Search Results - (Author, Cooperation:T. Kawaguchi)

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  1. 1
    Y. Okada ; D. Wu ; G. Trynka ; T. Raj ; C. Terao ; K. Ikari ; Y. Kochi ; K. Ohmura ; A. Suzuki ; S. Yoshida ; R. R. Graham ; A. Manoharan ; W. Ortmann ; T. Bhangale ; J. C. Denny ; R. J. Carroll ; A. E. Eyler ; J. D. Greenberg ; J. M. Kremer ; D. A. Pappas ; L. Jiang ; J. Yin ; L. Ye ; D. F. Su ; J. Yang ; G. Xie ; E. Keystone ; H. J. Westra ; T. Esko ; A. Metspalu ; X. Zhou ; N. Gupta ; D. Mirel ; E. A. Stahl ; D. Diogo ; J. Cui ; K. Liao ; M. H. Guo ; K. Myouzen ; T. Kawaguchi ; M. J. Coenen ; P. L. van Riel ; M. A. van de Laar ; H. J. Guchelaar ; T. W. Huizinga ; P. Dieude ; X. Mariette ; S. L. Bridges, Jr. ; A. Zhernakova ; R. E. Toes ; P. P. Tak ; C. Miceli-Richard ; S. Y. Bang ; H. S. Lee ; J. Martin ; M. A. Gonzalez-Gay ; L. Rodriguez-Rodriguez ; S. Rantapaa-Dahlqvist ; L. Arlestig ; H. K. Choi ; Y. Kamatani ; P. Galan ; M. Lathrop ; S. Eyre ; J. Bowes ; A. Barton ; N. de Vries ; L. W. Moreland ; L. A. Criswell ; E. W. Karlson ; A. Taniguchi ; R. Yamada ; M. Kubo ; J. S. Liu ; S. C. Bae ; J. Worthington ; L. Padyukov ; L. Klareskog ; P. K. Gregersen ; S. Raychaudhuri ; B. E. Stranger ; P. L. De Jager ; L. Franke ; P. M. Visscher ; M. A. Brown ; H. Yamanaka ; T. Mimori ; A. Takahashi ; H. Xu ; T. W. Behrens ; K. A. Siminovitch ; S. Momohara ; F. Matsuda ; K. Yamamoto ; R. M. Plenge
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-01-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Animals ; Arthritis, Rheumatoid/*drug therapy/*genetics/metabolism/pathology ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Computational Biology ; *Drug Discovery ; Drug Repositioning ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Hematologic Neoplasms/genetics/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; *Molecular Targeted Therapy ; Polymorphism, Single Nucleotide/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    N. Kawaguchi, T. Urata, T. Hatano, K. Iida, and H. Ikuta
    American Physical Society (APS)
    Published 2018
    Staff View
    Publication Date:
    2018-04-26
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Magnetism
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Murai, S. ; Saito, H. ; Shirato, R. ; Kawaguchi, T.

    Oxford, UK : Blackwell Science Ltd
    Published 2002
    Staff View
    ISSN:
    1474-8673
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    1 The purpose of this study was to demonstrate that the adrenergic nervous system regulates the in vivo choline levels in the mouse major salivary glands. 2 Methoxamine (α1-adrenoceptor agonist, 2.5–20 mg kg−1, s.c.) elevated choline levels dose-dependently and the effect of methoxamine (10 mg kg−1) was completely inhibited by the α-adrenoceptor antagonist phentolamine (5 mg kg−1, i.p.) but not by the β-adrenoceptor antagonist propranolol (3 mg kg−1, i.p.). 3 In contrast, isoprenaline (β-adrenoceptor agonist 0.25–20 mg kg−1, s.c.) lowered choline levels and the effect of isoprenaline (2 mg kg−1) was inhibited by propranolol, but not by phentolamine. 4 Noradrenaline (1–4 mg kg−1, s.c.) manifested both the α- and β-adrenergic actions depending on its dose. Noradrenaline at 1–2 mg kg−1, lowered choline levels and the effect of noradrenaline (1 mg kg−1) was inhibited by propranolol, but not by phentolamine. On the other hand, noradrenaline (4 mg kg−1) elevated choline levels and the effect was blocked by phentolamine, but not by propranolol. 5 Tyramine (5–80 mg kg−1, s.c.) elicited the release of noradrenaline from sympathetic nerve terminals and induced essentially the same effects on the choline levels as noradrenaline. Tyramine (10 mg kg−1) lowered choline levels and the effect was inhibited by propranolol, but not by phentolamine. However, tyramine (80 mg kg−1) elevated choline levels and the effect was inhibited by phentolamine, but not by propranolol. 6 These results suggest that choline levels in the salivary glands may be under separate α- and β-adrenergic control and suggest a possibility that the neurotransmitter noradrenaline released for sympathetic nerve terminals can manage the dual control of choline levels in some autonomic organs in a characteristic dose-dependent manner.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1474-8673.2002.00237.x

    Articles: DFG German National Licenses
  4. 4
    Kanaya, T. ; Kawaguchi, T. ; Kaji, K.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1996
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    We have studied the glass transition dynamics of trans-1,4-chloroprene from microscopic view points using a quasielastic neutron scattering technique in a time range of ∼4×10−13 to ∼4×10−10 s. It was found that the so-called fast process of picosecond order appears at around the Vogel–Fulcher temperature T0, similarly to cis-1,4-polybutadiene having no large side groups [J. Chem. Phys. 98, 8262 (1993)]. It is considered that the onset temperature at around T0 must be characteristic to polymers having no large side groups or no large internal degrees of freedom. In addition to the fast process, the slow process of subnanosecond order sets in at around the glass transition temperature Tg and the activation energy of the relaxation time was found to be ∼2.5 kcal/mol. The nature of the slow process is discussed in terms of conformational transition near Tg. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.472250

    Articles: DFG German National Licenses
  5. 5
    Kanaya, T. ; Kawaguchi, T. ; Kaji, K.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1996
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The dynamics of atactic polystyrene (PS) has been studied by a quasielastic neutron scattering technique in a temperature range of 21–475 K covering the glass transition temperature Tg (=373 K). The so-called fast process in picosecond order is observed similarly to other glass-forming materials in supercooled states so far reported. However, the onset temperature of the fast process is ∼170 K below Tg in PS, which is far below Tg in contrast to the previous observations. This result implies that the fast process is not necessarily the β process predicted by the recently noted mode coupling theory. By comparing the result of hydrogenated PS with that of partially deuterated polystyrene (PS-d5) where only phenyl rings were preferentially deuterated, the origin of the fast process occurring far below Tg has been assigned to librational motion of phenyl rings, which is coupled with main chain motion near Tg. Analysis of the spectra by curve fit has suggested that the nature of the fast process changes at a temperature ∼30 K above Tg. This change also involves the appearance of a slow relaxation process in the energy range of several tens μeV. The origin of the slow process is discussed in terms of conformational transitions of the main chain. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.471037

    Articles: DFG German National Licenses
  6. 6
    Kawaguchi, T. ; Herzer, P. J. ; Inouye, M. ; Inouye, S.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1365-2958
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    In the preceding paper, we showed that a new 1.3kb retron (retron-Ec 107) in Escherichia coli is responsible for the biosynthesis of a branched-RNA-linked multicopy single-stranded DNA (msDNA-Ec107). Here, we show that this retron occurs in strains from different branches. A, B1, and D of a well-defined phylogenetic tree of a collection of wild E. coli. Sequence comparisons of the retrons from these three branches were carried out. Sequence homology was well conserved among the strains within the same branch and the retron sequence from branch A was exactly the same with that from branch D, while there were 18 base substitutions between the retrons from branch B1 and A or D, resulting in seven amino acid substitutions in reverse transcriptase. No substitutions were found in the msDNA- and msdRNA-coding regions, and there was no difference in the ability of msDNA production between them. These results suggest that the retron has probably been integrated into at least one of the three branches at an early stage of evolution and subsequently transferred to the other two branches, and also that the msDNA-producing system has been conserved during evolution with some mutations in the retron.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2958.1992.tb01478.x

    Articles: DFG German National Licenses
  7. 7
    Kawaguchi, T. ; Konishi, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2736
    Keywords:
    (Ca^2^+ + Mg^2^+)-ATPase ; (Erythrocyte membrane) ; Ca^2^+ binding ; Polyphosphoinositide ; Tryptic digestion
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0005-2736(80)90229-1

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1994.2657

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1993.1256

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    0891-5849
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0891-5849(90)90665-6

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    0888-7543
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/geno.1993.1168

    Articles: DFG German National Licenses
  12. 12
    Kanaya, T. ; Kawaguchi, T. ; Kaji, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0921-4526
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0921-4526(92)90043-R

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    0921-4534
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0921-4534(91)91619-F

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0922-338X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0922-338X(89)90048-2

    Articles: DFG German National Licenses
  15. 15
    Ueda, M. ; Kawaguchi, T. ; Arai, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0922-338X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0922-338X(94)90291-7

    Articles: DFG German National Licenses
  16. 16
    Kawaguchi, T. ; Shiro, T. ; Iwata, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0925-4005
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Electrical Engineering, Measurement and Control Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0925-4005(91)80203-V

    Articles: DFG German National Licenses
  17. 17
    Arai, M. ; Tanaka, K. ; Kawaguchi, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0922-338X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0922-338X(94)90226-7

    Articles: DFG German National Licenses
  18. 18
    Irimura, T. ; Kawaguchi, T. ; Terao, T. ; Osawa, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0008-6215
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)86141-8

    Articles: DFG German National Licenses
  19. 19
    Kawaguchi, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0009-8981
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0009-8981(73)90143-5

    Articles: DFG German National Licenses
  20. 20
    Kawaguchi, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0009-8981
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0009-8981(73)90148-4

    Articles: DFG German National Licenses