective antipyretic and postoperative analgesic drug both in adults and children with few side effects. Pharmacokinetics of rectal ibuprofen has not been studied, although suppositories are frequently used for perioperative pain control in children.Methods : There were four study groups: full-term infants aged 1–7 weeks (n = 9), infants aged 8–25 weeks (n = 8), and infants aged 26–52 weeks (n = 7). Adult patients were 20–40 years old (n = 7). Ibuprofen suppository 20 mg·kg−1 was administered after induction of anesthesia. Blood samples were collected from 20 min to 10 h after dosing and pharmacokinetic analysis of ibuprofen enantiomers were done.Results : Both ibuprofen enantiomers were detectable in blood in 20 min. Total ibuprofen plasma concentrations 〉10 mg·l−1 were seen from 40 min to 8 h. Values for Tmax of ibuprofen enantiomers and total ibuprofen were higher in the adult group than any of the infant groups (P 〈 0.05). In addition, values for physiological (standardized) t1/2 of (R)-(−)- and (S)-(+)-ibuprofen were higher in infants aged 1–7 weeks than the adults (P 〈 0.05). None of the other pharmacokinetic variables, Cmax, AUC, chronological t1/2 or AUC ratio differed between the groups.Conclusions : A single dose of ibuprofen suppository 20 mg·kg−1 after induction of anesthesia guarantees analgesic plasma concentrations during the early postoperative period. Except for the delayed absorption of ibuprofen in adults and higher physiological t1/2 in infants aged 1–7 weeks, no major pharmacokinetic differences were observed between study groups.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-9592.2005.01499.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1546-170X
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine kinase Tie-2 (refs. 1,2). Paracrine Ang-1–mediated activation of Tie-2 acts as a regulator of vessel maturation and vascular quiescence. In turn, the antagonistic ligand Ang-2 acts by an autocrine ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nm1351

    Articles: DFG German National Licenses
  5. 5
    Hammes, Hans-Peter ; Brownlee, Michael ; Jonczyk, Alfred ; Sutter, Arne ; Preissner, Klaus T.

    [s.l.] : Nature Publishing Group
    Published 1996
    Staff View
    ISSN:
    1546-170X
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor–type integrins appears to be required for the survival and maturation of newly ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nm0596-529

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0022-2852
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/jmsp.1994.1211

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0022-2852
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/jmsp.1994.1274

    Articles: DFG German National Licenses
  8. 8
    PREISSNER, KLAUS T. ; MÜLLER-BERGHAUS, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1986.tb34610.x

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1546-170X
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Staphylococcus aureus is a human pathogen that secretes proteins that contribute to bacterial colonization. Here we describe the extracellular adherence protein (Eap) as a novel anti-inflammatory factor that inhibits host leukocyte recruitment. Due to its direct interactions with the host adhesive ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nm728

    Articles: DFG German National Licenses
  10. 10
    Preissner, Klaus T.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-0584
    Keywords:
    Vitronectin ; Complement S-protein ; Cell adhesion ; Blood coagulation ; Fibrinolysis ; Humoral immune response ; Vessel wall
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Vitronectin (= complement S-protein) belongs to the group of structurally and functionally homologous adhesive proteins (fibrinogen, fibronectin, von Willebrand factor) which are essential in the procoagulant phase of the hemostatic system, interacting with platelets and the vessel wall. In addition to a structural motif in vitronectin responsible for this interaction (cell attachment domain) other functional domains in the protein molecule exist that contribute to its multifunctional role as regulator in the immune system (complement) as well as in fibrinolysis. These various activities and the ubiquitous distribution of vitronectin in the organism are discussed with regard to structurefunction relationships of the protein molecule. Vitronectin may thus provide a conceptual molecular link between cell adhesion, humoral immune response and the hemostatic system, particularly at the blood-vessel wall interphase.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00349063

