Search Results - (Author, Cooperation:T. Iqbal)
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1Latest Papers from Table of Contents or Articles in PressC. J. Paddon ; P. J. Westfall ; D. J. Pitera ; K. Benjamin ; K. Fisher ; D. McPhee ; M. D. Leavell ; A. Tai ; A. Main ; D. Eng ; D. R. Polichuk ; K. H. Teoh ; D. W. Reed ; T. Treynor ; J. Lenihan ; M. Fleck ; S. Bajad ; G. Dang ; D. Dengrove ; D. Diola ; G. Dorin ; K. W. Ellens ; S. Fickes ; J. Galazzo ; S. P. Gaucher ; T. Geistlinger ; R. Henry ; M. Hepp ; T. Horning ; T. Iqbal ; H. Jiang ; L. Kizer ; B. Lieu ; D. Melis ; N. Moss ; R. Regentin ; S. Secrest ; H. Tsuruta ; R. Vazquez ; L. F. Westblade ; L. Xu ; M. Yu ; Y. Zhang ; L. Zhao ; J. Lievense ; P. S. Covello ; J. D. Keasling ; K. K. Reiling ; N. S. Renninger ; J. D. Newman
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antimalarials/economics/isolation & purification/metabolism/supply & distribution ; Artemisinins/chemistry/economics/isolation & purification/*metabolism/*supply & ; distribution ; *Biosynthetic Pathways ; Biotechnology ; Fermentation ; Genetic Engineering ; Malaria, Falciparum/drug therapy ; Molecular Sequence Data ; Saccharomyces cerevisiae/classification/genetics/growth & development/*metabolism ; Singlet Oxygen/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: The metaplastic columnar epithelium in Barrett's oesophagus has malignant potential. Aim: To determine whether decreasing acid reflux leads to regression of Barrett's epithelium. Method: Twenty-four patients with Barrett's oesophagus were treated with omeprazole 20 mg o.m. in an open, prospective study; 11 were treated for 12 months, and 13 for 24 months. Another group of 17 patients with Barrett's oesophagus was treated with an H2-receptor antagonist in standard dosage for 12-36 (mean 23) months. Patients were assessed endoscopically. Results: No evidence of significant shortening of the length of Barrett's oesophagus was seen in any patient treated for 12 or 24 months with omeprazole. Similarly, no shortening of the length of Barrett's oesophagus was seen in any patient treated with an H2-receptor antagonist. However, 6 of 11 patients treated with omeprazole for 12 months, and 7 of 13 treated for 24 months, developed macroscopic squamous islands visible below the squamo-columnar junction. This was not seen in any patient treated with an H2-receptor antagonist. Conclusion: Although there can be reappearance of squamous epithelium in Barrett's oesophagus of some patients during treatment with omeprazole 20 mg o.m. over 12–24 months, a significant shortening of the columnar lined segment is not seen.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesCooper, B. T. ; Neumann, C. S. ; Cox, M. A. ; Iqbal, T. H.
Oxford UK : Blackwell Science Ltd
Published 1998Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Because of the malignant potential of Barrett’s oesophagus, an aim of treatment is to cause the columnar epithelium to regress. A logical approach is to decrease acid reflux which is an important aetiological factor in Barrett’s oesophagus. Treatment with omeprazole 20–80 mg over 1–3 years has yielded conflicting but largely disappointing results.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To determine if treatment of Barrett’s oesophagus with omeprazole 20 mg daily for up to 6 years can cause regression of the Barrett’s epithelium.〈section xml:id="abs1-3"〉〈title type="main"〉Patients and Methods:Forty-seven patients with Barrett’s oesophagus were treated in an open prospective study. Nine patients were treated for 2 years, 12 for 3 years, 10 for 4 years, eight for 5 years and eight for 6 years. Patients were endoscoped at 1–2-year intervals and endoscoped at the end of the treatment period.〈section xml:id="abs1-4"〉〈title type="main"〉Results:No significant shortening of the length of the Barrett’s segment was seen during any treatment period, although omeprazole controlled reflux symptoms and was well tolerated. Macroscopic squamous islands appeared in 55% of patients, mostly in the first 2–3 years although in five patients they appeared later in treatment.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Treatment of Barrett’s oesophagus with omeprazole 20 mg daily for periods of up to 6 years did not cause regression in the length of the Barrett’s segment, but it did lead in over half of the patients to partial re-epithelialization in the form of squamous islands.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0040-6090Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0040-6090Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: