Search Results - (Author, Cooperation:T. J. Ryan)
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1Latest Papers from Table of Contents or Articles in PressD. S. Roy ; A. Arons ; T. I. Mitchell ; M. Pignatelli ; T. J. Ryan ; S. Tonegawa
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging ; Alzheimer Disease/*pathology/*physiopathology ; Amnesia/pathology/physiopathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Dendritic Spines/pathology/physiology ; Dentate Gyrus/*cytology/pathology/*physiology/physiopathology ; *Disease Models, Animal ; Early Medical Intervention ; Humans ; Long-Term Potentiation ; Male ; Memory, Episodic ; Memory, Long-Term/*physiology ; Mice ; Mice, Transgenic ; Optogenetics ; Plaque, Amyloid ; Presenilin-1/genetics ; Synapses/metabolism ; Transgenes/genetics ; tau Proteins/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. J. Ryan ; D. S. Roy ; M. Pignatelli ; A. Arons ; S. Tonegawa
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-05-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amnesia, Retrograde/chemically induced/*physiopathology ; Amygdala/chemistry/physiopathology ; Animals ; Conditioning, Classical ; Dendrites/chemistry/pathology/*physiology ; Dentate Gyrus/chemistry/pathology/physiopathology ; Fluorescent Dyes/analysis ; Luminescent Proteins/analysis ; Memory, Long-Term/*physiology ; Mice ; Neuronal Plasticity/physiology ; Protein Synthesis Inhibitors/pharmacology ; Staining and Labeling ; Synapses/physiologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. Ramirez ; X. Liu ; P. A. Lin ; J. Suh ; M. Pignatelli ; R. L. Redondo ; T. J. Ryan ; S. Tonegawa
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amygdala/physiology ; Animals ; Association ; CA1 Region, Hippocampal/cytology/*physiology ; *Conditioning (Psychology) ; Dentate Gyrus/cytology/*physiology ; Dependovirus/genetics ; Doxycycline/administration & dosage ; Fear ; Genes, fos ; Light ; Memory/*physiology ; Mental Recall/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/*physiology ; Optogenetics ; Rhodopsin/genetics/metabolismPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY. —The surface patterns of the microcirculation of the skin in the reticuloses have been examined by capillary microscopy in 26 patients.Nine representative case histories are summarized to illustrate the correlation of clinical, histological and capillary microscopic patterns.The dermal capillary changes in the reticuloses are not specific. Some of the many patterns observed are common to other disorders such as psoriasis and lichen planus.The wide range of clinical patterns reflects the variations in the capillary/epidermis relationship, in terms of which the observed changes are analysed.To provide a basis for further interpretation and for experimental investigation it is proposed as a speculative hypothesis that disordered function of reticuloendothelial cells induces the capillary and hence the epidermal changes. Possible mechanisms are discussed.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY. Delayed pressure urticaria in 15 patients has been investigated. It is characterized by the development of deep painful swelling 4–6 hours after pressure has been applied to the skin. It is sometitnes accompanied by systemic manifestations such as a leucocytosis and rigors.Delayed pressure urticaria is unaffected by antihistamines but it is controlled by steroids.The injection into the skin of saline and various pharmacological agents also causes delayed wealing. Prior treatment of the skin with 48/80 prevents the reaction.Immunofluorescent studies showed that the affected tissues contained no excess fibrinogen, immunoglobulins or complement.It is suggested that delayed pressure urticaria is related to delayed dermographism and may be due to a disorder of kinin activity.The timing and depth of the changes in vascular permeability characteristic of urticaria can be correlated. They are influenced by many mediators and by the pattern of the vasculature of the skin. A change in the timing or depth of the urticaria is the most that should be expected from the use of a single pharmacological agent in the treatment of urticaria.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesBerker, D. ; Marren, P. ; Powell and, S. M. ; Ryan, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesKAUFMAN, B. M. ; VICKERS, H. R. ; RAYNE, J. ; RYAN, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1967Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY.— Some of the factors contributing to severe intravascular stasis in the blood vessels supplying the epidermis are discussed. Changes in blood viscosity result from a variety of factors which act maximally at the peak and in the venous arm of the papillary vessel. The influence of cold on blood viscosity in the papillary vessel is particularly emphasized.The importance of aggregation of blood cells in the superficial vessels and of factors such as platelet aggregation, which may be irreversible and may influence disaggregation are discussed.The presence of “preferential channels” in the capillary meshwork of the skin is illustrated and their significance as passages permitting redistribution of blood away from the epidermis is emphasized.Studies of platelet stickiness in a group of patients suffering from sensitivity to cold and studies on blood flow in one patient with acrocyanosis are presented.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A housewife developed recurrent mouth soreness that was resistant to all topical treatments. Flatulence was also a problem at this time. Patch testing revealed a sensitivity to instant coffee (in granule form) and all symptoms regressed when contact ceased. The possible allergen is discussed. There is a need to patch test all patients with ‘idiopathic’ mouth soreness. The importance of keeping records of possible precipitating factors is discussed.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesBurge, S. M. ; Millard, P. R. ; Wojnarowska, F. ; Ryan, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Cell adhesion in clinically normal and involved skin in Darier's disease has been investigated using a suction blister technique. We have been unable to detect a subclinical abnormality in cell adhesion which could predispose to the development of acantholytic papules. There may be synthesis of functionally deficient desmosomes, increased breakdown of desmosomes or abnormalities in other adhesion proteins on the surface of the keradnocyte in Darier's disease, but the abnormality in adhesion is focal and restricted to the clinically and histologically abnormal papules.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesCOLVER, G. B. ; MORTIMER, P. S. ; MILLARD, P. R. ; DAWBER, R. P. R. ; RYAN, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Reticulate pigmentation of the neck is seen in some subjects with atopic eczema. It involves the anterior or antero-lateral aspects. It is often interpreted as an unwashed appearance and we have called it the ‘Dirty Neck’. Two patterns have emerged. One is found in mildly eczematous, young patients who have a marked increase in pigment during the summer months; it may be confluent in some parts and reticulate in others. The second pattern is a feature of severe atopic eczema, develops after puberty and shows little seasonal variation. Neither pattern is necessarily associated with eczema of the affected area. The morphological and histological characteristics of the ‘Dirty Neck’ are described and possible aetiologies discussed. Distinctions are drawn from ichthyotic ‘dirty necks’ and other types of reticulate pigmentations.Type of Medium: Electronic ResourceURL: