Search Results - (Author, Cooperation:T. J. Anderson)

2012-04-12

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Antimalarials/*pharmacology/therapeutic use ; Artemisinins/*pharmacology/therapeutic use ; Cambodia ; DNA Copy Number Variations ; Drug Resistance/*genetics ; Gene Frequency ; Genetic Association Studies ; *Genome, Protozoan ; Haplotypes ; Humans ; Laos ; Malaria, Falciparum/drug therapy/*parasitology ; Microsatellite Repeats ; Plasmodium falciparum/*drug effects/*genetics ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; *Selection, Genetic ; Thailand

2013-11-23

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Animals ; Drug Resistance/*genetics ; Gene Knockdown Techniques ; Genetic Linkage ; Helminth Proteins/*genetics ; Humans ; Molecular Sequence Data ; Mutation ; Oxamniquine/*pharmacology ; Phylogeny ; Protein Conformation ; Quantitative Trait Loci ; RNA Interference ; Schistosoma mansoni/*drug effects/*genetics ; Schistosomicides/*pharmacology ; Sulfotransferases/chemistry/classification/*genetics

2018-06-20

American Heart Association (AHA)

1941-9651

1942-0080

Medicine

Congenital Heart Disease

2012-09-01

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Alleles ; Amino Acid Sequence ; Amino Acid Substitution ; Arabidopsis/genetics/metabolism/parasitology ; *Brassicaceae/genetics/metabolism/parasitology ; Cytochrome P-450 Enzyme System/*genetics ; Gene Dosage ; Gene-Environment Interaction ; Glucosinolates/biosynthesis/*genetics ; Herbivory/physiology ; Methionine/genetics/metabolism ; Molecular Sequence Data ; Plant Leaves/genetics/metabolism/parasitology ; Plants, Genetically Modified/genetics/metabolism/parasitology ; Polymorphism, Genetic ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; *Selection, Genetic

1077-3118

AIP Digital Archive

Physics

We have studied the defect engineering in metalorganic vapor phase epitaxy InxGa1−x As by controlled oxygen doping. Diethylaluminum ethoxide (DEALO) was used as an oxygen precursor to provide the intentional deep level incorporation. DEALO doping in InxGa1−xAs:Si with x≤0.25 resulted in the reduction in carrier concentrations. The Al and O incorporation with a DEALO mole fraction was weakly dependent on alloy composition for x≤0.25. The degree of electrical compensation, however, decreased as the In content increased at the same oxygen content. Deep level transient spectroscopy investigations on a series of InxGa1−xAs:Si:O samples with x ranging from 0 to 0.18 reveal a set of oxygen-derived deep levels, similar to those found in DEALO-doped GaAs. These characteristic deep levels appear to remain at a relatively constant energy with respect to the valence band, as compared to the rapid decrease in the conduction band of InxGa1−xAs with x. © 1995 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Deep level transient spectroscopy (DLTS) and cathodoluminescence (CL) were used to study the hydrogen passivation of misfit dislocations in In0.06Ga0.94As/GaAs heterostructures. The CL observations indicate that hydrogen plasma exposure passivates most, but not all, of the dark line defects existing in the specimen prior to hydrogenation. The concentration of deep level defect states that cannot be passivated is below the detection limit of the DLTS instrument (approximately 4×1012 cm−3). We find the passivation is stable after anneals at temperatures as high as 600 °C, indicating that hydrogen passivation of misfit dislocations is at least as stable as that of the isolated point defect studied previously with DLTS [W. C. Dautremont-Smith, J. C. Nabity, V. Swaminathan, M. Stavola, J. Chevalier, C. W. Tu, and S. J. Pearton, Appl. Phys. Lett. 49 1098 (1986)].

Electronic Resource

1089-7550

AIP Digital Archive

Physics

A novel method of enhancing Schottky barrier height, while reducing the surface-state density on n-type In0.53Ga0.47 As surfaces using P2S5/(NH4)2S and (NH4)2Sx passivation is described in this communication. The current-voltage and capacitance-voltage characteristics show that passivated diodes have lower reverse leakage current and higher effective barrier height than that of the unpassivated diodes. The electrical characteristics of passivated diodes have not changed after one month of exposure to the air.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

On review of the histology of 1050 primary breast carcinomas, 103 cases of infiltrating lobular carcinoma were identified and clinical and survival data collected in each case. The tumours were then separated into four groups on the basis of histological pattern and these groups shown to have significantly different survival times. Assessment of the presence of in situ carcinoma, elastosis and intracyto-plasmic lumina was performed in each case and the effect of these features on survival investigated. In addition to stage of disease at presentation, the major significant factor in predicting survival of patients with this type of invasive carcinoma is histological type.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2761

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Medicine

Abstract. To prepare a diagnostic test, the polymerase chain reaction (PCR) with universal primers was used to amplify the internal transcribed spacer 1 (ITS1) of Marteilia sydneyi rDNA. A radiolabelled probe for M. sydneyi comprising putative ITS1 rDNA gave a strong signal for genomic DNA from M. sydneyi and no signal for host genomic DNA in Southern blots. A PCR to detect M. sydneyi used a forward primer designed from an internal site within the sequenced region and a reverse universal primer. It amplified a 650-bp fragment of M. sydneyi DNA when a combination of host and parasite DNA, extracted from an infected oyster, was used as the template.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

1432-0649

07.60 ; 33.00 ; 42.80

Springer Online Journal Archives 1860-2000

Physics

Abstract An approach to CARS, with considerable potential as a diagnostic for advanced airbreathing propulsion devices, is described and demonstrated. The technique is capable of providing simultaneous measurements of the major constitutents in H2/air combustion. The method employs both broadband and narrowband Stokes beams to generate CARS via two, two-color and two, three-color wave mixing processes. Temperature and concentration information are simultaneously available from N2, H2, and H2O. This permits the disappearance of fuel and appearance of product to be monitored. An analysis of the technique's capabilities and future improvements are discussed.

