Search Results - (Author, Cooperation:T. Hunt)
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1Sean E. Cavanagh; John P. Towers; Joni D. Wallis; Laurence T. Hunt; Steven W. Kennerley
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-08-30Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
2Staff View
Publication Date: 2018-03-07Publisher: American Chemical Society (ACS)Print ISSN: 0001-4842Electronic ISSN: 1520-4898Topics: Chemistry and PharmacologyPublished by: -
3Micah T. Nelp, Patrick A. Kates, John T. Hunt, John A. Newitt, Aaron Balog, Derrick Maley, Xiao Zhu, Lynn Abell, Alban Allentoff, Robert Borzilleri, Hal A. Lewis, Zeyu Lin, Steven P. Seitz, Chunhong Yan, John T. Groves
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-03-28Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
4S. T. Hunt ; M. Milina ; A. C. Alba-Rubio ; C. H. Hendon ; J. A. Dumesic ; Y. Roman-Leshkov
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5D. G. MacArthur ; S. Balasubramanian ; A. Frankish ; N. Huang ; J. Morris ; K. Walter ; L. Jostins ; L. Habegger ; J. K. Pickrell ; S. B. Montgomery ; C. A. Albers ; Z. D. Zhang ; D. F. Conrad ; G. Lunter ; H. Zheng ; Q. Ayub ; M. A. DePristo ; E. Banks ; M. Hu ; R. E. Handsaker ; J. A. Rosenfeld ; M. Fromer ; M. Jin ; X. J. Mu ; E. Khurana ; K. Ye ; M. Kay ; G. I. Saunders ; M. M. Suner ; T. Hunt ; I. H. Barnes ; C. Amid ; D. R. Carvalho-Silva ; A. H. Bignell ; C. Snow ; B. Yngvadottir ; S. Bumpstead ; D. N. Cooper ; Y. Xue ; I. G. Romero ; J. Wang ; Y. Li ; R. A. Gibbs ; S. A. McCarroll ; E. T. Dermitzakis ; J. K. Pritchard ; J. C. Barrett ; J. Harrow ; M. E. Hurles ; M. B. Gerstein ; C. Tyler-Smith
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-02-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Disease/genetics ; Gene Expression ; Gene Frequency ; *Genetic Variation ; *Genome, Human ; Humans ; Phenotype ; Polymorphism, Single Nucleotide ; Proteins/*genetics ; Selection, GeneticPublished by: -
6Staff View
Publication Date: 2014-07-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Biomedical Research/*manpower ; *Career Choice ; *Career Mobility ; Great Britain ; Nobel Prize ; Physiology/manpower ; Research PersonnelPublished by: -
7M. A. Groenen ; A. L. Archibald ; H. Uenishi ; C. K. Tuggle ; Y. Takeuchi ; M. F. Rothschild ; C. Rogel-Gaillard ; C. Park ; D. Milan ; H. J. Megens ; S. Li ; D. M. Larkin ; H. Kim ; L. A. Frantz ; M. Caccamo ; H. Ahn ; B. L. Aken ; A. Anselmo ; C. Anthon ; L. Auvil ; B. Badaoui ; C. W. Beattie ; C. Bendixen ; D. Berman ; F. Blecha ; J. Blomberg ; L. Bolund ; M. Bosse ; S. Botti ; Z. Bujie ; M. Bystrom ; B. Capitanu ; D. Carvalho-Silva ; P. Chardon ; C. Chen ; R. Cheng ; S. H. Choi ; W. Chow ; R. C. Clark ; C. Clee ; R. P. Crooijmans ; H. D. Dawson ; P. Dehais ; F. De Sapio ; B. Dibbits ; N. Drou ; Z. Q. Du ; K. Eversole ; J. Fadista ; S. Fairley ; T. Faraut ; G. J. Faulkner ; K. E. Fowler ; M. Fredholm ; E. Fritz ; J. G. Gilbert ; E. Giuffra ; J. Gorodkin ; D. K. Griffin ; J. L. Harrow ; A. Hayward ; K. Howe ; Z. L. Hu ; S. J. Humphray ; T. Hunt ; H. Hornshoj ; J. T. Jeon ; P. Jern ; M. Jones ; J. Jurka ; H. Kanamori ; R. Kapetanovic ; J. Kim ; J. H. Kim ; K. W. Kim ; T. H. Kim ; G. Larson ; K. Lee ; K. T. Lee ; R. Leggett ; H. A. Lewin ; Y. Li ; W. Liu ; J. E. Loveland ; Y. Lu ; J. K. Lunney ; J. Ma ; O. Madsen ; K. Mann ; L. Matthews ; S. McLaren ; T. Morozumi ; M. P. Murtaugh ; J. Narayan ; D. T. Nguyen ; P. Ni ; S. J. Oh ; S. Onteru ; F. Panitz ; E. W. Park ; H. S. Park ; G. Pascal ; Y. Paudel ; M. Perez-Enciso ; R. Ramirez-Gonzalez ; J. M. Reecy ; S. Rodriguez-Zas ; G. A. Rohrer ; L. Rund ; Y. Sang ; K. Schachtschneider ; J. G. Schraiber ; J. Schwartz ; L. Scobie ; C. Scott ; S. Searle ; B. Servin ; B. R. Southey ; G. Sperber ; P. Stadler ; J. V. Sweedler ; H. Tafer ; B. Thomsen ; R. Wali ; J. Wang ; S. White ; X. Xu ; M. Yerle ; G. Zhang ; J. Zhang ; S. Zhao ; J. Rogers ; C. Churcher ; L. B. Schook
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-11-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Demography ; Genome/*genetics ; Models, Animal ; Molecular Sequence Data ; *Phylogeny ; Population Dynamics ; Sus scrofa/*classification/*geneticsPublished by: -
8Durant, S. T., Zheng, L., Wang, Y., Chen, K., Zhang, L., Zhang, T., Yang, Z., Riches, L., Trinidad, A. G., Fok, J. H. L., Hunt, T., Pike, K. G., Wilson, J., Smith, A., Colclough, N., Reddy, V. P., Sykes, A., Janefeldt, A., Johnström, P., Varnäs, K., Takano, A., Ling, S., Orme, J., Stott, J., Roberts, C., Barrett, I., Jones, G., Roudier, M., Pierce, A., Allen, J., Kahn, J., Sule, A., Karlin, J., Cronin, A., Chapman, M., Valerie, K., Illingworth, R., Pass, M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-06-21Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