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-0584
    Keywords:
    Protein C ; Functional test ; Tendency to thrombosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The important role of protein C (PC) in the regulation of hemostasis has been appreciated since the description of patients who were deficient in PC and presented with severe thromboembolic events. The potentially fatal complications associated with PC-deficiency require an early and reliable identification of those patients affected with this inherited disorder. The present study introduces a test procedure for the functional assessment of PC in plasma samples. The test utilizes the thrombin/thrombomodulin complex to achieve complete and rapid formation of activated PC whose proteolytic capacity is subsequently determined with a chromogenic substrate. Homogenate obtained from rabbit lung effectively substituted the purified component thrombomodulin in the assay system. This new approach simplifies the test procedure without losing specificity and accuracy. Proteases, such as plasmin, streptokinase and urokinase did not influence the assay and the inhibitory effect of heparin on the PC-activation could easily be overcome by the addition of protamine sulphate. The PC-activity in a group of unselected patients (n=50), who did not reveal any abnormalities in global coagulation tests, amounted to 100±12% (mean±SD) with a range from 54 to 143% when analyzed in comparison to a plasma pool constituted from healthy volunteers. Since the synthesis of PC depends on the availability of vitamin K, patients receiving phenprocoumon have also been analyzed. These patients (n=103) presented 40±11% residual PC-activity accompanied by a concomitant decrease in PC-antigen levels to 43±10% (mean±SD). The test described is specific, sensitive, less time-consuming and can be performed on a routine basis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00320533

    Articles: DFG German National Licenses
  12. 12
    Joerger, R. ; Klaus, T. ; Pettersson, J. ; Granqvist, C. G.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-1130
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Notes:
    Abstract Silver is accumulated to high concentrations in certain microbial strains. Here a bomb digestion method is proposed, using HNO3 and HCl, for the extraction and digestion of silver and silver compounds from the organic matrix. The method is applicable for the quantitative determination of silver by inductively coupled plasma atomic emission spectroscopy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002160050060

    Articles: DFG German National Licenses
  13. 13
    Cicco, N. A. ; Frey, M. ; Klaus, T. ; Kurz, S.
    Springer
    Published 1998
    Staff View
    ISSN:
    1435-1420
    Keywords:
    Key words Unstable angina ; Platelet aggregation ; Thrombosis ; Glycoprotein IIb/IIIa receptor antagonists ; coronary artery disease ; Schlüsselwörter Instabile Angina pectoris ; Plättchenaggregation ; Thrombose ; Glykoprotein IIb/IIIa Rezeptor-Antagonist ; Koronare Herzkrankheit
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung Akute Koronar-Syndrome stellen ein heterogenes Krankheitsbild mit einer gemeinsamen Ursache dar: Ruptur oder Einriß eines stabilen atheromatösen Plaques und somit Entstehung eines instabilen Plaques, auf den sich thrombotisches Material auflagern kann. Angioskopisch fand sich bei Patienten mit instabiler Angina pectoris ein weißer oder grauer Thrombus, welcher hauptsächlich aus Plättchen bestand. Die Adhäsion, Aktivierung und Aggregation von Thrombozyten sind ein zentraler Punkt in der Pathophysiologie der instabilen Angina pectoris. Ein pharmakologischer Antagonismus dieses Prozesses ist daher ein vielversprechender Ansatzpunkt für eine antithrombotische Therapie. Aspirin, Ticlopidin und Clopidogrel hemmen die Plättchen-aggregation und vermindern die Häufigkeit kardialer Ereignisse. Diese Pharmaka bewirken jedoch nur eine teilweise Hemmung der Plättchenaggregation. Die Plättchen-Aktivierung durch Agonisten wie Thrombin wird durch sie nicht beeinflußt. Eine effektivere Hemmung der Plättchen-Aggregation ist vorstellbar durch Beeinflussung der gemeinsamen Endstrecke der Plättchen-Aggregation, gesteuert über den Glykoprotein IIb/IIIa Rezeptor. Für den Einsatz bei Patienten mit instabiler Angina pectoris oder nach PTCA wurden einige Inhibitoren des Glykoprotein IIb/IIIa Rezeptors entwickelt. Dieser Artikel soll eine Übersicht geben über die Ergebnisse klinischer Studien, die den Einsatz von GP IIb/IIIa Rezeptor-Antagonisten bei Patienten mit instabiler Angina pectoris oder nach PTCA betreffen. Außerdem wird die Rolle dieser neuen Wirkstoff-Gruppe bei der Behandlung von Patienten mit akutem Koronar-Syndrom kritisch diskutiert.
    Notes:
    Summary Acute cardiac ischemic syndromes represent a continuous spectrum of disease with the same underlying cause: rupture or fissuring of a stable atheromatous plaque to form an unstable lesion with superimposed thrombus formation. Angioscopic findings show that in patients with unstable angina the thrombus is white or gray and probably consists mostly of platelets. Platelet adhesion, activation and aggregation are central to the pathophysiology of unstable angina. Pharmacological antagonism of this process is thus an attractive strategy for antithrombotic therapy. Aspirin, Ticlopidine and Clopidogrel inhibit platelet aggregation and have been shown to decrease the frequency of clinical events. However these drugs provide only partial inhibition of platelet aggregation and they do not inhibit the stimulation of platelet aggregation by agonists such as thrombin. Inhibition of the final common pathway of platelet aggregation, with the glycoprotein IIb/IIIa receptor as a target, offers a logical method of achieving greater control of platelet function. Several inhibitors of glycoprotein IIb/IIIa receptors have been evaluated for use in patients undergoing coronary angioplasty and in those with unstable angina. This article will review the results of clinical trials evaluating the GP IIb/IIIa inhibitors in the settings of PTCA and unstable angina, and provide a critical discussion on the role of this new class of drugs in the management of patients with ischemic coronary syndromes.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s003900050178

    Articles: DFG German National Licenses
  14. 14
    Speicher, Andreas ; Klaus, T. ; Eicher, T.

    New York, NY : Wiley-Blackwell
    Published 1998
    Staff View
    ISSN:
    0941-1216
    Keywords:
    Chemistry ; Organic Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Notes:
    O-(1-Benzotriazolyl)-N,N,N′,N′-tetramethyluronium Hexafluorophosphat (HBTU) und O-(7-Aza-1-benzotriazolyl)-N,N,N′,N′-tetramethyluronium Hexafluorophosphat (HATU) - Two Modern Peptide Coupling Reagents
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/prac.19983400615

    Articles: DFG German National Licenses
  15. 15
    Staff View
    Type of Medium:
    article
    Publication Date:
    2003
    Keywords:
    Medieneinsatz ; Schule ; Unterrichtsmedien ; Video
    In:
    Medien-Impulse, Bd. 11 (2003) H. 44, S. 33-35, 1029-3825
    Language:
    German

    FIS Bildung Literaturdatenbank
  16. 16
    Staff View
    Type of Medium:
    book
    Publication Date:
    1993
    Keywords:
    Förderungsmaßnahme ; Kind ; Schule ; Beratung ; Interkulturelle Bildung ; Deutsch ; Zweitsprache ; Berufsberatung ; Weiterbildung ; Elternarbeit ; Ausländer ; Jugendlicher ; Nordrhein-Westfalen
    Language:
    German

    FIS Bildung Literaturdatenbank
  17. 17
    Staff View
    Type of Medium:
    article
    Publication Date:
    1998
    Keywords:
    Autonomie ; Selbstwirksamkeit ; Schulreform ; Schule ; Modellversuch ; Innovation ; Qualität ; Deutschland
    In:
    Pädagogische Führung, Bd. 9 (1998) H. 2, S. 63-65, 0939-0413
    Language:
    German

    FIS Bildung Literaturdatenbank
  18. 18
    Staff View
    Type of Medium:
    article
    Publication Date:
    1998
    Keywords:
    Pädagogik ; Erziehungswissenschaft ; Verhalten ; Schule ; Lernen ; Lebensraum ; Bedeutung ; Funktion (Struktur) ; Jugendlicher
    In:
    Lernchancen, Bd. 1 (1998) H. 5, S. 4-5, 1434-9817
    Language:
    German

    FIS Bildung Literaturdatenbank
  19. 19
    Staff View
    Type of Medium:
    article
    Publication Date:
    1991
    Keywords:
    Schule ; Schulkultur ; Offene Schule ; Beratung ; Interkulturelle Bildung ; Bibliografie ; Qualität ; Gemeinschaftsschule
    In:
    Pädagogik (Weinheim), Bd. 43 (1991) H. 4, S. 32-33, 0933-422X
    Language:
    German
    Note:
    Literaturangaben

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  20. 20
    Schroeder, Klaus T. [Hrsg.]
    Berlin, West u.a. : Springer
    Published 1986
    Staff View
    Type of Medium:
    book
    Publication Date:
    1986
    Keywords:
    Computer ; Arbeitswelt ; Büro ; Konferenzschrift ; Produktion ; Tagung ; Karlsruhe
    Language:
    German

    FIS Bildung Literaturdatenbank