Electronic Resource

1432-2307

Cell death ; Epithelium ; Breast ; Human ; Apoptosis

Springer Online Journal Archives 1860-2000

Medicine

Summary For the first time the process of epithelial cell deletion was studied within the parenchymal component of the “resting” human breast. The dying cells were initially recognised by specific nuclear changes involving peripheral condensation of the chromatin and nucleolar disintegration. At this stage the cells were retracted from the lumen and had lost desmosomal connections with their neighbours. Within the cytoplasm, there was evidence of ribosomal detachment from the endoplasmic reticulum with the formation of ribosome aggregates. The majority of dying cells were phagocytosed at this stage although a few underwent further morphological changes. These involved blebbing and fragmentation of the nucleus followed by cytoplasmic fragmentation. The dying cells and cell fragments were phagocytosed by epithelial or myoepithelial cells as well as mononuclear phagocytes and undergo lysosomal digestion within the phagosomes. These progressive morphological changes were consistent with cell deletion occurring by apoptosis.

Electronic Resource

1432-2307

Breast ; Human ; Pregnancy ; Ultrastructure ; Morphology

Springer Online Journal Archives 1860-2000

Medicine

Summary In this study the structural changes which occur during human pregnancy were examined by light and electron microscopy. Pregnancy was associated with proliferation and differentiation of the epithelial cells within the lobules. Proliferation was continuous throughout pregnancy with a progressive increase in the size of the lobules. The highest level of mitosis was observed in the first trimester with lower levels in the second and third trimesters. Unexpectedly a number of apoptotic cells were observed during pregnancy. Differentiation was initiated in the second trimester with an increase in the amount of rough endoplasmic reticulum and the appearance of a hypertrophic Golgi body and lipid droplets within a number of epithelial cells. A number of small vacuoles were present close to the apical plasmalemma of a few epithelial cells. As the pregnancy proceeded there was an increase in the number of cells exhibiting these features. There was also an increase in the size of the lipid droplets and the number of apical vacuoles. The apical vacuoles which have not been described previously range in size from 150–600 nm with the contents of the larger vacuoles having a whorled or labyrinth-like appearance.

Electronic Resource

1432-2307

Breast ; Human ; Pregnancy ; Proliferation ; Secretion

Springer Online Journal Archives 1860-2000

Medicine

Summary In this study the proliferative and secretory activity of human pregnant and lactating breast has been examined. 17 cases of pregnant tissue were obtained, comprising 9 from first trimester, 6 from the second and 2 from the third, together with 3 cases of lactating breast. Proliferation, measured by 3H thymidine autoradiography, gave a constant Thymidine labelling index of approximately 6% during the first 20 weeks, with a reduction by 50% thereafter. Levels of 0.2% were seen during lactation. Morphological assessment showed a high frequency of both mitosis and apoptosis throughout gestation. Although mitotic frequency did reduce with time, values were more variable than thymidine labelling. The reduction in thymidine uptake halfway through pregnancy coincided with generalised morphological lactational differentiation and the major immunocytochemical expression of alpha-lactalbumin. However, cytoplasmic expression of the secretory component of IgA was generalised and marked even during the first trimester and was closely related to increased proliferation and general synthetic cellular activity. These and other observations support a complex relationship of autocrine and paracrine factors in addition to the customary endocrine ones for breast regulation.

Electronic Resource

0032-1966

English, American Studies

Honorable Mentions

1432-0568

Breast ; Human ; Lactation ; Ultrastructure ; Morphology

Springer Online Journal Archives 1860-2000

Medicine

Summary In this study the morphological features of lactation in the human breast were examined by scanning and transmission electron microscopy. The lactating lobules comprised large numbers of interconnecting acini which were lined by a single layer of epithelial cells with underlying myoepithelial cells. Marked variations were noted in the shape of the epithelial cells. The myoepithelial cells formed an open meshwork of interconnecting cytoplasmic processes packed with myofibrils. The basal cytoplasm of the epithelial cells was packed with rough endoplasmic reticulum while the apical cytoplasm contained a hypertrophic Golgi body, numerous vacuoles (a few of which contained casein micelles), a number of lipid droplets and small coated and uncoated vesicles. The lipid droplets were released by progressive protrusion from the apical surface. They remained covered by the plasmalemma and were finally budded off into the lumen. In certain cases a portion of cytoplasm was released with the lipid droplet. The vacuoles and small vesicles fused with the plasmalemma and released their contents by exocytosis. Within the samples the majority of epithelial cells were actively lactating although examples of undifferentiated “resting” and dead (lysed) cells were also identified.

Electronic Resource

1432-0827

Springer Online Journal Archives 1860-2000

Biology

Medicine

Physics

Electronic Resource