9Ehrlich, H. Paul ; Zederfeldt, Bengt ; Hunt, T. K. ; Lindblad, William J.
Oxford, UK : Blackwell Science
Published 1993Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
10Aslam, R. S. ; Scheuenstuhl, H. ; Beckert, S. ; Hopf, H. ; Hussain, Z. ; Hunt, T. K.
Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
Published 2004Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: INTRODUCTION: High concentrations of lactate approx. 10 mM are characteristic of wound healing. We have previously shown that lactate instigates release of VEGF from macrophages and endothelial cells. Our present study uses an in vivo murine Matrigel model to study how lactate enhances vascular development and repair.METHODS: Matrigel is a reconstituted basement membrane complex, a liquid at 4 degree C. When injected subcutaneously, it reconstitutes as a gel. 30 mgs of finely divided polylactate polymer (DL-lactide-co-glycolide) was mixed with 1cc of Matrigel, and 2 injections were made into the dorsum of each of 60 (average 7/group), 6-month-old Swiss Webster mice. The gel implants were harvested at 3, 6, 9, 11 and 16 days post injection, and were fixed in buffered formalin or frozen. Cell migration and vascular development were assessed using H&E, anti-CD31 and anti-MAC3 antibody stainings for leukocytes, fibroblasts, endothelial cells, and macrophages. Cells and vessels were quantified microscopically.RESULTS: Control implants (without polylactate) developed little or no inflammation or angiogenesis. Polylactated implants developed highly significant number of endothelial cells and recognizable vessels at 6 and 9 days. At 11 and 16 days, sizeable vessels with surrounding connective tissue were found. Though a moderate inflammation occurred in the lactate groups, no foreign body reaction was seen. Larger implants of high molecular weight instigated little inflammation and few vessels.CONCLUSION: Slowly released lactate leads to the formation of new vessels. Our results provide support for further clinical applications of lactate polymer in wounds.NIH/NIGMS Trauma Training GrantType of Medium: Electronic ResourceURL: -
11Kelly, M. J. ; Hunt, T. M. ; Wicks, A. C. B. ; Mayne, C. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
12Fisher, J. W. ; Hunt, T. P. ; Putnam, M. E. ; Livingston, M. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1752-1688Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: : Static 96-hour median lethal concentrations were determined for the water-soluble fraction (WSF) of both petroleum-derived and shale-derived avaiation fuels (JP-4 and JP-8) using fathead minnows. JP-8 was more toxic than JP-4 except for one shale JP-4 sample that was as toxic as the JP-8. Petroleum and shale JP-8 were similar in toxicity. The toxicity of shale JP-4 was less clear. Shale JP-4 from three vendor sources revealed differing toxicity values. One shale JP-4 sample was more toxic and one less toxic than its petroleum analogue, with the third being equally toxic. Toxicity of the fuels may be enhanced by compounds in the WSF that correspond to chemicals containing 10 or more carbon atoms.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1467-8535Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EducationType of Medium: Electronic ResourceURL: -
14Deen, W ; Cousens, R ; Warringa, J ; Bastiaans, L ; Carberry, P ; Rebel, K ; Riha, S ; Murphy, C ; Benjamin, L R ; Cloughley, C ; Cussans, J ; Forcella, F ; Hunt, T. ; Jamieson, P ; Lindquist, J ; Wang, E
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-3180Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary To date, several crop : weed competition models have been developed. Developers of the various models were invited to compare model performance using a common data set. The data set consisted of wheat and Lolium rigidum grown in monoculture and mixtures under dryland and irrigated conditions. Results from four crop : weed competition models are presented: almanac, apsim, cropsim and intercom. For all models, deviations between observed and predicted values for monoculture wheat were only slightly lower than for wheat grown in competition with L. rigidum, even though the workshop participants had access to monoculture data while parameterizing models. Much of the error in simulating competition outcome was associated with difficulties in accurately simulating growth of individual species. Relatively simple competition algorithms were capable of accounting for the majority of the competition response. Increasing model complexity did not appear to dramatically improve model accuracy. Comparison of specific competition processes, such as radiation interception, was very difficult since the effects of these processes within each model could not be isolated. Algorithms for competition processes need to be modularised in such a way that exchange, evaluation and comparison across models is facilitated.Type of Medium: Electronic ResourceURL: -
15HUNT, T. C. ; SUMMERS, J. A. ; CAMPOS, M. G. ; RIMMER, S. J. ; STURTON, G. ; PALFAI, S. ; CHURCH, M. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Eosinophil, major basic protein (M BP), purified from guinea pig eosinophil granules was used to raise five monoclonal antibodies (MoAbs). Their reactivity with MBP was confirmed by immunoblotting and indirect ELISA. Two of the MoAbs were used to develop a sensitive and specific antigen capture (sandwich) ELISA for guinea pig eosinophil M BP which gives an accurate and reproducible standard curve over the range of 10-10000 ng/ml. The specificity of the ELISA for MBP was confirmed and its suitability for testing biological samples ascertained by measurement of MBP in bronchoalveolar lavage fluid (BALF) and plasma from guinea pigs sensitized and challenged with ovalbumin. The ELISA was also capable of detecting MBP in culture supernatants from purified eosinophil preparations challenged with calcium ionophore in vitro. One of the monoclonal could be used to strongly and specifically stain guinea pig eosinophils in immunocytochemistry, whilst all five could be used to visualize eosinophils in suspension in BALF or peritoneal lavage fluid by flow cytometry. There was no staining of other guinea pig leucocyte types, nor crossreactivity with human eosinophils by immunocytochemistry or Row cytometry.Type of Medium: Electronic ResourceURL: -
16HUNT, T. C. ; CAMPBELL, A. M. ; ROBINSON, C. ; HOLGATE, S. T.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have examined cells dispersed enzymatically from three different sites in (he bovine lung (tracheal mucosa, bronchial mucosa and parenchyma) and the skin, in order to ascertain whether the bovine model could be used to study mast cell heterogeneity. Histochemically there were two sub-populations of mast cells present in both lung and skin (on the basis of toluidine blue staining and the sensitivity to formalin fixation), but their proportions were similar in all sites studied. Skin mast cells contained approximately twice the amount of histamine than their counterparts in the lung (P 〈 0.05). Functional heterogeneity was examined by in vitro release of histamine following secretagogue challenge. Calcium ionophore induced a substantial release of histamine; skin mast cells releasing significantly more histamine than any of the lung mast cells (at 10 μm ionophore, 37.1% and 20.7% net histamine release, respectively, P 〈 0.05), although the time-course of release from the two tissues was similar. The neuropeptides vasoactive intestinal peptide and somatostatin induced a modest but statistically significant release of histamine from both skin and lung mast cells, whilst substance P only induced histamine secretion from skin mast cells. A range of other potential immunological and non-immunological secretagogues was unsuccessful in eliciting histamine release from mast cells in any of the tissues. We conclude that there were no convincing histochemical differences between mast cells from the sites examined in the lung or skin. Additionally, there was no discernabie functional heterogeneity between mast cells within the lung, but functional differences were evident between mast cells of the bovine lung and skin. However, in the absence of a suitable immunological stimulus the bovine model cannot be regarded as a good model of mast cell heterogeneity.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Culture supernatants from dogfish leucocytes, exposed to the Ca2+ ionophore A23187, were analyzed for eicosanoid production by gas chromatography-electron capture mass spectrometry. Consistently high levels of the prostaglandins (PG) D2, F2α and E2 were produced, while thromboxane B2 and leukotriene B4 were found in smaller amounts. No 6-oxo PGF1α, a degradation product of prostacyclin, or 13,14-dihydro-15-oxo-PGF2α, a metabolite of PGE2 and PGF2α, were detected. The results are compared with similar experiments using mammalian leucocytes.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 0047-2441Topics: General, InterdisciplinaryURL: -
19Staff View
ISSN: 0029-2397Topics: English, American StudiesHistoryNotes: NOTES AND COMMENTSURL: -
20Staff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: