Search Results - (Author, Cooperation:T. J. Mitchison)
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1Latest Papers from Table of Contents or Articles in PressS. Dumont ; E. D. Salmon ; T. J. Mitchison
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle Proteins/genetics/metabolism ; Chromosomal Proteins, Non-Histone/genetics/metabolism ; Chromosome Segregation/genetics/*physiology ; Kinetochores/chemistry/*physiology ; Mechanical Processes ; *Metaphase ; Motion ; Nuclear Proteins/genetics/metabolism ; PotoroidaePublished by: -
2Latest Papers from Table of Contents or Articles in PressR. D. Vale ; J. DeRisi ; R. Phillips ; R. D. Mullins ; C. Waterman ; T. J. Mitchison
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-12-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Curriculum ; *Education, Graduate ; Faculty ; *Interdisciplinary Communication ; Laboratories ; Massachusetts ; Physiology/*education ; *Research ; TeachingPublished by: -
3Latest Papers from Table of Contents or Articles in PressP. A. Nguyen ; A. C. Groen ; M. Loose ; K. Ishihara ; M. Wuhr ; C. M. Field ; T. J. Mitchison
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Membrane/chemistry/*physiology ; *Cell-Free System ; Centrosome/physiology ; *Cytokinesis ; DNA-Binding Proteins/genetics/metabolism ; Guanosine Triphosphate/metabolism ; Kinesin/genetics/metabolism ; Lipid Bilayers ; Microtubules/physiology ; Models, Biological ; Nuclear Proteins/genetics/metabolism ; *Signal Transduction ; Xenopus laevis ; rhoA GTP-Binding Protein/metabolismPublished by: -
4Articles: DFG German National LicensesYarrow, Justin C. ; Horton, Mike A. ; Mahadevan, L. ; Mitchison, T. J. ; Charras, Guillaume T.
[s.l.] : Macmillian Magazines Ltd.
Published 2005Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Current models for protrusive motility in animal cells focus on cytoskeleton-based mechanisms, where localized protrusion is driven by local regulation of actin biochemistry. In plants and fungi, protrusion is driven primarily by hydrostatic pressure. For hydrostatic pressure to drive localized ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Microtubules are long polymers of the protein tubulin that form a network within cells to help arrange the cell components and provide transport tracks for motor proteins. Rather than being static permanent structures, microtubules continuously grow and shrink through the polymerization and ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesHyman, A. A. ; Middleton, K. ; Centola, M. ; Mitchison, T. J. ; Carbon, J.
[s.l.] : Nature Publishing Group
Published 1992Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] A single point mutation in the CDEIII region of the centromere, RN2011, dramatically decreases the fidelity of chromosome transmission4'6. The CBF3 complex of proteins binds to a DNA-affinity column containing CEN DNA sequences, but not an affinity column containing CEN DNA sequences with the ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] DURING mitosis, chromosomes interact with the spindle through specialized structures called kinetochores, to which spindle microtubules attach. The importance of kinetochores in chromosome segregation has been clear since their discovery by early cytologists1, and recent studies of the ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesKoshland, Douglas E. ; Mitchison, T. J. ; Kirschner, Marc W.
[s.l.] : Nature Publishing Group
Published 1988Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We constructed complexes between isolated chromosomes and microtubules made from purified tubulin to study the movement of chromosomes towards the 'minus' end of microtubules in vitro, a process analogous to the movement of chromosomes towards the pole of the spindle at anaphase of mitosis. Our ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] DURING the past few years, visitors to the Schliwa-Euteneuer laboratory in the University of California at Berkeley have been entertained by the gradual spread of a large freshwater amoeba over the available bench space. This organism, which resembles a large piece of slime, first appeared on the ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0886-1544Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineAdditional Material: 1 Ill.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0886-1544Keywords: mitosis ; cytochalasin ; cell polarity ; tissue culture ; Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: When PtK2 cells round up in mitosis they leave retraction fibers attached between the substrate and the cell body. Retraction fibers and the region where they meet the cell body are rich in actin filaments as judged by phalloidin staining and electron microscopy. Video microscopy was used to study actin dependent motile processes on retraction fibers. Small, phase-dense nodules form spontaneously on the fibers, and move in to the cell body at a rate of 3 μm/minute. As they move in they increase progressively in phase-density. This movement appears to be related to actin dependent centripetal movement which has been previously studied in lamellipodia. Despite its generality, the mechanism of such movement is unknown, and retraction fibers present some special advantages for its study. Cytochalasin treatment causes nodules to stop moving and dissolve. Withdrawal of the drug causes them to reform and start moving. Surprisingly, movement after cytochalasin withdrawal was often outward, indicating a local reversal of cortical polarity. After a few minutes correct polarity is reestablished by a global control mechanism. The implications of these observations for the mechanism and polarity of actin dependent motility is discussed. © 1992 Wiley-Liss, Inc.Additional Material: 9 Ill.Type of Medium: Electronic ResourceURL: